MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleoprotein complexes.

PubWeight™: 1.14‹?› | Rank: Top 10%

🔗 View Article (PMC 111572)

Published in J Virol on January 01, 2000

Authors

F Weber1, O Haller, G Kochs

Author Affiliations

1: Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, D-79008 Freiburg, Germany.

Articles citing this

Antiviral actions of interferons. Clin Microbiol Rev (2001) 13.06

Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase. J Virol (2008) 1.62

Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome. Nucleic Acids Res (2004) 1.58

Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling. J Virol (2007) 1.58

The viral nucleoprotein determines Mx sensitivity of influenza A viruses. J Virol (2011) 1.51

Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes. Proc Natl Acad Sci U S A (2002) 1.34

Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA. Cell Host Microbe (2012) 1.29

Mx proteins: antiviral gatekeepers that restrain the uninvited. Microbiol Mol Biol Rev (2013) 1.22

RNA aptamers directed to human immunodeficiency virus type 1 Gag polyprotein bind to the matrix and nucleocapsid domains and inhibit virus production. J Virol (2010) 1.18

Negative regulation of the alpha interferon-induced antiviral response by the Ras/Raf/MEK pathway. J Virol (2006) 1.14

Asparagine 631 variants of the chicken Mx protein do not inhibit influenza virus replication in primary chicken embryo fibroblasts or in vitro surrogate assays. J Virol (2008) 1.03

A monomeric GTPase-negative MxA mutant with antiviral activity. J Virol (2000) 1.01

Thogoto virus matrix protein is encoded by a spliced mRNA. J Virol (2000) 0.88

The cytoplasmic location of chicken mx is not the determining factor for its lack of antiviral activity. PLoS One (2010) 0.80

Partial antiviral activities detection of chicken Mx jointing with neuraminidase gene (NA) against Newcastle disease virus. PLoS One (2013) 0.77

Functional Roles of Pattern Recognition Receptors That Recognize Virus Nucleic Acids in Human Adipose-Derived Mesenchymal Stem Cells. Biomed Res Int (2016) 0.75

Articles cited by this

Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc Natl Acad Sci U S A (1986) 32.58

Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell (1986) 4.92

Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology (1991) 4.45

A plasmid-based reverse genetics system for influenza A virus. J Virol (1996) 4.33

cDNA structures and regulation of two interferon-induced human Mx proteins. Mol Cell Biol (1989) 3.20

Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle. J Virol (1992) 2.88

Interferon-induced proteins and the antiviral state. Adv Virus Res (1990) 2.84

Mx proteins: mediators of innate resistance to RNA viruses. Rev Sci Tech (1998) 2.40

Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product. J Virol (1985) 2.38

Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids. Proc Natl Acad Sci U S A (1999) 1.78

Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus. J Virol (1995) 1.73

Mechanism of human MxA protein action: variants with changed antiviral properties. EMBO J (1992) 1.63

Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections. J Virol (1999) 1.62

Enhanced virus resistance of transgenic mice expressing the human MxA protein. J Virol (1995) 1.56

Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity. J Virol (1997) 1.44

Overexpression of the influenza virus polymerase can titrate out inhibition by the murine Mx1 protein. J Virol (1992) 1.36

GTP-bound human MxA protein interacts with the nucleocapsids of Thogoto virus (Orthomyxoviridae). J Biol Chem (1999) 1.34

Function of the mouse Mx1 protein is inhibited by overexpression of the PB2 protein of influenza virus. Virology (1993) 1.34

In vivo reconstitution of active Thogoto virus polymerase: assays for the compatibility with other orthomyxovirus core proteins and template RNAs. Virus Res (1998) 0.99

Parental influenza virion nucleocapsids are efficiently transported into the nuclei of murine cells expressing the nuclear interferon-induced Mx protein. J Virol (1990) 0.96

MxA GTPase: oligomerization and GTP-dependent interaction with viral RNP target structures. Methods (1998) 0.91

Expression of the human MxA protein is associated with hyperphosphorylation of VSV P protein in human neural Cells. Virology (1996) 0.86

Articles by these authors

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J Biol Chem (1993) 7.16

Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature (1993) 5.23

Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell (1986) 4.92

Genetic evidence for an interferon-antagonistic function of rift valley fever virus nonstructural protein NSs. J Virol (2001) 3.65

Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. J Virol (1990) 3.44

Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation. Mol Cell Biol (1988) 3.32

cDNA structures and regulation of two interferon-induced human Mx proteins. Mol Cell Biol (1989) 3.20

Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus. Proc Natl Acad Sci U S A (1983) 3.17

Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts. Eur J Immunol (1977) 3.05

