Published in J Gen Physiol on January 01, 2000
Sensing voltage across lipid membranes. Nature (2008) 2.66
Modeling diverse range of potassium channels with Brownian dynamics. Biophys J (2002) 2.12
Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels. PLoS Biol (2009) 2.12
Dynamics of the Kv1.2 voltage-gated K+ channel in a membrane environment. Biophys J (2007) 2.10
Modeling the structure of agitoxin in complex with the Shaker K+ channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles. Biophys J (2002) 1.98
Localization and molecular determinants of the Hanatoxin receptors on the voltage-sensing domains of a K(+) channel. J Gen Physiol (2000) 1.77
Interaction of KCNE subunits with the KCNQ1 K+ channel pore. J Physiol (2005) 1.66
Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer. Structure (2008) 1.64
Structural basis of two-stage voltage-dependent activation in K+ channels. Proc Natl Acad Sci U S A (2003) 1.61
Voltage sensor movements. J Gen Physiol (2002) 1.59
Helical structure of the COOH terminus of S3 and its contribution to the gating modifier toxin receptor in voltage-gated ion channels. J Gen Physiol (2001) 1.47
Structural similarities between glutamate receptor channels and K(+) channels examined by scanning mutagenesis. J Gen Physiol (2001) 1.44
Periodic perturbations in Shaker K+ channel gating kinetics by deletions in the S3-S4 linker. Proc Natl Acad Sci U S A (2001) 1.44
Mg(2+) modulates voltage-dependent activation in ether-à-go-go potassium channels by binding between transmembrane segments S2 and S3. J Gen Physiol (2000) 1.36
Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels. J Gen Physiol (2005) 1.30
Models of the structure and voltage-gating mechanism of the shaker K+ channel. Biophys J (2004) 1.24
A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels. J Gen Physiol (2000) 1.21
Localization of the extracellular end of the voltage sensor S4 in a potassium channel. Biophys J (2001) 1.20
The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure. J Biol Chem (2010) 1.19
Movement and crevices around a sodium channel S3 segment. J Gen Physiol (2002) 1.18
Kinetics of tethering quaternary ammonium compounds to K(+) channels. J Gen Physiol (2002) 1.16
The preference of tryptophan for membrane interfaces: insights from N-methylation of tryptophans in gramicidin channels. J Biol Chem (2008) 1.14
Molecular surface of tarantula toxins interacting with voltage sensors in K(v) channels. J Gen Physiol (2004) 1.14
Molecular determinants of coupling between the domain III voltage sensor and pore of a sodium channel. Nat Struct Mol Biol (2010) 1.13
Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed. J Physiol (2005) 1.10
Secondary structure of a KCNE cytoplasmic domain. J Gen Physiol (2006) 1.09
A model of voltage gating developed using the KvAP channel crystal structure. Biophys J (2004) 1.09
Coupled motions between pore and voltage-sensor domains: a model for Shaker B, a voltage-gated potassium channel. Biophys J (2004) 1.06
Role of the S6 C-terminus in KCNQ1 channel gating. J Physiol (2007) 1.05
Membrane stretch accelerates activation and slow inactivation in Shaker channels with S3-S4 linker deletions. Biophys J (2002) 1.05
A role for the S0 transmembrane segment in voltage-dependent gating of BK channels. J Gen Physiol (2007) 1.03
The interfacial lipid binding site on the potassium channel KcsA is specific for anionic phospholipids. Biophys J (2005) 1.01
Serial perturbation of MinK in IKs implies an alpha-helical transmembrane span traversing the channel corpus. Biophys J (2007) 0.98
Transfer of Kv3.1 voltage sensor features to the isolated Ci-VSP voltage-sensing domain. Biophys J (2012) 0.95
Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex. Elife (2016) 0.93
KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function. Biophys J (2010) 0.92
Allowed N-glycosylation sites on the Kv1.2 potassium channel S1-S2 linker: implications for linker secondary structure and the glycosylation effect on channel function. Biochem J (2003) 0.91
Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1. Eur Biophys J (2011) 0.87
Can Shaker potassium channels be locked in the deactivated state? J Gen Physiol (2004) 0.82
Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation. J Physiol (2006) 0.80
Structure and packing orientation of transmembrane segments in voltage-dependent channels. Lessons from perturbation analysis. J Gen Physiol (2000) 0.80
