Published in Mol Med on November 01, 1999
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell (2000) 10.72
Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells. Proc Natl Acad Sci U S A (2004) 1.25
Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosis. J Clin Invest (2002) 1.20
Expression of wild-type CFTR suppresses NF-kappaB-driven inflammatory signalling. PLoS One (2010) 1.08
Human lung project: evaluating variance of gene expression in the human lung. Am J Respir Cell Mol Biol (2006) 1.07
Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse. Proc Natl Acad Sci U S A (2003) 1.01
Omics approaches in cystic fibrosis research: a focus on oxylipin profiling in airway secretions. Ann N Y Acad Sci (2012) 0.81
CFTR activity and mitochondrial function. Redox Biol (2013) 0.79
Current awareness on comparative and functional genomics. Yeast (2000) 0.75
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science (1989) 40.22
Identification of the cystic fibrosis gene: genetic analysis. Science (1989) 33.61
High density synthetic oligonucleotide arrays. Nat Genet (1999) 29.99
Parallel human genome analysis: microarray-based expression monitoring of 1000 genes. Proc Natl Acad Sci U S A (1996) 24.18
Gene expression informatics--it's all in your mine. Nat Genet (1999) 12.35
Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis. Cell (1990) 9.21
CFTR as a cAMP-dependent regulator of sodium channels. Science (1995) 6.50
Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat Genet (1999) 5.06
Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc Natl Acad Sci U S A (1997) 4.82
Cystic fibrosis: molecular biology and therapeutic implications. Science (1992) 3.72
Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer. Cell (1990) 3.70
Novel gene transcripts preferentially expressed in human muscles revealed by quantitative hybridization of a high density cDNA array. Genome Res (1996) 3.41
Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis. Physiol Rev (1999) 2.89
The spectrum of cystic fibrosis mutations. Trends Genet (1992) 2.88
The risk of cancer among patients with cystic fibrosis. Cystic Fibrosis and Cancer Study Group. N Engl J Med (1995) 2.49
Pharmacology of CFTR chloride channel activity. Physiol Rev (1999) 2.41
In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR. J Clin Invest (1997) 2.29
Mutations and sequence variations detected in the cystic fibrosis transmembrane conductance regulator (CFTR) gene: a report from the Cystic Fibrosis Genetic Analysis Consortium. Hum Mutat (1992) 2.12
The epidemiology of cancer of the small bowel. Cancer Epidemiol Biomarkers Prev (1998) 2.04
CFTR is a conductance regulator as well as a chloride channel. Physiol Rev (1999) 1.90
Adenosine A3 receptors: novel ligands and paradoxical effects. Trends Pharmacol Sci (1998) 1.79
A pancreatic cancer-specific expression profile. Oncogene (1996) 1.50
Detection of differentially expressed genes in primary tumor tissues using representational differences analysis coupled to microarray hybridization. Nucleic Acids Res (1998) 1.46
Probing lymphocyte biology by genomic-scale gene expression analysis. J Clin Immunol (1998) 1.46
Regulation of epithelial sodium channels by the cystic fibrosis transmembrane conductance regulator. J Biol Chem (1996) 1.34
A cohort study of cystic fibrosis and malignancy. Br J Cancer (1993) 1.31
Profiling of differentially expressed genes in human primary cervical cancer by complementary DNA expression array. Clin Cancer Res (1998) 1.15
Two cystic fibrosis transmembrane conductance regulator mutations have different effects on both pulmonary phenotype and regulation of outwardly rectified chloride currents. Proc Natl Acad Sci U S A (1995) 1.13
A1 adenosine-receptor antagonists activate chloride efflux from cystic fibrosis cells. Proc Natl Acad Sci U S A (1992) 1.03
