Published in Lancet on March 25, 2000
Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med (2009) 7.89
The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements. Schizophr Bull (2009) 4.69
Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data. BMJ (2002) 2.46
A randomised, blinded, placebo-controlled trial in dementia patients continuing or stopping neuroleptics (the DART-AD trial). PLoS Med (2008) 2.20
Delusional infestation. Clin Microbiol Rev (2009) 2.16
Impact of the CSM advice on thioridazine on general practitioner prescribing behaviour in Leeds: time series analysis. Br J Gen Pract (2004) 2.05
QTc prolongation by psychotropic drugs and the risk of Torsade de Pointes. Dtsch Arztebl Int (2011) 1.93
Management of agitation and aggression associated with Alzheimer disease. Nat Rev Neurol (2009) 1.86
Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns? Curr Pharm Des (2004) 1.63
A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Circ Cardiovasc Genet (2011) 1.48
QTc and psychotropic drugs. Lancet (2000) 1.44
A randomized, double-blind, placebo-controlled study of rapid-acting intramuscular olanzapine in Japanese patients for schizophrenia with acute agitation. BMC Psychiatry (2013) 1.39
Electrocardiographic Screening for Prolonged QT Interval to Reduce Sudden Cardiac Death in Psychiatric Patients: A Cost-Effectiveness Analysis. PLoS One (2015) 1.39
Assessment and management of behavioral and psychological symptoms of dementia. BMJ (2015) 1.27
Population pharmacokinetics and pharmacodynamics of escitalopram in overdose and the effect of activated charcoal. Br J Clin Pharmacol (2012) 1.22
New Generation Antipsychotic Drugs and QTc Interval Prolongation. Prim Care Companion J Clin Psychiatry (2003) 1.13
Nonlinear complexity and spectral analyses of heart rate variability in medicated and unmedicated patients with schizophrenia. Neuropsychobiology (2004) 1.11
All-cause mortality associated with atypical and conventional antipsychotics among nursing home residents with dementia: a retrospective cohort study. J Clin Psychiatry (2009) 1.09
QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy. Ann Gen Psychiatry (2005) 1.08
Ether-a-go-go-related gene potassium channels: what's all the buzz about? Schizophr Bull (2007) 1.07
Old drugs--new uses. Br J Clin Pharmacol (2007) 1.03
Genetic polymorphisms in KCNQ1, HERG, KCNE1 and KCNE2 genes in the Chinese, Malay and Indian populations of Singapore. Br J Clin Pharmacol (2006) 1.02
Drug-induced arrhythmia: pharmacogenomic prescribing? Eur Heart J (2012) 1.00
Potential for drug interactions involving cytochromes P450 2D6 and 3A4 on general adult psychiatric and functional elderly psychiatric wards. Br J Clin Pharmacol (2004) 0.99
Effects of licence change on prescribing and poisons enquiries for antipsychotic agents in England and Scotland. Br J Clin Pharmacol (2003) 0.99
Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance. Curr Cardiol Rev (2009) 0.98
Thioridazine: resurrection as an antimicrobial agent? Br J Clin Pharmacol (2007) 0.95
Removal of thioridazine from primary care formulary will result in prescribing vacuum. BMJ (2001) 0.95
Comparative cardiac safety of low-dose thioridazine and low-dose haloperidol. Br J Clin Pharmacol (2004) 0.95
Pharmacological and nonpharmacological management of delirium in critically ill patients. Neurotherapeutics (2012) 0.94
Case ascertainment and estimated incidence of drug-induced long-QT syndrome: study in Southwest France. Br J Clin Pharmacol (2008) 0.93
The heart of psychotropic drug therapy. Lancet (2000) 0.91
Tricyclic antidepressant amitriptyline alters sarcoplasmic reticulum calcium handling in ventricular myocytes. Am J Physiol Heart Circ Physiol (2008) 0.89
The heart of psychotropic drug therapy. Lancet (2000) 0.87
Quetiapine in the treatment of schizophrenia and related disorders. Neuropsychiatr Dis Treat (2007) 0.87
Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin. Biochem Pharmacol (2007) 0.86
Open channel block of Kv1.5 currents by citalopram. Acta Pharmacol Sin (2010) 0.85
Effects of sex on the pharmacokinetic and pharmacodynamic properties of quinidine. Br J Clin Pharmacol (2003) 0.84
Treatment considerations for patients with neuropathic pain and other medical comorbidities. Mayo Clin Proc (2010) 0.84
A consensus statement for safety monitoring guidelines of treatments for major depressive disorder. Aust N Z J Psychiatry (2011) 0.84
The QT interval and psychotropic medications in children: recommendations for clinicians. Eur Child Adolesc Psychiatry (2006) 0.84
Guideline-concordant antipsychotic use and mortality in schizophrenia. Schizophr Bull (2012) 0.83
