Published in Proc Natl Acad Sci U S A on February 15, 2000
Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome. PLoS Biol (2007) 2.90
Evolutionary conservation of regulatory elements in vertebrate Hox gene clusters. Genome Res (2003) 2.64
Developmental roles of pufferfish Hox clusters and genome evolution in ray-fin fish. Genome Res (2004) 1.74
Biphasic Hoxd gene expression in shark paired fins reveals an ancient origin of the distal limb domain. PLoS One (2007) 1.49
Hox cluster duplications and the opportunity for evolutionary novelties. Proc Natl Acad Sci U S A (2003) 1.47
Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters. Proc Natl Acad Sci U S A (2006) 1.35
Elephant shark (Callorhinchus milii) provides insights into the evolution of Hox gene clusters in gnathostomes. Proc Natl Acad Sci U S A (2009) 1.33
Molecular evolution of the HoxA cluster in the three major gnathostome lineages. Proc Natl Acad Sci U S A (2002) 1.29
An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4. Nucleic Acids Res (2008) 1.22
Bichir HoxA cluster sequence reveals surprising trends in ray-finned fish genomic evolution. Genome Res (2004) 1.13
Evolutionary constraint on Otx2 neuroectoderm enhancers-deep conservation from skate to mouse and unique divergence in teleost. Proc Natl Acad Sci U S A (2006) 1.06
Atypical relaxation of structural constraints in Hox gene clusters of the green anole lizard. Genome Res (2009) 1.06
Hox gene clusters in the Indonesian coelacanth, Latimeria menadoensis. Proc Natl Acad Sci U S A (2003) 1.03
Construction of a nurse shark (Ginglymostoma cirratum) bacterial artificial chromosome (BAC) library and a preliminary genome survey. BMC Genomics (2006) 1.01
The Dlx gene complement of the leopard shark, Triakis semifasciata, resembles that of mammals: implications for genomic and morphological evolution of jawed vertebrates. Genetics (2004) 0.99
An evolutionary constraint: strongly disfavored class of change in DNA sequence during divergence of cis-regulatory modules. Proc Natl Acad Sci U S A (2005) 0.95
Sequence of the Tribolium castaneum homeotic complex: the region corresponding to the Drosophila melanogaster antennapedia complex. Genetics (2002) 0.92
Evolution of Hox gene clusters in deuterostomes. BMC Dev Biol (2013) 0.91
A general scenario of Hox gene inventory variation among major sarcopterygian lineages. BMC Evol Biol (2011) 0.89
SkateBase, an elasmobranch genome project and collection of molecular resources for chondrichthyan fishes. F1000Res (2014) 0.88
Molecular evolution of duplicated ray finned fish HoxA clusters: increased synonymous substitution rate and asymmetrical co-divergence of coding and non-coding sequences. J Mol Evol (2005) 0.87
The shark HoxN cluster is homologous to the human HoxD cluster. J Mol Evol (2004) 0.84
Evolution of conserved non-coding sequences within the vertebrate Hox clusters through the two-round whole genome duplications revealed by phylogenetic footprinting analysis. J Mol Evol (2010) 0.84
Hox gene clusters of early vertebrates: do they serve as reliable markers for genome evolution? Genomics Proteomics Bioinformatics (2011) 0.83
Conserved expression of Hoxa1 in neurons at the ventral forebrain/midbrain boundary of vertebrates. Dev Genes Evol (2003) 0.82
Genome enablement of the notothenioidei: genome size estimates from 11 species and BAC libraries from 2 representative taxa. J Exp Zool B Mol Dev Evol (2010) 0.82
The phylogenetic placement of chondrichthyes: inferences from analysis of multiple genes and implications for comparative studies. Genetica (2001) 0.81
Unexpectedly large number of conserved noncoding regions within the ancestral chordate Hox cluster. Dev Genes Evol (2008) 0.80
Hox cluster duplication in the basal teleost Hiodon alosoides (Osteoglossomorpha). Theory Biosci (2009) 0.80
Comparative genomics of chondrichthyan Hoxa clusters. BMC Evol Biol (2009) 0.80
Conservation of gene linkage in dispersed vertebrate NK homeobox clusters. Dev Genes Evol (2009) 0.76
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol (1987) 266.90
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res (1997) 175.36
Homeobox genes and axial patterning. Cell (1992) 12.03
Zebrafish hox clusters and vertebrate genome evolution. Science (1998) 8.50
Exon shuffling by L1 retrotransposition. Science (1999) 4.99
The murine and Drosophila homeobox gene complexes have common features of organization and expression. Cell (1989) 4.86
Locus control regions of mammalian beta-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights. Gene (1997) 3.77
Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes. J Biol Chem (1994) 3.22
The human HOX gene family. Nucleic Acids Res (1989) 3.13
Archetypal organization of the amphioxus Hox gene cluster. Nature (1994) 3.12
A homeotic gene cluster patterns the anteroposterior body axis of C. elegans. Cell (1993) 2.28
Human Hox-4.2 and Drosophila deformed encode similar regulatory specificities in Drosophila embryos and larvae. Cell (1990) 1.85
One-megabase sequence analysis of the human immunoglobulin lambda gene locus. Genome Res (1997) 1.77
Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products. EMBO J (1986) 1.74
Software tools for analyzing pairwise alignments of long sequences. Nucleic Acids Res (1991) 1.68