Antibodies to HTLV-III in Swiss patients with AIDS and pre-AIDS and in groups at risk for AIDS. N Engl J Med (1985) 2.95

Host gene influences sensitivity to interferon action selectively for influenza virus. Nature (1980) 2.88

Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle. J Virol (1992) 2.88

Inborn resistance of ice to orthomyxoviruses. Curr Top Microbiol Immunol (1981) 2.41

Interferon-alpha inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway. J Gen Virol (2001) 2.40

Mx proteins: mediators of innate resistance to RNA viruses. Rev Sci Tech (1998) 2.40

Role of non-conventional natural killer cells in resistance against syngeneic tumour cells in vivo. Nature (1977) 2.39

Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product. J Virol (1985) 2.38

Adult mouse hepatocytes in primary monolayer culture express genetic resistance to mouse hepatitis virus type 3. J Immunol (1982) 2.32

Interferon-induced protein Mx accumulates in nuclei of mouse cells expressing resistance to influenza viruses. Virology (1985) 2.26

Genetically determined, interferon-dependent resistance to influenza virus in mice. J Exp Med (1979) 2.14

Polyclonal and monoclonal antibodies to the interferon-inducible protein Mx of influenza virus-resistant mice. J Biol Chem (1985) 2.10

Transcriptional activation of the mouse Mx gene by type I interferon. Mol Cell Biol (1986) 2.04

Interferon-induced Mx protein: a mediator of cellular resistance to influenza virus. Interferon (1987) 1.99

Natural killer cells in the mouse: an alternative immune surveillance mechanism? Contemp Top Immunobiol (1978) 1.96

A family of interferon-induced Mx-related mRNAs encodes cytoplasmic and nuclear proteins in rat cells. J Virol (1988) 1.90

The central interactive region of human MxA GTPase is involved in GTPase activation and interaction with viral target structures. FEBS Lett (1999) 1.81

Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids. Proc Natl Acad Sci U S A (1999) 1.78

Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein. J Virol (1996) 1.76

Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus. J Virol (1995) 1.73

Mx-dependent resistance to influenza viruses is induced by mouse interferons alpha and beta but not gamma. Virology (1984) 1.71

Interferon-induced human protein with homology to protein Mx of influenza virus-resistant mice. Mol Cell Biol (1985) 1.70

Human cytomegalovirus immediate early and late transcripts are expressed in all major leukocyte populations in vivo. J Infect Dis (1995) 1.70

Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections. J Virol (1999) 1.62

A classical bipartite nuclear localization signal on Thogoto and influenza A virus nucleoproteins. Virology (1998) 1.60

Germinal centre CD4+ T cells are an important site of HIV replication in vivo. AIDS (1997) 1.58

Enhanced virus resistance of transgenic mice expressing the human MxA protein. J Virol (1995) 1.56

Tick-borne thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1. J Virol (1995) 1.52

Activity of rat Mx proteins against a rhabdovirus. J Virol (1990) 1.52

Inborn resistance of mice to myxoviruses: macrophages express phenotype in vitro. J Exp Med (1978) 1.46

Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity. J Virol (1997) 1.44

Protective role of interferon-induced Mx GTPases against influenza viruses. Rev Sci Tech (2009) 1.39

Genetically determined resistance to infection by hepatotropic influenza A virus in mice: effect of immunosuppression. Infect Immun (1976) 1.35

GTP-bound human MxA protein interacts with the nucleocapsids of Thogoto virus (Orthomyxoviridae). J Biol Chem (1999) 1.34

Enzymic synthesis of isoflavones. Eur J Biochem (1986) 1.33

Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon-induced Mx proteins. EMBO J (1988) 1.32

MxA gene expression after live virus vaccination: a sensitive marker for endogenous type I interferon. J Infect Dis (1994) 1.29

Rapid detection of influenza virus H1 by the polymerase chain reaction. Biochem Biophys Res Commun (1990) 1.26

Virus-specific interferon action. Protection of newborn Mx carriers against lethal infection with influenza virus. J Exp Med (1981) 1.24

Host gene influence on interferon action in adult mouse hepatocytes: specificity for influenza virus. Virology (1980) 1.23

Corynebacterium parvum-induced peritoneal exudate cells with rapid cytolytic activity against tumour cells are non-phagocytic cells with characteristics of natural killer cells. Scand J Immunol (1978) 1.23

Athymic (nude) mice express gene for myxovirus resistance. Nature (1974) 1.23

Nucleoprotein viral RNA and mRNA of Thogoto virus: a novel "cap-stealing" mechanism in tick-borne orthomyxoviruses? J Virol (1996) 1.20

Interferon-regulated influenza virus resistance gene Mx is localized on mouse chromosome 16. J Virol (1986) 1.20

