Published in Metabolism on October 01, 1999
The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature (1997) 33.47
Antisense transcription in the mammalian transcriptome. Science (2005) 15.69
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell (1998) 12.66
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett (1997) 11.19
A highly sensitive method to assay FK-506 levels in plasma. Transplant Proc (1987) 8.45
Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature (2000) 6.70
Maximal perfusion of skeletal muscle in man. J Physiol (1985) 6.05
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature (1988) 5.60
Evidence for prescribing exercise as therapy in chronic disease. Scand J Med Sci Sports (2006) 4.80
Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci U S A (1990) 4.40
X-ray diffraction evidence for the extensibility of actin and myosin filaments during muscle contraction. Biophys J (1994) 4.37
Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA). Nat Genet (1994) 4.36
Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation (2000) 4.32
Diet, muscle glycogen and physical performance. Acta Physiol Scand (1968) 4.12
Maximal oxygen uptake in athletes. J Appl Physiol (1967) 3.80
Simultaneous observation of individual ATPase and mechanical events by a single myosin molecule during interaction with actin. Cell (1998) 3.79
The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron (2001) 3.68
Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J (1998) 3.63
Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J (1994) 3.60
Rapid detection and evaluation of clinical characteristics of emerging multiple-drug-resistant gram-negative rods carrying the metallo-beta-lactamase gene blaIMP. Antimicrob Agents Chemother (1998) 3.57
Diagnostic criteria for primary osteoporosis: year 2000 revision. J Bone Miner Metab (2001) 3.43
Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene. Nat Genet (1994) 3.39
Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1. Dev Cell (2001) 3.29
Enzyme activity and fiber composition in skeletal muscle of untrained and trained men. J Appl Physiol (1972) 3.22
Prostaglandin D2 as a mediator of allergic asthma. Science (2000) 3.19
Electric and magnetic phenomena observed before the volcano-seismic activity in 2000 in the Izu Island Region, Japan. Proc Natl Acad Sci U S A (2002) 3.18
Physiological analysis of middle-aged and old former athletes. Comparison with still active athletes of the same ages. Circulation (1968) 3.16
Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol (2000) 3.09
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT. Nat Genet (1996) 3.07
Partitioning of Nitrogen among Ribulose-1,5-bisphosphate Carboxylase/Oxygenase, Phosphoenolpyruvate Carboxylase, and Pyruvate Orthophosphate Dikinase as Related to Biomass Productivity in Maize Seedlings. Plant Physiol (1984) 3.02
Retracted Comparison of ramosetron and granisetron for preventing postoperative nausea and vomiting after gynecologic surgery. Anesth Analg (1999) 2.85
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature (2001) 2.83
Dynamic knee extension as model for study of isolated exercising muscle in humans. J Appl Physiol (1985) (1985) 2.82
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene. Nat Genet (2001) 2.79
Effect of training on enzyme activity and fiber composition of human skeletal muscle. J Appl Physiol (1973) 2.78
Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc Natl Acad Sci U S A (1998) 2.76
In vitro activities of a new lipopeptide antifungal agent, FK463, against a variety of clinically important fungi. Antimicrob Agents Chemother (2000) 2.73
Visualization of dystrophic muscle fibers in mdx mouse by vital staining with Evans blue: evidence of apoptosis in dystrophin-deficient muscle. J Biochem (1995) 2.69
Programmable matter by folding. Proc Natl Acad Sci U S A (2010) 2.65
Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. Mol Cell Biol (2000) 2.61
Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol (1991) 2.52
Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. Am J Physiol Endocrinol Metab (2000) 2.52
Muscle glycogen during prolonged severe exercise. Acta Physiol Scand (1968) 2.51
Esophageal, rectal, and muscle temperature during exercise. J Appl Physiol (1966) 2.47
Selective glycogen depletion pattern in human muscle fibres after exercise of varying intensity and at varying pedalling rates. J Physiol (1974) 2.45
Changes in presynaptic inhibition of Ia fibres at the onset of voluntary contraction in man. J Physiol (1987) 2.45
Overtime work, insufficient sleep, and risk of non-fatal acute myocardial infarction in Japanese men. Occup Environ Med (2002) 2.43
Episome-mediated Transfer of Drug Resistance in Enterobacteriaceae X. Restriction and Modification of Phages by fi R Factors. J Bacteriol (1966) 2.43
Limb blood flow and vascular conductance are reduced with age in healthy humans: relation to elevations in sympathetic nerve activity and declines in oxygen demand. Circulation (1999) 2.40
Gene cloning of chitinase A1 from Bacillus circulans WL-12 revealed its evolutionary relationship to Serratia chitinase and to the type III homology units of fibronectin. J Biol Chem (1990) 2.38
Recanalization after coil embolotherapy of pulmonary arteriovenous malformations: study of long-term outcome and mechanism for recanalization. AJR Am J Roentgenol (1998) 2.38
