Noggin is a mesenchymally derived stimulator of hair-follicle induction.

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Published in Nat Cell Biol on July 01, 1999


V A Botchkarev1, N V Botchkareva, W Roth, M Nakamura, L H Chen, W Herzog, G Lindner, J A McMahon, C Peters, R Lauster, A P McMahon, R Paus

Author Affiliations

1: Department of Dermatology, Charité, Humboldt-University Berlin, Germany.

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Thousandfold change in resistivity in magnetoresistive la-ca-mn-o films. Science (1994) 2.64

Griseofulvin interacts with microtubules both in vivo and in vitro. J Mol Biol (1976) 2.61

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Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran. Science (1999) 2.59

The world according to hedgehog. Trends Genet (1997) 2.52

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Nucleotide sequence of the asnA gene coding for asparagine synthetase of E. coli K-12. Nucleic Acids Res (1981) 2.42

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