Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta.

PubWeight™: 2.15‹?› | Rank: Top 2%

🔗 View Article (PMC 15975)

Published in Proc Natl Acad Sci U S A on March 14, 2000

Authors

K Meng1, A Rodriguez-Peña, T Dimitrov, W Chen, M Yamin, M Noda, T F Deuel

Author Affiliations

1: Division of Growth Regulation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Articles citing this

Anaplastic lymphoma kinase: signalling in development and disease. Biochem J (2009) 3.05

The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors. Br J Pharmacol (2013) 2.29

VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J (2002) 2.05

Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med (2010) 1.94

CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells. Nat Biotechnol (2011) 1.83

Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy. Expert Rev Anticancer Ther (2009) 1.73

Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction. FEBS J (2013) 1.68

Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma. Mol Cell Biol (2002) 1.43

Receptor-like protein tyrosine phosphatase alpha homodimerizes on the cell surface. Mol Cell Biol (2000) 1.35

Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases. Proc Natl Acad Sci U S A (2004) 1.33

Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system. Proc Natl Acad Sci U S A (2001) 1.19

Receptor tyrosine phosphatase beta (RPTPbeta) activity and signaling are attenuated by glycosylation and subsequent cell surface galectin-1 binding. J Biol Chem (2008) 1.17

Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases. Proc Jpn Acad Ser B Phys Biol Sci (2010) 1.16

Regulation of receptor protein-tyrosine phosphatase alpha by oxidative stress. EMBO J (2002) 1.11

Pleiotrophin regulates serine phosphorylation and the cellular distribution of beta-adducin through activation of protein kinase C. Proc Natl Acad Sci U S A (2005) 1.10

Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. Cell Rep (2012) 1.08

Pleiotrophin disrupts calcium-dependent homophilic cell-cell adhesion and initiates an epithelial-mesenchymal transition. Proc Natl Acad Sci U S A (2006) 1.07

Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Physiol Genomics (2009) 1.06

Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin. Oncogene (2009) 1.05

Midkine: a promising molecule for drug development to treat diseases of the central nervous system. Curr Pharm Des (2011) 1.04

Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP β/ζ signaling by menin. Oncogene (2010) 1.03

Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway. Am J Pathol (2007) 1.02

N-cadherin is an in vivo substrate for protein tyrosine phosphatase sigma (PTPsigma) and participates in PTPsigma-mediated inhibition of axon growth. Mol Cell Biol (2006) 1.01

Cadherin-8 and N-cadherin differentially regulate pre- and postsynaptic development of the hippocampal mossy fiber pathway. Hippocampus (2008) 1.01

Dimerization of receptor protein-tyrosine phosphatase alpha in living cells. BMC Cell Biol (2001) 1.01

Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironment. Proc Natl Acad Sci U S A (2007) 1.00

Receptor protein tyrosine phosphatases and cancer: new insights from structural biology. Cell Adh Migr (2012) 1.00

Dimerization of protein tyrosine phosphatase sigma governs both ligand binding and isoform specificity. Mol Cell Biol (2006) 0.99

The molecular profiles of neural stem cell niche in the adult subventricular zone. PLoS One (2012) 0.97

Insulin-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling. Mol Cell Biol (2012) 0.97

A review of the evidence for the canonical Wnt pathway in autism spectrum disorders. Mol Autism (2012) 0.97

Enhanced antitumorigenic effects in glioblastoma on double targeting of pleiotrophin and its receptor ALK. Neoplasia (2009) 0.97

Proteoglycans and neuronal migration in the cerebral cortex during development and disease. Front Neurosci (2015) 0.95

Tyrosine kinase inhibitor STI-571/Gleevec down-regulates the beta-catenin signaling activity. Cancer Lett (2003) 0.95

Consensus substrate sequence for protein-tyrosine phosphatase receptor type Z. J Biol Chem (2011) 0.95

Structure and function of midkine as the basis of its pharmacological effects. Br J Pharmacol (2014) 0.94

