Published in Crit Care Med on December 01, 1999
Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev (2005) 14.71
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial. JAMA (2015) 3.32
Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals. Crit Care Med (2009) 2.77
Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma (2008) 2.46
Use of non-invasive ventilation to wean critically ill adults off invasive ventilation: meta-analysis and systematic review. BMJ (2009) 2.44
Delirium in the intensive care unit. Crit Care (2008) 2.34
Reducing iatrogenic risks: ICU-acquired delirium and weakness--crossing the quality chasm. Chest (2010) 2.28
State Behavioral Scale: a sedation assessment instrument for infants and young children supported on mechanical ventilation. Pediatr Crit Care Med (2006) 2.26
Validity of a Modified Sequential Organ Failure Assessment Score Using the Richmond Agitation-Sedation Scale. Crit Care Med (2016) 2.10
Ventilator-associated pneumonia: diagnosis, treatment, and prevention. Clin Microbiol Rev (2006) 1.99
Literature review and global consensus on management of acute radiation syndrome affecting nonhematopoietic organ systems. Disaster Med Public Health Prep (2011) 1.93
Intensivist physician staffing and the process of care in academic medical centres. Qual Saf Health Care (2007) 1.89
Noninvasive ventilation as a weaning strategy for mechanical ventilation in adults with respiratory failure: a Cochrane systematic review. CMAJ (2013) 1.82
Sedation, sleep promotion, and delirium screening practices in the care of mechanically ventilated children: a wake-up call for the pediatric critical care community*. Crit Care Med (2014) 1.71
Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial. Am J Respir Crit Care Med (2010) 1.70
Clinical practice guidelines for hospital-acquired pneumonia and ventilator-associated pneumonia in adults. Can J Infect Dis Med Microbiol (2008) 1.68
Effect of a scoring system and protocol for sedation on duration of patients' need for ventilator support in a surgical intensive care unit. BMJ (2002) 1.66
The relationship between hospital volume and mortality in mechanical ventilation: an instrumental variable analysis. Health Serv Res (2009) 1.63
Presence of electroencephalogram burst suppression in sedated, critically ill patients is associated with increased mortality. Crit Care Med (2008) 1.48
Outcomes of patients with melioidosis treated with meropenem. Antimicrob Agents Chemother (2004) 1.48
Tolerance and withdrawal from prolonged opioid use in critically ill children. Pediatrics (2010) 1.46
The association between comorbid illness, colonization status, and acute hospitalization in patients receiving prolonged mechanical ventilation. Respir Care (2013) 1.41
Clinical review: Emergency department overcrowding and the potential impact on the critically ill. Crit Care (2004) 1.33
Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care--short version. Ger Med Sci (2010) 1.30
Critical care nurses' role in implementing the "ABCDE bundle" into practice. Crit Care Nurse (2012) 1.18
A systematic review of the impact of sedation practice in the ICU on resource use, costs and patient safety. Crit Care (2010) 1.16
Protocol-driven care in the intensive care unit: a tool for quality. Crit Care (2001) 1.15
Risk factors for physical impairment after acute lung injury in a national, multicenter study. Am J Respir Crit Care Med (2014) 1.14
Sedation practice in the intensive care unit: a UK national survey. Crit Care (2008) 1.14
Comparison of different pain scoring systems in critically ill patients in a general ICU. Crit Care (2008) 1.12
Long-term psychological effects of a no-sedation protocol in critically ill patients. Crit Care (2011) 1.09
Strategies to optimize analgesia and sedation. Crit Care (2008) 1.08
Alcohol-use disorders in the critically ill patient. Chest (2010) 1.07
Prevalence and risk factors for development of delirium in burn intensive care unit patients. J Burn Care Res (2010) 1.07
Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients. Crit Care (2008) 1.05
Intensive Care Unit-acquired infection as a side effect of sedation. Crit Care (2010) 1.03
Current practices of mobilization, analgesia, relaxants and sedation in Indian ICUs: A survey conducted by the Indian Society of Critical Care Medicine. Indian J Crit Care Med (2014) 1.02
Bispectral index correlates well with Richmond agitation sedation scale in mechanically ventilated critically ill patients. J Anesth (2010) 0.96
