Published in Cardiovasc Res on May 01, 1999
Transmural dispersion of repolarization in failing and nonfailing human ventricle. Circ Res (2010) 3.02
Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature (2012) 2.59
Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium. J Physiol (2000) 2.59
Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current. J Cardiovasc Electrophysiol (2006) 2.56
Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiol Rev (2009) 2.53
Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes. Am J Physiol Heart Circ Physiol (2007) 2.28
Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells. Cardiovasc Res (2014) 2.25
Heart failure enhances susceptibility to arrhythmogenic cardiac alternans. Heart Rhythm (2008) 2.17
Drug-induced torsades de pointes and implications for drug development. J Cardiovasc Electrophysiol (2004) 2.05
Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles. J Physiol (2004) 1.96
NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function. EMBO J (2003) 1.87
Rate-dependent action potential alternans in human heart failure implicates abnormal intracellular calcium handling. Heart Rhythm (2010) 1.79
Electrophysiologic substrate and intraventricular left ventricular dyssynchrony in nonischemic heart failure patients undergoing cardiac resynchronization therapy. Heart Rhythm (2011) 1.67
Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes. Europace (2007) 1.57
Conduction remodeling in human end-stage nonischemic left ventricular cardiomyopathy. Circulation (2012) 1.53
Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability. Eur J Heart Fail (2006) 1.47
Electrophysiological and structural remodeling in heart failure modulate arrhythmogenesis. 2D simulation study. PLoS One (2014) 1.46
Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve. Br J Pharmacol (2002) 1.44
Phenomics of cardiac chloride channels: the systematic study of chloride channel function in the heart. J Physiol (2009) 1.42
Mechanisms contributing to myocardial potassium channel diversity, regulation and remodeling. Trends Cardiovasc Med (2015) 1.42
Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ Cycling. PLoS One (2015) 1.41
Heterogeneity and cardiac arrhythmias: an overview. Heart Rhythm (2007) 1.41
Mixed signals in heart failure: cancer rules. J Clin Invest (2002) 1.36
Noninvasive electrocardiographic imaging of arrhythmogenic substrates in humans. Circ Res (2013) 1.36
Autonomic aspects of arrhythmogenesis: the enduring and the new. Curr Opin Cardiol (2004) 1.35
Cellular mechanisms of arrhythmogenic cardiac alternans. Prog Biophys Mol Biol (2008) 1.32
Sudden cardiac death secondary to antidepressant and antipsychotic drugs. Expert Opin Drug Saf (2008) 1.30
Spontaneous calcium release in tissue from the failing canine heart. Am J Physiol Heart Circ Physiol (2009) 1.25
Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1. J Physiol (2003) 1.21
Angiotensin II and stretch activate NADPH oxidase to destabilize cardiac Kv4.3 channel mRNA. Circ Res (2006) 1.20
Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts. Pflugers Arch (2009) 1.20
Mechanisms and potential therapeutic targets for ventricular arrhythmias associated with impaired cardiac calcium cycling. J Mol Cell Cardiol (2007) 1.17
mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study. PLoS One (2013) 1.16
Cardiac myosin binding protein-C: redefining its structure and function. Biophys Rev (2012) 1.15
Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure. PLoS One (2007) 1.14
Effects of aldosterone on transient outward K+ current density in rat ventricular myocytes. J Physiol (2001) 1.08
Amplification of spatial dispersion of repolarization underlies sudden cardiac death associated with catecholaminergic polymorphic VT, long QT, short QT and Brugada syndromes. J Intern Med (2006) 1.08
Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization. FASEB J (2010) 1.08
