Peptides corresponding to the N and C termini of IkappaB-alpha, -beta, and -epsilon as probes of the two catalytic subunits of IkappaB kinase, IKK-1 and IKK-2.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 10593898)

Published in J Biol Chem on December 17, 1999

Authors

J R Burke1, M K Wood, R P Ryseck, S Walther, C A Meyers

Author Affiliations

1: Drug Discovery Research, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA. james.burke@bms.com

Articles by these authors

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem (1983) 9.32

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Cell (1995) 4.70

The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity. EMBO J (1989) 4.27

A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site. Mol Cell Biol (1992) 3.63

Characterization of junD: a new member of the jun proto-oncogene family. EMBO J (1989) 3.55

Purification and initial characterization of a type beta transforming growth factor from human placenta. Proc Natl Acad Sci U S A (1983) 3.52

Purification and properties of a type beta transforming growth factor from bovine kidney. Biochemistry (1983) 3.49

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation. Cell (1989) 2.84

Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells. Cancer Res (1982) 2.70

The Functional Assessment of Cancer Therapy (FACT) scale. Development of a brain subscale and revalidation of the general version (FACT-G) in patients with primary brain tumors. Cancer (1995) 2.55

Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2. J Exp Med (1997) 2.13

Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies. J Biol Chem (1984) 1.96

Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor. J Immunol (1998) 1.92

Cognitive functioning and quality of life in malignant glioma patients: a review of the literature. Psychooncology (1997) 1.87

A prospective study of the incidence and open-label treatment of interferon-induced major depressive disorder in patients with hepatitis C. Mol Psychiatry (2002) 1.73

Pattern of neurobehavioral deficits associated with interferon alfa therapy for leukemia. Neurology (1995) 1.71

Phase II study of accelerated fractionation radiation therapy with carboplatin followed by PCV chemotherapy for the treatment of anaplastic gliomas. Int J Radiat Oncol Biol Phys (2002) 1.61

Hypothalamic regulatory hormones. Annu Rev Biochem (1978) 1.60

Klüver-Bucy syndrome after bilateral selective damage of amygdala and its cortical connections. J Neuropsychiatry Clin Neurosci (1998) 1.59

Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells. Development (1993) 1.48

Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif. Mol Cell Biol (1993) 1.46

Functional redundancy of the nuclear factor kappa B inhibitors I kappa B alpha and I kappa B beta. J Exp Med (1998) 1.45

Recombinant HIV-1 reverse transcriptase: purification, primary structure, and polymerase/ribonuclease H activities. Arch Biochem Biophys (1989) 1.41

Primary structure of a developmentally regulated nicotinic acetylcholine receptor protein from Drosophila. EMBO J (1986) 1.40

Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients. J Invest Dermatol (1995) 1.39

Antigen-induced eosinophilic lung inflammation develops in mice deficient in chemokine eotaxin. Blood (1998) 1.33

Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor. Oncogene (1994) 1.30

Tissue-specific expression of c-jun and junB during organogenesis in the mouse. Development (1989) 1.29

Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity. EMBO J (1994) 1.23

Specific inhibition of RelB/p52 transcriptional activity by the C-terminal domain of p100. Oncogene (1995) 1.22

Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway. Proc Natl Acad Sci U S A (1996) 1.22

Mood and cognitive side effects of interferon-alpha therapy. Semin Oncol (1998) 1.16

Purification and characterization of human recombinant interleukin-1 beta. J Biol Chem (1987) 1.16

Neuropsychological dysfunction associated with cancer and cancer therapies: a conceptual review of an emerging target. Br J Cancer (2004) 1.15

Postoperative mutism in neurosurgery. Report of two cases. J Neurosurg (1994) 1.13

Genetic approaches to study Rel/NF-kappa B/I kappa B function in mice. Semin Cancer Biol (1997) 1.12

The product of a novel growth factor-activated gene, fic, is a biologically active "C-C"-type cytokine. Mol Cell Biol (1993) 1.09