Delirium: an emerging frontier in the management of critically ill children. Crit Care Clin (2009) 0.95
Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) - short version. Ger Med Sci (2015) 0.94
Prevention of ventilator-associated pneumonia in the intensive care unit: a review of the clinically relevant recent advancements. Indian J Med Res (2014) 0.92
Comparison of post-operative ICU sedation between dexmedetomidine and propofol in Indian population. Indian J Crit Care Med (2014) 0.91
Prevalence and impact of alcohol and other drug use disorders on sedation and mechanical ventilation: a retrospective study. BMC Anesthesiol (2007) 0.91
Agreement between common goals discussed and documented in the ICU. J Am Med Inform Assoc (2010) 0.91
Improved analgesia, sedation, and delirium protocol associated with decreased duration of delirium and mechanical ventilation. Ann Am Thorac Soc (2014) 0.89
Hospital-level factors associated with report of physical activity in patients on mechanical ventilation across Washington State. Ann Am Thorac Soc (2015) 0.89
ABCDE, but in that order? A cross-sectional survey of Michigan intensive care unit sedation, delirium, and early mobility practices. Ann Am Thorac Soc (2015) 0.89
Sedation in the intensive care setting. Clin Pharmacol (2012) 0.88
[Diagnosis and therapy of sepsis]. Clin Res Cardiol (2006) 0.87
The implementation of an analgesia-based sedation protocol reduced deep sedation and proved to be safe and feasible in patients on mechanical ventilation. Rev Bras Ter Intensiva (2013) 0.85
Intensive care sedation: the past, present and the future. Crit Care (2013) 0.84
Effect of a scoring system and protocol for sedation on duration of patients' need for ventilator support in a surgical intensive care unit. Qual Saf Health Care (2004) 0.83
Daily sedative interruption versus intermittent sedation in mechanically ventilated critically ill patients: a randomized trial. Ann Intensive Care (2014) 0.83
Dexmedetomidine use in the ICU: are we there yet? Crit Care (2013) 0.82
The effect of interruption to propofol sedation on auditory event-related potentials and electroencephalogram in intensive care patients. Crit Care (2004) 0.82
Association between hospital volume and network membership and an analgesia, sedation and delirium order set quality score: a cohort study. Crit Care (2012) 0.82
The efficacy of the COMFORT scale in assessing optimal sedation in critically ill children requiring mechanical ventilation. J Korean Med Sci (2007) 0.81
Sedation in neurological intensive care unit. Ann Indian Acad Neurol (2013) 0.81
Evaluation of a minimal sedation protocol using ICU sedative consumption as a monitoring tool: a quality improvement multicenter project. Crit Care (2014) 0.81
Do clinical guidelines improve management of sepsis in critically ill elderly patients? A before-and-after study of the implementation of a sepsis protocol. Wien Klin Wochenschr (2012) 0.80
Analgesia and sedation in the intensive care unit: an overview of the issues. Crit Care (2008) 0.80
Current practices and barriers impairing physicians' and nurses' adherence to analgo-sedation recommendations in the intensive care unit--a national survey. Crit Care (2014) 0.80
Sedation in adults receiving mechanical ventilation: physiological and comfort outcomes. Am J Crit Care (2012) 0.79
Evaluation of a local ICU sedation guideline on goal-directed administration of sedatives and analgesics. J Pain Res (2011) 0.79
Low mechanical ventilation times and reintubation rates associated with a specific weaning protocol in an intensive care unit setting: a retrospective study. Clinics (Sao Paulo) (2012) 0.79
Responses to noxious stimuli in sedated mechanically ventilated adults. Heart Lung (2013) 0.78
Remifentanil for analgesia-based sedation in the intensive care unit. Crit Care (2003) 0.78
BIS and spectral entropy monitoring during sedation with midazolam/remifentanil and dexmedetomidine/remifentanil. Crit Care (2009) 0.78
Wean Earlier and Automatically with New technology (the WEAN study): a protocol of a multicentre, pilot randomized controlled trial. Trials (2009) 0.78
Replacement of fentanyl infusion by enteral methadone decreases the weaning time from mechanical ventilation: a randomized controlled trial. Crit Care (2012) 0.78
Some tips about statistics on medical research. J Thorac Dis (2015) 0.78
Sepsis pathophysiology and anesthetic consideration. Cardiovasc Hematol Disord Drug Targets (2015) 0.77
Monitoring the nociception level: a multi-parameter approach. J Clin Monit Comput (2013) 0.77
