Published in Genes Dev on February 15, 2000
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev (2000) 11.49
Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev (2007) 7.41
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol (2001) 7.26
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol (2000) 7.26
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature (2005) 7.18
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell (2007) 6.02
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci U S A (2000) 5.64
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol (2005) 4.54
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev (2003) 4.40
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev (2000) 4.38
In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature (2000) 4.38
Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer (2009) 4.06
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev (2000) 3.96
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev (2000) 3.86
Causes and consequences of replication stress. Nat Cell Biol (2014) 3.70
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. J Cell Biol (2001) 3.35
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat Struct Mol Biol (2011) 3.10
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol Biol Cell (2005) 3.08
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev (2008) 2.86
The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage. EMBO J (2001) 2.80
ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc Natl Acad Sci U S A (2001) 2.75
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet (2009) 2.68
The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev (2009) 2.56
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways. J Cell Sci (2000) 2.37
ATR signalling: more than meeting at the fork. Biochem J (2011) 2.37
CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Mol Cell (2010) 2.29
ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. EMBO J (2006) 2.25
Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest. Mol Cell Biol (2004) 2.20
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage. Mol Cell Biol (2002) 2.19
ATR signaling can drive cells into senescence in the absence of DNA breaks. Genes Dev (2008) 2.17
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol Cell Biol (2002) 2.09
Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs. Mol Oncol (2011) 2.07
Hypoxia links ATR and p53 through replication arrest. Mol Cell Biol (2002) 2.03
Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2002) 1.97
ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem Sci (2010) 1.96
Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans. EMBO J (2005) 1.94
Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex. Oncogene (2006) 1.93
ATR regulates a G2-phase cell-cycle checkpoint in Arabidopsis thaliana. Plant Cell (2004) 1.93
DNA repair deficiency and neurological disease. Nat Rev Neurosci (2009) 1.91
Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX. Nat Struct Mol Biol (2010) 1.87
Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol Cell Biol (2007) 1.87
The human decatenation checkpoint. Proc Natl Acad Sci U S A (2001) 1.84
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. EMBO J (2003) 1.82
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner. Cancer Res (2010) 1.82
Embryonic cleavage cycles: how is a mouse like a fly? Curr Biol (2004) 1.80
Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights. Mutat Res (2009) 1.80
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Res (2011) 1.78
Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J (2004) 1.75
Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control. Proc Natl Acad Sci U S A (2008) 1.74
Common mechanisms of PIKK regulation. DNA Repair (Amst) (2009) 1.73
DNA damage sensing by the ATM and ATR kinases. Cold Spring Harb Perspect Biol (2013) 1.72
Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling. Genes Dev (2005) 1.71
ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes Dev (2013) 1.70
ATR autophosphorylation as a molecular switch for checkpoint activation. Mol Cell (2011) 1.70
Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress. Genes Dev (2000) 1.70
Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol Cell Biol (2003) 1.69
Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J (2003) 1.67
Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. J Mol Biol (2006) 1.66
Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J Cell Biol (2009) 1.66
Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality. Mol Cell Biol (2004) 1.63
BRCT domain-containing protein PTIP is essential for progression through mitosis. Mol Cell Biol (2003) 1.63
Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition. EMBO J (2002) 1.58
Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol Cell Biol (2004) 1.57
Focus on histone variant H2AX: to be or not to be. FEBS Lett (2010) 1.56
ATR and H2AX cooperate in maintaining genome stability under replication stress. J Biol Chem (2008) 1.55
MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem (2007) 1.55
Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics (2002) 1.51
Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53. Nat Genet (2009) 1.51
ATRIP oligomerization is required for ATR-dependent checkpoint signaling. J Biol Chem (2005) 1.51
The ATR barrier to replication-born DNA damage. DNA Repair (Amst) (2010) 1.50
Reduced expression of GINS complex members induces hallmarks of pre-malignancy in primary untransformed human cells. Cell Cycle (2009) 1.49
DNA damage response: three levels of DNA repair regulation. Cold Spring Harb Perspect Biol (2013) 1.48
Ionizing radiation-dependent gamma-H2AX focus formation requires ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related. Mol Biol Cell (2005) 1.48
Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response. Proc Natl Acad Sci U S A (2003) 1.48
Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis. Proc Natl Acad Sci U S A (2011) 1.48
Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo. J Virol (2006) 1.47
ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1. Mol Cell (2015) 1.46
Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR. J Clin Invest (2011) 1.46
Exploiting synthetic lethal interactions for targeted cancer therapy. Cell Cycle (2009) 1.44
Replication stress and cancer. Nat Rev Cancer (2015) 1.43