Expansion of the Hox gene family and the evolution of chordates. Proc Natl Acad Sci U S A (1993) 1.52
Modification of expression and cis-regulation of Hoxc8 in the evolution of diverged axial morphology. Proc Natl Acad Sci U S A (1998) 1.36
Retinoic acid-responsive enhancers located 3' of the Hox A and Hox B homeobox gene clusters. Functional analysis. J Biol Chem (1997) 1.32
Organization of the Fugu rubripes Hox clusters: evidence for continuing evolution of vertebrate Hox complexes. Nat Genet (1997) 1.28
Colinear and segmental expression of amphioxus Hox genes. Dev Biol (1999) 1.11
Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element. Development (1998) 1.10
Comparative studies on mammalian Hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element. Proc Natl Acad Sci U S A (1998) 1.07
Functional interaction between a RARE and an AP-2 binding site in the regulation of the human HOX A4 gene promoter. Nucleic Acids Res (1996) 1.05
Control of genes by mammalian retroposons. Int Rev Cytol (1999) 1.03
Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can function as an enhancer element in Drosophila. Proc Natl Acad Sci U S A (1996) 1.03
Organization of an echinoderm Hox gene cluster. Proc Natl Acad Sci U S A (1999) 1.00
Functional analysis of the mouse homeobox gene HoxB9 in Drosophila development. Mech Dev (1993) 0.99
Evidence for four Hox clusters in the killifish Fundulus heteroclitus (teleostei). Mol Phylogenet Evol (1996) 0.98
A conserved cluster of homeodomain binding sites in the mouse Hoxa-4 intron functions in Drosophila embryos as an enhancer that is directly regulated by Ultrabithorax. Dev Biol (1997) 0.94
Estimation of Hox gene cluster number in lampreys. Int J Dev Biol (1998) 0.91
Evolution of chordate hox gene clusters. Ann N Y Acad Sci (1999) 0.89
Polypurine/polypyrimidine sequence elements of the murine homeo box loci, Hox-1, -2 and -3. Nucleic Acids Res (1987) 0.84
A nonradioactive method for improved restriction analysis and fingerprinting of large P1 artificial chromosome clones. Genet Anal (1996) 0.81
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
Basic local alignment search tool. J Mol Biol (1990) 659.07
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
A greedy algorithm for aligning DNA sequences. J Comput Biol (2000) 47.89
Optimal alignments in linear space. Comput Appl Biosci (1988) 38.10
The DNA sequence of human chromosome 22. Nature (1999) 30.88
Protein sequence similarity searches using patterns as seeds. Nucleic Acids Res (1998) 23.87
The UCSC Genome Browser Database: 2008 update. Nucleic Acids Res (2007) 23.13
A computer program for aligning a cDNA sequence with a genomic DNA sequence. Genome Res (1998) 22.69
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology (2005) 21.67
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature (1998) 21.49
Aligning two sequences within a specified diagonal band. Comput Appl Biosci (1992) 19.31
PipMaker--a web server for aligning two genomic DNA sequences. Genome Res (2000) 17.46
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature (2001) 16.89
Comparative analyses of multi-species sequences from targeted genomic regions. Nature (2003) 13.31
The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology (1997) 13.27
A physical map of the human genome. Nature (2001) 12.39
The DNA sequence of human chromosome 21. Nature (2000) 10.66
Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med (1996) 10.60
Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science (2000) 10.14
Myotonic dystrophy mutation: an unstable CTG repeat in the 3' untranslated region of the gene. Science (1992) 9.32
Zebrafish hox clusters and vertebrate genome evolution. Science (1998) 8.50
Long human-mouse sequence alignments reveal novel regulatory elements: a reason to sequence the mouse genome. Genome Res (1997) 8.49
Scoring pairwise genomic sequence alignments. Pac Symp Biocomput (2002) 8.42
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet (2000) 7.83
Comparison of DNA sequences with protein sequences. Genomics (1997) 7.76
Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering. Biochem Biophys Res Commun (1983) 7.26
Mapping sequenced E.coli genes by computer: software, strategies and examples. Nucleic Acids Res (1991) 6.29
Positional cloning of the APECED gene. Nat Genet (1997) 5.47
trans activation of the latent Epstein-Barr virus (EBV) genome after transfection of the EBV DNA fragment. J Virol (1986) 5.25
Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. Genome Res (1997) 4.82
Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect data. Biochemistry (2000) 4.52
Cloning of the essential myotonic dystrophy region and mapping of the putative defect. Nature (1992) 4.45
Localization of the human alpha-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay. Cell (1977) 4.34
Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene. Proc Natl Acad Sci U S A (1985) 4.28
Isolation of microtubule protein from cultured mouse neuroblastoma cells. Proc Natl Acad Sci U S A (1970) 4.20
Alignment of Escherichia coli K12 DNA sequences to a genomic restriction map. Nucleic Acids Res (1990) 4.07
A controlled trial of a formalin-inactivated hepatitis A vaccine in healthy children. N Engl J Med (1992) 4.05
