Published in Nat Med on February 01, 2000
The safety and side effects of monoclonal antibodies. Nat Rev Drug Discov (2010) 2.23
Host alloreactive memory T cells influence tolerance to kidney allografts in nonhuman primates. Sci Transl Med (2011) 1.97
Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. J Exp Med (2010) 1.68
Translating costimulation blockade to the clinic: lessons learned from three pathways. Immunol Rev (2009) 1.66
Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft. Am J Transplant (2007) 1.64
Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice. J Clin Invest (2010) 1.55
Clinical targeting of the TNF and TNFR superfamilies. Nat Rev Drug Discov (2013) 1.53
Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases. Biomark Res (2014) 1.49
The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients. Transplantation (2009) 1.47
Use of CTLA4Ig for induction of mixed chimerism and renal allograft tolerance in nonhuman primates. Am J Transplant (2014) 1.44
Treatment of murine lupus with cDNA encoding IFN-gammaR/Fc. J Clin Invest (2000) 1.40
Clinical islet xenotransplantation: how close are we? Diabetes (2012) 1.26
Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning. J Clin Invest (2003) 1.25
Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates. J Clin Invest (2005) 1.24
Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis. Crit Care (2011) 1.23
Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation. J Immunol (2009) 1.21
Recipient tissue factor expression is associated with consumptive coagulopathy in pig-to-primate kidney xenotransplantation. Am J Transplant (2010) 1.21
CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model. Am J Transplant (2011) 1.18
Current status of xenotransplantation and prospects for clinical application. Xenotransplantation (2009) 1.15
Embryonic pig pancreatic tissue transplantation for the treatment of diabetes. PLoS Med (2006) 1.14
Immuno-intervention for the induction of transplantation tolerance through mixed chimerism. Semin Immunol (2011) 1.12
Targeting co-stimulatory pathways: transplantation and autoimmunity. Nat Rev Nephrol (2013) 1.11
Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice. Blood (2006) 1.08
Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154. J Clin Invest (2006) 1.08
Costimulation blockade in pig artery patch xenotransplantation - a simple model to monitor the adaptive immune response in nonhuman primates. Xenotransplantation (2012) 1.06
Pig-to-baboon heterotopic heart transplantation--exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens. Xenotransplantation (2015) 1.04
Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model. Xenotransplantation (2013) 1.02
Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice. Circ Res (2011) 1.01
Mechanism of cellular rejection in transplantation. Pediatr Nephrol (2010) 1.01
A novel monoclonal antibody to CD40 prolongs islet allograft survival. Am J Transplant (2012) 1.00
Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates. Am J Transplant (2011) 0.99
Induction of tolerance through mixed chimerism. Cold Spring Harb Perspect Med (2014) 0.97
Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade. Proc Natl Acad Sci U S A (2011) 0.97
Pluripotent stem cells: immune to the immune system? Sci Transl Med (2012) 0.97
Costimulation-adhesion blockade is superior to cyclosporine A and prednisone immunosuppressive therapy for preventing rejection of differentiated human embryonic stem cells following transplantation. Stem Cells (2013) 0.95
Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs. Transpl Immunol (2015) 0.95
CD28/CD154 blockade prevents autoimmune diabetes by inducing nondeletional tolerance after effector t-cell inhibition and regulatory T-cell expansion. Diabetes (2008) 0.94
Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc Natl Acad Sci U S A (2014) 0.94
CD40 gene silencing reduces the progression of experimental lupus nephritis modulating local milieu and systemic mechanisms. PLoS One (2013) 0.93
Nonhuman primate transplant models finally evolve: detailed immunogenetic analysis creates new models and strengthens the old. Am J Transplant (2011) 0.91
LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L. Blood (2011) 0.91
CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis. Gut (2005) 0.91
Costimulatory pathways in transplantation. Semin Immunol (2011) 0.90
Islet cell transplantation today. Langenbecks Arch Surg (2007) 0.90
Immune tolerance and transplantation. Semin Oncol (2012) 0.90
CD40/CD154 blockade inhibits dendritic cell expression of inflammatory cytokines but not costimulatory molecules. J Immunol (2012) 0.90
Kidney xenotransplantation. Kidney Int (2013) 0.88
Gene therapy for liver transplantation using adenoviral vectors: CD40-CD154 blockade by gene transfer of CD40Ig protects rat livers from cold ischemia and reperfusion injury. Mol Ther (2004) 0.88