Brachial-ankle pulse wave velocity: an index of central arterial stiffness? J Hum Hypertens (2005) 2.36
Phenotypic difference of normal plasma cells from mature myeloma cells. Blood (1993) 2.35
Metabolic characteristics of fibre types in human skeletal muscle. Acta Physiol Scand (1975) 2.33
Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord. Cell (1991) 2.31
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. J Med Chem (1996) 2.29
Identification of glutamic acid 204 and aspartic acid 200 in chitinase A1 of Bacillus circulans WL-12 as essential residues for chitinase activity. J Biol Chem (1993) 2.28
Fiber types and metabolic potentials of skeletal muscles in sedentary man and endurance runners. Ann N Y Acad Sci (1977) 2.26
Sensitivity of serological assays to identify blood donors with hepatitis C viraemia. Lancet (1992) 2.25
1 alpha,25-Dihydroxyvitamin D3 induces differentiation of human myeloid leukemia cells. Biochem Biophys Res Commun (1981) 2.21
Evaluation of topical pharyngeal anesthesia for upper endoscopy including factors associated with patient tolerance. Gastrointest Endosc (2001) 2.19
The gene for Machado-Joseph disease maps to human chromosome 14q. Nat Genet (1993) 2.18
Cardiac involvement in mitochondrial diseases. A study on 17 patients with documented mitochondrial DNA defects. Circulation (1995) 2.15
Evidence for interneuronally mediated Ia excitatory effects to human quadriceps motoneurones. J Physiol (1986) 2.15
Benefit of bilateral over single internal mammary artery grafts for multiple coronary artery bypass grafting. Circulation (2001) 2.15
New and reliable MRI diagnosis for progressive supranuclear palsy. Neurology (2005) 2.14
Side effects of high-dose interferon therapy for chronic hepatitis C. J Hepatol (1996) 2.14
Human circulatory and thermoregulatory adaptations with heat acclimation and exercise in a hot, dry environment. J Physiol (1993) 2.12
A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila. Cell (1993) 2.10
Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. EMBO J (1999) 2.10
Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase. Proc Natl Acad Sci U S A (1991) 2.08
Increasing numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized, recruited to synaptic sites, and required for potentiation. Neuron (2000) 2.07
Cardiovascular adaptations to physical training. Annu Rev Physiol (1983) 2.05
Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1989) 2.01
Evidence of an increased number of type IIb muscle fibers in insulin-resistant first-degree relatives of patients with NIDDM. Diabetes (1997) 2.00
Determinants of maximal oxygen uptake in severe acute hypoxia. Am J Physiol Regul Integr Comp Physiol (2002) 1.99
Detection and typing of multiple genital human papillomaviruses by DNA amplification with consensus primers. Jpn J Cancer Res (1991) 1.99
Absence of hepatitis C viral RNA from saliva and semen of patients with chronic hepatitis C. Gastroenterology (1992) 1.99
Muscle oxygen kinetics at onset of intense dynamic exercise in humans. Am J Physiol Regul Integr Comp Physiol (2000) 1.99
Cell lineage analysis in ascidian embryos by intracellular injection of a tracer enzyme. III. Up to the tissue restricted stage. Dev Biol (1987) 1.97
Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axons. Neuron (1999) 1.97
Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury. Kidney Int (2008) 1.97
Laparoscopic removal of a large gastric trichobezoar. J Pediatr Surg (1998) 1.96
Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content. FASEB J (2001) 1.96
Nitric oxide in the regulation of vasomotor tone in human skeletal muscle. Am J Physiol (1999) 1.93
Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch. Nat Genet (1998) 1.91
Water and ion shifts in skeletal muscle of humans with intense dynamic knee extension. Am J Physiol (1985) 1.91
The roles of the C-terminal domain and type III domains of chitinase A1 from Bacillus circulans WL-12 in chitin degradation. J Bacteriol (1994) 1.91
Deficiency of osteoclasts in osteopetrotic mice is due to a defect in the local microenvironment provided by osteoblastic cells. Endocrinology (1991) 1.90
Central arterial compliance is associated with age- and habitual exercise-related differences in cardiovagal baroreflex sensitivity. Circulation (2001) 1.89
Three distinct types of Ca(2+) waves in Langendorff-perfused rat heart revealed by real-time confocal microscopy. Circ Res (2000) 1.88
The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem Biophys Res Commun (1990) 1.88
Why is VO2 max after altitude acclimatization still reduced despite normalization of arterial O2 content? Am J Physiol Regul Integr Comp Physiol (2002) 1.87
Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. J Antibiot (Tokyo) (1991) 1.86
A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells. Blood (2000) 1.86
Expression of a gibberellin 2-oxidase gene around the shoot apex is related to phase transition in rice. Plant Physiol (2001) 1.86
Multitissue circadian expression of rat period homolog (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain. J Biol Chem (1998) 1.86
The ageing muscle. Clin Physiol (1983) 1.86
Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients. J Clin Invest (1993) 1.85