Published in Neuron on February 01, 2000
HITS-CLIP yields genome-wide insights into brain alternative RNA processing. Nature (2008) 14.17
Genome-wide detection of tissue-specific alternative splicing in the human transcriptome. Nucleic Acids Res (2002) 6.71
Variation in alternative splicing across human tissues. Genome Biol (2004) 5.70
RNA processing and its regulation: global insights into biological networks. Nat Rev Genet (2010) 5.34
Finding signals that regulate alternative splicing in the post-genomic era. Genome Biol (2002) 4.73
Unusual intron conservation near tissue-regulated exons found by splicing microarrays. PLoS Comput Biol (2006) 4.63
Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. Mol Cell Biol (2000) 4.12
Diverse molecular functions of Hu proteins. Cell Mol Life Sci (2008) 4.09
Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities. Nucleic Acids Res (2005) 4.06
The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Mol Cell Biol (2001) 3.68
A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG. EMBO J (2003) 3.44
Distribution and characterization of regulatory elements in the human genome. Genome Res (2002) 3.34
A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing. Proc Natl Acad Sci U S A (2000) 3.11
Function of quaking in myelination: regulation of alternative splicing. Proc Natl Acad Sci U S A (2002) 3.04
The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA. Mol Cell Biol (2001) 2.87
Genome-wide prediction of imprinted murine genes. Genome Res (2005) 2.76
Alternative splicing events identified in human embryonic stem cells and neural progenitors. PLoS Comput Biol (2007) 2.71
Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing. Nucleic Acids Res (2001) 2.70
HITS-CLIP: panoramic views of protein-RNA regulation in living cells. Wiley Interdiscip Rev RNA (2010) 2.59
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes Dev (2005) 2.38
The splicing regulatory element, UGCAUG, is phylogenetically and spatially conserved in introns that flank tissue-specific alternative exons. Nucleic Acids Res (2005) 2.20
Regulation of TMEM16A chloride channel properties by alternative splicing. J Biol Chem (2009) 2.16
A hierarchical Bayesian model for comparing transcriptomes at the individual transcript isoform level. Nucleic Acids Res (2009) 2.12
Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice. Mol Cell Biol (2004) 2.08
A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol (2005) 2.08
Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. Mol Cell Biol (2003) 2.00
Nova autoregulation reveals dual functions in neuronal splicing. EMBO J (2005) 1.97
The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain. Proc Natl Acad Sci U S A (2000) 1.92
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet (2012) 1.88
Region-specific alternative splicing in the nervous system: implications for regulation by the RNA-binding protein NAPOR. RNA (2002) 1.65
Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA. Mol Biol Cell (2003) 1.60
Intronic alternative splicing regulators identified by comparative genomics in nematodes. PLoS Comput Biol (2006) 1.59
A comprehensive computational characterization of conserved mammalian intronic sequences reveals conserved motifs associated with constitutive and alternative splicing. Genome Res (2007) 1.58
The search for alternative splicing regulators: new approaches offer a path to a splicing code. Genes Dev (2008) 1.50
Tissue-specific splicing factor gene expression signatures. Nucleic Acids Res (2008) 1.49
The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Genes Dev (2012) 1.48
Two RNA binding proteins, HEN4 and HUA1, act in the processing of AGAMOUS pre-mRNA in Arabidopsis thaliana. Dev Cell (2003) 1.47
Antagonistic regulation of alpha-actinin alternative splicing by CELF proteins and polypyrimidine tract binding protein. RNA (2003) 1.47
The Musashi 1 Controls the Splicing of Photoreceptor-Specific Exons in the Vertebrate Retina. PLoS Genet (2016) 1.42
Analysis of alternative splicing associated with aging and neurodegeneration in the human brain. Genome Res (2011) 1.35
Phosphoproteomics reveals extensive in vivo phosphorylation of Arabidopsis proteins involved in RNA metabolism. Nucleic Acids Res (2006) 1.34
The neuron-specific RNA-binding protein ELAV regulates neuroglian alternative splicing in neurons and binds directly to its pre-mRNA. Genes Dev (2001) 1.33
Pre-mRNA splicing and retinitis pigmentosa. Mol Vis (2006) 1.32
A nuclear function of Hu proteins as neuron-specific alternative RNA processing regulators. Mol Biol Cell (2006) 1.31
RNA protein interaction in neurons. Annu Rev Neurosci (2013) 1.31
ELAV inhibits 3'-end processing to promote neural splicing of ewg pre-mRNA. Genes Dev (2003) 1.29
Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing. Proc Natl Acad Sci U S A (2009) 1.27
Regulation of neuron-specific alternative splicing of neurofibromatosis type 1 pre-mRNA. Mol Cell Biol (2007) 1.27
A computational approach for genome-wide mapping of splicing factor binding sites. Genome Biol (2009) 1.25