The Addition of Dexmedetomidine to Analgesia for Patients After Abdominal Operations: A Prospective Randomized Clinical Trial. World J Surg (2017) 0.77
A randomized controlled proof-of-concept trial of early sedation management using Responsiveness Index monitoring in mechanically ventilated critically ill patients. Crit Care (2015) 0.77
Influence of algorithm-based analgesia and sedation in patients after sudden cardiac arrest. Clin Res Cardiol (2011) 0.77
Practice guidelines for sedation and analgesia management of critically ill children: a pilot study evaluating guideline impact and feasibility in the PICU. BMJ Open (2015) 0.77
Sedation in French intensive care units: a survey of clinical practice. Ann Intensive Care (2013) 0.76
Effects of dexmedetomidine and propofol on patient-ventilator interaction in difficult-to-wean, mechanically ventilated patients: a prospective, open-label, randomised, multicentre study. Crit Care (2016) 0.76
Optimizing Sedation Management to Promote Early Mobilization for Critically Ill Children. J Pediatr Intensive Care (2015) 0.76
The quality of the evidence base for clinical pathway effectiveness: room for improvement in the design of evaluation trials. BMC Med Res Methodol (2012) 0.76
22nd International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium, 19-22 March 2002. Crit Care (2002) 0.75
Recently published papers: all the usual suspects and carbon dioxide. Crit Care (2004) 0.75
Evaluating the transition from dexmedetomidine to clonidine for agitation management in the intensive care unit. SAGE Open Med (2015) 0.75
Effects of nurses' practice of a sedation protocol on sedation and consciousness levels of patients on mechanical ventilation. Iran J Nurs Midwifery Res (2013) 0.75
Computerized physician order entry of a sedation protocol is not associated with improved sedation practice or outcomes in critically ill patients. BMC Anesthesiol (2015) 0.75
Implementation of a neonatal pain management module in the computerized physician order entry system. Ann Intensive Care (2012) 0.75
Defining sedation-related adverse events in the pediatric intensive care unit. Heart Lung (2013) 0.75
ICU staffing and patient outcomes: more work remains. Crit Care (2009) 0.75
Standardizing morphine use for ventilated preterm neonates with a nursing-driven comfort protocol. J Perinatol (2014) 0.75
Delirium in the intensive care unit. Korean J Anesthesiol (2013) 0.75
Narcotic-based sedation regimens for critically ill mechanically ventilated patients. Crit Care (2005) 0.75
Clinical effectiveness of a sedation protocol minimizing benzodiazepine infusions and favoring early dexmedetomidine: a before-after study. Crit Care (2015) 0.75
Frontal EEG for intensive care unit sedation: treating numbers or patients? Crit Care (2008) 0.75
Association Between Vitamin D Status and Weaning From Prolonged Mechanical Ventilation in Survivors of Critical Illness. Respir Care (2015) 0.75
Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation. JAMA (2001) 16.98
The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest (2000) 9.51
Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest (1999) 7.40
The use of continuous i.v. sedation is associated with prolongation of mechanical ventilation. Chest (1998) 5.98
A new short form individual quality of life measure (SEIQoL-DW): application in a cohort of individuals with HIV/AIDS. BMJ (1996) 3.19
The use of noninvasive positive pressure ventilation in the emergency department: results of a randomized clinical trial. Chest (1998) 2.91
Clinical guidelines: their implementation in general practice. Br J Gen Pract (1995) 2.67
Clinical predictors and outcomes for patients requiring tracheostomy in the intensive care unit. Crit Care Med (1999) 2.40
Experience with a clinical guideline for the treatment of ventilator-associated pneumonia. Crit Care Med (2001) 2.35
A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation. Crit Care Med (1997) 2.18
Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies. Hum Mol Genet (2001) 2.11
A randomized, placebo-controlled trial of antimicrobial treatment for children with clinically diagnosed acute sinusitis. Pediatrics (2001) 2.00
BLEED: a classification tool to predict outcomes in patients with acute upper and lower gastrointestinal hemorrhage. Crit Care Med (1997) 1.89
DNA processing in temperature-sensitive morphogenic mutants of HSV-1. Virology (1987) 1.79
Role of the laboratory in ensuring global access to ARV treatment for HIV-infected children: consensus statement on the performance of laboratory assays for early infant diagnosis. Open AIDS J (2008) 1.74