Protein tyrosine phosphatases in glioma biology. Acta Neuropathol (2009) 0.92

RPTPζ/phosphacan is abnormally glycosylated in a model of muscle-eye-brain disease lacking functional POMGnT1. Neuroscience (2012) 0.92

Characterization of the activation of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) by hypoxia inducible factor-2 alpha. PLoS One (2010) 0.91

Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34. J Biol Chem (2013) 0.91

Dimerization in vivo and inhibition of the nonreceptor form of protein tyrosine phosphatase epsilon. Mol Cell Biol (2003) 0.90

Thrombospondin-1 acts as a ligand for CD148 tyrosine phosphatase. Proc Natl Acad Sci U S A (2012) 0.90

Functions of the ectodomain and cytoplasmic tyrosine phosphatase domains of receptor protein tyrosine phosphatase Dlar in vivo. Mol Cell Biol (2003) 0.89

Pleiotrophin regulates lung epithelial cell proliferation and differentiation during fetal lung development via beta-catenin and Dlk1. J Biol Chem (2009) 0.89

Pleiotrophin suppression of receptor protein tyrosine phosphatase-β/ζ maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells. J Neurosci (2012) 0.89

Effect of single-chain antibody targeting of the ligand-binding domain in the anaplastic lymphoma kinase receptor. Oncogene (2009) 0.88

Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model. Mol Ther (2011) 0.88

Receptor type protein tyrosine phosphatases (RPTPs) - roles in signal transduction and human disease. J Cell Commun Signal (2012) 0.88

Receptor type protein tyrosine phosphatase zeta-pleiotrophin signaling controls endocytic trafficking of DNER that regulates neuritogenesis. Mol Cell Biol (2008) 0.87

Chicken pleiotrophin: regulation of tissue specific expression by estrogen in the oviduct and distinct expression pattern in the ovarian carcinomas. PLoS One (2012) 0.87

Anaplastic lymphoma kinase is expressed in different subtypes of human breast cancer. Biochem Biophys Res Commun (2007) 0.87

Targeting midkine and pleiotrophin signalling pathways in addiction and neurodegenerative disorders: recent progress and perspectives. Br J Pharmacol (2014) 0.87

The role of pleiotrophin and beta-catenin in fetal lung development. Respir Res (2010) 0.87

Receptor-type tyrosine phosphatase ligands: looking for the needle in the haystack. FEBS J (2012) 0.86

Menin represses tumorigenesis via repressing cell proliferation. Am J Cancer Res (2011) 0.85

The receptor protein tyrosine phosphatase (RPTP)beta/zeta is expressed in different subtypes of human breast cancer. Biochem Biophys Res Commun (2007) 0.85

Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility. Oncotarget (2014) 0.84

The role of midkine in skeletal remodelling. Br J Pharmacol (2014) 0.84

Influence of the extracellular matrix on endogenous and transplanted stem cells after brain damage. Front Cell Neurosci (2014) 0.83

Loss of receptor protein tyrosine phosphatase β/ζ (RPTPβ/ζ) promotes prostate cancer metastasis. J Biol Chem (2012) 0.82

ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancers. Front Oncol (2012) 0.82

PTN signaling: Components and mechanistic insights in human ovarian cancer. Mol Carcinog (2014) 0.82

FEZ2 has acquired additional protein interaction partners relative to FEZ1: functional and evolutionary implications. PLoS One (2011) 0.81

Pleiotrophin mediates hematopoietic regeneration via activation of RAS. J Clin Invest (2014) 0.81

Pleiotrophin is a potential colorectal cancer prognostic factor that promotes VEGF expression and induces angiogenesis in colorectal cancer. Int J Colorectal Dis (2011) 0.80

Should I stay or should I go? Shedding of RPTPs in cancer cells switches signals from stabilizing cell-cell adhesion to driving cell migration. Cell Adh Migr (2011) 0.80