Tryptophan scanning of the acetylcholine receptor's betaM4 transmembrane domain: decoding allosteric linkage at the lipid-protein interface with ion-channel gating. Channels (Austin) (2008) 0.79
Tryptophan scanning mutagenesis of the first transmembrane domain of the innexin Shaking-B(Lethal). Biophys J (2011) 0.79
Fourier transform coupled to tryptophan-scanning mutagenesis: lessons from its application to the prediction of secondary structure in the acetylcholine receptor lipid-exposed transmembrane domains. Biochim Biophys Acta (2008) 0.79
Novel phenotype associated with a mutation in the KCNA1(Kv1.1) gene. Front Physiol (2015) 0.78
The S1 Helix Critically Regulates the Finely-tuned Gating of Kv11.1 Channels. J Biol Chem (2017) 0.75
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science (1998) 39.86
Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science (1990) 15.75
Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs. Neuron (1992) 10.25
Electrostatic interactions of S4 voltage sensor in Shaker K+ channel. Neuron (1995) 4.49
The moving parts of voltage-gated ion channels. Q Rev Biophys (1998) 4.46
Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila. Nature (1988) 4.18
Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits. Biophys J (1997) 3.17
An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors. J Mol Biol (1997) 2.66
Helical structure and packing orientation of the S2 segment in the Shaker K+ channel. J Gen Physiol (1999) 2.10
Features of MotA proton channel structure revealed by tryptophan-scanning mutagenesis. Proc Natl Acad Sci U S A (1995) 1.63
Modeling alpha-helical transmembrane domains: the calculation and use of substitution tables for lipid-facing residues. Protein Sci (1993) 1.53
Three distinct structural environments of a transmembrane domain in the inwardly rectifying potassium channel ROMK1 defined by perturbation. Proc Natl Acad Sci U S A (1995) 1.35
Chemical basis for alkali cation selectivity in potassium-channel proteins. Chem Biol (1998) 1.09
Consequences of reducing nonresponse in a national telephone survey. Public Opin Q (2000) 7.67
Conduction and selectivity in potassium channels. J Membr Biol (1983) 6.41
Open-state substructure of single chloride channels from Torpedo electroplax. Philos Trans R Soc Lond B Biol Sci (1982) 5.26
Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle. Nature (1985) 4.95
An improved technique for multiple organ harvesting. Surg Gynecol Obstet (1987) 4.73
Human p53 gene localized to short arm of chromosome 17. Nature (1986) 4.67
Nonequilibrium gating and voltage dependence of the ClC-0 Cl- channel. J Gen Physiol (1996) 4.24
Rearrangement of the p53 gene in human osteogenic sarcomas. Proc Natl Acad Sci U S A (1987) 4.21
Discrete Ba2+ block as a probe of ion occupancy and pore structure in the high-conductance Ca2+ -activated K+ channel. J Gen Physiol (1988) 4.05
Fertilization-independent seed development in Arabidopsis thaliana. Proc Natl Acad Sci U S A (1997) 3.87
Potassium blocks barium permeation through a calcium-activated potassium channel. J Gen Physiol (1988) 3.82
Single chloride channels from Torpedo electroplax. Activation by protons. J Gen Physiol (1983) 3.76
Emergence of domestically acquired ceftriaxone-resistant Salmonella infections associated with AmpC beta-lactamase. JAMA (2000) 3.64
Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel. J Gen Physiol (1988) 3.48
Homodimeric architecture of a ClC-type chloride ion channel. Nature (1996) 3.47
Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein. Mol Cell Biol (1991) 3.45
Single streptomyces lividans K(+) channels: functional asymmetries and sidedness of proton activation. J Gen Physiol (1999) 3.42
Consensus statement on the live organ donor. JAMA (2000) 3.29
Multi-ion conduction and selectivity in the high-conductance Ca++-activated K+ channel from skeletal muscle. Biophys J (1986) 3.24
KcsA: it's a potassium channel. J Gen Physiol (2001) 3.23
Dimeric structure of single chloride channels from Torpedo electroplax. Proc Natl Acad Sci U S A (1984) 3.22
Ionic selectivity, saturation, and block in a K+-selective channel from sarcoplasmic reticulum. J Gen Physiol (1980) 3.16
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J Exp Med (1993) 3.13
