Published in Biochemistry on October 05, 1999
Mutational spectrum analysis of RNase H(35) deficient Saccharomyces cerevisiae using fluorescence-based directed termination PCR. Nucleic Acids Res (2000) 1.50
The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1. Proc Natl Acad Sci U S A (2004) 1.49
Functional regulation of FEN1 nuclease and its link to cancer. Nucleic Acids Res (2010) 1.35
The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis. J Biol Chem (2009) 1.27
The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair. EMBO J (2002) 1.23
Flap endonuclease 1. Annu Rev Biochem (2013) 1.21
Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates. J Biol Chem (2009) 1.18
Molecular interactions of human Exo1 with DNA. Nucleic Acids Res (2002) 1.16
Flap endonuclease 1 mechanism analysis indicates flap base binding prior to threading. J Biol Chem (2010) 1.09
The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations. Nucleic Acids Res (2006) 1.09
Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex. J Biol Chem (2009) 1.08
Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends. Nucleic Acids Res (2012) 1.06
Interactions of mutant and wild-type flap endonucleases with oligonucleotide substrates suggest an alternative model of DNA binding. Proc Natl Acad Sci U S A (2002) 0.96
Double strand binding-single strand incision mechanism for human flap endonuclease: implications for the superfamily. Mech Ageing Dev (2012) 0.90
The wonders of flap endonucleases: structure, function, mechanism and regulation. Subcell Biochem (2012) 0.90
Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1. Nucleic Acids Res (2012) 0.86
Telomere proteins POT1, TRF1 and TRF2 augment long-patch base excision repair in vitro. Cell Cycle (2012) 0.85
Reconstitution of eukaryotic lagging strand DNA replication. Methods (2010) 0.84
The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication. Nucleic Acids Res (2015) 0.84
Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding. Nucleic Acids Res (2014) 0.81
Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand. J Biol Chem (2015) 0.80
Direct observation of DNA threading in flap endonuclease complexes. Nat Struct Mol Biol (2016) 0.80
Evidence for base excision repair processing of DNA interstrand crosslinks. Mutat Res (2012) 0.80
Base excision repair in chromatin: Insights from reconstituted systems. DNA Repair (Amst) (2015) 0.80
Unusually wide co-factor tolerance in a metalloenzyme; divalent metal ions modulate endo-exonuclease activity in T5 exonuclease. Nucleic Acids Res (2001) 0.79
Base excision repair in physiology and pathology of the central nervous system. Int J Mol Sci (2012) 0.78
A model for transition of 5'-nuclease domain of DNA polymerase I from inert to active modes. PLoS One (2011) 0.78
Activity of FEN1 endonuclease on nucleosome substrates is dependent upon DNA sequence but not flap orientation. J Biol Chem (2011) 0.78
Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins. Archaea (2014) 0.77
Rate-determining Step of Flap Endonuclease 1 (FEN1) Reflects a Kinetic Bias against Long Flaps and Trinucleotide Repeat Sequences. J Biol Chem (2015) 0.76
Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines. Nature (1996) 4.70
RPA involvement in the damage-recognition and incision steps of nucleotide excision repair. Nature (1995) 3.06
Enzymes and reactions at the eukaryotic DNA replication fork. J Biol Chem (1997) 2.87
Calf 5' to 3' exo/endonuclease must slide from a 5' end of the substrate to perform structure-specific cleavage. J Biol Chem (1995) 2.62
Enzymatic completion of mammalian lagging-strand DNA replication. Proc Natl Acad Sci U S A (1994) 2.11
Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1. J Biol Chem (2000) 1.97
Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J Immunol (1995) 1.84
Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase. J Virol (1992) 1.80
Influence of human immunodeficiency virus nucleocapsid protein on synthesis and strand transfer by the reverse transcriptase in vitro. J Biol Chem (1995) 1.79
Purification and characterization of two new high molecular weight forms of DNA polymerase delta. Biochemistry (1986) 1.75
Polymerization and RNase H activities of the reverse transcriptases from avian myeloblastosis, human immunodeficiency, and Moloney murine leukemia viruses are functionally uncoupled. J Biol Chem (1991) 1.74
Revised nomenclature for eukaryotic DNA polymerases. Eur J Biochem (1990) 1.73
Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am J Pathol (1997) 1.71