Oxidative stress-induced oligomerization inhibits the activity of the non-receptor tyrosine phosphatase STEP61. J Neurochem (2011) 0.80

Pleiotrophin expression during odontogenesis. J Histochem Cytochem (2012) 0.80

PTPRZ1 regulates calmodulin phosphorylation and tumor progression in small-cell lung carcinoma. BMC Cancer (2012) 0.80

Neurons and glia modify receptor protein-tyrosine phosphatase ζ (RPTPζ)/phosphacan with cell-specific O-mannosyl glycans in the developing brain. J Biol Chem (2015) 0.80

Phosphacan and receptor protein tyrosine phosphatase β expression mediates deafferentation-induced synaptogenesis. Hippocampus (2011) 0.79

Dominant negative pleiotrophin induces tetraploidy and aneuploidy in U87MG human glioblastoma cells. Biochem Biophys Res Commun (2006) 0.79

A Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζ. Mol Cancer (2010) 0.79

Menin represses malignant phenotypes of melanoma through regulating multiple pathways. J Cell Mol Med (2011) 0.78

Pleiotrophin regulates microglia-mediated neuroinflammation. J Neuroinflammation (2017) 0.78

Anaplastic lymphoma kinase regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area. Addict Biol (2016) 0.77

Neurodevelopment in schizophrenia: the role of the wnt pathways. Curr Neuropharmacol (2013) 0.77

Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. Gut (2015) 0.77

Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation. Dev Biol (2013) 0.77

Pleiotrophin commits human bone marrow mesenchymal stromal cells towards hypertrophy during chondrogenesis. PLoS One (2014) 0.77

Functional comparison of long and short splice forms of RPTPbeta: implications for glioblastoma treatment. Neuro Oncol (2005) 0.77

Specific dephosphorylation at tyr-554 of git1 by ptprz promotes its association with paxillin and hic-5. PLoS One (2015) 0.77

The synthetic peptide P111-136 derived from the C-terminal domain of heparin affin regulatory peptide inhibits tumour growth of prostate cancer PC-3 cells. BMC Cancer (2011) 0.76

Differential expression of receptor protein tyrosine phosphatases accompanies the reorganisation of the retina upon laser lesion. Exp Brain Res (2009) 0.76

Pleiotrophin is expressed in avian somites and tendon anlagen. Histochem Cell Biol (2009) 0.76

Clinical significance of midkine expression in sporadic desmoid tumors. Oncol Lett (2016) 0.75

The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice. PLoS One (2015) 0.75

Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus. Front Cell Neurosci (2015) 0.75

Expression of receptor protein tyrosine phosphatase ζ is a risk factor for triple negative breast cancer relapse. Biomed Rep (2016) 0.75

Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION. J Biol Chem (2016) 0.75

Early gene expression in salivary gland after isoproterenol treatment. J Cell Biochem (2015) 0.75

Modulation of VEGF receptor 2 signaling by protein phosphatases. Pharmacol Res (2016) 0.75

Regulation of Pleiotrophin, Midkine, Receptor Protein Tyrosine Phosphatase β/ζ, and Their Intracellular Signaling Cascades in the Nucleus Accumbens During Opiate Administration. Int J Neuropsychopharmacol (2015) 0.75

Midkine's Role in Cardiac Pathology. J Cardiovasc Dev Dis (2017) 0.75

Protein tyrosine phosphatase ζ enhances proliferation by increasing β-catenin nuclear expression in VHL-inactive human renal cell carcinoma cells. World J Urol (2013) 0.75

Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease. Angiogenesis (2017) 0.75

Articles cited by this

Functional interaction of beta-catenin with the transcription factor LEF-1. Nature (1996) 15.88

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science (1996) 9.12

Growth factor signaling by receptor tyrosine kinases. Neuron (1992) 5.70

Signal transduction through beta-catenin and specification of cell fate during embryogenesis. Genes Dev (1996) 5.20

Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes. Science (1991) 4.72

From form to function: signaling by protein tyrosine phosphatases. Cell (1996) 4.57