Direct activation of cystic fibrosis transmembrane conductance regulator channels by 8-cyclopentyl-1,3-dipropylxanthine (CPX) and 1,3-diallyl-8-cyclohexylxanthine (DAX). J Biol Chem (1998) 0.97
Slow conversions among subconductance states of cystic fibrosis transmembrane conductance regulator chloride channel. Biophys J (1996) 0.97
A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine selectively activates chloride efflux from human epithelial and mouse fibroblast cell lines expressing the cystic fibrosis transmembrane regulator delta F508 mutation. Biochemistry (1995) 0.92
Association of pancreatic adenocarcinoma, mild lung disease, and delta F508 mutation in a cystic fibrosis patient. Clin Chem (1994) 0.91
Colonic carcinoma in two adult cystic fibrosis patients. Can J Gastroenterol (1997) 0.90
The cystic fibrosis delta F508 gene mutation and cancer. Hum Mutat (1997) 0.89
Gene chips and arrays revealed: a primer on their power and their uses. Biol Psychiatry (1999) 0.85
Stimulation of B and T cells activates expression of transcription and differentiation factors. Biochem Biophys Res Commun (1998) 0.84
Stimulation by alkylxanthines of chloride efflux in CFPAC-1 cells does not involve A1 adenosine receptors. Biochemistry (1995) 0.83
Adenosine modulates cell proliferation in human colonic adenocarcinoma. I. Possible involvement of adenosine A1 receptor subtypes in HT29 cells. Eur J Pharmacol (1998) 0.81
Mitogenic action of adenosine on osteoblast-like cells, MC3T3-E1. Calcif Tissue Int (1998) 0.81
CPX, a selective A1-adenosine-receptor antagonist, regulates intracellular pH in cystic fibrosis cells. Am J Physiol (1995) 0.81
Microdissection, microchip arrays, and molecular analysis of tumor cells (primary and metastases). Semin Radiat Oncol (1998) 0.80
CFTR deltaF508 carrier status, risk of breast cancer before the age of 40 and histological grading in a population-based case-control study. Int J Cancer (1998) 0.80
Pharmacogenomics: a new approach to individual therapy of hypertension? Curr Opin Nephrol Hypertens (1998) 0.78
Breast abnormalities in patients with cystic fibrosis: previously unrecognized changes. Ann Diagn Pathol (1998) 0.78
Adenosine stimulation of DNA synthesis in mammary epithelial cells. Proc Soc Exp Biol Med (1998) 0.78
Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins. Biochim Biophys Acta (1994) 4.36
Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum. Proc Natl Acad Sci U S A (1993) 3.16
Molecular dissection of nucleolin's role in growth and cell proliferation: new insights. FASEB J (1999) 3.00
The purification of beta-galactosidase from Escherichia coli by affinity chromatography. J Biol Chem (1971) 2.58
pH-dependent fusion of vesicular stomatitis virus with Vero cells. Measurement by dequenching of octadecyl rhodamine fluorescence. J Biol Chem (1987) 2.46
Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes. Proc Natl Acad Sci U S A (1993) 2.41
Initial stages of influenza hemagglutinin-induced cell fusion monitored simultaneously by two fluorescent events: cytoplasmic continuity and lipid mixing. J Cell Biol (1989) 2.40
Identification and purification of an adrenal medullary protein (synexin) that causes calcium-dependent aggregation of isolated chromaffin granules. J Biol Chem (1978) 1.98
Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells. J Biol Chem (1990) 1.86
Evidence for control of serotonin secretion from human platelets by hydroxyl ion transport and osmotic lysis. Proc Natl Acad Sci U S A (1977) 1.75
Cloning and sequencing of the human nucleolin cDNA. FEBS Lett (1989) 1.64
Micelle-vesicle transition of egg phosphatidylcholine and octyl glucoside. Biochemistry (1988) 1.54
Zn2+ interaction with Alzheimer amyloid beta protein calcium channels. Proc Natl Acad Sci U S A (1996) 1.49
