Epitope mapping of human anti-adeno-associated virus type 2 neutralizing antibodies: implications for gene therapy and virus structure.

PubWeight™: 1.98‹?› | Rank: Top 2%

🔗 View Article (PMC 111652)

Published in J Virol on February 01, 2000

Authors

M Moskalenko1, L Chen, M van Roey, B A Donahue, R O Snyder, J G McArthur, S D Patel

Author Affiliations

1: Department of Preclinical Biology and Immunology, Cell Genesys Inc., Foster City, California 94404, USA.

Articles citing this

The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy. Proc Natl Acad Sci U S A (2002) 4.30

Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection. J Virol (2000) 3.10

Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding. J Virol (2003) 2.93

Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial. J Card Fail (2009) 2.89

Engineering adeno-associated viruses for clinical gene therapy. Nat Rev Genet (2014) 2.16

Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain. J Virol (2004) 2.12

Mutations on the external surfaces of adeno-associated virus type 2 capsids that affect transduction and neutralization. J Virol (2006) 2.07

Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain. Mol Ther (2008) 2.06

Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector. Mol Ther (2011) 2.04

Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina. Mol Ther (2010) 1.77

DNA shuffling of adeno-associated virus yields functionally diverse viral progeny. Mol Ther (2008) 1.70

Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential. Mol Vis (2008) 1.59

Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo. J Virol (2007) 1.52

Designer gene delivery vectors: molecular engineering and evolution of adeno-associated viral vectors for enhanced gene transfer. Pharm Res (2007) 1.50

Enhancement of adeno-associated virus infection by mobilizing capsids into and out of the nucleolus. J Virol (2008) 1.50

Biodistribution of adeno-associated virus type-2 in nonhuman primates after convection-enhanced delivery to brain. Mol Ther (2008) 1.40

Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain. J Virol (2002) 1.30

AAV's anatomy: roadmap for optimizing vectors for translational success. Curr Gene Ther (2010) 1.27

Adeno-associated virus capsids displaying immunoglobulin-binding domains permit antibody-mediated vector retargeting to specific cell surface receptors. J Virol (2002) 1.27

Humoral Immune Response to AAV. Front Immunol (2013) 1.27

Marker rescue of adeno-associated virus (AAV) capsid mutants: a novel approach for chimeric AAV production. J Virol (2003) 1.24

Adeno-associated virus vectors: potential applications for cancer gene therapy. Cancer Gene Ther (2005) 1.19

Parkinson's disease: gene therapies. Cold Spring Harb Perspect Med (2012) 1.13

Complement is an essential component of the immune response to adeno-associated virus vectors. J Virol (2008) 1.11

Structure of adeno-associated virus-2 in complex with neutralizing monoclonal antibody A20. Virology (2012) 1.09

Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity. Front Microbiol (2011) 1.08

Prevalence and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissue. Gene Ther (2012) 1.06

Intranasal vaccination with recombinant adeno-associated virus type 5 against human papillomavirus type 16 L1. J Virol (2006) 1.06

Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8. J Virol (2012) 1.05

Cardiac gene therapy with SERCA2a: from bench to bedside. J Mol Cell Cardiol (2010) 1.05

Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles. J Virol (2012) 1.04

Pre-existing anti-adeno-associated virus antibodies as a challenge in AAV gene therapy. Hum Gene Ther Methods (2013) 1.02

Immune response against gene therapy vectors: influence of synovial fluid on adeno-associated virus mediated gene transfer to chondrocytes. J Clin Immunol (2004) 1.02

Enhanced gene transfer to arthritic joints using adeno-associated virus type 5: implications for intra-articular gene therapy. Ann Rheum Dis (2005) 1.01

Capsid antibodies to different adeno-associated virus serotypes bind common regions. J Virol (2013) 1.01

Host and vector-dependent effects on the risk of germline transmission of AAV vectors. Mol Ther (2009) 1.00

Minimizing the inhibitory effect of neutralizing antibody for efficient gene expression in the liver with adeno-associated virus 8 vectors. Mol Ther (2012) 0.96

Examining the cross-reactivity and neutralization mechanisms of a panel of mAbs against adeno-associated virus serotypes 1 and 5. J Gen Virol (2011) 0.93

Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates. Gene Ther (2014) 0.92

The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5. Gene Ther (2011) 0.90

E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal-Tailored Acceleration of AAV Evolution. Mol Ther (2015) 0.90

Perspective on Adeno-Associated Virus Capsid Modification for Duchenne Muscular Dystrophy Gene Therapy. Hum Gene Ther (2015) 0.87