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Biol (1994) 4.46

Oncoprotein networks. Cell (1997) 3.42

Signal transduction of beta-catenin. Curr Opin Cell Biol (1995) 2.96

Switching signals on or off by receptor dimerization. Cell (1998) 2.49

Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. Science (1990) 2.00

Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization. Nature (1996) 1.98

Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo. J Cell Biol (1995) 1.93

The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin. Cell (1995) 1.91

Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase. Cell (1993) 1.78

Differential expression of pleiotrophin and midkine in advanced neuroblastomas. Cancer Res (1995) 1.72

Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex. J Cell Biol (1996) 1.69

Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin. J Cell Biol (1996) 1.60

An 18-kd heparin-binding protein of developing brain that is distinct from fibroblast growth factors. EMBO J (1989) 1.57

A new family of heparin-binding growth/differentiation factors: increased midkine expression in Wilms' tumor and other human carcinomas. Cancer Res (1993) 1.55

Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. Science (1998) 1.52

Dynamic interaction of PTPmu with multiple cadherins in vivo. J Cell Biol (1998) 1.42

6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM). J Biol Chem (1996) 1.40

A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases. Proc Natl Acad Sci U S A (1992) 1.40

Midkine, a retinoic acid-inducible growth/differentiation factor: immunochemical evidence for the function and distribution. Dev Biol (1993) 1.39

Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3). J Biol Chem (1994) 1.38

Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer. J Biol Chem (1992) 1.37

Association of human protein-tyrosine phosphatase kappa with members of the armadillo family. J Biol Chem (1996) 1.33

The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. J Biol Chem (1993) 1.31

Involvement of receptor-like protein tyrosine phosphatase zeta/RPTPbeta and its ligand pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) in neuronal migration. J Cell Biol (1998) 1.30

Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice. Proc Natl Acad Sci U S A (1993) 1.22

Upregulation of pleiotrophin gene expression in developing microvasculature, macrophages, and astrocytes after acute ischemic brain injury. J Neurosci (1998) 1.15

A novel 17 kD heparin-binding growth factor (HBGF-8) in bovine uterus: purification and N-terminal amino acid sequence. Biochem Biophys Res Commun (1989) 1.13

Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface. J Biol Chem (1996) 1.12

Ribozyme-targeting elucidates a direct role of pleiotrophin in tumor growth. J Biol Chem (1994) 1.11

Human breast cancer growth inhibited in vivo by a dominant negative pleiotrophin mutant. J Biol Chem (1997) 1.09

A heparin-binding growth factor secreted from breast cancer cells homologous to a developmentally regulated cytokine. J Biol Chem (1992) 1.08

Three forms of RPTP-beta are differentially expressed during gliogenesis in the developing rat brain and during glial cell differentiation in culture. J Neurosci Res (1996) 1.07

High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule. J Biol Chem (1998) 1.05

Mitogenic properties of a new endothelial cell growth factor related to pleiotrophin. Biochem Biophys Res Commun (1991) 1.04

Mitogenic and in vitro angiogenic activity of human recombinant heparin affin regulatory peptide. Growth Factors (1994) 1.01

Expression of polypeptide variants of receptor-type protein tyrosine phosphatase beta: the secreted form, phosphacan, increases dramatically during embryonic development and modulates glial cell behavior in vitro. J Neurosci Res (1996) 0.98

N-syndecan and HB-GAM (heparin-binding growth-associated molecule) associate with early axonal tracts in the rat brain. Eur J Neurosci (1998) 0.95

Localization of pleiotrophin and its mRNA in subpopulations of neurons and their corresponding axonal tracts suggests important roles in neural-glial interactions during development and in maturity. J Neurobiol (1996) 0.92

Effect of heparin on bovine epithelial lens cell proliferation induced by heparin affin regulatory peptide. J Cell Physiol (1995) 0.88

