Published in Nat Genet on November 01, 1999
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci U S A (2002) 6.00
Genetic dissection of polyunsaturated fatty acid synthesis in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2002) 2.89
Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism. Curr Opin Lipidol (2008) 2.22
Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. J Clin Invest (2005) 2.03
Genetic control of de novo lipogenesis: role in diet-induced obesity. Crit Rev Biochem Mol Biol (2010) 1.89
Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc Natl Acad Sci U S A (2003) 1.71
Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia. Am J Pathol (2000) 1.71
A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. Infect Immun (2005) 1.55
Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development. Proc Natl Acad Sci U S A (2005) 1.31
Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol (2008) 1.29
Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity. Biochim Biophys Acta (2009) 1.27
Stearoyl CoA desaturase 1: role in cellular inflammation and stress. Adv Nutr (2011) 1.16
Sebaceous gland lipids. Dermatoendocrinol (2009) 1.15
Mutations in sterol O-acyltransferase 1 (Soat1) result in hair interior defects in AKR/J mice. J Invest Dermatol (2010) 1.15
A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters. J Lipid Res (2005) 1.11
Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice. J Lipid Res (2007) 1.09
The pathogenesis of primary cicatricial alopecias. Am J Pathol (2010) 1.09
Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness. J Clin Endocrinol Metab (2008) 1.07
Epidermal surface lipids. Dermatoendocrinol (2009) 1.06
Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells. J Lipid Res (2008) 1.04
Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery. Curr Opin Lipidol (2010) 0.96
Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol (2009) 0.94
Cystathionine beta-synthase deficiency causes fat loss in mice. PLoS One (2011) 0.93
Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element. Biochem J (2001) 0.92
Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance. J Biol Chem (2013) 0.92
Group III secreted phospholipase A2 transgenic mice spontaneously develop inflammation. Biochem J (2009) 0.91
Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism. PLoS One (2011) 0.89
Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands. J Biol Chem (2011) 0.88
Requirement of fatty acid transport protein 4 for development, maturation, and function of sebaceous glands in a mouse model of ichthyosis prematurity syndrome. J Biol Chem (2012) 0.86
Ulcerative dermatitis in C57BL/6 mice lacking stearoyl CoA desaturase 1. Comp Med (2012) 0.86
Lipid mediators in acne. Mediators Inflamm (2010) 0.85
Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin. J Biol Chem (2011) 0.83
Fatty acid transporters in skin development, function and disease. Biochim Biophys Acta (2013) 0.82
Differentiation of the sebaceous gland. Dermatoendocrinol (2009) 0.82
Mutations in the cholesterol transporter gene ABCA5 are associated with excessive hair overgrowth. PLoS Genet (2014) 0.81
Does prostaglandin D2 hold the cure to male pattern baldness? Exp Dermatol (2014) 0.81
Scd1ab-Xyk: a new asebia allele characterized by a CCC trinucleotide insertion in exon 5 of the stearoyl-CoA desaturase 1 gene in mouse. Mol Genet Genomics (2004) 0.80
TGFβ signaling regulates lipogenesis in human sebaceous glands cells. BMC Dermatol (2013) 0.79
Unique mode of lipogenic activation in rat preputial sebocytes. J Nutr Metab (2011) 0.78
dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth. Dev Biol (2013) 0.77
Drosophila Myc: A master regulator of cellular performance. Biochim Biophys Acta (2014) 0.77
The role of fatty acid desaturases in epidermal metabolism. Dermatoendocrinol (2011) 0.77
Sebaceous gland, hair shaft, and epidermal barrier abnormalities in keratosis pilaris with and without filaggrin deficiency. Am J Pathol (2015) 0.75
Global deletion of lipocalin 2 does not reverse high-fat diet-induced obesity resistance in stearoyl-CoA desaturase-1 skin-specific knockout mice. Biochem Biophys Res Commun (2014) 0.75
Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females. Indian Dermatol Online J (2014) 0.75
Lrig1 Expression in Human Sebaceous Gland Tumors. Dermatopathology (Basel) (2016) 0.75
Serial analysis of gene expression. Science (1995) 60.15
Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med (1999) 14.30
Characterization of the yeast transcriptome. Cell (1997) 11.33
The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med (1996) 10.62
A public database for gene expression in human cancers. Cancer Res (1999) 8.81
Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med (1995) 8.23
PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95
14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell (1997) 7.20
Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88
REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell (1995) 6.43
Analysis of human transcriptomes. Nat Genet (1999) 6.14
A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol (2001) 6.12
The evolution of H5N1 influenza viruses in ducks in southern China. Proc Natl Acad Sci U S A (2004) 5.87
The early clinical manifestations of Lyme disease. Ann Intern Med (1983) 5.73
Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation (2000) 5.09
Ligand binding to integrins. J Biol Chem (2000) 4.94
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest (2000) 4.36
Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet (1999) 4.36
Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurement. J Clin Virol (2004) 4.28
Delay or probability discounting in a model of impulsive behavior: effect of alcohol. J Exp Anal Behav (1999) 4.23
Pericentrin and gamma-tubulin form a protein complex and are organized into a novel lattice at the centrosome. J Cell Biol (1998) 4.23
Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet (2000) 4.17
The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nat Med (2000) 4.08
Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria. Science (1997) 4.07
CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Nat Cell Biol (2000) 3.96
A quantum dot single-photon turnstile device. Science (2000) 3.89
Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase. Science (1996) 3.85
DNA supercoiling promotes formation of a bent repression loop in lac DNA. J Mol Biol (1987) 3.81
The genome reconstruction manager: a software environment for supporting high-throughput DNA sequencing. Genomics (1994) 3.69
Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J Am Chem Soc (1997) 3.69
Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran. Science (1999) 3.66
Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. J Exp Med (1992) 3.63
Rapid multi-element analysis of groundwater by high-resolution inductively coupled plasma mass spectrometry. Anal Bioanal Chem (2004) 3.50
The Dbl family of oncogenes. Curr Opin Cell Biol (1996) 3.50
TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. EMBO J (1998) 3.49
HIV-1 drug resistance in newly infected individuals. JAMA (1999) 3.49
An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene (2006) 3.48
Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem (2001) 3.38
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell (1995) 3.34
Inhibition of RhoA by p120 catenin. Nat Cell Biol (2000) 3.33
Multiple Morphologies of "Crew-Cut" Aggregates of Polystyrene-b-poly(acrylic acid) Block Copolymers. Science (1995) 3.16
Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy. J Virol (1999) 3.15
A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nat Med (1998) 3.15
The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A (2000) 3.12
Construction of a uniform-abundance (normalized) cDNA library. Proc Natl Acad Sci U S A (1991) 3.12
PUMA, a potent killer with or without p53. Oncogene (2008) 3.09
TraI, a LuxI homologue, is responsible for production of conjugation factor, the Ti plasmid N-acylhomoserine lactone autoinducer. Proc Natl Acad Sci U S A (1994) 3.08
Identification and classification of p53-regulated genes. Proc Natl Acad Sci U S A (1999) 3.07
Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. J Biol Chem (1994) 3.03
CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J Exp Med (1998) 3.01
Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity. Neuroimage (1996) 2.98
Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res (2001) 2.98
5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex. Proc Natl Acad Sci U S A (2000) 2.98
Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5. J Biol Chem (1995) 2.93
Sustained photobiological hydrogen gas production upon reversible inactivation of oxygen evolution in the green alga Chlamydomonas reinhardtii. Plant Physiol (2000) 2.92
Hydrogen peroxide is involved in abscisic acid-induced stomatal closure in Vicia faba. Plant Physiol (2001) 2.91
Characterization of two related Drosophila gamma-tubulin complexes that differ in their ability to nucleate microtubules. J Cell Biol (1999) 2.88
Role of importin-beta in coupling Ran to downstream targets in microtubule assembly. Science (2001) 2.87
Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neuroscience (2001) 2.84
Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities. Nat Cell Biol (2001) 2.78
Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol (1998) 2.76
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature (2005) 2.74
Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides. J Mol Biol (2000) 2.73
Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clin Cancer Res (2000) 2.71
Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol (2000) 2.67
Adhesion formation after previous caesarean section-a meta-analysis and systematic review. BJOG (2010) 2.66
An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. J Immunol (2001) 2.62
Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature (1994) 2.61
Regulation of cortical actin cytoskeleton assembly during polarized cell growth in budding yeast. J Cell Biol (1995) 2.59
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proc Natl Acad Sci U S A (2001) 2.58
Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J Biol Chem (2001) 2.57
cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. Mol Cell Biol (1992) 2.55
Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model. J Allergy Clin Immunol (2001) 2.51
Effect of shipment, storage, anticoagulant, and cell separation on lymphocyte proliferation assays for human immunodeficiency virus-infected patients. Clin Diagn Lab Immunol (1998) 2.48
HIV-1 subtype and second-receptor use. Nature (1996) 2.46
Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection. Antimicrob Agents Chemother (1998) 2.44
Flow-cytometric separation and enrichment of hepatic progenitor cells in the developing mouse liver. Hepatology (2000) 2.43
A new function for the gamma-tubulin ring complex as a microtubule minus-end cap. Nat Cell Biol (2000) 2.43
Recruitment of the gamma-tubulin ring complex to Drosophila salt-stripped centrosome scaffolds. J Cell Biol (1998) 2.42
HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy. J Clin Invest (1999) 2.42
Behavioural and functional anatomical correlates of deception in humans. Neuroreport (2001) 2.41
Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes. Physiol Genomics (2006) 2.38
Meta-analysis: prevalence of HIV infection and syphilis among MSM in China. Sex Transm Infect (2009) 2.36
Ultrasonic hydrophone based on short in-fiber bragg gratings. Appl Opt (1998) 2.35
Fragile-X-associated tremor/ataxia syndrome (FXTAS) in females with the FMR1 premutation. Am J Hum Genet (2004) 2.33
Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med (2000) 2.31
Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast. J Cell Biol (1994) 2.29
Survival time comparison between Hawley and clear overlay retainers: a randomized trial. J Dent Res (2011) 2.26
Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice. J Neurosci (1999) 2.26
Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection. J Virol (2000) 2.26
Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness. Science (1999) 2.25
Accurate control of contrast on microcomputer displays. Vision Res (1991) 2.21
New structural picture of the Ge2Sb2Te5 phase-change alloy. Phys Rev Lett (2011) 2.21
Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42. J Neurosci (2001) 2.20
Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice. Development (1999) 2.20