Evolution of Nova-dependent splicing regulation in the brain. PLoS Genet (2007) 1.23
The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife (2014) 1.19
Clinical, agricultural, and evolutionary biology of myostatin: a comparative review. Endocr Rev (2008) 1.18
Networking in a global world: establishing functional connections between neural splicing regulators and their target transcripts. RNA (2011) 1.14
Activation of alpha-tropomyosin exon 2 is regulated by the SR protein 9G8 and heterogeneous nuclear ribonucleoproteins H and F. Mol Cell Biol (2006) 1.12
Building robust transcriptomes with master splicing factors. Cell (2014) 1.12
Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice. BMC Cell Biol (2008) 1.08
Prediction of clustered RNA-binding protein motif sites in the mammalian genome. Nucleic Acids Res (2013) 1.05
The Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the Dendrite. Front Neural Circuits (2010) 1.05
An in vitro-selected RNA-binding site for the KH domain protein PSI acts as a splicing inhibitor element. RNA (2001) 1.05
Alternative splicing: functional diversity among voltage-gated calcium channels and behavioral consequences. Biochim Biophys Acta (2012) 1.04
The impact of alternative splicing in vivo: mouse models show the way. RNA (2007) 1.03
NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Elife (2013) 1.03
Emerging Roles of Alternative Pre-mRNA Splicing Regulation in Neuronal Development and Function. Front Neurosci (2012) 1.02
The function of spliceosome components in open mitosis. Nucleus (2010) 1.01
Drosophila couch potato mutants exhibit complex neurological abnormalities including epilepsy phenotypes. Genetics (2005) 1.01
Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1. Structure (2011) 1.01
Genomic landscape of developing male germ cells. Birth Defects Res C Embryo Today (2009) 1.00
Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans. Nat Protoc (2010) 0.99
The end of the message: multiple protein-RNA interactions define the mRNA polyadenylation site. Genes Dev (2015) 0.96
The 3' untranslated region complex involved in stabilization of human alpha-globin mRNA assembles in the nucleus and serves an independent role as a splice enhancer. Mol Cell Biol (2007) 0.96
Control of alternative pre-mRNA splicing by Ca(++) signals. Biochim Biophys Acta (2008) 0.95
Promotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members. Nucleic Acids Res (2010) 0.95
Strategies for identifying RNA splicing regulatory motifs and predicting alternative splicing events. PLoS Comput Biol (2008) 0.94
Transcript diversification in the nervous system: a to I RNA editing in CNS function and disease development. Front Neurosci (2012) 0.94
The hnRNP family: insights into their role in health and disease. Hum Genet (2016) 0.94
The hepatitis B virus PRE contains a splicing regulatory element. Nucleic Acids Res (2006) 0.93
The neurogenetics of alternative splicing. Nat Rev Neurosci (2016) 0.91
A pair of RNA-binding proteins controls networks of splicing events contributing to specialization of neural cell types. Mol Cell (2014) 0.91
Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL. BMC Genomics (2001) 0.91
Differential recruitment of pre-mRNA splicing factors to alternatively spliced transcripts in vivo. PLoS Biol (2005) 0.90
Determination and augmentation of RNA sequence specificity of the Nova K-homology domains. Nucleic Acids Res (2004) 0.90
Genetic changes shaping the human brain. Dev Cell (2015) 0.89
Genetic evidence for a Nova regulator of alternative splicing in the brain. Neuron (2000) 0.89
Microarray-based transcriptomic analysis of differences between long-term gregarious and solitarious desert locusts. PLoS One (2011) 0.87
A large-scale functional screen identifies Nova1 and Ncoa3 as regulators of neuronal miRNA function. EMBO J (2015) 0.87
The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation. Elife (2015) 0.87
Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins. RNA (2002) 0.86
Yin Yang 1 intronic binding sequences and splicing elicit intron-mediated enhancement of ubiquitin C gene expression. PLoS One (2013) 0.85
Divergence of exonic splicing elements after gene duplication and the impact on gene structures. Genome Biol (2009) 0.85
Genome-wide analysis of alternative splicing in medulloblastoma identifies splicing patterns characteristic of normal cerebellar development. Cancer Res (2011) 0.83
Paraneoplastic brainstem encephalitis with tetraparesis in a patient with anti-Ri antibodies. J Neurol (2004) 0.83
Nova1 is a master regulator of alternative splicing in pancreatic beta cells. Nucleic Acids Res (2014) 0.83
Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system. Front Neurosci (2013) 0.83
TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication. PLoS One (2013) 0.82
The neuronal splicing factor Nova controls alternative splicing in N-type and P-type CaV2 calcium channels. Channels (Austin) (2010) 0.82
Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4. J Biol Chem (2009) 0.82
JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships. Microbiol Mol Biol Rev (2016) 0.81
NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord. Elife (2016) 0.81
Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival. J Biol Chem (2017) 0.80
AUF-1 and YB-1 are critical determinants of β-globin mRNA expression in erythroid cells. Blood (2011) 0.80
Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell (2001) 8.04
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell (2001) 6.50
Successful small-bowel/liver transplantation. Lancet (1990) 4.85
Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration. Ann Neurol (2000) 3.61
Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome. Cell (2000) 3.59
CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells. J Cell Biol (1997) 3.52
A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing. Proc Natl Acad Sci U S A (2000) 3.11
Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells. Nat Immunol (2001) 2.98
Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. Neuron (1993) 2.81
A hierarchy of Hu RNA binding proteins in developing and adult neurons. J Neurosci (1997) 2.76
A novel adaptor-related protein complex. J Cell Biol (1996) 2.69
The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo. Mol Cell Biol (1997) 2.69
A katanin-like protein regulates normal cell wall biosynthesis and cell elongation. Plant Cell (2001) 2.63
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci U S A (1997) 2.57
Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol Cell (2000) 2.39
The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia. Proc Natl Acad Sci U S A (1998) 2.22
The primary structure and expression of four cloned human histone genes. Nucleic Acids Res (1983) 2.21
Genetic rearrangements in the rfb regions of Vibrio cholerae O1 and O139. Proc Natl Acad Sci U S A (1995) 2.15
Tumor-specific killer cells in paraneoplastic cerebellar degeneration. Nat Med (1998) 2.11
The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies. J Neurosci (1996) 2.03
FMRP RNA targets: identification and validation. Genes Brain Behav (2005) 1.97
Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems. Proc Natl Acad Sci U S A (1999) 1.93
The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain. Proc Natl Acad Sci U S A (2000) 1.92
Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein. Cell (1995) 1.81
Regulation of gibberellin biosynthesis genes during flower and early fruit development of tomato. Plant J (1999) 1.67
ATM binds to beta-adaptin in cytoplasmic vesicles. Proc Natl Acad Sci U S A (1998) 1.63
Improved techniques for kidney transplantation in mice. Microsurgery (1995) 1.63
The axis of interleukin 12 and gamma interferon regulates acute vascular xenogeneic rejection. Nat Med (2000) 1.60
Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains. Structure (1999) 1.59
The splice of life: alternative splicing and neurological disease. Nat Rev Neurosci (2001) 1.57
Novel Vibrio cholerae O139 genes involved in lipopolysaccharide biosynthesis. J Bacteriol (1997) 1.56
Differential expression of the human gonadotropin alpha gene in ectopic and eutopic cells. Mol Cell Biol (1985) 1.53
Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta. J Biol Chem (1998) 1.45
cdr2-specific CTLs are detected in the blood of all patients with paraneoplastic cerebellar degeneration analyzed. Ann Neurol (2000) 1.42
Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population. Clin Exp Immunol (2009) 1.40
Xenotransplantation. Can J Surg (1999) 1.39
Fluoxetine-related suicidality and muscle aches in a patient with poststroke depression. J Clin Psychopharmacol (1996) 1.38
Successful intestinal transplantation in pigs treated with cyclosporine. Transplantation (1988) 1.36
The role of dendritic cell precursors in tumour vasculogenesis. Br J Cancer (2005) 1.35
The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival. Genes Dev (1999) 1.32
Paraneoplastic neurologic disease antigens: RNA-binding proteins and signaling proteins in neuronal degeneration. Annu Rev Neurosci (2001) 1.29
Low molecular weight polyethylenimines linked by beta-cyclodextrin for gene transfer into the nervous system. J Gene Med (2006) 1.19
Successful small intestine transplantation. Transplant Proc (1992) 1.17
Complement inhibition with an anti-C5 monoclonal antibody prevents hyperacute rejection in a xenograft heart transplantation model. Transplantation (1999) 1.16
Molecular evolution of the synapsin gene family. J Exp Zool (1999) 1.12
Cdr2, a target antigen of naturally occuring human tumor immunity, is widely expressed in gynecological tumors. Cancer Res (2000) 1.11
Overweight, obesity and thyroid cancer risk: a meta-analysis of cohort studies. J Int Med Res (2012) 1.09
Human breast cancer growth inhibited in vivo by a dominant negative pleiotrophin mutant. J Biol Chem (1997) 1.09
Molecular cloning and comparative sequence analyses of bluetongue virus S1 segments by selective synthesis of specific full-length DNA copies of dsRNA genes. Virology (1990) 1.08