Pleiotrophin gene expression is highly restricted and is regulated by platelet-derived growth factor. Biochem Biophys Res Commun (1992) 0.84

Expression and purification of biologically active human OSF-1 in Escherichia coli. Biochem Biophys Res Commun (1992) 0.83

Pleiotrophin stimulates tyrosine phosphorylation in NIH 3T3 and NB41A3 cells. Biochem Biophys Res Commun (1993) 0.80

Articles by these authors

(truncated to the top 100)

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (1995) 34.97

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med (2002) 14.15

Structural parts involved in activation and inactivation of the sodium channel. Nature (1989) 8.72

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature (1983) 8.60

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence. Nature (1984) 8.02

Existence of distinct sodium channel messenger RNAs in rat brain. Nature (1986) 7.87

Differential regulation and properties of MAPKs. Oncogene (2007) 6.36

A ras-related gene with transformation suppressor activity. Cell (1989) 5.81

Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome. JAMA (2001) 5.13

Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat Biotechnol (2001) 4.82

Structural homology of Torpedo californica acetylcholine receptor subunits. Nature (1983) 4.70

Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest (2001) 4.63

Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell (2000) 4.45

Crystal structure of human serum albumin at 2.5 A resolution. Protein Eng (1999) 4.37

Anesthesiologist direction and patient outcomes. Anesthesiology (2000) 4.31

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor. Nature (1986) 4.30

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes Dev (1994) 4.19

Amino acid sequence of human platelet factor 4. Proc Natl Acad Sci U S A (1977) 4.04

Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta. Science (1987) 4.03

GPCRDB: an information system for G protein-coupled receptors. Nucleic Acids Res (1998) 3.94

Chemotaxis of monocytes and neutrophils to platelet-derived growth factor. J Clin Invest (1982) 3.77

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature (1994) 3.70

Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence. Nature (1982) 3.69

Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun (1992) 3.66

A large-scale insertional mutagenesis screen in zebrafish. Genes Dev (1999) 3.57

International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia (2008) 3.41

Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature (1985) 3.28

Distinguishing between mechanisms of eukaryotic transcriptional activation with bacteriophage T7 RNA polymerase. Cell (1987) 3.26

Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature (2001) 3.24

Human platelet-derived growth factor. Purification and resolution into two active protein fractions. J Biol Chem (1981) 3.21

SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6. J Biol Chem (2000) 3.20

Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun. Mol Cell Biol (1994) 3.15

Nomenclature of voltage-gated sodium channels. Neuron (2000) 3.10

Cloning and sequence analysis of cDNA for porcine beta-neo-endorphin/dynorphin precursor. Nature (1982) 3.09

Platelet factor 4 is chemotactic for neutrophils and monocytes. Proc Natl Acad Sci U S A (1981) 3.03

The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell (2001) 2.97

Expression of functional sodium channels from cloned cDNA. Nature (1986) 2.95

Yeast mRNA initiation sites are determined primarily by specific sequences, not by the distance from the TATA element. EMBO J (1985) 2.87

Intranasal lidocaine for treatment of migraine: a randomized, double-blind, controlled trial. JAMA (1996) 2.83

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line. Nature (1985) 2.82

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry (2006) 2.80

Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin. Nature (1982) 2.79

Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor. Nature (1983) 2.78

The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J (1984) 2.77

Critical care transport: outcome evaluation after interfacility transfer and hospitalization. Ann Emerg Med (1999) 2.71

In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell (1995) 2.68

Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet (1999) 2.60

Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures. Genes Dev (1997) 2.60

Primary structures of beta- and delta-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences. Nature (1983) 2.55

Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms. J Cell Biol (1989) 2.54

Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro. J Bone Miner Res (1998) 2.49

Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. Proc Natl Acad Sci U S A (1998) 2.48

Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet (1999) 2.46

Flat revertants isolated from Kirsten sarcoma virus-transformed cells are resistant to the action of specific oncogenes. Proc Natl Acad Sci U S A (1983) 2.44