Smoking cessation in patients with chronic obstructive pulmonary disease: a double-blind, placebo-controlled, randomised trial. Lancet (2001) 3.96
Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res (1998) 3.80
Locus control regions of mammalian beta-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights. Gene (1997) 3.77
Canalization in evolutionary genetics: a stabilizing theory? Bioessays (2000) 3.62
Conformation and function of the N-linked glycan in the adhesion domain of human CD2. Science (1995) 3.62
The natural history of recurrent herpes simplex labialis: implications for antiviral therapy. N Engl J Med (1977) 3.61
A local alignment tool for very long DNA sequences. Comput Appl Biosci (1995) 3.58
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood (1997) 3.56
Spatial working memory in humans as revealed by PET. Nature (1993) 3.42
Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. J Urol (2000) 3.39
Guidelines for calibration of stimulus and recording parameters used in clinical electrophysiology of vision. Calibration Standard Committee of the International Society for Clinical Electrophysiology of Vision (ISCEV). Doc Ophthalmol (1998) 3.39
The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science (1999) 3.23
Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nat Struct Biol (1997) 3.14
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT. Nat Genet (1996) 3.07
Host range mutant of human immunodeficiency virus type 1: modification of cell tropism by a single point mutation at the neutralization epitope in the env gene. J Virol (1991) 3.07
Sequential resonance assignments as a basis for determination of spatial protein structures by high resolution proton nuclear magnetic resonance. J Mol Biol (1982) 3.05
Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat Cell Biol (2001) 3.03
Post-processing long pairwise alignments. Bioinformatics (1999) 3.00
Verbal Working Memory Load Affects Regional Brain Activation as Measured by PET. J Cogn Neurosci (1997) 3.00
A space-efficient algorithm for local similarities. Comput Appl Biosci (1990) 2.98
NMR spectroscopy: a multifaceted approach to macromolecular structure. Q Rev Biophys (2000) 2.98
Modulation of the two promoters of the galactose operon of Escherichia coli. Nature (1979) 2.91
Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain (2003) 2.90
Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. Nucleic Acids Res (2001) 2.89
Polycystic ovaries treated by laparoscopic laser vaporization. Fertil Steril (1989) 2.77
Analysis of the quality and utility of random shotgun sequencing at low redundancies. Genome Res (1998) 2.74
Improved resolution in triple-resonance spectra by nonlinear sampling in the constant-time domain. J Biomol NMR (1994) 2.72
Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell (1999) 2.58
Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. Cell (1998) 2.57
Physiology of penile erection. Physiol Rev (1995) 2.57
Correlation of the highest-energy cosmic rays with nearby extragalactic objects. Science (2007) 2.57
Pulmonary function, postoperative pain, and serum cytokine level after lobectomy: a comparison of VATS and conventional procedure. Ann Thorac Surg (2001) 2.55
Metabolism of (14C) cefaclor, a cephalosporin antibiotic, in three species of laboratory animals. Antimicrob Agents Chemother (1976) 2.52
Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Nat Struct Biol (2000) 2.49
A SNP resource for human chromosome 22: extracting dense clusters of SNPs from the genomic sequence. Genome Res (2001) 2.49
Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster. Hum Mol Genet (2001) 2.46
Reduced pulmonary function in patients with spinal osteoporotic fractures. Osteoporos Int (1998) 2.45
Dispersion of alpha-like globin genes of the mouse to three different chromosomes. Nature (1981) 2.44
Amide protein exchange and surface conformation of the basic pancreatic trypsin inhibitor in solution. Studies with two-dimensional nuclear magnetic resonance. J Mol Biol (1982) 2.44
Infectious cell entry mechanism of influenza virus. J Virol (1982) 2.41
Treatment of moderate/severe acute graft-versus-host disease after allogeneic bone marrow transplantation: an analysis of clinical risk features and outcome. Blood (1990) 2.38
Brain activation in PTSD in response to trauma-related stimuli. Biol Psychiatry (1999) 2.38
Globin gene server: a prototype E-mail database server featuring extensive multiple alignments and data compilation for electronic genetic analysis. Genomics (1994) 2.36
Interaction of influenza virus hemagglutinin with target membrane lipids is a key step in virus-induced hemolysis and fusion at pH 5.2. Proc Natl Acad Sci U S A (1981) 2.31
Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins. J Immunol (1997) 2.31
Localization of multidrug resistance-associated DNA sequences to human chromosome 7. Somat Cell Mol Genet (1986) 2.27
The solution structure of eglin c based on measurements of many NOEs and coupling constants and its comparison with X-ray structures. Protein Sci (1992) 2.25
The eIF1A solution structure reveals a large RNA-binding surface important for scanning function. Mol Cell (2000) 2.24