Published in Exp Gerontol on September 01, 1999
Lysosomes in iron metabolism, ageing and apoptosis. Histochem Cell Biol (2008) 1.60
Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death. Antioxid Redox Signal (2009) 0.99
The role of proteolytic cellular systems in trabecular meshwork homeostasis. Exp Eye Res (2008) 0.89
The involvement of lysosomes in myocardial aging and disease. Curr Cardiol Rev (2008) 0.88
Hormetic modulation of aging and longevity by mild heat stress. Dose Response (2006) 0.87
Potential involvement of LOX-1 in functional consequences of endothelial senescence. PLoS One (2011) 0.86
Redox control of protein degradation. Redox Biol (2015) 0.86
Molecular mechanisms of anti-aging hormetic effects of mild heat stress on human cells. Nonlinearity Biol Toxicol Med (2004) 0.82
Role of macrophages in age-related oxidative stress and lipofuscin accumulation in mice. Redox Biol (2017) 0.79
TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits. eNeuro (2016) 0.75
Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features. Cell Death Differ (2009) 2.33
Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. Free Radic Biol Med (1993) 2.22
Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem J (2001) 1.80
Autophagy, organelles and ageing. J Pathol (2007) 1.64
Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture. Biochem J (2001) 1.56
Induction of cell death by the lysosomotropic detergent MSDH. FEBS Lett (2000) 1.46
Hydrogen peroxide production by liver mitochondria in different species. Mech Ageing Dev (1990) 1.35
Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free Radic Biol Med (1995) 1.30
Lipofuscin: mechanisms of formation and increase with age. APMIS (1998) 1.29
Mitochondrial production of pro-oxidants and cellular senescence. Mutat Res (1992) 1.21
The toxicity to macrophages of oxidized low-density lipoprotein is mediated through lysosomal damage. Atherosclerosis (1997) 1.17
Lysosomal labilization. IUBMB Life (2006) 1.16
Photooxidative damage to lysosomes of cultured macrophages by acridine orange. Photochem Photobiol (1990) 1.13
The comparative biology of neuromelanin and lipofuscin in the human brain. Cell Mol Life Sci (2008) 1.13
Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and lysosomal proteolysis. Mech Ageing Dev (1998) 1.12
Lysosomal heterogeneity between and within cells with respect to resistance against oxidative stress. Histochem J (1998) 1.10
alpha-tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisation. FEBS Lett (1999) 1.09
Lipofuscin as an indicator of oxidative stress and aging. Adv Exp Med Biol (1989) 1.06
Lysosomal destabilization during macrophage damage induced by cholesterol oxidation products. Free Radic Biol Med (2000) 1.05
Cytochemical evidence for the leakage of acid phosphatase through ultrastructurally intact lysosomal membranes. Histochem J (1972) 1.05
The demonstration of acid phosphatase in vitro cultured tissue cells. Studies on the significance of fixation, tonicity and permeability. Histochem J (1972) 1.01
Delayed oxidant-induced cell death involves activation of phospholipase A2. FEBS Lett (2001) 1.01
Superoxide anion radical production in different animal species. Mech Ageing Dev (1989) 1.01
Protection against oxidant-mediated lysosomal rupture: a new anti-apoptotic activity of Bcl-2? FEBS Lett (2000) 1.00
Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation. Arterioscler Thromb Vasc Biol (1998) 0.99
Relationship between antioxidant defenses and longevity in different mammalian species. Mech Ageing Dev (1990) 0.99
Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation. Exp Gerontol (1999) 0.97
Bcl-2 phosphorylation is required for inhibition of oxidative stress-induced lysosomal leak and ensuing apoptosis. FEBS Lett (2001) 0.96
On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes. Mech Ageing Dev (1998) 0.95