Adenosine triphosphate stimulates inositol phospholipid metabolism and prostacyclin formation in adrenal medullary endothelial cells by means of P2-purinergic receptors. Proc Natl Acad Sci U S A (1987) 1.48
Activation of vesicular stomatitis virus fusion with cells by pretreatment at low pH. J Biol Chem (1988) 1.45
In vivo bypass of hemophilia A coagulation defect by factor XIIa implant. Nat Biotechnol (2000) 1.45
Self-association of synexin in the presence of calcium. Correlation with synexin-induced membrane fusion and examination of the structure of synexin aggregates. J Biol Chem (1979) 1.45
New permeability pathways induced in membranes of Plasmodium falciparum infected erythrocytes. Mol Biochem Parasitol (1983) 1.45
Theoretical models of the ion channel structure of amyloid beta-protein. Biophys J (1994) 1.44
pH-dependent fusion induced by vesicular stomatitis virus glycoprotein reconstituted into phospholipid vesicles. J Biol Chem (1984) 1.44
Internal pH and state of ATP in adrenergic chromaffin granules determined by 31P nuclear magnetic resonance spectroscopy. J Biol Chem (1979) 1.43
The presence of F3-F2a1 dimers and F1 oligomers in chromatin. Biochem Biophys Res Commun (1975) 1.40
Regulation of the transmembrane potential of isolated chromaffin granules by ATP, ATP analogs, and external pH. J Biol Chem (1976) 1.39
Evidence for stimulation of anion transport in ATP-evoked transmitter release from isolated secretory vesicles. J Biol Chem (1978) 1.37
Role of anions in parathyroid hormone release from dispersed bovine parathyroid cells. Proc Natl Acad Sci U S A (1978) 1.36
Calcium channel activity of purified human synexin and structure of the human synexin gene. Proc Natl Acad Sci U S A (1989) 1.33
Identification of isolate-specific proteins on sorbitol-enriched Plasmodium falciparum infected erythrocytes from Gambian patients. Parasitology (1986) 1.30
Calcium-activated endonexin II forms calcium channels across acidic phospholipid bilayer membranes. J Biol Chem (1990) 1.29
ANX7, a candidate tumor suppressor gene for prostate cancer. Proc Natl Acad Sci U S A (2001) 1.26
An osmotic mechanism for exocytosis from dissociated chromaffin cells. J Biol Chem (1984) 1.21
Control of the proinflammatory state in cystic fibrosis lung epithelial cells by genes from the TNF-alphaR/NFkappaB pathway. Mol Med (2001) 1.16
beta-Amyloid Ca(2+)-channel hypothesis for neuronal death in Alzheimer disease. Mol Cell Biochem (1994) 1.16
Genomic organization and chromosomal localization of the human nucleolin gene. J Biol Chem (1990) 1.13
The chromaffin granule and possible mechanisms of exocytosis. Int Rev Cytol (1979) 1.12
Intrinsic anion channel activity of the recombinant first nucleotide binding fold domain of the cystic fibrosis transmembrane regulator protein. Proc Natl Acad Sci U S A (1992) 1.12
Membrane fusion protein synexin (annexin VII) as a Ca2+/GTP sensor in exocytotic secretion. Proc Natl Acad Sci U S A (1996) 1.12
Endothelial cells from bovine adrenal medulla develop capillary-like growth patterns in culture. Proc Natl Acad Sci U S A (1985) 1.11
Muscarinic receptor enhancement of nicotine-induced catecholamine secretion may be mediated by phosphoinositide metabolism in bovine adrenal chromaffin cells. J Biol Chem (1986) 1.09
Membrane capacity measurements suggest a calcium-dependent insertion of synexin into phosphatidylserine bilayers. FEBS Lett (1987) 1.09
Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse. Proc Natl Acad Sci U S A (1999) 1.09
The ability of amyloid beta-protein [A beta P (1-40)] to form Ca2+ channels provides a mechanism for neuronal death in Alzheimer's disease. Ann N Y Acad Sci (1994) 1.07
Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain. J Biol Chem (1991) 1.06
