Conditionally immortalized cell lines, engineered to produce and release GABA, modulate the development of behavioral seizures.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMID 10686070)

Published in Exp Neurol on February 01, 2000

Authors

K Thompson1, V Anantharam, S Behrstock, E Bongarzone, A Campagnoni, A J Tobin

Author Affiliations

1: Department of Physiological Sciences, Neuropsychiatric Institute, Los Angeles, California, 90995, USA.

Articles citing this

Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice. Proc Natl Acad Sci U S A (2009) 2.06

Medial ganglionic eminence-derived neural stem cell grafts ease spontaneous seizures and restore GDNF expression in a rat model of chronic temporal lobe epilepsy. Stem Cells (2010) 1.31

Update on the role of substantia nigra pars reticulata in the regulation of seizures. Epilepsy Curr (2006) 1.19

Cell and gene therapies for refractory epilepsy. Curr Neuropharmacol (2007) 1.06

GABAergic lineage differentiation of AF5 neural progenitor cells in vitro. Cell Tissue Res (2006) 0.95

Transplantation of GABA-producing cells for seizure control in models of temporal lobe epilepsy. Neurotherapeutics (2009) 0.93

Intraventricular and intracerebral delivery of anti-epileptic drugs in the kindling model. Neurotherapeutics (2009) 0.93

Regional neural activity within the substantia nigra during peri-ictal flurothyl generalized seizure stages. Neurobiol Dis (2005) 0.92

Gene therapy in epilepsy. Epilepsia (2008) 0.87

Involvement of the limbic basal ganglia in ethanol withdrawal convulsivity in mice is influenced by a chromosome 4 locus. J Neurosci (2008) 0.85

Intranigral transplants of a GABAergic cell line produce long-term alleviation of established motor seizures. Behav Brain Res (2008) 0.83

Metabolic environment in substantia nigra reticulata is critical for the expression and control of hypoglycemia-induced seizures. J Neurosci (2008) 0.82

GABAergic neuronal precursor grafting: implications in brain regeneration and plasticity. Neural Plast (2011) 0.81

Benefits and risks of intranigral transplantation of GABA-producing cells subsequent to the establishment of kindling-induced seizures. Neurobiol Dis (2008) 0.81

Commentary: the prospect of cell-based therapy for epilepsy. Neurotherapeutics (2009) 0.77

Human fetal brain-derived neural stem/progenitor cells grafted into the adult epileptic brain restrain seizures in rat models of temporal lobe epilepsy. PLoS One (2014) 0.76

Articles by these authors

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature (1993) 5.47

Two genes encode distinct glutamate decarboxylases. Neuron (1991) 3.68

Molecular biology of GABAA receptors. FASEB J (1990) 2.66

Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J Neurochem (1991) 2.66

Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nat Med (1996) 2.35

Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms. J Neurosci (1994) 2.24

Carbonic anhydrase from parsley leaves. J Biol Chem (1970) 2.03

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. Proc Natl Acad Sci U S A (1992) 1.93

The structural and functional heterogeneity of glutamic acid decarboxylase: a review. Neurochem Res (1991) 1.93

Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein. J Neurosci (1987) 1.78

Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet (1992) 1.73

Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest (1992) 1.67

Brain glutamate decarboxylase cloned in lambda gt-11: fusion protein produces gamma-aminobutyric acid. Science (1986) 1.60

Identification, purification, and reconstitution of OxlT, the oxalate: formate antiport protein of Oxalobacter formigenes. J Biol Chem (1992) 1.56

A novel alpha subunit in rat brain GABAA receptors. Neuron (1989) 1.51

Distribution of developmentally regulated hemoglobins in embryonic erythroid populations. Dev Biol (1979) 1.47

Different distributions of GAD65 and GAD67 mRNAs suggest that the two glutamate decarboxylases play distinctive functional roles. J Neurosci Res (1993) 1.42

Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells. Free Radic Biol Med (2001) 1.41

Ethanol increases the activity of Ca(++)-dependent K+ (mslo) channels: functional interaction with cytosolic Ca++. J Pharmacol Exp Ther (1998) 1.35

Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Neuroscience (2003) 1.30

Comparative localization of mRNAs encoding two forms of glutamic acid decarboxylase with nonradioactive in situ hybridization methods. J Comp Neurol (1993) 1.26

Increased expression of glutamate decarboxylase (GAD(67)) in feline lumbar spinal cord after complete thoracic spinal cord transection. J Neurosci Res (2000) 1.25

Chronic intermittent ethanol treatment in rats increases GABA(A) receptor alpha4-subunit expression: possible relevance to alcohol dependence. J Neurochem (1997) 1.21

Uniqueness and redundancy in GABA production. Perspect Dev Neurobiol (1998) 1.20

Abolition of G protein inhibition of alpha 1A and alpha 1B calcium channels by co-expression of the beta 3 subunit. FEBS Lett (1995) 1.08

Evaluating the contribution of posttranscriptional processing to differential gene expression. Dev Biol (1979) 1.06