Genome instability, cancer and aging. Biochim Biophys Acta (2009) 1.40
MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem (2009) 1.39
Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. Br J Cancer (2011) 1.39
The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nat Rev Mol Cell Biol (2017) 1.38
Functional genomic screens identify CINP as a genome maintenance protein. Proc Natl Acad Sci U S A (2009) 1.38
Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions. Genetics (2001) 1.38
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J (2004) 1.36
Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. J Virol (2008) 1.35
DNA damage tolerance: a double-edged sword guarding the genome. Transl Cancer Res (2013) 1.33
Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR. Genetics (2003) 1.33
Replication stress and cancer: it takes two to tango. Exp Cell Res (2014) 1.33
Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response. Cancer Cell (2014) 1.30
How ATR turns on: TopBP1 goes on ATRIP with ATR. Genes Dev (2008) 1.30
Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage. Mol Cell Biol (2002) 1.28
Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage. Cancer Res (2007) 1.27
Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus. Mol Biol Cell (2006) 1.27
ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes. J Clin Oncol (2009) 1.25
Strategies for optimizing the response of cancer and normal tissues to radiation. Nat Rev Drug Discov (2013) 1.25
Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis. J Biol Chem (2008) 1.23
Tumor spectrum analysis in p53-mutant mice. Curr Biol (1994) 16.60
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (1998) 11.90
A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature (1994) 11.50
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science (1998) 8.74
Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev (1994) 8.53
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature (1997) 8.04
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res (1999) 7.82
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science (1999) 6.93
A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev (1999) 6.34
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell (1997) 5.92
A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol Cell Biol (1996) 5.75
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature (1999) 5.44
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell (1999) 5.28
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J (1998) 5.25
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell (1996) 5.10
PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science (1995) 4.51
The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J (1996) 4.45
Involvement of Brca2 in DNA repair. Mol Cell (1998) 4.41
Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell (1993) 4.37
TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell (1995) 4.34
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev (1998) 3.92
ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr Biol (1998) 3.77
The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev (1996) 3.70
Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev (1996) 3.59
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc Natl Acad Sci U S A (1996) 3.31
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene (1999) 3.23
DNA damage and checkpoint pathways: molecular anatomy and interactions with repair. Cell (1998) 3.04
Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. Science (1986) 2.89
The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene. Cell (1995) 2.88
Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control. Proc Natl Acad Sci U S A (1998) 2.81
The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia. Cancer Res (1994) 2.41
Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev (1997) 2.20
Checkpoints on the road to mitosis. Trends Biochem Sci (1998) 1.62
Atm haploinsufficiency results in increased sensitivity to sublethal doses of ionizing radiation in mice. Nat Genet (1999) 1.36
Caspase activity is required for commitment to Fas-mediated apoptosis. EMBO J (1997) 1.30
Cell cycle. Checkpoint on the nuclear frontier. Nature (1999) 1.22
Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell (1983) 25.46
Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci U S A (1993) 22.33
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell (1989) 21.54
Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell (1986) 20.08
RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature (1970) 19.38
An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature (1987) 19.23
I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science (1988) 16.40
Immunoglobulin gene transcription is activated by downstream sequence elements. Cell (1983) 15.53
Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell (1986) 15.30
A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature (1986) 14.34
An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science (1996) 13.87
Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase. J Virol (1981) 13.11
NF-kappa B: ten years after. Cell (1996) 12.80
Cloned poliovirus complementary DNA is infectious in mammalian cells. Science (1981) 12.50
Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome. Proc Natl Acad Sci U S A (1981) 12.00
Ribonucleic acid synthesis of vesicular stomatitis virus, II. An RNA polymerase in the virion. Proc Natl Acad Sci U S A (1970) 11.83
Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor. Cell (1988) 11.62
NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell (1989) 11.19
The "initiator" as a transcription control element. Cell (1989) 11.13
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science (1990) 10.59
Polypeptide cleavages in the formation of poliovirus proteins. Proc Natl Acad Sci U S A (1968) 10.43
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature (1995) 10.36
The V(D)J recombination activating gene, RAG-1. Cell (1989) 9.79
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region. Cell (1981) 9.54
Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression. J Virol (1989) 9.37
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science (1990) 9.33
Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. Nature (1990) 9.31
Further evidence on the formation of poliovirus proteins. J Mol Biol (1970) 9.29
Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell (1990) 9.24
A detailed model of reverse transcription and tests of crucial aspects. Cell (1979) 8.93
A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes. Nature (1986) 8.64
Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc Natl Acad Sci U S A (1982) 8.53
Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements. Cell (1985) 8.16
Covalent linkage of a protein to a defined nucleotide sequence at the 5'-terminus of virion and replicative intermediate RNAs of poliovirus. Proc Natl Acad Sci U S A (1977) 8.12
Identification of a ten-amino acid proline-rich SH3 binding site. Science (1993) 8.05
Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science (1987) 7.63
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell (1995) 7.55
Defective viral particles and viral disease processes. Nature (1970) 7.24
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature (1998) 6.94
A functional ribonucleoprotein complex forms around the 5' end of poliovirus RNA. Cell (1990) 6.85
Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood (1998) 6.81
The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity (1999) 6.80
5'-terminal structure of poliovirus polyribosomal RNA is pUp. Proc Natl Acad Sci U S A (1976) 6.78
Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine. Nature (1980) 6.76
Structure of a cloned circular Moloney murine leukemia virus DNA molecule containing an inverted segment: implications for retrovirus integration. Proc Natl Acad Sci U S A (1980) 6.73
Gene conversion: some implications for immunoglobulin genes. Cell (1981) 6.70
Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J (1984) 6.67
DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell (1991) 6.63
Morphogenesis of poliovirus. I. Association of the viral RNA with coat protein. J Mol Biol (1968) 6.58
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol (1990) 6.57
Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell (1991) 6.48
Identification of an Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells. Proc Natl Acad Sci U S A (1978) 6.38
Modular binding domains in signal transduction proteins. Cell (1995) 6.34
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev (1996) 6.32
Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes. Cell (1981) 6.31
Standardized and simplified nomenclature for proteins common to all retroviruses. J Virol (1988) 6.31
Poliovirus RNA synthesis utilizes an RNP complex formed around the 5'-end of viral RNA. EMBO J (1993) 6.29
The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev (1988) 6.23
RNA metabolism of murine leukemia virus: detection of virus-specific RNA sequences in infected and uninfected cells and identification of virus-specific messenger RNA. J Mol Biol (1973) 6.19
RNA-directed DNA synthesis and RNA tumor viruses. Adv Virus Res (1972) 6.11
Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus. Cell (1979) 6.03
Ribonucleic acid synthesis of vesicular stomatitis virus. 3. Multiple complementary messenger RNA molecules. Virology (1970) 5.99
Aspects of the synthesis of poliovirus RNA and the formation of virus particles. Virology (1966) 5.85
In vitro synthesis of a 9 kbp terminally redundant DNA carrying the infectivity of Moloney murine leukemia virus. Cell (1979) 5.78
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature (1984) 5.75
Ribonucleic acid synthesis of vesicular stomatitis virus. I. Species of ribonucleic acid found in Chinese hamster ovary cells infected with plaque-forming and defective particles. J Virol (1969) 5.73
High frequency of aberrant expression of Moloney murine leukemia virus in clonal infections. Cell (1978) 5.72
Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA. Cell (1980) 5.68
A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB. Genes Dev (1989) 5.61
Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends. Cell (1980) 5.59
Primer requirement and template specificity of the DNA polymerase of RNA tumor viruses. Proc Natl Acad Sci U S A (1971) 5.55
The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell (1989) 5.50
A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell (1990) 5.39
The mechanism of RNA recombination in poliovirus. Cell (1986) 5.35
Translation of MuLV and MSV RNAs in nuclease-treated reticulocyte extracts: enhancement of the gag-pol polypeptide with yeast suppressor tRNA. Cell (1978) 5.31
Varying the position of a retrovirus packaging sequence results in the encapsidation of both unspliced and spliced RNAs. J Virol (1985) 5.21
A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J Exp Med (1976) 5.13
Poliovirus mutant that does not selectively inhibit host cell protein synthesis. Mol Cell Biol (1985) 4.94
An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers. Cell (1991) 4.80
Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID. Proc Natl Acad Sci U S A (1990) 4.79
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med (1996) 4.79
Ordered transcription of RNA tumor virus genomes. J Mol Biol (1976) 4.78
Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency. Cell (1990) 4.78
The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation. Proc Natl Acad Sci U S A (1991) 4.66
Inhibition of translation by poliovirus: inactivation of a specific initiation factor. Proc Natl Acad Sci U S A (1978) 4.59
Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor. Nature (1990) 4.59
Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. Science (1992) 4.57
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature (1992) 4.46
Tumor viruses: 1974. Cold Spring Harb Symp Quant Biol (1975) 4.44
Retracted Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity (1999) 4.42
Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol (1991) 4.42
HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus. Cell (1989) 4.40
Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell (1997) 4.39
Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice. Genes Dev (1995) 4.38
Modelling T-cell memory by genetic marking of memory T cells in vivo. Nature (1999) 4.34
Expression of animal virus genomes. Bacteriol Rev (1971) 4.33
Purification and properties of poliovirus double-stranded ribonucleic acid. J Mol Biol (1966) 4.31
Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system. Curr Opin Cell Biol (1993) 4.29
Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Mol Cell Biol (1982) 4.26