Inflammation and immune response of intra-articular serotype 2 adeno-associated virus or adenovirus vectors in a large animal model. Arthritis (2012) 0.85

Intranasal administration of adeno-associated virus type 12 (AAV12) leads to transduction of the nasal epithelia and can initiate transgene-specific immune response. Mol Ther (2011) 0.85

Prevalence of AAV1 neutralizing antibodies and consequences for a clinical trial of gene transfer for advanced heart failure. Gene Ther (2015) 0.82

Determination of anti-adeno-associated virus vector neutralizing antibody titer with an in vitro reporter system. Hum Gene Ther Methods (2015) 0.81

The structure of AAVrh32.33, a novel gene delivery vector. J Struct Biol (2014) 0.81

Gene replacement therapies for duchenne muscular dystrophy using adeno-associated viral vectors. Curr Gene Ther (2012) 0.81

Prediction of adeno-associated virus neutralizing antibody activity for clinical application. Gene Ther (2015) 0.81

Characterization of the capsid protein glycosylation of adeno-associated virus type 2 by high-resolution mass spectrometry. J Virol (2006) 0.81

Strategies to circumvent humoral immunity to adeno-associated viral vectors. Expert Opin Biol Ther (2015) 0.81

Improving clinical efficacy of adeno associated vectors by rational capsid bioengineering. J Biomed Sci (2014) 0.80

Augmentation of transgene-encoded protein after neonatal injection of adeno-associated virus improves hepatic copy number without immune responses. Pediatr Res (2015) 0.79

AAV Gene Therapy for Liver Disease. Hum Gene Ther (2016) 0.79

Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors. Gene Ther (2015) 0.78

Retinal Gene Therapy: Current Progress and Future Prospects. Expert Rev Ophthalmol (2015) 0.78

Characterization of naturally-occurring humoral immunity to AAV in sheep. PLoS One (2013) 0.77

Enhanced gene delivery in porcine vasculature tissue following incorporation of adeno-associated virus nanoparticles into porous silicon microparticles. J Control Release (2014) 0.77

Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer. Mol Ther (2015) 0.77

Structure of neurotropic adeno-associated virus AAVrh.8. J Struct Biol (2015) 0.77

Emerging Vaccine Technologies. Vaccines (Basel) (2015) 0.77

Systemic Vascular Transduction by Capsid Mutant Adeno-Associated Virus After Intravenous Injection. Hum Gene Ther (2015) 0.76

The lung as a metabolic factory for gene therapy. J Clin Invest (2002) 0.75

Recombinant adeno-associated virus vectors in the treatment of rare diseases. Expert Opin Orphan Drugs (2015) 0.75

Identification of an adeno-associated virus binding epitope for AVB sepharose affinity resin. Mol Ther Methods Clin Dev (2015) 0.75

Articles cited by this

Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J Virol (1998) 8.45

Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J Virol (1996) 6.22

Genetics of adeno-associated virus: isolation and preliminary characterization of adeno-associated virus type 2 mutants. J Virol (1984) 5.89

Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2. Nat Med (1999) 5.50

AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection. Nat Med (1999) 5.26

Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors. Nat Genet (1997) 4.72

Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV type 2. J Virol (1998) 4.71

Gene therapy vectors based on adeno-associated virus type 1. J Virol (1999) 4.63

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector. Nat Med (1999) 4.61

The three-dimensional structure of canine parvovirus and its functional implications. Science (1991) 3.87

Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus. Proc Natl Acad Sci U S A (1997) 3.84

Serologic evidence for human infection with adenovirus-associated viruses. J Natl Cancer Inst (1968) 3.44

Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors. Nat Med (1999) 3.39

Structural proteins of adenovirus-associated viruses. J Virol (1971) 3.03

Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector. Brain Res (1996) 3.03

Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration. J Virol (1997) 2.65

Subcellular compartmentalization of adeno-associated virus type 2 assembly. J Virol (1997) 2.31

Multiple amino acids in the capsid structure of canine parvovirus coordinately determine the canine host range and specific antigenic and hemagglutination properties. J Virol (1992) 2.15

Successful readministration of adeno-associated virus vectors to the mouse lung requires transient immunosuppression during the initial exposure. J Virol (1998) 2.11

Efficient and stable adeno-associated virus-mediated transduction in the skeletal muscle of adult immunocompetent mice. Hum Gene Ther (1997) 2.09

Structure, sequence, and function correlations among parvoviruses. Virology (1993) 2.06

Canine parvovirus host range is determined by the specific conformation of an additional region of the capsid. J Virol (1997) 2.00

Intermediates of adeno-associated virus type 2 assembly: identification of soluble complexes containing Rep and Cap proteins. J Virol (1995) 1.86