The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes. J Virol (1995) 1.72
The impact of the introduction of a rapid D-dimer assay on the diagnostic evaluation of suspected pulmonary embolism. Arch Intern Med (2001) 1.65
Mechanical ventilator weaning protocols driven by nonphysician health-care professionals: evidence-based clinical practice guidelines. Chest (2001) 1.60
The occurrence of ventilator-associated pneumonia in a community hospital: risk factors and clinical outcomes. Chest (2001) 1.48
A comparative analysis of patients with early-onset vs late-onset nosocomial pneumonia in the ICU setting. Chest (2000) 1.46
The North Dublin randomized controlled trial of structured diabetes shared care. Fam Pract (2004) 1.44
Childhood immunisation uptake in the Republic of Ireland. Ir Med J (1996) 1.43
Noncardiogenic pulmonary edema associated with intravenous radiocontrast administration. Chest (1992) 1.39
The impact of comorbidity on mortality following in-hospital diagnosis of tuberculosis. Chest (1998) 1.32
The point of view of the trainee. J R Coll Gen Pract (1970) 1.30
Delays in the suspicion and treatment of tuberculosis among hospitalized patients. Ann Intern Med (1999) 1.27
Patient transport from intensive care increases the risk of developing ventilator-associated pneumonia. Chest (1997) 1.23
Case-control study of congenital anomalies in children of cancer patients. BMJ (1993) 1.18
Chemicals, birth defects and stillbirths in New Brunswick: associations with agricultural activity. CMAJ (1988) 1.15
Enoxaparin-associated dermal necrosis: a consequence of cross-reactivity with heparin-mediated antibodies. Ann Pharmacother (1997) 1.15
A qualitative investigation of the views and health beliefs of patients with Type 2 diabetes following the introduction of a diabetes shared care service. Diabet Med (2003) 1.11
Early versus late tracheostomy in patients who require prolonged mechanical ventilation. Am J Crit Care (2000) 1.11
Risk factors for ICU-acquired pneumonia. JAMA (1998) 1.06
Cutaneous basosquamous carcinoma of the head and neck: a comparative analysis. Otolaryngol Head Neck Surg (1979) (1980) 1.05
Inadequate treatment of nosocomial infections is associated with certain empiric antibiotic choices. Crit Care Med (2000) 1.03
End-tidal carbon dioxide measurements as a prognostic indicator of outcome in cardiac arrest. Am J Crit Care (2001) 1.00
Correlation between CD4+ lymphocyte counts, concurrent antigen skin test and tuberculin skin test reactivity in human immunodeficiency virus type 1-infected and -uninfected children with tuberculosis. Pediatr Infect Dis J (1999) 0.98
Sequential increases in the intrahepatic expression of epidermal growth factor, basic fibroblast growth factor, and transforming growth factor beta in a bile duct ligated rat model of cirrhosis. Hepatology (1997) 0.98
A randomized clinical trial comparing an extended-use hygroscopic condenser humidifier with heated-water humidification in mechanically ventilated patients. Chest (1998) 0.96
A randomized, prospective evaluation of an interventional program to discontinue intravenous antibiotics at two tertiary care teaching institutions. Pharmacotherapy (1997) 0.94
Successful treatment of macrophage activation syndrome complicating adult Still disease with anakinra. Intern Med J (2012) 0.94
Postpartum pulmonary infiltrates with peripheral eosinophilia. Chest (1991) 0.94
In vitro cytokine production by normal human peripheral blood mononuclear cells as a measure of immunocompetence or the state of activation. Clin Diagn Lab Immunol (1994) 0.92
Safety and yield of transbronchial biopsy in mechanically ventilated patients. Crit Care Med (1997) 0.91
Communication skills training in undergraduate medicine: attitudes and attitude change. Ir Med J (1992) 0.91
Vulvovaginitis and vaginal discharge in general practice. J R Coll Gen Pract (1975) 0.91
Rotatory dispersion and circular dichroism of brain "proteolipid" protein. J Neurochem (1970) 0.89
Risks of premature death and cancer predicted by body weight in early adult life. Hum Exp Toxicol (1991) 0.89
Elimination of mother-to-child transmission of HIV in South Africa: rapid scale-up using quality improvement. S Afr Med J (2014) 0.89
Identification of lysine residues essential for microtubule assembly. Demonstration of enhanced reactivity during reductive methylation. J Biol Chem (1983) 0.88
Pulmonary involvement in the hypereosinophilic syndrome. Chest (1994) 0.88