Lipofuscin accumulation in cultured retinal pigment epithelial cells reduces their phagocytic capacity. Curr Eye Res (1998) 0.95
Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress. Free Radic Res (1998) 0.95
Iron in human atheroma and LDL oxidation by macrophages following erythrophagocytosis. Atherosclerosis (1996) 0.93
Lipofuscin accumulation and ageing of fibroblasts. Gerontology (1995) 0.92
Visualization of iron in cultured macrophages: a cytochemical light and electron microscopic study using autometallography. Free Radic Biol Med (1993) 0.90
Novel cellular defenses against iron and oxidation: ferritin and autophagocytosis preserve lysosomal stability in airway epithelium. Redox Rep (2001) 0.89
Lipofuscin-formation in cultured retinal pigment epithelial cells is related to their melanin content. Free Radic Biol Med (2001) 0.88
Evaluation of lysosomal stability in living cultured macrophages by cytofluorometry. Effect of silver lactate and hypotonic conditions. Virchows Arch B Cell Pathol Incl Mol Pathol (1989) 0.87
Ultrastructural features of cultured human glia and glioma cells. Acta Pathol Microbiol Scand A (1979) 0.87
Effects of iron- and hemoglobin-loaded human monocyte-derived macrophages on oxidation and uptake of LDL. Arterioscler Thromb Vasc Biol (1995) 0.85
Discharge of newly-synthesized dolichol and ubiquinone with lipoproteins to rat liver perfusate and to the bile. Lipids (1989) 0.85
Acridine orange-mediated photodamage of microsomal- and lysosomal fractions. Virchows Arch B Cell Pathol Incl Mol Pathol (1989) 0.85
Lipofuscin accumulation in cultured retinal pigment epithelial cells causes enhanced sensitivity to blue light irradiation. Free Radic Biol Med (1997) 0.85
Beta-cells, oxidative stress, lysosomal stability, and apoptotic/necrotic cell death. Antioxid Redox Signal (1999) 0.84
High resolution SEM of cultured cells: preparatory procedures. Scan Electron Microsc (1981) 0.84
Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis. Redox Rep (2001) 0.83
Fenton reagents may not initiate lipid peroxidation in an emulsified linoleic acid model system. Free Radic Biol Med (1992) 0.83
Effect of ambient oxygen concentration on lipofuscin accumulation in cultured rat heart myocytes--a novel in vitro model of lipofuscinogenesis. Free Radic Biol Med (1989) 0.83
Redox availability of lens iron and copper: implications for HO* generation in cataract. Redox Rep (1999) 0.82
A short exposure to a high-glucose milieu stabilizes the acidic vacuolar apparatus of insulinoma cells in culture to ensuing oxidative stress. APMIS (1997) 0.82
Formation of lipofuscin in cultured retinal pigment epithelial cells exposed to pre-oxidized photoreceptor outer segments. APMIS (1996) 0.82
Alloxan cytotoxicity is highly potentiated by plasma membrane- and lysosomal-associated iron--a study on a model system of cultured J-774 cells. Diabetologia (1993) 0.82
On the cytoprotective role of ferritin in macrophages and its ability to enhance lysosomal stability. Free Radic Res (1997) 0.81
Vitamin E analogues as inducers of apoptosis: implications for their potential antineoplastic role. Redox Rep (2001) 0.81
Iron and LDL-oxidation in atherogenesis. APMIS (1998) 0.80
Characterization of residual bodies fromed in phase II cultivated human glia cells. Mech Ageing Dev (1976) 0.80
Microfluorometric and fluorometric lipofuscin spectral discrepancies: a concentration-dependent metachromatic effect? Mech Ageing Dev (1991) 0.80
Intracellular interactions under oxidative stress and aging: a hypothesis. Z Gerontol (1993) 0.79
Lysosomal enzyme leakage during the hypoxanthine/xanthine oxidase reaction. Virchows Arch B Cell Pathol Incl Mol Pathol (1989) 0.79
Congenital disorders sharing oxidative stress and cancer proneness as phenotypic hallmarks: prospects for joint research in pharmacology. Med Hypotheses (1998) 0.79