UhpT, the sugar phosphate antiporter of Escherichia coli, functions as a monomer. J Biol Chem (1990) 1.05

Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration. Mol Pharmacol (2010) 1.05

In situ hybridization to localize mRNA encoding the neurotransmitter synthetic enzyme glutamate decarboxylase in mouse cerebellum. Proc Natl Acad Sci U S A (1986) 1.03

The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD. Genomics (1994) 1.02

Ethanol inhibition of recombinant heteromeric NMDA channels in the presence and absence of modulators. J Neurochem (1995) 1.02

Population structure and residency patterns of the blacktip reef shark Carcharhinus melanopterus in turbid coastal environments. J Fish Biol (2013) 1.00

Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes. J Clin Invest (1993) 0.97

Complete amino acid sequences of the major early embryonic alpha-like globins of the chicken. J Biol Chem (1980) 0.97

4-Aminobutyrate aminotransferase (GABA-transaminase) deficiency. J Inherit Metab Dis (1999) 0.97

Postnatal expression of glutamate decarboxylases in developing rat cerebellum. Neurochem Res (1991) 0.97

Distinctive patterns of GABAA receptor subunit mRNAs in 13 cell lines. J Neurosci (1994) 0.95

Measurement of the substrate dissociation constant of a solubilized membrane carrier. Substrate stabilization of OxlT, the anion exchange protein of Oxalobacter formigenes. J Biol Chem (1992) 0.95

Differential localization of two glutamic acid decarboxylases (GAD65 and GAD67) in adult monkey visual cortex. J Comp Neurol (1994) 0.94

Glutamate decarboxylases in nonneural cells of rat testis and oviduct: differential expression of GAD65 and GAD67. J Neurochem (1992) 0.94

The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation. Genomics (1995) 0.93

Assignment of the rhodopsin gene to human chromosome 3. Invest Ophthalmol Vis Sci (1986) 0.92

Design and optimization of lentiviral vectors for transfer of GALC expression in Twitcher brain. J Gene Med (2006) 0.92

Transient increase in expression of a glutamate decarboxylase (GAD) mRNA during the postnatal development of the rat striatum. Dev Biol (1992) 0.91

Proteolytic activation of proapoptotic kinase PKCdelta is regulated by overexpression of Bcl-2: implications for oxidative stress and environmental factors in Parkinson's disease. Ann N Y Acad Sci (2003) 0.91

Detection of point mutations associated with genetic diseases by an exon scanning technique. Genomics (1990) 0.91

Independent cellular and ontogenetic expression of mRNAs encoding three alpha polypeptides of the rat GABAA receptor. Neuroscience (1991) 0.90

Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration. Neurotoxicology (2011) 0.89

Comparative distribution of mRNAs for glutamic acid decarboxylase, tyrosine hydroxylase, and tachykinins in the basal ganglia: an in situ hybridization study in the rodent brain. J Comp Neurol (1987) 0.89

Few transcribed RNAs are translated in avian erythroid cells. Dev Biol (1978) 0.89

Isolation, macromolecular properties, and combining site of a chito-oligosaccharide-specific lectin from the exudate of ridge gourd (Luffa acutangula). J Biol Chem (1986) 0.88

Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells. Neuroscience (2012) 0.88

Influence of the embryonic preplate on the organization of the cerebral cortex: a targeted ablation model. J Neurosci (2002) 0.88

Long-term increase of glutamate decarboxylase mRNA in a rat model of temporal lobe epilepsy. Neuron (1990) 0.88

Analysis of galactocerebrosidase activity in the mouse brain by a new histological staining method. J Neurosci Res (2004) 0.88

Methamphetamine induces autophagy and apoptosis in a mesencephalic dopaminergic neuronal culture model: role of cathepsin-D in methamphetamine-induced apoptotic cell death. Ann N Y Acad Sci (2006) 0.87

Hemoglobin synthesis in isolated erythroid colonies from the chick embryo. Dev Biol (1976) 0.87

A novel method for expression and large-scale production of human brain l-glutamate decarboxylase. Biochem Biophys Res Commun (2000) 0.87

Chemical modification studies on Abrus agglutinin. Involvement of tryptophan residues in sugar binding. Biochem J (1984) 0.86

Assignment of the rhodopsin gene to human chromosome three, region 3q21-3q24 by in situ hybridization studies. Curr Eye Res (1986) 0.86

Molecular cloning of mammalian 28,000 Mr vitamin D-dependent calcium binding protein (calbindin-D28K): expression of calbindin-D28K RNAs in rodent brain and kidney. DNA (1988) 0.86

Comparative distribution of messenger RNAs encoding glutamic acid decarboxylases (Mr 65,000 and Mr 67,000) in the basal ganglia of the rat. J Comp Neurol (1992) 0.86

Immortalized hypothalamic GT1-7 neurons express functional gamma-aminobutyric acid type A receptors. Mol Pharmacol (1992) 0.86