Structure of concanavalin A at 4.25-ångström resolution. Proc Natl Acad Sci U S A (1971) 1.09

Relationship between quality of life and mood in long-term survivors of breast cancer treated with mastectomy. Support Care Cancer (1997) 1.07

Highly active position eight analogues of somatostatin and separation of peptide diastereomers by partition chromatography. Biochemistry (1978) 1.07

Synthesis and biological actions of prosomatostatin. Proc Natl Acad Sci U S A (1980) 1.07

A randomized trial on the efficacy of methylphenidate and modafinil for improving cognitive functioning and symptoms in patients with a primary brain tumor. J Neurooncol (2011) 1.05

The Drosophila ebony gene is closely related to microbial peptide synthetases and shows specific cuticle and nervous system expression. Gene (1998) 1.04

Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy. Biochemistry (1994) 1.02

Treatment of neurotoxic side effects of interferon-alpha with naltrexone. Cancer Invest (1995) 0.98

Solution structure of the Grb2 N-terminal SH3 domain complexed with a ten-residue peptide derived from SOS: direct refinement against NOEs, J-couplings and 1H and 13C chemical shifts. J Mol Biol (1997) 0.98

Chromosome abnormalities in congenital heart disease. Am J Med Genet (1997) 0.98

A phase I study of TNP-470 administered to patients with advanced squamous cell cancer of the cervix. Clin Cancer Res (1997) 0.98

Constitutive expression of FosB and its short form, FosB/SF, induces malignant cell transformation in rat-1A cells. New Biol (1991) 0.97

Mechanism of cGMP-mediated protection in a cellular model of myocardial reperfusion injury. Cardiovasc Res (2005) 0.96

X-ray crystallographic studies of concanavalin A. Cold Spring Harb Symp Quant Biol (1972) 0.95

Advantages of the paramedian approach for lumbar epidural analgesia with catheter technique. A clinical comparison between midline and paramedian approaches. Anaesthesia (1989) 0.95

Psychosocial functioning and quality of life in patients with primary brain tumors. J Neurosurg (1996) 0.94

A crystallographic investigation of a human IgG immunoglobulin. J Biol Chem (1970) 0.94

Ventricular enlargement after closed head injury. Arch Neurol (1981) 0.94

Efficacy of retrograde ureteropyeloscopic holmium laser lithotripsy for intrarenal calculi >2 cm. Urol Res (2010) 0.94

Cognitive dysfunction following surgery for intracerebral glioma: influence of histopathology, lesion location, and treatment. J Neurooncol (1996) 0.93

A porcine model of acute quadriplegic myopathy: a feasibility study. Acta Anaesthesiol Scand (2006) 0.93

Cloning of heat-shock locus 93D from Drosophila melanogaster. EMBO J (1984) 0.92

Evaluation of cognitive function in patients with limited small cell lung cancer prior to and shortly following prophylactic cranial irradiation. Int J Radiat Oncol Biol Phys (1995) 0.92

Heat shock loci 93D of Drosophila melanogaster and 48B of Drosophila hydei exhibit a common structural and transcriptional pattern. Nucleic Acids Res (1987) 0.92

Developing a care giver quality-of-life instrument. Preliminary steps. Cancer Pract (1997) 0.92

Patterns and potential value of cardiac troponin I elevations after pediatric cardiac operations. Ann Thorac Surg (1998) 0.90

Potent, highly selective inhibition of growth hormone secretion by position 4 somatostatin analogs. Endocrinology (1981) 0.90

Actigraphy in agitated patients with dementia. Monitoring treatment outcomes. Z Gerontol Geriatr (2007) 0.90

Secretion of N-glycosylated interleukin-1 beta in Saccharomyces cerevisiae using a leader peptide from Candida albicans. Effect of N-linked glycosylation on biological activity. J Biol Chem (1991) 0.90

Cognitive and mood disturbance as causes and symptoms of fatigue in cancer patients. Cancer (2001) 0.90

Three-dimensional structure of the Mcg IgG1 immunoglobulin. Mol Immunol (1983) 0.89