Transient immunosuppression allows transgene expression following readministration of adeno-associated viral vectors. Hum Gene Ther (1998) 1.79

The kinetics of rAAV integration in the liver. Nat Genet (1998) 1.79

Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors. Exp Neurol (1998) 1.68

Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver. Proc Natl Acad Sci U S A (1997) 1.35

The structure of a neutralized virus: canine parvovirus complexed with neutralizing antibody fragment. Structure (1994) 1.30

Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proc Natl Acad Sci U S A (1997) 1.26

B-cell epitopes of canine parvovirus: distribution on the primary structure and exposure on the viral surface. J Virol (1993) 1.23

Articles by these authors

(truncated to the top 100)

The sequence of the human genome. Science (2001) 101.55

A whole-genome assembly of Drosophila. Science (2000) 38.48

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med (1999) 16.91

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature (1992) 7.15

The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90

Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci U S A (1994) 5.74

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J (1999) 5.49

NF-AT components define a family of transcription factors targeted in T-cell activation. Nature (1994) 4.90

The Human Connectome Project: a data acquisition perspective. Neuroimage (2012) 4.64

B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol (2001) 4.10

A transcriptional hierarchy involved in mammalian cell-type specification. Nature (1992) 4.08

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med (1997) 3.89

A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A (1996) 3.89

Rad23 links DNA repair to the ubiquitin/proteasome pathway. Nature (1998) 3.54

Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res (1998) 3.44

Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors. Nat Med (1999) 3.39

Establishment and characterization of a cell line of human breast carcinoma origin. Eur J Cancer (1979) 3.37

Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell (2001) 3.37

Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell (2001) 3.30

TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol (2001) 3.22

The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Cell (1995) 3.17

Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A (2001) 2.93

Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC). Ann Oncol (2013) 2.92

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. Proc Natl Acad Sci U S A (1994) 2.91

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci U S A (1999) 2.81

Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers. Br J Cancer (2006) 2.67

Binding properties of replication protein A from human and yeast cells. Mol Cell Biol (1992) 2.66

ATP is essential for protein translocation into Escherichia coli membrane vesicles. Proc Natl Acad Sci U S A (1985) 2.65

Mutation of the Bacillus subtilis alkyl hydroperoxide reductase (ahpCF) operon reveals compensatory interactions among hydrogen peroxide stress genes. J Bacteriol (1996) 2.57

Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot. Nat Struct Biol (1999) 2.57

A prospective 4-year follow-up study of attention-deficit hyperactivity and related disorders. Arch Gen Psychiatry (1996) 2.55

Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children? Am J Psychiatry (1996) 2.54

The complete DNA sequence of myxoma virus. Virology (1999) 2.44

Xa21D encodes a receptor-like molecule with a leucine-rich repeat domain that determines race-specific recognition and is subject to adaptive evolution. Plant Cell (1998) 2.43

A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol (1994) 2.42

SecA protein is required for secretory protein translocation into E. coli membrane vesicles. Cell (1988) 2.41

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene (1998) 2.39

Solution structure of a bovine immunodeficiency virus Tat-TAR peptide-RNA complex. Science (1995) 2.35

Primitive deuterostomes from the Chengjiang Lagerstätte (Lower Cambrian, China). Nature (2001) 2.31

Seventh cervical nerve root transfer from the contralateral healthy side for treatment of brachial plexus root avulsion. J Hand Surg Br (1992) 2.30

T1rho-relaxation in articular cartilage: effects of enzymatic degradation. Magn Reson Med (1997) 2.30

LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J Immunol (2000) 2.27

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Mol Cell Biol (2000) 2.27

Survival time comparison between Hawley and clear overlay retainers: a randomized trial. J Dent Res (2011) 2.26

Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice. Neuron (2001) 2.24

Predictors of persistence and remission of ADHD into adolescence: results from a four-year prospective follow-up study. J Am Acad Child Adolesc Psychiatry (1996) 2.24

Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nat Med (2000) 2.18

Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China. Infection (2013) 2.18

NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell Immunol (1998) 2.11

Effect of ADP and ionic strength on the kinetic and motile properties of recombinant mouse myosin V. J Biol Chem (2000) 2.09

ADHD is associated with early initiation of cigarette smoking in children and adolescents. J Am Acad Child Adolesc Psychiatry (1997) 2.09

The DNA repair protein rad23 is a negative regulator of multi-ubiquitin chain assembly. Nat Cell Biol (2000) 2.07

Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. Mol Psychiatry (2012) 2.07

