Published in Methods Mol Biol on January 01, 2000
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
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Primer3--new capabilities and interfaces. Nucleic Acids Res (2012) 20.34
Characterizing the cancer genome in lung adenocarcinoma. Nature (2007) 16.48
Primer3Plus, an enhanced web interface to Primer3. Nucleic Acids Res (2007) 13.47
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet (2006) 9.56
Database resources of the National Center for Biotechnology Information. Nucleic Acids Res (2011) 8.62
Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction. BMC Bioinformatics (2012) 8.61
A comprehensive analysis of common copy-number variations in the human genome. Am J Hum Genet (2006) 8.61
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Critical factors for assembling a high volume of DNA barcodes. Philos Trans R Soc Lond B Biol Sci (2005) 7.13
Mobile elements create structural variation: analysis of a complete human genome. Genome Res (2009) 7.06
Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarrays. Proc Natl Acad Sci U S A (2002) 6.93
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection. Nat Methods (2011) 6.90
Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study. Lancet Infect Dis (2011) 6.08
Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS). Genome Res (2005) 5.71
Human Y chromosome base-substitution mutation rate measured by direct sequencing in a deep-rooting pedigree. Curr Biol (2009) 5.70
Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature (2014) 5.61
Whole-genome resequencing reveals loci under selection during chicken domestication. Nature (2010) 5.48
Measurement of gene expression in archival paraffin-embedded tissues: development and performance of a 92-gene reverse transcriptase-polymerase chain reaction assay. Am J Pathol (2004) 5.29
Database resources of the National Center for Biotechnology Information. Nucleic Acids Res (2013) 5.25
BatchPrimer3: a high throughput web application for PCR and sequencing primer design. BMC Bioinformatics (2008) 5.24
Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary. J Pathol (2010) 5.23
PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification. Nucleic Acids Res (2009) 5.03
Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00
High-density universal 16S rRNA microarray analysis reveals broader diversity than typical clone library when sampling the environment. Microb Ecol (2007) 4.81
Correlation between plasmid content and infectivity in Borrelia burgdorferi. Proc Natl Acad Sci U S A (2000) 4.81
An efficient procedure for genotyping single nucleotide polymorphisms. Nucleic Acids Res (2001) 4.77
Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines. PLoS Genet (2006) 4.65
SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes. Nucleic Acids Res (2006) 4.63
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Genomics (2007) 4.62
Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans. Nature (2011) 4.61
Multiplex sequencing of paired-end ditags (MS-PET): a strategy for the ultra-high-throughput analysis of transcriptomes and genomes. Nucleic Acids Res (2006) 4.51
Validating internal controls for quantitative plant gene expression studies. BMC Plant Biol (2004) 4.45
Haematopoietic stem cells derive directly from aortic endothelium during development. Nature (2010) 4.42
Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science (2013) 4.42
Large-scale discovery of induced point mutations with high-throughput TILLING. Genome Res (2003) 4.39
Genome-wide computational prediction of transcriptional regulatory modules reveals new insights into human gene expression. Genome Res (2006) 4.32
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. Nature (2012) 4.26
From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response. Proc Natl Acad Sci U S A (2005) 4.16
A standard curve based method for relative real time PCR data processing. BMC Bioinformatics (2005) 3.85
Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome. Genome Res (2005) 3.85
Nipah virus in Lyle's flying foxes, Cambodia. Emerg Infect Dis (2005) 3.77
Complex Loci in human and mouse genomes. PLoS Genet (2006) 3.74
Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia. Blood (2007) 3.73
Rapid microsatellite identification from Illumina paired-end genomic sequencing in two birds and a snake. PLoS One (2012) 3.71
Spectrum of chemically induced mutations from a large-scale reverse-genetic screen in Arabidopsis. Genetics (2003) 3.70
Direct isolation and identification of promoters in the human genome. Genome Res (2005) 3.68
Mutations in GNAL cause primary torsion dystonia. Nat Genet (2012) 3.66
Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol (2008) 3.65
Large deletions within the first intron in VRN-1 are associated with spring growth habit in barley and wheat. Mol Genet Genomics (2005) 3.63
Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: insights into the pneumococcal supragenome. J Bacteriol (2007) 3.62
QuantPrime--a flexible tool for reliable high-throughput primer design for quantitative PCR. BMC Bioinformatics (2008) 3.62
A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. PLoS Genet (2007) 3.61
Efficient target-selected mutagenesis in zebrafish. Genome Res (2003) 3.61
Rapid single nucleotide polymorphism mapping in C. elegans. BMC Genomics (2005) 3.57
Selection of internal control genes for quantitative real-time RT-PCR studies during tomato development process. BMC Plant Biol (2008) 3.57