Suppression of natural killer cell activity with radioactive strontium: effector cells are marrow dependent. J Immunol (1977) 1.19

Generation of natural killer cells: an autonomous function of the bone marrow. J Exp Med (1977) 1.19

Interferon-regulated Mx genes are not responsive to interleukin-1, tumor necrosis factor, and other cytokines. J Virol (1991) 1.17

An analysis of conditions allowing Corynebacterium parvum to cause either augmentation or inhibition of natural killer cell activity against tumor cells in mice. Int J Cancer (1978) 1.13

A functional comparison of tumor cell killing by activated macrophages and natural killer cells. Eur J Immunol (1979) 1.12

Natural, genetically determined resistance toward influenza virus in hemopoietic mouse chimeras. Role of mononuclear phagocytes. J Exp Med (1979) 1.11

Characterization and expression of the Mx1 gene in wild mouse species. Biochem Genet (1998) 1.10

A double-stranded RNA-inducible fish gene homologous to the murine influenza virus resistance gene Mx. Mol Cell Biol (1989) 1.09

Intragenic variability of human cytomegalovirus glycoprotein B in clinical strains. J Infect Dis (1998) 1.07

Interferon-dependent genetic resistance to influenza virus in mice: virus replication in macrophages is inhibited at an early step. J Gen Virol (1980) 1.07

Identification of the murine Mx2 gene: interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus. J Virol (1999) 1.06

Genetic control of interferon action: mouse strain distribution and inheritance of an induced protein with guanylate-binding property. Virology (1984) 1.04

Conserved vRNA end sequences of Thogoto-orthomyxovirus suggest a new panhandle structure. Arch Virol (1997) 1.03

Resistance to Rift Valley fever virus in Rattus norvegicus: genetic variability within certain 'inbred' strains. J Gen Virol (2000) 1.03

Mx transgenic mice--animal models of health. Curr Top Microbiol Immunol (1996) 1.03

The fourth genus in the Orthomyxoviridae: sequence analyses of two Thogoto virus polymerase proteins and comparison with influenza viruses. Virus Res (1997) 1.03

A mouse hepatotropic variant of influenza virus. Arch Virol (1975) 1.02

A monomeric GTPase-negative MxA mutant with antiviral activity. J Virol (2000) 1.01

Monospecific polyclonal antibodies directed against purified cinnamate 4-hydroxylase from Helianthus tuberosus. Immunopurification, immunoquantitation, and interspecies cross-reactivity. Plant Physiol (1993) 1.00

Interferon independence of genetically controlled resistance to flaviviruses. Infect Immun (1982) 1.00

Human cytomegalovirus immediate early and late transcripts in peripheral blood leukocytes: diagnostic value in renal transplant recipients. J Infect Dis (1995) 0.99

In vivo reconstitution of active Thogoto virus polymerase: assays for the compatibility with other orthomyxovirus core proteins and template RNAs. Virus Res (1998) 0.99

Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies. Exp Cell Res (2001) 0.99

Rescue of recombinant Thogoto virus from cloned cDNA. J Virol (2001) 0.97

Mx genes show weaker primary response to virus than other interferon-regulated genes. Virology (1992) 0.96

Inhibition of coxsackievirus B4 replication in stably transfected cells expressing human MxA protein. Virology (2001) 0.95

Mouse natural killer (NK) cell activity against human cell lines is not influenced by superinfection of the target cell with xenotropic murine C-type virus. Int J Cancer (1978) 0.94

Multiple forms of NADPH-cytochrome P450 reductase in higher plants. Biochem Biophys Res Commun (1991) 0.94

Antibody to mouse interferon alpha/beta abrogates resistance to the multiplication of Friend erythroleukemia cells in the livers of allogeneic mice. J Exp Med (1988) 0.94

Glycoprotein B genotype of human cytomegalovirus: distribution in HIV-infected patients. Scand J Infect Dis (1996) 0.92

MxA GTPase: oligomerization and GTP-dependent interaction with viral RNP target structures. Methods (1998) 0.91

Formation of virus-like particles from cloned cDNAs of Thogoto virus. J Gen Virol (2000) 0.91

Molecular characterization and functional expression of dihydroxypterocarpan 6a-hydroxylase, an enzyme specific for pterocarpanoid phytoalexin biosynthesis in soybean (Glycine max L.). FEBS Lett (1998) 0.90

Genetic resistance to influenza virus in wild mice. Curr Top Microbiol Immunol (1986) 0.90

Mx gene control of interferon action: different kinetics of the antiviral state against influenza virus and vesicular stomatitis virus. J Virol (1983) 0.90