Temperature dependence of the vesicle-micelle transition of egg phosphatidylcholine and octyl glucoside. Biochemistry (1989) 1.06
Real-time measurements of acetylcholine-induced release of ATP from bovine medullary chromaffin cells. FEBS Lett (1985) 1.05
A1 adenosine-receptor antagonists activate chloride efflux from cystic fibrosis cells. Proc Natl Acad Sci U S A (1992) 1.03
Chromaffin granule membrane-F-actin interactions are calcium sensitive. Nature (1982) 1.02
Doxorubicin resistance in P388 leukemia--evidence for reduced drug influx. Int J Cancer (1989) 1.00
Calcium-dependent regulation of chromaffin granule movement, membrane contact, and fusion during exocytosis. Cold Spring Harb Symp Quant Biol (1982) 0.99
A polarized salivary cell monolayer useful for studying transepithelial fluid movement in vitro. Pflugers Arch (1998) 0.99
Rapid dissolution of phytobezoar by cellulase enzyme. Am J Surg (1968) 0.98
Synexin and chromaffin granule membrane fusion. A novel "hydrophobic bridge" hypothesis for the driving and directing of the fusion process. Ann N Y Acad Sci (1987) 0.98
Permeant anion activation of MgATPase activity in chromaffin granules. Evidence for direct coupling of proton and anion transport. J Biol Chem (1980) 0.98
Direct activation of cystic fibrosis transmembrane conductance regulator channels by 8-cyclopentyl-1,3-dipropylxanthine (CPX) and 1,3-diallyl-8-cyclohexylxanthine (DAX). J Biol Chem (1998) 0.97
Electrical activity in chromaffin cells of intact mouse adrenal gland. Am J Physiol (1988) 0.96
Application of Bradford's protein assay to adrenal gland subcellular fractions. Anal Biochem (1978) 0.96
Barium ions enter chromaffin cells via voltage-dependent calcium channels and induce secretion by a mechanism independent of calcium. J Biol Chem (1989) 0.96
Highly sensitive and stable phosphatidylserine liposome aggregation assay for annexins. Anal Biochem (1997) 0.95
A role for anion transport in the regulation of release from chromaffin granules and exocytosis from cells. J Supramol Struct (1977) 0.94
Mechanism of calcium action and release of vesicle-bound hormones during exocytosis. Recent Prog Horm Res (1981) 0.94
Role of ATP and beta-gamma-iminoadenosinetriphosphate in the stimulation of epinephrine and protein release from isolated adrenal secretory vesicles. Arch Biochem Biophys (1976) 0.94
Role of intracellular proteins in the regulation of calcium action and transmitter release during exocytosis. Monogr Neural Sci (1980) 0.94
A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine selectively activates chloride efflux from human epithelial and mouse fibroblast cell lines expressing the cystic fibrosis transmembrane regulator delta F508 mutation. Biochemistry (1995) 0.92
Voltage-sensitive calcium flux into bovine chromaffin cells occurs through dihydropyridine-sensitive and dihydropyridine- and omega-conotoxin-insensitive pathways. Neuroscience (1989) 0.92
Immunolocalization of synexin (annexin VII) in adrenal chromaffin granules and chromaffin cells: evidence for a dynamic role in the secretory process. Cell Tissue Res (1992) 0.92
A Cell-free Model for Protein-Lipid Interactions in Exocytosis: Aggregation and Fusion of Chromaffin Granules in the Presence of Calcium, Synexin, and CIS-Unsaturated Fatty Acids. Biophys J (1982) 0.90
Enhancement of Ca2+-induced catecholamine release by the phorbol ester TPA in digitonin-permeabilized cultured bovine adrenal chromaffin cells. FEBS Lett (1985) 0.89
In vitro reconstitution of chromaffin granule-cytoskeleton interactions: ionic factors influencing the association of F-actin with purified chromaffin granule membranes. J Cell Biochem (1982) 0.89
A biophysical model of the chromaffin granule. Accurate description of the kinetics of ATP and Cl- dependent granule lysis. Biophys J (1980) 0.89