Database resources of the National Center for Biotechnology Information. Nucleic Acids Res (2014) 3.55
Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop of resource-poor farmers. Nat Biotechnol (2011) 3.51
SNP500Cancer: a public resource for sequence validation and assay development for genetic variation in candidate genes. Nucleic Acids Res (2004) 3.47
A simple genetic architecture underlies morphological variation in dogs. PLoS Biol (2010) 3.46
Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas. Clin Cancer Res (2009) 3.45
Target site specificity of the Tos17 retrotransposon shows a preference for insertion within genes and against insertion in retrotransposon-rich regions of the genome. Plant Cell (2003) 3.45
Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites. Proc Natl Acad Sci U S A (2004) 3.41
High-throughput SNP discovery through deep resequencing of a reduced representation library to anchor and orient scaffolds in the soybean whole genome sequence. BMC Genomics (2010) 3.40
Hepatitis C virus entry depends on clathrin-mediated endocytosis. J Virol (2006) 3.33
PROBEmer: A web-based software tool for selecting optimal DNA oligos. Nucleic Acids Res (2003) 3.32
Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc Diabetol (2006) 3.31
Whole-genome microarrays of fission yeast: characteristics, accuracy, reproducibility, and processing of array data. BMC Genomics (2003) 3.30
Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains. Genome Biol (2007) 3.29
Prevalence of somatic alterations in the colorectal cancer cell genome. Proc Natl Acad Sci U S A (2002) 3.25
Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor. PLoS Genet (2007) 3.24
High-throughput in vivo analysis of gene expression in Caenorhabditis elegans. PLoS Biol (2007) 3.22
Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease. Nat Genet (2010) 3.22
Projector 2: contig mapping for efficient gap-closure of prokaryotic genome sequence assemblies. Nucleic Acids Res (2005) 3.22
The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet (2007) 3.21
Arabidopsis PEN3/PDR8, an ATP binding cassette transporter, contributes to nonhost resistance to inappropriate pathogens that enter by direct penetration. Plant Cell (2006) 3.20
Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients. PLoS One (2009) 3.18
Evolution of DNA sequence nonhomologies among maize inbreds. Plant Cell (2005) 3.17
A universal DNA mini-barcode for biodiversity analysis. BMC Genomics (2008) 3.16
Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients. Proc Natl Acad Sci U S A (2003) 3.14
The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource. Genetics (2007) 3.08
Comparative phylogenomics of Clostridium difficile reveals clade specificity and microevolution of hypervirulent strains. J Bacteriol (2006) 3.05
Identification of the yellow skin gene reveals a hybrid origin of the domestic chicken. PLoS Genet (2008) 3.04
Versatile gene-specific sequence tags for Arabidopsis functional genomics: transcript profiling and reverse genetics applications. Genome Res (2004) 3.02
Snap: an integrated SNP annotation platform. Nucleic Acids Res (2006) 2.99
Osprey: a comprehensive tool employing novel methods for the design of oligonucleotides for DNA sequencing and microarrays. Nucleic Acids Res (2004) 2.91
Molecular composition of the endocannabinoid system at glutamatergic synapses. J Neurosci (2006) 2.81
A complete collection of single-gene deletion mutants of Acinetobacter baylyi ADP1. Mol Syst Biol (2008) 2.79
WebSat--a web software for microsatellite marker development. Bioinformation (2009) 2.78
Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer. Br J Cancer (2009) 2.76
Heritability of alternative splicing in the human genome. Genome Res (2007) 2.76
coliBASE: an online database for Escherichia coli, Shigella and Salmonella comparative genomics. Nucleic Acids Res (2004) 2.75
Single nucleotide variation analysis in 65 candidate genes for CNS disorders in a representative sample of the European population. Genome Res (2003) 2.75
Exploring valid reference genes for gene expression studies in Brachypodium distachyon by real-time PCR. BMC Plant Biol (2008) 2.73
Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion. Proc Natl Acad Sci U S A (2011) 2.72
Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature (2009) 2.68
All possible modes of gene action are observed in a global comparison of gene expression in a maize F1 hybrid and its inbred parents. Proc Natl Acad Sci U S A (2006) 2.68
Thousands of corresponding human and mouse genomic regions unalignable in primary sequence contain common RNA structure. Genome Res (2006) 2.68
Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. Nat Genet (2013) 2.66
The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men. Nat Genet (2001) 4.24
Unexpectedly similar rates of nucleotide substitution found in male and female hominids. Nature (2000) 2.39
Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. Genomics (2000) 2.16
The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. Nat Genet (1996) 2.16
An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y. Nat Genet (1999) 1.91
A physical map of the human Y chromosome. Nature (2001) 1.58
Deletion of azoospermia factor a (AZFa) region of human Y chromosome caused by recombination between HERV15 proviruses. Hum Mol Genet (2000) 1.53
The Old World monkey DAZ (Deleted in AZoospermia) gene yields insights into the evolution of the DAZ gene cluster on the human Y chromosome. Hum Mol Genet (1999) 1.00