RNA recognition by an isolated alpha helix. Cell (1993) 2.05

PPARalpha agonist fenofibrate improves diabetic nephropathy in db/db mice. Kidney Int (2006) 2.05

Rapid angiographic progression of coronary artery disease in patients with angina pectoris. The role of complex stenosis morphology. Circulation (1995) 2.04

MDM2 suppresses p73 function without promoting p73 degradation. Mol Cell Biol (1999) 2.00

Chinese Hemophilia Joint Health Score 2.1 reliability study. Haemophilia (2013) 1.98

Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy. J Exp Med (1997) 1.96

Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population: the Shanghai Diabetes Studies, a cross-sectional 3-year follow-up study in Shanghai urban communities. Diabetologia (2006) 1.96

Role of RNA structure in arginine recognition of TAR RNA. Proc Natl Acad Sci U S A (1993) 1.94

Nucleotide sequence of a multiple-copy gene for the B protein of photosystem II of a cyanobacterium. Proc Natl Acad Sci U S A (1984) 1.92

Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms. Am J Med Genet B Neuropsychiatr Genet (2009) 1.92

LIPSIA--a new software system for the evaluation of functional magnetic resonance images of the human brain. Comput Med Imaging Graph (2001) 1.90

Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers. Cancer Epidemiol Biomarkers Prev (1998) 1.87

Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes. Science (1990) 1.85

Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. J Biol Chem (1994) 1.85

Clathrin self-assembly is mediated by a tandemly repeated superhelix. Nature (1999) 1.84

The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J Clin Invest (2001) 1.82

Elements regulating cell- and stage-specific expression of the C. elegans MyoD family homolog hlh-1. Dev Biol (1994) 1.82

Alkaline phosphatase and OmpA protein can be translocated posttranslationally into membrane vesicles of Escherichia coli. J Bacteriol (1985) 1.82

Effects of PMP22 duplication and deletions on the axonal cytoskeleton. Ann Neurol (1999) 1.81

Pleiotropic defects caused by loss of the proteasome-interacting factors Rad23 and Rpn10 of Saccharomyces cerevisiae. Genetics (1999) 1.81

The kinetics of rAAV integration in the liver. Nat Genet (1998) 1.79

Identifying blood biomarkers for mood disorders using convergent functional genomics. Mol Psychiatry (2008) 1.78

Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood (2000) 1.76

Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005-2007. Clin Microbiol Infect (2009) 1.76

Improvement in retinal image quality with dynamic correction of the eye's aberrations. Opt Express (2001) 1.76

On pelvic reference lines and the MR evaluation of genital prolapse: a proposal for standardization using the Pelvic Inclination Correction System. Int Urogynecol J (2013) 1.74

Photolabelling of a mitochondrially encoded subunit of NADH dehydrogenase with [3H]dihydrorotenone. FEBS Lett (1987) 1.74

Effects of angiotensin-converting enzyme inhibition on exercise-induced angina and ST segment depression in patients with microvascular angina. J Am Coll Cardiol (1994) 1.74

Head and backbone of the Early Cambrian vertebrate Haikouichthys. Nature (2003) 1.73

A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Hum Mol Genet (1999) 1.72

Neuropathy progression in Charcot-Marie-Tooth disease type 1A. Neurology (2008) 1.70

Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol Biomarkers Prev (1995) 1.70

EMBRYONIC FLOWER2, a novel polycomb group protein homolog, mediates shoot development and flowering in Arabidopsis. Plant Cell (2001) 1.69

B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood (2001) 1.69

Dynamics of ferroelastic domains in ferroelectric thin films. Nat Mater (2003) 1.69

Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected. J Immunol (1995) 1.68

Field observations on the antimalarial piperaquine. Chin Med J (Engl) (1982) 1.68

Cleavage of membrane-associated pref-1 generates a soluble inhibitor of adipocyte differentiation. Mol Cell Biol (1997) 1.68

Prevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28. J Virol (1999) 1.68

Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model. Am J Transplant (2010) 1.68

Identification of blood biomarkers for psychosis using convergent functional genomics. Mol Psychiatry (2009) 1.68

Deficient cerebellar long-term depression, impaired eyeblink conditioning, and normal motor coordination in GFAP mutant mice. Neuron (1996) 1.67

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice. Oncogene (2000) 1.65

Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins. Oncogene (2008) 1.64

Complete genomic sequence and phylogenetic analysis of the lactate dehydrogenase-elevating virus (LDV). Virology (1993) 1.63

Structure, mapping, and expression of erp, a growth factor-inducible gene encoding a nontransmembrane protein tyrosine phosphatase, and effect of ERP on cell growth. Mol Cell Biol (1993) 1.62

Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60