Multipotential neural precursors transplanted into the metachromatic leukodystrophy brain fail to generate oligodendrocytes but contribute to limit brain dysfunction. Dev Neurosci (2008) 0.86

GABA signalling: therapeutic targets for epilepsy, Parkinson's disease and Huntington's disease. Expert Opin Ther Targets (2001) 0.86

Postnatal localization and morphogenesis of cells expressing the dopaminergic D2 receptor gene in rat brain: expression in non-neuronal cells. J Comp Neurol (1998) 0.86

Parallel increases in striatal glutamic acid decarboxylase activity and mRNA levels in rats with lesions of the nigrostriatal pathway. Brain Res (1990) 0.85

Myelin deterioration in Twitcher mice: motor evoked potentials and magnetic resonance imaging as in vivo monitoring tools. J Neurosci Res (2005) 0.85

Cyclic AMP decreases the expression of a neuronal marker (GAD67) and increases the expression of an astroglial marker (GFAP) in C6 cells. J Neurochem (1994) 0.85

Use of c-fos to identify activity-dependent spinal neurons after stepping in intact adult rats. Spinal Cord (2005) 0.85

Splicing defect at the ornithine aminotransferase (OAT) locus in gyrate atrophy. Am J Hum Genet (1990) 0.83

Metabolic compromise with systemic 3-nitropropionic acid produces striatal apoptosis in Sprague-Dawley rats but not in BALB/c ByJ mice. Exp Neurol (1998) 0.83

Biphasic modulation of GABA(A) receptor binding by steroids suggests functional correlates. Neurochem Res (1999) 0.83

Isolation and cloning of a voltage-dependent anion channel-like Mr 36,000 polypeptide from mammalian brain. J Biol Chem (1992) 0.83

Calcium binding protein (calbindin-D28k) and glutamate decarboxylase gene expression after kindling induced seizures. Brain Res Mol Brain Res (1991) 0.82

Alterations in GABAA receptor alpha 1 and alpha 4 subunit mRNA levels in thalamic relay nuclei following absence-like seizures in rats. Exp Neurol (1998) 0.82

Cellular distribution of calbindin D28K mRNAs in the adult mouse brain. J Neurosci Res (1994) 0.82

Multiple elements regulate GAD65 transcription. Dev Neurosci (1997) 0.82

GABA alters GABAA receptor mRNAs and increases ligand binding. J Neurochem (1993) 0.81

Two invariant tryptophans on the alpha1 subunit define domains necessary for GABA(A) receptor assembly. J Biol Chem (1999) 0.81

Homomeric assemblies of NMDAR1 splice variants are sensitive to ethanol. Neurosci Lett (1993) 0.80

Glutamate decarboxylases and autoimmunity in insulin-dependent diabetes. Trends Pharmacol Sci (1993) 0.80

Beta-adrenergic receptor activation promotes process outgrowth in an embryonic rat basal forebrain cell line and in primary neurons. Eur J Neurosci (1996) 0.80

Glutamate decarboxylase: an autoantigen in IDDM. Diabetes Care (1992) 0.80

Conditionally-immortalized astrocytic cell line expresses GAD and secretes GABA under tetracycline regulation. J Neurosci Res (2000) 0.79

Complete amino acid sequence of the major early embryonic beta-like globin in chickens. J Biol Chem (1981) 0.79

Brain implantations of engineered GABA-releasing cells suppress tremor in an animal model of Parkinsonism. Neuroscience (2003) 0.79

Effect of divalent metals on the neuronal proteasomal system, prion protein ubiquitination and aggregation. Toxicol Lett (2012) 0.79

Halothane acts on many potassium channels, including a minimal potassium channel. Neurosci Lett (1993) 0.79

Reduced inhibitory capacity in prefrontal cortex of schizophrenics. Arch Gen Psychiatry (1995) 0.78

Sequence and regional distribution of the mRNA encoding the alpha 2 polypeptide of rat gamma-aminobutyric acidA receptors. J Neurochem (1991) 0.77

Minor early embryonic chick hemoglobin M. Amino acid sequences of the epsilon and alpha D chains. J Biol Chem (1982) 0.77

RNA synthesis in avian erythroid cells. Dev Biol (1978) 0.77

Isolation of pharmacologically distinct GABA-benzodiazepine receptors by protein chemistry and molecular cloning. Adv Biochem Psychopharmacol (1990) 0.77

Inhibitory effects of ketamine and halothane on recombinant potassium channels from mammalian brain. Anesthesiology (1996) 0.77

A transcriptional regulatory element of the gene encoding the 67,000-M(r) form of human glutamate decarboxylase is similar to a Drosophila regulatory element. J Neurochem (1992) 0.77

A rat brain cDNA encodes enzymatically active GABA transaminase and provides a molecular probe for GABA-catabolizing cells. J Neurochem (1994) 0.77

Block of the N-methyl-D-aspartate receptor by phencyclidine-like drugs is influenced by alternative splicing. Neurosci Lett (1995) 0.77