OxLDL-induced macrophage cytotoxicity is mediated by lysosomal rupture and modified by intralysosomal redox-active iron. Free Radic Res (1998) 0.79
Vitamin E analogs: a new class of multiple action agents with anti-neoplastic and anti-atherogenic activity. Apoptosis (2002) 0.79
Test-tube simulated lipofuscinogenesis. Effect of oxidative stress on autophagocytotic degradation. Mech Ageing Dev (1995) 0.79
Influence of intracellular glutathione concentration of lipofuscin accumulation in cultured neonatal rat cardiac myocytes. Free Radic Biol Med (1994) 0.78
Lipofuscin formation in cultured retinal pigment epithelial cells exposed to photoreceptor outer segment material under different oxygen concentrations. APMIS (1996) 0.78
Bismuth-induced lysosomal rupture in J774 cells. APMIS (2002) 0.77
Oxidized ascorbic acid and reaction products between ascorbic and amino acids might constitute part of age pigments. Mech Ageing Dev (1991) 0.77
Effect of ferric iron and desferrioxamine on lipofuscin accumulation in cultured rat heart myocytes. Mech Ageing Dev (1988) 0.77
Extracellular reduction of alloxan results in oxygen radical-mediated attack on plasma and lysosomal membranes. APMIS (1992) 0.76
Effect of alpha-tocopherol and some metal chelators on lipofuscin accumulation in cultured neonatal rat cardiac myocytes. Anal Cell Pathol (1990) 0.76
Translocation of human glial and glioma cells in culture. Virchows Arch B Cell Pathol Incl Mol Pathol (1986) 0.76
Lipofuscinogenesis in a model system of cultured cardiac myocytes. EXS (1992) 0.75
Influence of oxygen tension, pro-oxidants and antioxidants on the formation of lipid peroxidation products (lipofuscin) in individual cultivated human glial cells. Mech Ageing Dev (1984) 0.75
Is lipofuscin eliminated from cells? Invest Ophthalmol Vis Sci (1999) 0.75
Growth and morphological characteristics of two brain metastases of human large cell carcinomas of the lung in vivo and in monolayer and spheroid cultures. Scan Electron Microsc (1982) 0.75
Quantitation of residual bodies in cultured human glial cells during stationary and logarithmic growth phases. Mech Ageing Dev (1978) 0.75
An approach to the assessment of membrane stability of cultured cells. Eur J Cell Biol (1983) 0.75
Starvation-induced autophagocytosis paradoxically decreases the susceptibility to oxidative stress of the extremely oxidative stress-sensitive NIT insulinoma cells. Redox Rep (1998) 0.75
Effects of alloxan and reducing agents on macrophages in culture. APMIS (1991) 0.75
Alloxan cytotoxicity involves lysosomal damage. APMIS (1992) 0.75
TEM and SEM findings in cat fibroblasts cultivated in vitro with and without Mycoplasma. Acta Pathol Microbiol Scand A (1981) 0.75
The fine structure of growing human glia and glioma cells. Whole cell preparations. Acta Pathol Microbiol Scand A (1979) 0.75
Effect of ethanol on lipofuscin accumulation in cultured rat cardiac myocytes. Free Radic Biol Med (1989) 0.75
Cytoplasmic effects of x-irradiation on cultured cells in a nondividing stage. 1. Establishment of an experimental model. Acta Pathol Microbiol Scand A (1976) 0.75
Acute and irreversible injury following exposure of cultured cells to reactive oxygen metabolites. Eur J Cell Biol (1983) 0.75
Changes associated with the growth stimulation of in vitro cultivated spheroids of human glioma cells. Scan Electron Microsc (1981) 0.75
Minute oxidative stress is sufficient to induce apoptotic death of NIT-1 insulinoma cells. APMIS (1999) 0.75
Fine structural studies on cultured human glial and glioma cells: techniques and applications. Ultrastruct Pathol (1984) 0.75
Cytoplasmic effects of X-irradiation on cultured cells in a non-dividing stage. 4. Studies of sparsely grown, serum-deprived cells. Acta Pathol Microbiol Scand A (1980) 0.75
Motility pattern of density growth inhibited glial cells with partially free borders. Eur J Cell Biol (1979) 0.75