Modulation of transmural repolarization. Ann N Y Acad Sci (2005) 1.07
Electrophysiological remodeling in heart failure. J Mol Cell Cardiol (2010) 1.05
Inhibition of the rapid component of the delayed rectifier potassium current in ventricular myocytes by angiotensin II via the AT1 receptor. Br J Pharmacol (2008) 1.05
Deleting the accessory subunit KChIP2 results in loss of I(to,f) and increased I(K,slow) that maintains normal action potential configuration. Heart Rhythm (2008) 1.04
Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block. J Physiol (2006) 1.03
Cardiac repolarization. The long and short of it. Europace (2005) 1.00
Overview of Basic Mechanisms of Cardiac Arrhythmia. Card Electrophysiol Clin (2011) 0.99
Fever accentuates transmural dispersion of repolarization and facilitates development of early afterdepolarizations and torsade de pointes under long-QT Conditions. Circ Arrhythm Electrophysiol (2008) 0.99
The ClC-3 chloride channels in cardiovascular disease. Acta Pharmacol Sin (2011) 0.99
PKA phosphorylation of HERG protein regulates the rate of channel synthesis. Am J Physiol Heart Circ Physiol (2009) 0.99
New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy. Trends Cardiovasc Med (2007) 0.98
The role of sodium channel current in modulating transmural dispersion of repolarization and arrhythmogenesis. J Cardiovasc Electrophysiol (2006) 0.97
KChIP2 attenuates cardiac hypertrophy through regulation of Ito and intracellular calcium signaling. J Mol Cell Cardiol (2010) 0.96
Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts. J Am Heart Assoc (2013) 0.95
Cytoskeletal actin microfilaments and the transient outward potassium current in hypertrophied rat ventriculocytes. J Physiol (2002) 0.95
Drug-induced spatial dispersion of repolarization. Cardiol J (2008) 0.94
Mammalian enabled (Mena) is a critical regulator of cardiac function. Am J Physiol Heart Circ Physiol (2011) 0.94
Simulation and mechanistic investigation of the arrhythmogenic role of the late sodium current in human heart failure. PLoS One (2012) 0.93
A simulation study of cellular hypertrophy and connexin lateralization in cardiac tissue. Biophys J (2010) 0.92
Robust L-type calcium current expression following heterozygous knockout of the Cav1.2 gene in adult mouse heart. J Physiol (2011) 0.92
Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias. Front Physiol (2014) 0.92
Diet-induced obesity causes long QT and reduces transcription of voltage-gated potassium channels. J Mol Cell Cardiol (2013) 0.91
Cardiac electrical remodeling in health and disease. Trends Pharmacol Sci (2011) 0.91
Remodeling of calcium handling in human heart failure. Adv Exp Med Biol (2012) 0.91
Modulation of CaV1.2 channels by Mg2+ acting at an EF-hand motif in the COOH-terminal domain. J Gen Physiol (2005) 0.91
Simultaneous parasympathetic and sympathetic activation reveals altered autonomic control of heart rate, vascular tension, and epinephrine release in anesthetized hypertensive rats. Front Neurol (2011) 0.90
The interaction of Ca2+ with sarcomeric proteins: role in function and dysfunction of the heart. Am J Physiol Heart Circ Physiol (2011) 0.90
AUF1 is upregulated by angiotensin II to destabilize cardiac Kv4.3 channel mRNA. J Mol Cell Cardiol (2008) 0.90
Downregulation of neuronal sodium channel subunits Nav1.1 and Nav1.6 in the sinoatrial node from volume-overloaded heart failure rat. Pflugers Arch (2007) 0.89
Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling. Physiol Genomics (2008) 0.89
Gender differences in electrophysiological gene expression in failing and non-failing human hearts. PLoS One (2013) 0.89
Right ventricular arrhythmogenesis in failing human heart: the role of conduction and repolarization remodeling. Am J Physiol Heart Circ Physiol (2012) 0.88
Ionic bases for electrical remodeling of the canine cardiac ventricle. Am J Physiol Heart Circ Physiol (2013) 0.87
Cardiac metabolism and arrhythmias. Circ Arrhythm Electrophysiol (2009) 0.87