Sex difference in QTc prolongation in chronic institutionalized patients with schizophrenia on long-term treatment with typical and atypical antipsychotics. Psychopharmacology (Berl) (2011) 0.83
The antipsychotic drug chlorpromazine inhibits HERG potassium channels. Br J Pharmacol (2003) 0.83
Electrocardiogram and cardiovascular changes in thioridazine and chlorpromazine poisoning. Eur J Clin Pharmacol (2004) 0.82
Blockade of Kv1.5 by paroxetine, an antidepressant drug. Korean J Physiol Pharmacol (2015) 0.82
Primary care use of antipsychotic drugs: an audit and intervention study. Ann Gen Psychiatry (2005) 0.81
Anorexia nervosa. BMJ Clin Evid (2011) 0.79
Detachment of surface membrane invagination systems by cationic amphiphilic drugs. Sci Rep (2016) 0.78
Gender difference in QTc prolongation of people with mental disorders. Ann Gen Hosp Psychiatry (2004) 0.78
Etiology of cardiovascular disease in patients with schizophrenia: current perspectives. Neuropsychiatr Dis Treat (2015) 0.78
Co-Prescription of QT-Interval Prolonging Drugs: An Analysis in a Large Cohort of Geriatric Patients. PLoS One (2016) 0.76
Anorexia nervosa. BMJ Clin Evid (2009) 0.76
Ventricular repolarization measures for arrhythmic risk stratification. World J Cardiol (2016) 0.76
Olanzapine induced Q-Tc shortening. Ther Adv Psychopharmacol (2014) 0.75
Antipsychotic Dose Mediates the Association between Polypharmacy and Corrected QT Interval. PLoS One (2016) 0.75
A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. J Med Genet (2016) 0.75
A naturalistic comparison of the efficacy and safety of intramuscular olanzapine and intramuscular levomepromazine in agitated elderly patients with schizophrenia. Neuropsychiatr Dis Treat (2013) 0.75
QT prolongation and torsades de pointes with psychotropic agents. Indian J Psychiatry (2015) 0.75
Drug-induced Inhibition and Trafficking Disruption of ion Channels: Pathogenesis of QT Abnormalities and Drug-induced Fatal Arrhythmias. Curr Cardiol Rev (2016) 0.75
Molecular determinants of repolarization time. Exp Clin Cardiol (2003) 0.75
Aromatherapy and Aromatic Plants for the Treatment of Behavioural and Psychological Symptoms of Dementia in Patients with Alzheimer's Disease: Clinical Evidence and Possible Mechanisms. Evid Based Complement Alternat Med (2017) 0.75
Analysis of West Virginia medicaid claims data for the prevalence of medical conditions and use of drugs likely to cause QT prolongation in patients with schizophrenia. Curr Ther Res Clin Exp (2003) 0.75
A naturalistic comparison of the efficacy and safety of intramuscular olanzapine and intramuscular haloperidol in agitated elderly patients with schizophrenia. Ther Adv Psychopharmacol (2013) 0.75
Web of Objects Based Ambient Assisted Living Framework for Emergency Psychiatric State Prediction. Sensors (Basel) (2016) 0.75
Repeated dosing with donepezil does not affect the safety, tolerability or pharmacokinetics of single-dose thioridazine in young volunteers. Br J Clin Pharmacol (2004) 0.75
Psychotropic drugs, HERG, and the heart. Lancet (2000) 0.75
QT is longer in drug-free patients with schizophrenia compared with age-matched healthy subjects. PLoS One (2014) 0.75
Risk of Adverse Outcomes for Older People with Dementia Prescribed Antipsychotic Medication: A Population Based e-Cohort Study. Neurol Ther (2017) 0.75
QTc interval lengthening and debrisoquine metabolic ratio in psychiatric patients treated with oral haloperidol monotherapy. Eur J Clin Pharmacol (2002) 0.75
Effects of sevoflurane or ketamine on the QTc interval during electroconvulsive therapy. J Anesth (2014) 0.75
Comparative genomics of the eukaryotes. Science (2000) 26.62
Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature (2000) 9.82
A global profile of germline gene expression in C. elegans. Mol Cell (2000) 5.97
Lithium neurotoxicity at normal therapeutic levels. Br J Psychiatry (1993) 3.76
Reduction in incidence of severe paracetamol poisoning. Lancet (2000) 3.06
Dyspepsia in England and Scotland. Gut (1990) 2.73
Thioridazine and sudden unexplained death in psychiatric in-patients. Br J Psychiatry (2002) 2.69
Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology (1988) 2.60
Streptococcus pyogenes type 12 M protein gene regulation by upstream sequences. J Bacteriol (1987) 2.54
Screening for glaucoma in the community by non-ophthalmologically trained staff using semi automated equipment. Eye (Lond) (1990) 2.48
Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Mol Psychiatry (2008) 2.38
D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics (1997) 2.28
Autobiographical memory in depression: state or trait marker? Br J Psychiatry (1993) 2.24