A retrospective study of the psychiatric management and outcome of delirium in the cancer patient. Support Care Cancer (1996) 0.89

Methylphenidate in the treatment of neurobehavioral slowing associated with cancer and cancer treatment. J Neuropsychiatry Clin Neurosci (1995) 0.89

Deletion within chromosome 22 is common in patients with absent pulmonary valve syndrome. Am J Cardiol (1995) 0.89

The hippocampus: normal anatomy and pathology. AJR Am J Roentgenol (1998) 0.88

NGF gene transfer to intrinsic basal forebrain neurons increases cholinergic cell size and protects from age-related, spatial memory deficits in middle-aged rats. Brain Res (2000) 0.88

Identification of growth-factor-inducible genes in mouse fibroblasts. Cold Spring Harb Symp Quant Biol (1988) 0.87

Phase II study of i.v. CI-980 in patients with advanced platinum refractory epithelial ovarian carcinoma. Anticancer Drugs (1998) 0.86

Small albumin-immunoglobulin complexes in patients with liver disease. Immunology (1983) 0.86

Prophylactic treatment of depression induced by interferon-alpha. Psychosomatics (2000) 0.86

Characterization of ES cells deficient for the p105 precursor (NF-kappa B1): role of p50 NLS. Oncogene (1996) 0.86

Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity. J Med Chem (1996) 0.86

Structure-activity studies with somatostatin: the role of tryptophan in position 8. Regul Pept (1980) 0.85

Time for a new era in the evaluation of targeted therapies for patients with chronic myeloid leukemia: inclusion of quality of life and other patient-reported outcomes. Crit Rev Oncol Hematol (2011) 0.85

[Quality of reporting of systematic reviews and meta-analyses: PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses)]. Rofo (2011) 0.84

Efficacy of postacute brain injury rehabilitation for patients with primary malignant brain tumors. Cancer (1997) 0.84

Mutism after closed head injury. Arch Neurol (1983) 0.84

Inhibition of NF-kappaB in T cells blocks lymphoproliferation and partially rescues autoimmune disease in gld/gld mice. Eur J Immunol (2001) 0.83

Transforming growth factors from a human tumor cell: characterization of transforming growth factor beta and identification of high molecular weight transforming growth factor alpha. Biochemistry (1985) 0.83

Prolonged activation EEG differentiates dementia with and without delirium in frail elderly patients. J Neurol Neurosurg Psychiatry (2007) 0.83

The multisubunit IkappaB kinase complex shows random sequential kinetics and is activated by the C-terminal domain of IkappaB alpha. J Biol Chem (1998) 0.82

Linguistic recovery after closed head injury. Brain Lang (1981) 0.82

Early versus late lateral ventricular enlargement following closed head injury. J Neurol Neurosurg Psychiatry (1983) 0.82

[Phe4]somatostatin: a potent, selective inhibitor of growth hormone release. Proc Natl Acad Sci U S A (1980) 0.81

Endothelin-1-induced proliferation of human endothelial cells depends on activation of K+ channels and Ca+ influx. Acta Physiol Scand (2005) 0.81

Extended myectomy for hypertrophic obstructive cardiomyopathy after failure or contraindication of septal ablation or with combined surgical procedures. Thorac Cardiovasc Surg (2004) 0.81

'A-pin-dicitis' and liver abscess. JAMA (1981) 0.81

Activity of VIP, somatostatin and other peptides in the mouse vas deferens assay. Pharmacol Biochem Behav (1978) 0.81

Two major RNA products are transcribed from heat-shock locus 93D of Drosophila melanogaster. Chromosoma (1985) 0.81

Influence of polyclonal ATGs on expression of adhesion molecules: an experimental study. Transplant Proc (2005) 0.80

A rare cause of ischemic colitis: polyarteritis nodosa. Dis Colon Rectum (1979) 0.80

A preliminary crystallographic investigation of human L-type Bence-Jones protein. J Biol Chem (1970) 0.80