Therapeutic issues in the treatment of vascularized xenotransplants using gal-knockout donors in nonhuman primates. Curr Opin Organ Transplant (2011) 0.88
Progress in Clinical Encapsulated Islet Xenotransplantation. Transplantation (2016) 0.88
Crucial role of CD40 signaling in vascular wall cells in neointimal formation and vascular remodeling after vascular interventions. Arterioscler Thromb Vasc Biol (2011) 0.87
Current Treatment, Emerging Translational Therapies, and New Therapeutic Targets for Autoimmune Myasthenia Gravis. Neurotherapeutics (2016) 0.87
The blockade of T-cell co-stimulation as a therapeutic stratagem for immunosuppression: Focus on belatacept. Biologics (2007) 0.87
An anti-CD154 domain antibody prolongs graft survival and induces Foxp3(+) iTreg in the absence and presence of CTLA-4 Ig. Am J Transplant (2013) 0.87
Tumor necrosis factor receptor associated factor 6 is not required for atherogenesis in mice and does not associate with atherosclerosis in humans. PLoS One (2010) 0.86
Immunoregulatory properties of rapamycin-conditioned monocyte-derived dendritic cells and their role in transplantation. Transplant Res (2012) 0.85
Immunomodulation for inhibitors in hemophilia A: the important role of Treg cells. Expert Rev Hematol (2010) 0.85
Mixed chimerism to induce tolerance: lessons learned from nonhuman primates. Transplant Rev (Orlando) (2009) 0.85
T-cell-based immunosuppressive therapy inhibits the development of natural antibodies in infant baboons. Transplantation (2012) 0.85
New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression. Ann N Y Acad Sci (2010) 0.84
T cells interact with T cells via CD40-CD154 to promote autoimmunity in type 1 diabetes. Eur J Immunol (2012) 0.84
CTLA4Ig prevents alloantibody formation following nonhuman primate islet transplantation using the CD40-specific antibody 3A8. Am J Transplant (2012) 0.84
Pharmacokinetics and pharmacodynamics of ASKP1240, a fully human anti-CD40 antibody, in normal and renal transplanted Cynomolgus monkeys. Transplantation (2014) 0.84
The role of costimulatory molecules in directing the functional differentiation of alloreactive T helper cells. Am J Transplant (2012) 0.83
CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study. Arthritis Res Ther (2015) 0.83
Recipient dendritic cells, but not B cells, are required antigen-presenting cells for peripheral alloreactive CD8+ T-cell tolerance. Am J Transplant (2010) 0.83
Hematopoietic chimerism and transplantation tolerance: a role for regulatory T cells. Front Immunol (2011) 0.83
Murine Models of Transplantation Tolerance through Mixed Chimerism: Advances and Roadblocks. Clin Exp Immunol (2017) 0.83
Effects of ASKP1240 combined with tacrolimus or mycophenolate mofetil on renal allograft survival in Cynomolgus monkeys. Transplantation (2014) 0.82
Application of liposomes in drug development--focus on gastroenterological targets. Int J Nanomedicine (2013) 0.81
The role of costimulatory receptors of the tumour necrosis factor receptor family in atherosclerosis. J Biomed Biotechnol (2011) 0.81
Clinical xenotransplantation of organs: why aren't we there yet? PLoS Med (2007) 0.81
T cell tolerance induced by therapeutic antibodies. Philos Trans R Soc Lond B Biol Sci (2005) 0.81
Introduction to the use of belatacept: a fusion protein for the prevention of posttransplant kidney rejection. Biologics (2012) 0.81
Neuroimmunotherapies Targeting T Cells: From Pathophysiology to Therapeutic Applications. Neurotherapeutics (2016) 0.81
Inhibition of CD8+ T cell-derived CD40 signals is necessary but not sufficient for Foxp3+ induced regulatory T cell generation in vivo. J Immunol (2013) 0.81
CD154 blockade abrogates allospecific responses and enhances CD4(+) regulatory T-cells in mouse orthotopic lung transplant. Am J Transplant (2011) 0.81
Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death. Immunology (2013) 0.80
Loss of DRAK2 signaling enhances allogeneic transplant survival by limiting effector and memory T cell responses. Am J Transplant (2012) 0.80
The road to purified hematopoietic stem cell transplants is paved with antibodies. Curr Opin Immunol (2012) 0.80
Lung transplantation: chronic allograft dysfunction and establishing immune tolerance. Hum Immunol (2014) 0.79
CD154 blockade alters innate immune cell recruitment and programs alloreactive CD8+ T cells into KLRG-1(high) short-lived effector T cells. PLoS One (2012) 0.79
STAT-1 decoy oligodeoxynucleotide inhibition of acute rejection in mouse heart transplants. Basic Res Cardiol (2009) 0.79
Monoclonal antibodies in multiple sclerosis treatment: current and future steps. Ther Adv Neurol Disord (2009) 0.79
Promoting long-term survival of insulin-producing cell grafts that differentiate from adipose tissue-derived stem cells to cure type 1 diabetes. PLoS One (2011) 0.79
Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement. Transplantation (2016) 0.79
T Cell Cosignaling Molecules in Transplantation. Immunity (2016) 0.79
Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts. Xenotransplantation (2017) 0.78
Pulmonary angiography for the diagnosis of thromboembolic events in the non-human primate. Transplantation (2004) 0.78
Update on CD40 and CD154 blockade in transplant models. Immunotherapy (2015) 0.78
Characterization of ASKP1240, a fully human antibody targeting human CD40 with potent immunosuppressive effects. Am J Transplant (2014) 0.78
Multiple costimulatory blockade in the peripheral nerve allograft. Neurol Res (2009) 0.78
T-cell activation and transplantation tolerance. Transplant Rev (Orlando) (2011) 0.78
T Helper Cells Fate Mapping by Co-stimulatory Molecules and its Functions in Allograft Rejection and Tolerance. Int J Organ Transplant Med (2014) 0.78
Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy. Immunol Rev (2017) 0.78
Impact of Immune-Modulatory Drugs on Regulatory T Cell. Transplantation (2016) 0.77
TNF superfamily protein-protein interactions: feasibility of small- molecule modulation. Curr Drug Targets (2015) 0.77
Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding. MAbs (2016) 0.77
Mesenchymal stem cells facilitate mixed hematopoietic chimerism induction and prevent onset of diabetes in nonobese diabetic mice. Pancreas (2011) 0.77
A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity (1999) 17.40
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol (1999) 16.86
Ensembl 2005. Nucleic Acids Res (2005) 15.13
Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl Acad Sci U S A (1987) 14.24
Ensembl 2002: accommodating comparative genomics. Nucleic Acids Res (2003) 12.26
Ensembl 2004. Nucleic Acids Res (2004) 11.88
Ensembl 2006. Nucleic Acids Res (2006) 11.66
The Banff 97 working classification of renal allograft pathology. Kidney Int (1999) 9.02
Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens. J Immunol (1980) 8.56
Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant (2008) 8.09
Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest (1981) 6.89
Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression. J Immunol (1981) 6.75
Establishment and characterization of BALB/c lymphoma lines with B cell properties. J Immunol (1979) 6.70
Epidermal Langerhans cells are derived from cells originating in bone marrow. Nature (1979) 5.58
A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex. J Exp Med (1973) 5.55
Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant (2007) 5.39
Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol (2001) 5.36
Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature (1984) 4.26
Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ (2007) 4.12
Monoclonal antibodies to mouse major histocompatibility complex antigens. Transplantation (1982) 4.11
Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol (2000) 4.10
Limb and skin abnormalities in mice lacking IKKalpha. Science (1999) 3.85
Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest (1996) 3.73
Use of monoclonal antibodies to T-cell subsets for immunologic monitoring and treatment in recipients of renal allografts. N Engl J Med (1981) 3.63
Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions. Am J Transplant (2014) 3.43
Transplantation in miniature swine. I. Fixation of the major histocompatibility complex. Transplantation (1976) 3.41
Monoclonal antibodies to mouse MHC antigens. II. Antibodies to the H-2Ld antigen, the products of a third polymorphic locus of the mouse major histocompatibility complex. J Immunol (1980) 3.39
Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses. Am J Transplant (2006) 3.34
Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J Exp Med (1989) 3.34
Activation of T and B lymphocytes in vitro. III. Presence of Ia determinants on allogeneic effect factor. J Exp Med (1974) 3.29
Banff '09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups. Am J Transplant (2010) 3.29
Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol (2001) 3.26
Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation (1995) 3.18
International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology. Kidney Int (1993) 3.11
Evidence for identity or close association of the Fc receptor of B lymphocytes and alloantigens determined by the Ir region of the H-2 complex. J Exp Med (1974) 3.07
Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125. Int J Gynecol Pathol (1983) 2.90
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol (1999) 2.84
Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest (2001) 2.79
Role of the clotting system in cell-mediated hypersensitivity. I. Fibrin deposition in delayed skin reactions in man. J Exp Med (1973) 2.75
Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J (2000) 2.65