Interactions between chlorophyll and water in the solid state: electron spin resonance. Nature (1968) 0.87
Mechanical ventilation with or without daily changes of in-line suction catheters. Am J Respir Crit Care Med (1997) 0.87
Passively transmitted gp41 antibodies in babies born from HIV-1 subtype C-seropositive women: correlation between fine specificity and protection. J Virol (2012) 0.86
Antimicrobial therapy of ventilator-associated pneumonia: how to select an appropriate drug regimen. Chest (1999) 0.86
A rapid assay for the detection of circulating D-dimer is associated with clinical outcomes among critically ill patients. Crit Care Med (1998) 0.85
Primary small intestinal lymphomas and alpha-heavy-chain disease. A study of 43 cases from a pathology department in Israel. Isr J Med Sci (1979) 0.84
A comparison of high versus low dose recombinant human erythropoietin versus blood transfusion in the management of anaemia of prematurity in a developing country. J Trop Pediatr (2002) 0.84
Strategy of FK 506 therapy in liver transplant patients: effect of graft function. Transplant Proc (1991) 0.83
Acute respiratory failure due to extramedullary hematopoiesis. Chest (1995) 0.82
Evaluation of zinc bacitracin capsules versus placebo for enteric eradication of vancomycin-resistant Enterococcus faecium. Clin Infect Dis (2001) 0.82
Chlorophyll-dioxane interaction in the solid state. Arch Biochem Biophys (1969) 0.82
Temporal regulation of light-induced Fos and Fos-like protein expression in the ventrolateral subdivision of the rat suprachiasmatic nucleus. Neuroscience (1994) 0.82
Preparation of viable tumour cell vaccine from human solid tumours: relationship between tumour mass and cell yield. The Tissue Bank, Pittsburgh Cancer Institute. Melanoma Res (1993) 0.81
Endocrine profiles for outcome prediction from the intensive care unit. Crit Care Med (1993) 0.81
Ventilator-associated pneumonia complicating the acute respiratory distress syndrome. Semin Respir Crit Care Med (2001) 0.81
A school and community outbreak of tuberculosis in Auckland. N Z Med J (2000) 0.80
The Biosure Study: influence of composition of diet and food consumption on longevity, degenerative diseases and neoplasia in Wistar rats studied for up to 30 months post weaning. Food Chem Toxicol (1995) 0.80
Compositional changes of AP-1 DNA-binding proteins are regulated by light in a mammalian circadian clock. Neuron (1993) 0.80
A tool to organize instructions at discharge after treatment of asthmatic children in an emergency department. J Asthma (1999) 0.80
Four-hour versus 24-hour intravenous infusion of FK 506 in liver transplantation. Transplant Proc (1991) 0.80
Using protocols to improve the outcomes of mechanically ventilated patients. Focus on weaning and sedation. Crit Care Clin (2001) 0.80
Acute respiratory distress syndrome. Dis Mon (1996) 0.79
The North Dublin Diabetes Shared Care (DiSC) Project: a profile of current diabetes care in Ireland. Ir Med J (2001) 0.79
Utility of transbronchial biopsy in patients with acute respiratory failure: a postmortem study. Chest (1998) 0.79
Nonbacterial thrombotic endocarditis associated with gold-induced pulmonary disease. Ann Intern Med (1988) 0.79
Effects of embryo transfer and cortical ectopias upon the behavior of BXSB-Yaa and BXSB-Yaa + mice. Brain Res Dev Brain Res (1996) 0.78
Body awareness and medical care utilization among older adults in an HMO. J Gerontol (1991) 0.78
Hemodynamic measurements during a tension pneumothorax. Crit Care Med (1994) 0.78
Improving outcomes in the ICU setting: are we effectively using all of the information that is potentially available to us? Chest (1999) 0.78
Immunocytochemical localization of estrogen receptors within neurotensin cells in the rostral preoptic area of the rat hypothalamus. Neurosci Lett (1992) 0.78
Avoidance of tracheal intubation as a strategy to prevent ventilator-associated pneumonia. Intensive Care Med (1999) 0.77
Hospital-acquired pneumonia and de-escalation of antimicrobial treatment. Crit Care Med (2001) 0.77
Evaluation of anti-vibration interventions for the hand during sheet metal assembly work. Work (2011) 0.77
Influence of intragenic CCL3 haplotypes and CCL3L copy number in HIV-1 infection in a sub-Saharan African population. Genes Immun (2012) 0.77
Discriminative response control by naloxone in morphine pretreated rats. Psychopharmacology (Berl) (1981) 0.77
Concentrations of antimony in infants dying from SIDS and infants dying from other causes. Arch Dis Child (2000) 0.77