Language discrimination by human newborns and by cotton-top tamarin monkeys. Science (2000) 2.89
Charybdotoxin block of single Ca2+-activated K+ channels. Effects of channel gating, voltage, and ionic strength. J Gen Physiol (1988) 2.87
Bis-quaternary ammonium blockers as structural probes of the sarcoplasmic reticulum K+ channel. J Gen Physiol (1982) 2.87
A controlled trial of isoniazid in persons with anergy and human immunodeficiency virus infection who are at high risk for tuberculosis. Terry Beirn Community Programs for Clinical Research on AIDS. N Engl J Med (1997) 2.84
Problems associated with early discharge of newborn infants. Early discharge of newborns and mothers: a critical review of the literature. Pediatrics (1995) 2.82
Steady-state coupling of ion-channel conformations to a transmembrane ion gradient. Science (1990) 2.80
Silver as a probe of pore-forming residues in a potassium channel. Science (1995) 2.78
Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science (1989) 2.75
Functional reconstitution of a prokaryotic K+ channel. J Gen Physiol (1998) 2.66
A voltage-gated anion channel from the electric organ of Torpedo californica. J Biol Chem (1979) 2.65
Voltage-gated cation conductance channel from fragmented sarcoplasmic reticulum: steady-state electrical properties. J Membr Biol (1978) 2.57
The charybdotoxin receptor of a Shaker K+ channel: peptide and channel residues mediating molecular recognition. Neuron (1994) 2.55
Effects of phospholipid surface charge on ion conduction in the K+ channel of sarcoplasmic reticulum. Biophys J (1984) 2.46
Laboratory and bedside evaluation of portable glucose meters. Am J Clin Pathol (1995) 2.35
Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia. J Immunol (1992) 2.32
A voltage-dependent chloride conductance channel from Torpedo electroplax membrane. Ann N Y Acad Sci (1980) 2.26
Batrachotoxin-activated Na+ channels in planar lipid bilayers. Competition of tetrodotoxin block by Na+. J Gen Physiol (1984) 2.26
Epstein-Barr virus nuclear protein 3C modulates transcription through interaction with the sequence-specific DNA-binding protein J kappa. J Virol (1995) 2.25
Role of surface electrostatics in the operation of a high-conductance Ca2+-activated K+ channel. Biochemistry (1989) 2.25
Human immunodeficiency virus infection in disadvantaged adolescents. Findings from the US Job Corps. JAMA (1991) 2.24
Purification, reconstitution, and subunit composition of a voltage-gated chloride channel from Torpedo electroplax. Biochemistry (1994) 2.21
Cardiovascular risk factors associated with lower baseline cognitive performance in HIV-positive persons. Neurology (2010) 2.17
Food service and foods and beverages available at school: results from the School Health Policies and Programs Study 2000. J Sch Health (2001) 2.16
Allosteric effects of Mg2+ on the gating of Ca2+-activated K+ channels from mammalian skeletal muscle. J Exp Biol (1986) 2.14
High-level expression, functional reconstitution, and quaternary structure of a prokaryotic ClC-type chloride channel. J Gen Physiol (1999) 2.12
Helical structure and packing orientation of the S2 segment in the Shaker K+ channel. J Gen Physiol (1999) 2.10
Thermodynamic and kinetic studies of the gating behavior of a K+-selective channel from the sarcoplasmic reticulum membrane. J Gen Physiol (1980) 2.06
Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes. Diabetologia (2007) 2.06
Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation. J Clin Oncol (2001) 2.05
A K+-selective, three-state channel from fragmented sarcoplasmic reticulum of frog leg muscle. J Membr Biol (1981) 2.04
Ca++-induced fusion of fragmented sarcoplasmic reticulum with artificial planar bilayers. J Membr Biol (1976) 2.04
Conduction and block by organic cations in a K+-selective channel from sarcoplasmic reticulum incorporated into planar phospholipid bilayers. J Gen Physiol (1982) 2.00
Mechanism of charybdotoxin block of a voltage-gated K+ channel. Biophys J (1993) 1.99
Health service use among low-risk newborns after early discharge with and without nurse home visiting. J Am Board Fam Pract (1997) 1.97
Trapping single ions inside single ion channels. Biophys J (1987) 1.94
Tetrameric stoichiometry of a prokaryotic K+ channel. Biochemistry (1997) 1.94
More on epidural needle wings. Anaesthesia (2006) 1.92
Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy. Am J Pathol (2000) 1.90