Intra-uterine growth restriction and the programming of left ventricular remodelling in female rats. J Physiol (2005) 0.86
Low-intensity interval exercise training attenuates coronary vascular dysfunction and preserves Ca²⁺-sensitive K⁺ current in miniature swine with LV hypertrophy. Am J Physiol Heart Circ Physiol (2011) 0.86
Sarcolemmal ATP-sensitive potassium channels modulate skeletal muscle function under low-intensity workloads. J Gen Physiol (2013) 0.86
The functional role of electrophysiological heterogeneity in the rabbit ventricle during rapid pacing and arrhythmias. Am J Physiol Heart Circ Physiol (2013) 0.86
Pathogenesis of arrhythmias in a model of CKD. J Am Soc Nephrol (2014) 0.86
Phenomics of cardiac chloride channels. Compr Physiol (2013) 0.86
Arrhythmogenic remodelling of activation and repolarization in the failing human heart. Europace (2012) 0.86
Ion channelopathies in human induced pluripotent stem cell derived cardiomyocytes: a dynamic clamp study with virtual IK1. Front Physiol (2015) 0.86
Reduced response to IKr blockade and altered hERG1a/1b stoichiometry in human heart failure. J Mol Cell Cardiol (2015) 0.86
Long-term blockade of L/N-type Ca(2+) channels by cilnidipine ameliorates repolarization abnormality of the canine hypertrophied heart. Br J Pharmacol (2009) 0.85
Adult progenitor cell transplantation influences contractile performance and calcium handling of recipient cardiomyocytes. Am J Physiol Heart Circ Physiol (2009) 0.85
Protein kinase A activity at the endoplasmic reticulum surface is responsible for augmentation of human ether-a-go-go-related gene product (HERG). J Biol Chem (2011) 0.85
Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy. PLoS One (2012) 0.85
Increased response to β₂-adrenoreceptor stimulation augments inhibition of IKr in heart failure ventricular myocytes. PLoS One (2012) 0.84
Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk. Br J Pharmacol (2004) 0.84
Integrative modeling of the cardiac ventricular myocyte. Wiley Interdiscip Rev Syst Biol Med (2010) 0.84
Effects of cardioselective KATP channel antagonism on basal, stimulated, and ischaemic myocardial function in in vivo failing canine heart. Br J Pharmacol (2002) 0.84
Enhanced Ca²+ influx through cardiac L-type Ca²+ channels maintains the systolic Ca²+ transient in early cardiac atrophy induced by mechanical unloading. Pflugers Arch (2013) 0.84
Intercalated disc-associated protein, mXin-alpha, influences surface expression of ITO currents in ventricular myocytes. Front Biosci (Elite Ed) (2011) 0.83
Role of TGF-beta on cardiac structural and electrical remodeling. Vasc Health Risk Manag (2008) 0.83
A method to measure myocardial calcium handling in adult Drosophila. Circ Res (2011) 0.83
T-tubule disruption promotes calcium alternans in failing ventricular myocytes: mechanistic insights from computational modeling. J Mol Cell Cardiol (2014) 0.82
Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy. Br J Pharmacol (2013) 0.82
Overexpression of M₃ muscarinic receptor is a novel strategy for preventing sudden cardiac death in transgenic mice. Mol Med (2011) 0.82
Regulation of the human ether-a-go-go-related gene (hERG) channel by Rab4 protein through neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2). J Biol Chem (2013) 0.82
The Importance of Biological Sex and Estrogen in Rodent Models of Cardiovascular Health and Disease. Circ Res (2016) 0.82
Enhanced sensitivity to drug-induced QT interval lengthening in patients with heart failure due to left ventricular systolic dysfunction. J Clin Pharmacol (2011) 0.81
Molecular and cellular mechanisms of myocardial stunning. Physiol Rev (1999) 3.16
Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies. Circ Res (1999) 3.03
Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circ Res (1999) 2.65
Inducible genetic suppression of neuronal excitability. J Neurosci (1999) 2.32
Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes. Nat Cell Biol (2001) 2.14
Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy. Circulation (2001) 2.07
Molecular composition of mitochondrial ATP-sensitive potassium channels probed by viral Kir gene transfer. J Mol Cell Cardiol (2000) 1.88
Modulation of mitochondrial ATP-dependent K+ channels by protein kinase C. Circ Res (1998) 1.71
Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure. Circ Res (1999) 1.71
Transgenic mouse model of stunned myocardium. Science (2000) 1.62
Selective pharmacological agents implicate mitochondrial but not sarcolemmal K(ATP) channels in ischemic cardioprotection. Circulation (2000) 1.61
Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection. Circ Res (2001) 1.59
Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice. Circ Res (2001) 1.56
Functional association of the beta 1 subunit with human cardiac (hH1) and rat skeletal muscle (mu 1) sodium channel alpha subunits expressed in Xenopus oocytes. J Gen Physiol (1995) 1.53
Molecular basis of electrocardiographic ST-segment elevation. Circ Res (2000) 1.51
Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells. Circ Res (2001) 1.46
Focal modification of electrical conduction in the heart by viral gene transfer. Nat Med (2000) 1.45
Activation of mitochondrial ATP-dependent potassium channels by nitric oxide. Circulation (2000) 1.39
Cellular basis of ventricular arrhythmias and abnormal automaticity in heart failure. Am J Physiol (1999) 1.38
Functional properties of cardiac L-type calcium channels transiently expressed in HEK293 cells. Roles of alpha 1 and beta subunits. J Gen Physiol (1995) 1.34
Cardiac sodium channels (hH1) are intrinsically more sensitive to block by lidocaine than are skeletal muscle (mu 1) channels. J Gen Physiol (1995) 1.33
Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels. Mol Pharmacol (2001) 1.31
Novel myofilament Ca2+-sensitizing property of xanthine oxidase inhibitors. Circ Res (1998) 1.31
Pharmacological and histochemical distinctions between molecularly defined sarcolemmal KATP channels and native cardiac mitochondrial KATP channels. Mol Pharmacol (1999) 1.24
Clockwise domain arrangement of the sodium channel revealed by (mu)-conotoxin (GIIIA) docking orientation. J Biol Chem (2001) 1.24
ATP consumption by uncoupled mitochondria activates sarcolemmal K(ATP) channels in cardiac myocytes. Am J Physiol Heart Circ Physiol (2001) 1.22
Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis. Circ Res (2001) 1.21
The stuttering progress of cell therapy for heart disease. Clin Pharmacol Ther (2011) 1.20
Adenovirus-mediated inducible gene expression in vivo by a hybrid ecdysone receptor. Mol Ther (2000) 1.19
Electrical and structural remodeling of the failing ventricle. Pharmacol Ther (2002) 1.18
Non-cell-autonomous effects of vector-expressed regulatory RNAs in mammalian heart cells. Gene Ther (2009) 1.18
Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels. J Am Coll Cardiol (2000) 1.12
Mitochondrial ATP-dependent potassium channels. Viable candidate effectors of ischemic preconditioning. Ann N Y Acad Sci (1999) 1.11
Mitochondria: a new target for K channel openers? Trends Pharmacol Sci (1999) 1.10
Origin of contractile dysfunction in heart failure: calcium cycling versus myofilaments. Circulation (1999) 1.09
Molecular dynamics of the sodium channel pore vary with gating: interactions between P-segment motions and inactivation. J Neurosci (1999) 1.09
Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1. Circ Res (2001) 1.08
Lidocaine induces a slow inactivated state in rat skeletal muscle sodium channels. J Physiol (2000) 1.06
A revised view of cardiac sodium channel "blockade" in the long-QT syndrome. J Clin Invest (2000) 1.01
Sudden cardiac death, genes, and arrhythmogenesis : consideration of new population and mechanistic approaches from a national heart, lung, and blood institute workshop, part I. Circulation (2001) 1.01