Strand transfer mediated by human immunodeficiency virus reverse transcriptase in vitro is promoted by pausing and results in misincorporation. J Biol Chem (1995) 1.68
Proteolytic mapping of human replication protein A: evidence for multiple structural domains and a conformational change upon interaction with single-stranded DNA. Biochemistry (1996) 1.63
Site-specific pausing of deoxyribonucleic acid synthesis catalyzed by four forms of Escherichia coli DNA polymerase III. Biochemistry (1983) 1.63
Evidence for a unique mechanism of strand transfer from the transactivation response region of HIV-1. J Biol Chem (1997) 1.62
Exonucleolytic proofreading by calf thymus DNA polymerase delta. Proc Natl Acad Sci U S A (1987) 1.61
Completion of mammalian lagging strand DNA replication using purified proteins. J Biol Chem (1993) 1.57
Size classes of products synthesized processively by DNA polymerase III and DNA polymerase III holoenzyme of Escherichia coli. J Biol Chem (1981) 1.52
The calf 5'- to 3'-exonuclease is also an endonuclease with both activities dependent on primers annealed upstream of the point of cleavage. J Biol Chem (1994) 1.49
Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptase. Nucleic Acids Res (1993) 1.46
Fidelity of mammalian DNA replication and replicative DNA polymerases. Biochemistry (1991) 1.43
Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. J Biol Chem (1996) 1.43
Inhibition of flap endonuclease 1 by flap secondary structure and relevance to repeat sequence expansion. J Biol Chem (2000) 1.42
Mutations within the primer grip region of HIV-1 reverse transcriptase result in loss of RNase H function. J Biol Chem (1997) 1.38
Human immunodeficiency virus reverse transcriptase displays a partially processive 3' to 5' endonuclease activity. J Biol Chem (1991) 1.35
Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest. J Biol Chem (1997) 1.33
Helix structure and ends of RNA/DNA hybrids direct the cleavage specificity of HIV-1 reverse transcriptase RNase H. J Biol Chem (1996) 1.32
Activation of human monocytes through CD40 induces matrix metalloproteinases. J Immunol (1996) 1.32
Sequence requirements for estrogen receptor binding to estrogen response elements. J Biol Chem (1998) 1.32
A 5' to 3' exonuclease functionally interacts with calf DNA polymerase epsilon. Proc Natl Acad Sci U S A (1992) 1.31
Junction ribonuclease: an activity in Okazaki fragment processing. Proc Natl Acad Sci U S A (1998) 1.31
Size classes of products synthesized processively by two subassemblies of Escherichia coli DNA polymerase III holoenzyme. J Biol Chem (1982) 1.30
Human DNA ligase I efficiently seals nicks in nucleosomes. EMBO J (2000) 1.30
Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H. Proc Natl Acad Sci U S A (2000) 1.30
Cell cycle-dependent phosphorylation of human DNA polymerase alpha. J Biol Chem (1991) 1.27
Activation of p34cdc2 coincident with taxol-induced apoptosis. Cell Growth Differ (1994) 1.26
Elongation of RNA-primed DNA templates by DNA polymerase alpha from Drosophila melanogaster embryos. J Biol Chem (1981) 1.24
Parameters that influence the binding of human immunodeficiency virus reverse transcriptase to nucleic acid structures. Biochemistry (1993) 1.24
The kissing hairpin sequence promotes recombination within the HIV-I 5' leader region. J Biol Chem (2001) 1.24
DNA ligase I and proliferating cell nuclear antigen form a functional complex. J Biol Chem (2001) 1.22
Calf RTH-1 nuclease can remove the initiator RNAs of Okazaki fragments by endonuclease activity. J Biol Chem (1996) 1.22
Parameters that influence processive synthesis and site-specific termination by human immunodeficiency virus reverse transcriptase on RNA and DNA templates. Biochim Biophys Acta (1992) 1.20
Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage. Mol Cell Biol (2001) 1.19
Use of an oligoribonucleotide containing the polypurine tract sequence as a primer by HIV reverse transcriptase. J Biol Chem (1995) 1.17
Properties of two forms of DNA polymerase delta from calf thymus. Biochemistry (1986) 1.16
Creation and removal of embedded ribonucleotides in chromosomal DNA during mammalian Okazaki fragment processing. J Biol Chem (1997) 1.15
Calf thymus DNA polymerases alpha and delta are capable of highly processive DNA synthesis. Biochemistry (1988) 1.14
Purification of a calf thymus DNA-dependent adenosinetriphosphatase that prefers a primer-template junction effector. Biochemistry (1986) 1.13
Regulation of inflammatory responses by oncostatin M. J Immunol (1999) 1.13