Short latency potentials recorded from the neck and scalp following median nerve stimulation in man. Electroencephalogr Clin Neurophysiol (1977) 2.18
Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2000 British Association for Psychopharmacology guidelines. J Psychopharmacol (2008) 2.11
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic. Chem Biol (1998) 2.02
Mortality from venous thromboembolism and myocardial infarction in young adults in England and Wales. Lancet (1996) 1.97
Small DNA deletions creating avirulence in Streptococcus pyogenes. Science (1984) 1.92
PhyloBLAST: facilitating phylogenetic analysis of BLAST results. Bioinformatics (2001) 1.89
Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis. Development (1996) 1.88
Do we need thyroid follow-up registers? A cost-effective study. Lancet (1982) 1.87
Socioeconomic variation in injury in children and older people: a population based study. Inj Prev (2003) 1.82
Effect of silicon on gastrointestinal absorption of aluminium. Lancet (1993) 1.80
Raised levels of plasma interleukin-1beta in major and postviral depression. Acta Psychiatr Scand (2001) 1.80
Potentials evoked in human and monkey cerebral cortex by stimulation of the median nerve. A review of scalp and intracranial recordings. Brain (1991) 1.75
Nonmethylated transposable elements and methylated genes in a chordate genome. Science (1999) 1.75
Steering, entanglement, nonlocality, and the Einstein-Podolsky-Rosen paradox. Phys Rev Lett (2007) 1.68
Potential time savings by prehospital administration of activated charcoal. Prehosp Emerg Care (1998) 1.65
Decay in quality of closed-chest compressions over time. Ann Emerg Med (1995) 1.64
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry (2010) 1.63
Do parents of children with caries choose to opt out of positive consent dental surveys in Wales? Br Dent J (2011) 1.63
Effects of intravenous methylprednisolone on outcome in MRI-based prognostic subgroups in acute optic neuritis. Neurology (1998) 1.62
Resorption of dentine by isolated osteoclasts in vitro. Br Dent J (1984) 1.60
Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype. Br J Psychiatry (2001) 1.56
Autoantibodies to GBM and neutrophil cytoplasm in rapidly progressive glomerulonephritis. Kidney Int (1990) 1.55
Relapse in chronic depressives on withdrawal of L-tryptophan. Lancet (1990) 1.53
A neuropathological study of vascular factors in late-life depression. J Neurol Neurosurg Psychiatry (2001) 1.53
Drug-induced syndrome of inappropriate antidiuretic hormone secretion. Postgrad Med J (1999) 1.52
Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis. Acta Psychiatr Scand (2013) 1.52
The neurocognitive performance of drug-free and medicated euthymic bipolar patients do not differ. Acta Psychiatr Scand (2009) 1.51
A system for the electrophysiological monitoring of the spinal cord during operations for scoliosis. J Bone Joint Surg Br (1983) 1.47
The accident and emergency department management of deliberate self-poisoning. Br J Psychiatry (1988) 1.46
Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. Br J Psychiatry (2009) 1.45
Effects of medium acidification by alteration of carbon dioxide or bicarbonate concentrations on the resorptive activity of rat osteoclasts. J Bone Miner Res (1994) 1.45
Urinary chromatographic profiles in schizophrenia. Biol Psychiatry (1990) 1.42
The pathophysiology of acute optic neuritis. An association of gadolinium leakage with clinical and electrophysiological deficits. Brain (1991) 1.41
Amrinone as an antidote in experimental verapamil overdose. Acad Emerg Med (1996) 1.39
Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans. Clin Pharmacol Ther (1996) 1.39
Glucagon and phenylephrine combination vs glucagon alone in experimental verapamil overdose. Acad Emerg Med (1996) 1.39
Lateral gene transfer and metabolic adaptation in the human parasite Trichomonas vaginalis. Mol Biol Evol (2000) 1.37
Water intoxication in patients with psychiatric illness. Br Med J (Clin Res Ed) (1985) 1.35
A special relationship between spherical and filamentous microorganisms in mature human dental plaque. Arch Oral Biol (1972) 1.34
A comparison of proxy measures of abdominal obesity in Chinese, European and South Asian adults. Diabet Med (1999) 1.31
Gene number in an invertebrate chordate, Ciona intestinalis. Proc Natl Acad Sci U S A (1998) 1.27
Congenital anomalies after prenatal ecstasy exposure. Lancet (1999) 1.26
Are mobile speed cameras effective? A controlled before and after study. Inj Prev (2003) 1.26
Bactericidal/permeability-increasing protein (BPI) is an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis. Clin Exp Immunol (1995) 1.24