Molecular architecture of the voltage-dependent Na channel: functional evidence for alpha helices in the pore. J Gen Physiol (2001) 1.00
Manipulation of cellular excitability by cell fusion: effects of rapid introduction of transient outward K+ current on the guinea pig action potential. Circ Res (1999) 0.99
Overexpression of a human potassium channel suppresses cardiac hyperexcitability in rabbit ventricular myocytes. J Clin Invest (1999) 0.97
Adenosine primes the opening of mitochondrial ATP-sensitive potassium channels: a key step in ischemic preconditioning? Circulation (2000) 0.97
Phosphodiesterase inhibitor-mediated potentiation of adenovirus delivery to myocardium. J Mol Cell Cardiol (2001) 0.96
Charged residues between the selectivity filter and S6 segments contribute to the permeation phenotype of the sodium channel. J Gen Physiol (2000) 0.96
The role of mitochondrial K(ATP) channels in cardioprotection. Basic Res Cardiol (2000) 0.95
Sarcoplasmic reticulum Ca(2+) atpase (SERCA) 1a structurally substitutes for SERCA2a in the cardiac sarcoplasmic reticulum and increases cardiac Ca(2+) handling capacity. Circ Res (2001) 0.93
Altered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathy. J Clin Invest (1999) 0.93
Sudden cardiac death, genes, and arrhythmogenesis: consideration of new population and mechanistic approaches from a National Heart, Lung, and Blood Institute workshop, Part II. Circulation (2001) 0.93
A mouse model of myocardial stunning. Mol Med Today (2000) 0.92
Viral gene transfer of dominant-negative Kv4 construct suppresses an O2-sensitive K+ current in chemoreceptor cells. J Neurosci (2000) 0.92
Inaugural editorial: a new era for Circulation Research. Circ Res (1999) 0.91
Distinct gene-specific mechanisms of arrhythmia revealed by cardiac gene transfer of two long QT disease genes, HERG and KCNE1. Proc Natl Acad Sci U S A (2001) 0.91
A novel mechanism of anode-break stimulation predicted by bidomain modeling. Circ Res (1999) 0.91
A functional assay for paralytic shellfish toxins that uses recombinant sodium channels. Toxicon (2001) 0.91
Latent specificity of molecular recognition in sodium channels engineered to discriminate between two "indistinguishable" mu-conotoxins. Biochemistry (2001) 0.87
Molecular dissection of cardiac repolarization by in vivo Kv4.3 gene transfer. J Clin Invest (2000) 0.87
Evidence against functional heteromultimerization of the KATP channel subunits Kir6.1 and Kir6.2. J Biol Chem (2000) 0.86
Isoform-specific lidocaine block of sodium channels explained by differences in gating. Biophys J (2000) 0.85
Novel structural determinants of mu-conotoxin (GIIIB) block in rat skeletal muscle (mu1) Na+ channels. J Biol Chem (2000) 0.85
Frequency-dependent changes in calcium cycling and contractile activation in SERCA2a transgenic mice. Basic Res Cardiol (2000) 0.84
Maintained contractile reserve in a transgenic mouse model of myocardial stunning. Am J Physiol Heart Circ Physiol (2001) 0.80
Functional consequences of the arrhythmogenic G306R KvLQT1 K+ channel mutant probed by viral gene transfer in cardiomyocytes. J Physiol (2001) 0.78
Preservation of myocardial function after adenoviral gene transfer in isolated myocardium. Am J Physiol Heart Circ Physiol (2000) 0.78
Gene therapy for common acquired diseases of the heart : the Sirens' song. Circulation (2000) 0.75
Preservation of myofilament calcium responsiveness underlies protection against myocardial stunning by ischemic preconditioning. Cardiovasc Res (1999) 0.75
Two AHA councils become one. Ringing out the old and bringing in the new. Circ Res (1999) 0.75
Circulation research impact factor sets new record. Circ Res (2001) 0.75
Somatic gene transfer of tagged K+ channel fragments to probe trafficking and electrical function in epithelial cells and cardiac myocytes. J Membr Biol (2002) 0.75
Under new management: A six-month progress report on Circulation Research. Circ Res (2000) 0.75