Chicken ovalbumin upstream promoter-transcription factor interacts with estrogen receptor, binds to estrogen response elements and half-sites, and inhibits estrogen-induced gene expression. J Biol Chem (1997) 1.12
The mechanism of human immunodeficiency virus reverse transcriptase-catalyzed strand transfer from internal regions of heteropolymeric RNA templates. J Biol Chem (1994) 1.12
Nevirapine alters the cleavage specificity of ribonuclease H of human immunodeficiency virus 1 reverse transcriptase. J Biol Chem (1995) 1.12
Requirements for the catalysis of strand transfer synthesis by retroviral DNA polymerases. J Biol Chem (1991) 1.12
Human RAD2 homolog 1 5'- to 3'-exo/endonuclease can efficiently excise a displaced DNA fragment containing a 5'-terminal abasic lesion by endonuclease activity. J Biol Chem (1996) 1.11
On the processive mechanism of Escherichia coli DNA polymerase I. Quantitative assessment of processivity. J Biol Chem (1978) 1.10
Requirement for proliferating cell nuclear antigen expression during stages of the Chinese hamster ovary cell cycle. Biochemistry (1989) 1.09
Relationship between plus strand DNA synthesis removal of downstream segments of RNA by human immunodeficiency virus, murine leukemia virus and avian myeloblastoma virus reverse transcriptases. Nucleic Acids Res (1996) 1.09
hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress. Oncogene (2008) 1.09
The sequential mechanism of HIV reverse transcriptase RNase H. J Biol Chem (2000) 1.08
Strand displacement synthesis of the long terminal repeats by HIV reverse transcriptase. J Biol Chem (1996) 1.07
Kinetic characteristics which distinguish two forms of calf thymus DNA polymerase alpha. Biochemistry (1981) 1.07
Mutations in the primer grip region of HIV reverse transcriptase can increase replication fidelity. J Biol Chem (1999) 1.06
Quantitative analysis of RNA cleavage during RNA-directed DNA synthesis by human immunodeficiency and avian myeloblastosis virus reverse transcriptases. Nucleic Acids Res (1994) 1.06
Immunoaffinity purification and properties of a high molecular weight calf thymus DNA alpha-polymerase. Biochemistry (1984) 1.03
Pausing by retroviral DNA polymerases promotes strand transfer from internal regions of RNA donor templates to homopolymeric acceptor templates. Biochim Biophys Acta (1993) 1.02
Effects of multiple estrogen responsive elements, their spacing, and location on estrogen response of reporter genes. Mol Endocrinol (1997) 1.02
Regulatory roles of p21 and apurinic/apyrimidinic endonuclease 1 in base excision repair. J Biol Chem (2001) 1.02
Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease. Med Hypotheses (1999) 1.00
The beta subunit of the Escherichia coli DNA polymerase III holoenzyme interacts functionally with the catalytic core in the absence of other subunits. J Biol Chem (1986) 1.00
Properties of a high-affinity DNA binding site for estrogen receptor. Proc Natl Acad Sci U S A (1988) 1.00
Strand displacement synthesis in the central polypurine tract region of HIV-1 promotes DNA to DNA strand transfer recombination. J Biol Chem (1996) 0.99
Cytotoxicity of the anticancer agents cisplatin and taxol during cell proliferation and the cell cycle. Int J Cancer (1994) 0.99
Control of initiation of viral plus strand DNA synthesis by HIV reverse transcriptase. J Biol Chem (1998) 0.99
Structural relationships between two forms of DNA polymerase epsilon from calf thymus. J Biol Chem (1992) 0.98
Transcriptionally active Xenopus laevis somatic 5 S ribosomal RNA genes are packaged with hyperacetylated histone H4, whereas transcriptionally silent oocyte genes are not. J Biol Chem (1998) 0.98
Mutation of the methylated tRNA(Lys)(3) residue A58 disrupts reverse transcription and inhibits replication of human immunodeficiency virus type 1. J Virol (2001) 0.97
Cooperative estrogen receptor interaction with consensus or variant estrogen responsive elements in vitro. Cancer Res (1992) 0.96
Inhibition of HIV-1 replication using a mutated tRNALys-3 primer. J Biol Chem (1997) 0.95
Replication protein A stimulates long patch DNA base excision repair. J Biol Chem (1998) 0.95
Role of calf RTH-1 nuclease in removal of 5'-ribonucleotides during Okazaki fragment processing. Biochemistry (1996) 0.94
Mechanism of tracking and cleavage of adduct-damaged DNA substrates by the mammalian 5'- to 3'-exonuclease/endonuclease RAD2 homologue 1 or flap endonuclease 1. J Biol Chem (1996) 0.93
On the processive mechanism of Escherichia coli DNA polymerase I. Delayed initiation of polymerization. J Biol Chem (1976) 0.93
Processing of an HIV replication intermediate by the human DNA replication enzyme FEN1. J Biol Chem (1998) 0.92