alpha5beta1 integrin expression and luminal edge fibronectin matrix assembly by smooth muscle cells after arterial injury. Am J Pathol (2000) 1.08
Preventing renal ischemia-reperfusion injury using small interfering RNA by targeting complement 3 gene. Am J Transplant (2006) 1.06
Depressive disorders among older residents in a Chinese rural community. Psychol Med (1997) 1.05
Development of an immunochromatographic lateral flow test strip for detection of beta-adrenergic agonist Clenbuterol residues. J Immunol Methods (2006) 1.05
Pattern of liver, kidney, heart, and intestine allograft rejection in different mouse strain combinations. Transplantation (1996) 1.03
Population-averaged standard template brain atlas for the common marmoset (Callithrix jacchus). Neuroimage (2010) 1.00
Cloning and characterization of cDNA encoding human A-type endothelin receptor. Biochem Biophys Res Commun (1991) 0.99
A post-transcriptional regulatory mechanism restricts expression of the paraneoplastic cerebellar degeneration antigen cdr2 to immune privileged tissues. J Neurosci (1997) 0.99
Catatonic features: differential diagnosis and treatments at an emergency unit. Psychiatry Clin Neurosci (1999) 0.99
Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly. Proc Natl Acad Sci U S A (1996) 0.98
Independent regulation by sodium butyrate of gonadotropin alpha gene expression and cell cycle progression in HeLa cells. Mol Cell Biol (1984) 0.98
The correlation of depression with functional activity in Parkinson's disease. J Neurol (1997) 0.96
Vascular smooth muscle cells of recipient origin mediate intimal expansion after aortic allotransplantation in mice. Am J Pathol (2001) 0.96
Granule cell specification in the developing mouse brain as defined by expression of the zinc finger transcription factor RU49. Development (1996) 0.94
The neuronal nuclear antigen recognized by the human anti-Ri autoantibody is expressed in central but not peripheral nervous system neurons. Neurosci Lett (1993) 0.94
Intestinal permeability and bacterial translocation following small bowel transplantation in the rat. Transplantation (1991) 0.91
Rapid simultaneous screening for DNA integrity and antigen specificity of clones selected by phage display. Biotechniques (1994) 0.90
Adoptively transferable tolerance induced by CD45RB monoclonal antibody. J Am Soc Nephrol (1999) 0.90
Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. Genomics (1997) 0.89
Inhibition of transplant vasculopathy in a rat aortic allograft model after infusion of anti-inflammatory viral serpin. Circulation (2000) 0.89
High-sequence conservation among the United States bluetongue viruses cognate M2 genes which encode the nonstructural NS1 tubule protein. Virology (1993) 0.89
Effects of symptomatic severity on elevation of plasma soluble interleukin-2 receptor in bipolar mania. J Affect Disord (2001) 0.89
Biological control agent of common scab disease by antagonistic strain Bacillus sp. sunhua. J Appl Microbiol (2005) 0.89
CD40-deficient dendritic cells producing interleukin-10, but not interleukin-12, induce T-cell hyporesponsiveness in vitro and prevent acute allograft rejection. Immunology (1999) 0.88
Graft-versus-host reactions induced by intestinal transplantation in the rat produce host immunosuppression. Transplant Proc (1988) 0.88
Selective separation of virus proteins and double-stranded RNAs by SDS-KCl precipitation. J Virol Methods (1989) 0.88
Inflammatory myofibroblastic tumour of the maxillary sinus: CT and MRI findings. Clin Radiol (2012) 0.88
Thermally sensitive micelles self-assembled from poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(D,L-lactide-co-glycolide) for controlled delivery of paclitaxel. Mol Biosyst (2005) 0.87
Assessment of the longevity of the liver using a rat transplant model. Hepatology (1997) 0.86
Correlations between scores on Chinese versions of long and short forms of the Geriatric Depression Scale among elderly Chinese. Psychol Rep (1998) 0.86
Delusional disorder: retrospective analysis of 86 Chinese outpatients. Psychiatry Clin Neurosci (1999) 0.86
Atlas of the developing brain of the marmoset monkey constructed using magnetic resonance histology. Neuroscience (2012) 0.86
The importance of defining the paraneoplastic neurologic disorders. N Engl J Med (1999) 0.86
Cellular uptake of intracerebrally administered oligodeoxynucleotides in mouse brain. Regul Pept (1995) 0.86
Influence of macrophage depletion on bacterial translocation and rejection in small bowel transplantation. Transplantation (1996) 0.86
Analysis of CRP-CytR interactions at the Escherichia coli udp promoter. J Bacteriol (1996) 0.86
Cell type-specific expression of a human histone H1 gene. J Biol Chem (1988) 0.85
An estimation of daily food usage factors for assessing radionuclide intakes in the U.S. population. Health Phys (1986) 0.85
Treatment with continuous high-dose intravenous cyclosporine following clinical intestinal transplantation. Transplantation (1989) 0.85