Serial magnetization transfer imaging in acute optic neuritis. Brain (2004) 1.24
Cerebral white matter lesions in bipolar affective disorder: relationship to outcome. Br J Psychiatry (2001) 1.23
Cognitive vulnerability in patients with bipolar disorder. Psychol Med (2000) 1.22
Magnetisation transfer ratios and transverse magnetisation decay curves in optic neuritis: correlation with clinical findings and electrophysiology. J Neurol Neurosurg Psychiatry (1995) 1.21
Possible virus in schizophrenia and some neurological disorders. Lancet (1979) 1.21
Late onset hypothyroidism after subtotal thyroidectomy for hyperthyroidism: implications for long term follow-up. Br J Surg (1983) 1.20
Severe pulmonary hemorrhage and systemic vasculitis in association with circulating anti-neutrophil cytoplasm antibodies of IgM class only. Clin Nephrol (1989) 1.19
Factors influencing the ocular pulse--the heart rate. Graefes Arch Clin Exp Ophthalmol (1991) 1.19
Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice. Development (2001) 1.19
The mineralization density of iliac crest bone from children with osteogenesis imperfecta. Calcif Tissue Int (1999) 1.19
An evaluation of the predictive validity and inter-rater reliability of clinical diagnostic criteria for senile dementia of Lewy body type. Neurology (1994) 1.18
Modification of the home environment for the reduction of injuries. Cochrane Database Syst Rev (2006) 1.17
Polygenic dissection of the bipolar phenotype. Br J Psychiatry (2011) 1.17
Tooth surfaces treated in situ with periodontal instruments. Scanning electron microscopic studies. Br Dent J (1972) 1.17
Spinal and sub-cortical evoked potentials following stimulation of the posterior tibial nerve in man. Electroencephalogr Clin Neurophysiol (1978) 1.15
Electrophysiological and cognitive function in young euthymic patients with bipolar affective disorder. Bipolar Disord (2001) 1.12
The N-terminal domains target TNF receptor-associated factor-2 to the nucleus and display transcriptional regulatory activity. J Immunol (1998) 1.10
Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans. Mol Gen Genet (2000) 1.09
Breast cancer in thyroid disease: fact or fallacy? Lancet (1981) 1.08
Corticosteroids do not prevent optic nerve atrophy following optic neuritis. J Neurol Neurosurg Psychiatry (2003) 1.08
Delivery of a nebulized aerosol to a lung model during mechanical ventilation. Effect of ventilator settings and nebulizer type, position, and volume of fill. Am Rev Respir Dis (1992) 1.08
The role of somatosensory evoked potentials and nerve conduction studies in the surgical management of brachial plexus injuries. J Bone Joint Surg Br (1980) 1.08
Ventriculoperitoneal shunt block: what are the best predictive clinical indicators? Arch Dis Child (2002) 1.08
Diagnosis of brachial plexus traction lesions by sensory nerve action potentials and somatosensory evoked potentials. Injury (1981) 1.07
Methotrexate pneumonitis in a patient with rheumatoid arthritis. Postgrad Med J (1997) 1.06
Characteristics of patients with schizophrenia or neurological disorder and virus-like agent in cerebrospinal fluid. Lancet (1979) 1.06
Inhibition of bone resorption by selective inactivators of cysteine proteinases. J Cell Biochem (1994) 1.06
Long-term remyelination after optic neuritis: A 2-year visual evoked potential and psychophysical serial study. Brain (2001) 1.06
Lack of effect of inhaled morphine on exercise-induced breathlessness in chronic obstructive pulmonary disease. Thorax (1995) 1.06
Alteration of serum and urinary lipolytic activity with weight loss in cachectic cancer patients. Br J Cancer (1990) 1.05
Mood and neuropsychological function in depression: the role of corticosteroids and serotonin. Psychol Med (1998) 1.04
Peptone, a low-cost growth-promoting nutrient for intensive animal cell culture. Cytotechnology (1994) 1.03
Peripheral and central somatosensory nerve conduction defects in Friedreich's ataxia. J Neurol Neurosurg Psychiatry (1980) 1.03
A comparison of neurocognitive impairment in younger and older adults with major depression. Psychol Med (2008) 1.03
An 'interference" approach to the study of somatosensory evoked potentials in man. Electroencephalogr Clin Neurophysiol (1981) 1.03
The speed of post mortem change to the human skeleton and its taphonomic significance. Forensic Sci Int (1996) 1.02
Scanning electron microscopy of bone: instrument, specimen, and issues. Microsc Res Tech (1996) 1.02
Investigation of brachial plexus traction lesions by peripheral and spinal somatosensory evoked potentials. J Neurol Neurosurg Psychiatry (1979) 1.01
Oral anticoagulants: a cost-effectiveness approach. J R Coll Physicians Lond (1985) 1.01