Development of a cell-free model for compound exocytosis using components of the chromaffin cell. J Auton Nerv Syst (1983) 0.89
Differential control of insulin secretion and somatostatin-receptor recruitment in isolated pancreatic islets. Biochem J (1983) 0.89
Genomic organization and chromosomal localization of the mouse synexin gene. Biochem J (1994) 0.89
Synaptic vesicles: structure of chromaffin granule membranes. J Supramol Struct (1973) 0.88
Hormone secretion by exocytosis with emphasis on information from the chromaffin cell system. Vitam Horm (1985) 0.88
Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10. Biochemistry (1994) 0.88
Characterization of protein kinase C and its role in catecholamine secretion from bovine adrenal-medullary cells. Biochem J (1985) 0.88
8-cyclopentyl-1,3-dipropylxanthine and other xanthines differentially bind to the wild-type and delta F508 first nucleotide binding fold (NBF-1) domains of the cystic fibrosis transmembrane conductance regulator. Biochemistry (1997) 0.88
Restricted diffusion of tyrosine hydroxylase and phenylethanolamine N-methyltransferase from digitonin-permeabilized adrenal chromaffin cells. Proc Natl Acad Sci U S A (1986) 0.87
Steroid regulation of monoamine oxidase activity in the adrenal medulla. FASEB J (1989) 0.86
Mouse synexin (annexin VII) polymorphisms and a phylogenetic comparison with other synexins. Biochem J (1993) 0.86
A rise in nuclear calcium translocates annexins IV and V to the nuclear envelope. FEBS Lett (1996) 0.86
ANX7 as a bio-marker in prostate and breast cancer progression. Dis Markers (2001) 0.86
Construction of a three-dimensional iso-density map of the low-density lipoprotein particle from human serum. Biochem Biophys Res Commun (1971) 0.86
Activation of annexin 7 by protein kinase C in vitro and in vivo. J Biol Chem (2001) 0.86
Effect of MPTP on dopaminergic neurons in the goldfish brain: a light and electron microscope study. Brain Res (1995) 0.85
A geometric sequence that accurately describes allowed multiple conductance levels of ion channels: the "three-halves (3/2) rule". Biophys J (1994) 0.85
Calcium-independent K(+)-selective channel from chromaffin granule membranes. J Membr Biol (1992) 0.85
Calcium binding properties of monovalent anions commonly used to substitute for chloride in physiological salt solutions. Anal Biochem (1977) 0.85
ATP-stimulated transmitter release and cyclic AMP synthesis in isolated chromaffin granules. J Supramol Struct (1976) 0.85
Isolated chromaffin cells from adrenal medulla contain primarily monoamine oxidase B. Science (1984) 0.85
Pertussis toxin stimulation of catecholamine release from adrenal medullary chromaffin cells: mechanism may be by direct activation of L-type and G-type calcium channels. J Membr Biol (1991) 0.84
Cell cycle and post-transcriptional regulation of annexin expression in IMR-90 human fibroblasts. Biochem J (1997) 0.84
Further characterization of the aggregation and fusion of chromaffin granules by synexin as a model for compound exocytosis. J Cell Biochem (1982) 0.84
Identification of annexins as calcium channels in biological membranes. Bone Miner (1992) 0.84
A simple and novel method for radiometric analysis of glucose utilization by adrenal chromaffin cells. Anal Biochem (1981) 0.83
Mixed nicotinic and muscarinic features of cholinergic receptor coupled to secretion in bovine chromaffin cells. Proc Natl Acad Sci U S A (1991) 0.83
Anatomic genomics: systems of genes supporting the biology of systems. Anat Rec (2000) 0.83
Comparison of chemical properties of purified plasma membranes and secretory vesicle membranes from bovine adrenal medulla. Cell Tissue Res (1978) 0.83
A method for measuring anion transfer across red cell membranes by continuous monitoring of fluorescence. Anal Biochem (1980) 0.83