Tethered blockers as molecular 'tape measures' for a voltage-gated K+ channel. Nat Struct Biol (2000) 1.89
Orthotopic liver transplantation for primary sclerosing cholangitis. Ann Surg (1988) 1.89
A decade of CLC chloride channels: structure, mechanism, and many unsettled questions. Annu Rev Biophys Biomol Struct (2000) 1.89
Interaction of charybdotoxin with permeant ions inside the pore of a K+ channel. Neuron (1992) 1.87
Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins. J Gen Physiol (1984) 1.84
Communicating health information through the entertainment media. Health Aff (Millwood) (2001) 1.83
LR white resin and improved on-grid immunogold detection of vicilin, a pea seed storage protein. Cell Biol Int Rep (1984) 1.82
Effects of sleep and sleep deprivation on catecholamine and interleukin-2 levels in humans: clinical implications. J Clin Endocrinol Metab (1999) 1.81
Purification of charybdotoxin, a specific inhibitor of the high-conductance Ca2+-activated K+ channel. J Biol Chem (1986) 1.80
Isolated-patch recording from liposomes containing functionally reconstituted chloride channels from Torpedo electroplax. Proc Natl Acad Sci U S A (1982) 1.77
Role of rpoS (katF) in oxyR-independent regulation of hydroperoxidase I in Escherichia coli. Mol Microbiol (1994) 1.77
Distribution and activation of the Golgi apparatus in geotropism. Plant Physiol (1972) 1.75
Hepatic artery in liver transplantation. Transplant Proc (1987) 1.73
A large-scale, placebo-controlled, dose-ranging trial of peroral valaciclovir for episodic treatment of recurrent herpes genitalis. Valaciclovir HSV Study Group. Arch Intern Med (1996) 1.73
Construction, safety, and immunogenicity in nonhuman primates of a chimeric yellow fever-dengue virus tetravalent vaccine. J Virol (2001) 1.73
A comparison of eubacterial and archaeal structure-specific 5'-exonucleases. J Biol Chem (1999) 1.72
Intimations of K+ channel structure from a complete functional map of the molecular surface of charybdotoxin. Biochemistry (1994) 1.69
Surviving the sex trade: a comparison of HIV risk behaviours among street-involved women in two Canadian cities who inject drugs. AIDS Care (2003) 1.69
Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review. Oral Dis (2011) 1.69
Characterization of cDNA clones for human myeloperoxidase: predicted amino acid sequence and evidence for multiple mRNA species. Nucleic Acids Res (1987) 1.67
Be wary of subsidising nicotine replacement therapy. Tob Control (2002) 1.67
Probes of the conduction process of a voltage-gated Cl- channel from Torpedo electroplax. J Gen Physiol (1981) 1.66
The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogaster. Mol Cell Biol (1999) 1.66
The K+ channel of sarcoplasmic reticulum. A new look at Cs+ block. Biophys J (1985) 1.65
Surveillance of symptoms following MMR vaccine in children. Practitioner (1989) 1.63
A strongly interacting pair of residues on the contact surface of charybdotoxin and a Shaker K+ channel. Neuron (1996) 1.63
Fourier transform infrared spectroscopy reveals a rigid alpha-helical assembly for the tetrameric Streptomyces lividans K+ channel. Proc Natl Acad Sci U S A (1998) 1.62
Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxin. Biochemistry (1992) 1.61
Electrostatic binding of proteins to membranes. Theoretical predictions and experimental results with charybdotoxin and phospholipid vesicles. Biophys J (1997) 1.58
Functional modification of a Ca2+-activated K+ channel by trimethyloxonium. Biochemistry (1989) 1.57
Attempts at prophylaxis for murine Pneumocystis carinii pneumonitis. Curr Ther Res Clin Exp (1973) 1.57
Hanging gondola structure of the T1 domain in a voltage-gated K(+) channel. Biochemistry (2000) 1.55
Human apolipoprotein B: partial amino acid sequence. FEBS Lett (1984) 1.54
Coupling of water and ion fluxes in a K+-selective channel of sarcoplasmic reticulum. Biophys J (1982) 1.54
Site-specific mutations in a minimal voltage-dependent K+ channel alter ion selectivity and open-channel block. Neuron (1991) 1.53
von Willebrand disease and other inherited bleeding disorders in women with diagnosed menorrhagia. Obstet Gynecol (2001) 1.51
Decamethonium and hexamethonium block K+ channels of sarcoplasmic reticulum. Nature (1980) 1.51
Nystatin-induced liposome fusion. A versatile approach to ion channel reconstitution into planar bilayers. Biophys J (1990) 1.50