Microstrip RF surface coil design for extremely high-field MRI and spectroscopy. Magn Reson Med (2001) 2.43

Expression of functional acetylcholine receptor from cloned cDNAs. Nature (1984) 2.41

Expression of a platelet-derived growth factor-like protein in simian sarcoma virus transformed cells. Science (1983) 2.41

Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors. Cell (1984) 2.41

Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes. Proc Natl Acad Sci U S A (1982) 2.39

Primary structure of rat brain sodium channel III deduced from the cDNA sequence. FEBS Lett (1988) 2.39

Chemotactic activity of platelet alpha granule proteins for fibroblasts. J Cell Biol (1983) 2.28

CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine. Oncogene (1995) 2.23

Some kinetic properties of Bacillus subtilis glutamine synthetase. J Biol Chem (1970) 2.22

Transcriptome analysis and molecular signature of human retinal pigment epithelium. Hum Mol Genet (2010) 2.20

Osteopontin expression and function: role in bone remodeling. J Cell Biochem Suppl (1998) 2.20

Multivariate matching and bias reduction in the surgical outcomes study. Med Care (2001) 2.19

Ginsenoside-Rd improves outcome of acute ischaemic stroke - a randomized, double-blind, placebo-controlled, multicenter trial. Eur J Neurol (2012) 2.18

A microplate assay for the detection of oxidative products using 2',7'-dichlorofluorescin-diacetate. J Immunol Methods (1992) 2.17

The number and location of glycans on influenza hemagglutinin determine folding and association with calnexin and calreticulin. J Cell Biol (1997) 2.14

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma. Proc Natl Acad Sci U S A (1995) 2.13

Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nat Med (1998) 2.12

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol Cell Biol (1999) 2.12

Essential role of growth hormone in ischemia-induced retinal neovascularization. Science (1997) 2.11

Bacillus subtilis glutamine synthetase. Purification and physical characterization. J Biol Chem (1970) 2.10

Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. Mol Cell Biol (1995) 2.10

Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer. Cancer Res (1994) 2.10

Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons. Lancet (1997) 2.09

Falling cholecystectomy thresholds since the introduction of laparoscopic cholecystectomy. JAMA (1995) 2.08

Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells. J Exp Med (1988) 2.07

A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc Natl Acad Sci U S A (1997) 2.07

Completely diverted tube ileostomy compared with loop ileostomy for protection of low colorectal anastomosis: a pilot study. Colorectal Dis (2014) 2.06

Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. Nat Genet (1994) 2.06

Refinement of the alpha aminooleic acid bioprosthetic valve anticalcification technique. Ann Thorac Surg (1997) 2.05

Biodegradation of organophosphorus pesticides by surface-expressed organophosphorus hydrolase. Nat Biotechnol (1997) 2.04

Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. Proc Natl Acad Sci U S A (1999) 2.04

The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. J Biol Chem (1987) 2.02

Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell (2000) 2.01

Angiographic findings of Takayasu arteritis: new classification. Int J Cardiol (1996) 2.00

Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. Science (1990) 2.00

Reduced serum amino acid concentrations in infants with necrotizing enterocolitis. J Pediatr (2000) 1.97

Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Mol Cell Biol (1995) 1.97

Is obesity a high-risk factor for laparoscopic colorectal surgery? Surg Endosc (2002) 1.95

Patch clamp characterization of sodium channels expressed from rat brain cDNA. Eur Biophys J (1987) 1.95

An epidemiological study of lung cancer in Xuan Wei County, China: current progress. Case-control study on lung cancer and cooking fuel. Environ Health Perspect (1991) 1.95

The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog Horm Res (1996) 1.94

MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene (2011) 1.94

Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes. J Biol Chem (1997) 1.92

Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development. EMBO J (1989) 1.91

A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction. Proc Natl Acad Sci U S A (2001) 1.88

Clinical manifestations of Takayasu arteritis in India and Japan--new classification of angiographic findings. Angiology (1997) 1.87