T lymphocyte-enriched murine peritoneal exudate cells. III. Inhibition of antigen-induced T lymphocyte Proliferation with anti-Ia antisera. J Immunol (1976) 2.64
Preparation and characterization of monoclonal antibodies reactive with porcine PBL. J Immunol (1984) 2.62
Diagnosis and management of renal cell carcinoma. A clinical and pathologic study of 309 cases. Cancer (1971) 2.56
TLR6: A novel member of an expanding toll-like receptor family. Gene (1999) 2.55
A subpopulation of adherent accessory cells bearing both I-A and I-E or C subregion antigens is required for antigen-specific murine T lymphocyte proliferation. J Immunol (1978) 2.54
B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens. J Exp Med (1977) 2.44
Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J Immunol (2000) 2.41
Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nat Med (1998) 2.40
Mouse alloantibodies capable of blocking cytotoxic T-cell function. I. Relationship between the antigen reactive with blocking antibodies and the Lyt-2 locus. J Exp Med (1979) 2.39
Production of human alpha-interferon in silkworm using a baculovirus vector. Nature (1985) 2.37
Clonal dominance among T-lymphocyte infiltrates in arthritis. Proc Natl Acad Sci U S A (1988) 2.36
Widespread and selective induction of major histocompatibility complex-determined antigens in vivo by gamma interferon. J Exp Med (1985) 2.34
Immunopathologic characterization of a monoclonal antibody that recognizes common surface antigens of human ovarian tumors of serous, endometrioid, and clear cell types. Am J Clin Pathol (1983) 2.33
Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc Natl Acad Sci U S A (1998) 2.29
Banff 2011 Meeting report: new concepts in antibody-mediated rejection. Am J Transplant (2012) 2.28
Antibody to intercellular adhesion molecule 1 protects the kidney against ischemic injury. Proc Natl Acad Sci U S A (1994) 2.26
Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation. Lancet (1999) 2.26
Treatment of acute renal allograft rejection with OKT3 monoclonal antibody. Transplantation (1981) 2.22
Role of platelet-derived growth factor in wound healing: synergistic effects with other growth factors. Proc Natl Acad Sci U S A (1987) 2.17
The immunologic response to xenografts. Recognition of mouse H-2 histocompatibility antigens by the rat. J Immunol (1971) 2.17
Crystallization of a poly(ethylene-co-octene): I. A precursor structure and two competing mechanisms. Eur Phys J E Soft Matter (2005) 2.17
A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody. Am J Transplant (2011) 2.16
Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation (1999) 2.16
Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade. Transplantation (2002) 2.15
Effective treatment of lymphedema of the extremities. Arch Surg (1998) 2.11
Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization. J Invest Dermatol (1982) 2.10
Resistance to Listeria monocytogenes in mice: genetic control by genes that are not linked to the H-2 complex. J Infect Dis (1979) 2.09
Native portal vein embolization for persistent hyperoxaluria following kidney and auxiliary partial liver transplantation. Am J Transplant (2013) 2.05
Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds. J Clin Invest (1989) 2.04
The immunopathology of experimental allergic encephalomyelitis. II. Endothelial cell Ia increases prior to inflammatory cell infiltration. J Immunol (1984) 2.02
Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance. J Exp Med (1985) 2.00
A new chromogenic endotoxin-specific assay using recombined limulus coagulation enzymes and its clinical applications. Clin Chim Acta (1985) 1.99
Kidney transplants in mice. An analysis of the immune status of mice bearing long-term, H-2 incompatible transplants. J Exp Med (1978) 1.95
Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation (2000) 1.88
Skin graft tolerance across a discordant xenogeneic barrier. Nat Med (1996) 1.86
Mixed chimerism and tolerance without whole body irradiation in a large animal model. J Clin Invest (2000) 1.86
An immunologic approach to the conformational equilibria of polypeptides. Proc Natl Acad Sci U S A (1972) 1.85
Changing pattern of organ donation at a single center: are potential brain dead donors being lost to donation after cardiac death? Am J Transplant (2010) 1.84
Controlled clinical trial of prophylactic human-leukocyte interferon in renal transplantation. Effects on cytomegalovirus and herpes simplex virus infections. N Engl J Med (1979) 1.83
Murine anti-swine T4 and T8 monoclonal antibodies: distribution and effects on proliferative and cytotoxic T cells. J Immunol (1985) 1.83
Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries. J Am Soc Nephrol (1999) 1.77
Glomerulopathy associated with cytomegalovirus viremia in renal allografts. N Engl J Med (1981) 1.77