Published in J Immunol on April 15, 2000
Biochemical and functional characterization of three activated macrophage populations. J Leukoc Biol (2006) 4.87
Ectopic lymphoid tissues and local immunity. Semin Immunol (2008) 2.18
A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator. Proc Natl Acad Sci U S A (2005) 2.00
Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis. J Exp Med (2002) 1.95
The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J Clin Invest (2001) 1.82
The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J Clin Invest (2005) 1.82
A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med (2008) 1.67
Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue. Int J Obes (Lond) (2009) 1.59
Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways. Immunol Rev (2008) 1.49
Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure (2014) 1.44
NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors. Blood (2005) 1.43
Fibroblast-type reticular stromal cells regulate the lymph node vasculature. J Immunol (2008) 1.39
Tumor necrosis factor (TNF) protects resistant C57BL/6 mice against herpes simplex virus-induced encephalitis independently of signaling via TNF receptor 1 or 2. J Virol (2006) 1.27
Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. J Clin Invest (2006) 1.20
Modulation of T-cell responses to alloantigens by TR6/DcR3. J Clin Invest (2001) 1.16
Regulation of inflammation, autoimmunity, and infection immunity by HVEM-BTLA signaling. J Leukoc Biol (2010) 1.15
Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease. Blood (2006) 1.12
Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival. J Exp Med (2002) 1.10
Dichotomous regulation of GVHD through bidirectional functions of the BTLA-HVEM pathway. Blood (2011) 1.10
The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells. Eur J Immunol (2008) 1.09
Herpes simplex virus glycoprotein D interferes with binding of herpesvirus entry mediator to its ligands through downregulation and direct competition. J Virol (2010) 1.07
Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease. J Clin Invest (2002) 1.07
Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine. Arthritis Res Ther (2006) 1.06
Fas ligand-induced murine pulmonary inflammation is reduced by a stable decoy receptor 3 analogue. Immunology (2003) 1.03
Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations. J Exp Med (2011) 1.01
Immunoregulation by tumor necrosis factor superfamily member LIGHT. Immunol Rev (2009) 0.98
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners. Semin Immunopathol (2009) 0.96
The role of coinhibitory signaling pathways in transplantation and tolerance. Front Immunol (2012) 0.95
Novel antibodies targeting immune regulatory checkpoints for cancer therapy. Br J Clin Pharmacol (2013) 0.94
LIGHT is involved in the pathogenesis of rheumatoid arthritis by inducing the expression of pro-inflammatory cytokines and MMP-9 in macrophages. Immunology (2005) 0.92
Functional interaction between herpes simplex virus type 2 gD and HVEM transiently dampens local chemokine production after murine mucosal infection. PLoS One (2011) 0.92
HVEM signalling promotes colitis. PLoS One (2011) 0.92
The nature of activatory and tolerogenic dendritic cell-derived signal II. Front Immunol (2013) 0.91
LIGHT regulates inflamed draining lymph node hypertrophy. J Immunol (2011) 0.90
Turning on LIGHT. J Clin Invest (2001) 0.90
Lymphotoxin signalling in immune homeostasis and the control of microorganisms. Nat Rev Immunol (2013) 0.90
Genetic evidence that intratumoral T-cell proliferation and activation are associated with recurrence and survival in patients with resected colorectal liver metastases. Cancer Immunol Res (2015) 0.89
CD160 activation by herpesvirus entry mediator augments inflammatory cytokine production and cytolytic function by NK cells. J Immunol (2013) 0.88
The tumor necrosis factor superfamily of cytokines in the inflammatory myopathies: potential targets for therapy. Clin Dev Immunol (2011) 0.88
T-cell costimulatory molecules in acute-graft-versus host disease: therapeutic implications. Bone Marrow Res (2010) 0.87
LIGHT/TNFSF14 increases osteoclastogenesis and decreases osteoblastogenesis in multiple myeloma-bone disease. Oncotarget (2014) 0.86
Excess LIGHT contributes to placental impairment, increased secretion of vasoactive factors, hypertension, and proteinuria in preeclampsia. Hypertension (2013) 0.86
A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis. Clin Dev Immunol (2011) 0.86
Cell to Cell Interaction Can Activate Membrane-bound APRIL Which Are Expressed on Inflammatory Macrophages. Immune Netw (2010) 0.85
Differential expression of LIGHT and its receptors in human placental villi and amniochorion membranes. Am J Pathol (2002) 0.85
Soluble receptor (DcR3) and cellular inhibitor of apoptosis-2 (cIAP-2) protect human cytotrophoblast cells against LIGHT-mediated apoptosis. Am J Pathol (2004) 0.85
Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice. J Clin Invest (2011) 0.85
Differential CD4(+) T-cell memory responses induced by two subsets of human monocyte-derived dendritic cells. Immunology (2007) 0.85
The tumor necrosis factor family member TNFSF14 (LIGHT) is required for resolution of intestinal inflammation in mice. Gastroenterology (2014) 0.84
PD-1 on immature and PD-1 ligands on migratory human Langerhans cells regulate antigen-presenting cell activity. J Invest Dermatol (2010) 0.84
TNF superfamily: costimulation and clinical applications. Cell Biol Int (2009) 0.83
Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT. Proc Natl Acad Sci U S A (2014) 0.82
Proinflammatory and prothrombotic effects on human vascular endothelial cells of immune-cell-derived LIGHT. Eur J Med Res (2009) 0.82
CD160 isoforms and regulation of CD4 and CD8 T-cell responses. J Transl Med (2014) 0.81
Gene therapy of gastric cancer using LIGHT-secreting human umbilical cord blood-derived mesenchymal stem cells. Gastric Cancer (2012) 0.81
Increased plasma LIGHT levels in patients with atopic dermatitis. Clin Exp Immunol (2012) 0.81
Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during Leishmania donovani infection. PLoS Pathog (2011) 0.81
Aberrant expression and function of death receptor-3 and death decoy receptor-3 in human cancer. Exp Ther Med (2011) 0.81
The presence of high level soluble herpes virus entry mediator in sera of gastric cancer patients. Exp Mol Med (2012) 0.80
The interaction of monocytes with rheumatoid synovial cells is a key step in LIGHT-mediated inflammatory bone destruction. Immunology (2008) 0.80
Tumor-specific T cells signal tumor destruction via the lymphotoxin beta receptor. J Transl Med (2007) 0.79
The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells. J Exp Med (2004) 0.79
Improvement in efficacy of DNA vaccine encoding HIV-1 Vif by LIGHT gene adjuvant. Viral Immunol (2013) 0.79
LIGHT induces distinct signals to clear an AAV-expressed persistent antigen in the mouse liver and to induce liver inflammation. PLoS One (2010) 0.78
Adenovirus-mediated LIGHT gene modification in murine B-cell lymphoma elicits a potent antitumor effect. Cell Mol Immunol (2010) 0.77
Therapeutic blockade of LIGHT interaction with herpesvirus entry mediator and lymphotoxin β receptor attenuates in vivo cytotoxic allogeneic responses. Transplantation (2014) 0.77
Death Receptors in the Selective Degeneration of Motoneurons in Amyotrophic Lateral Sclerosis. J Neurodegener Dis (2013) 0.77
Immunotherapeutic targeting of LIGHT/LTβR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells. MAbs (2016) 0.77
The control of tissue fibrosis by the inflammatory molecule LIGHT (TNF Superfamily member 14). Pharmacol Res (2015) 0.76
LIGHT/IFN-γ triggers β cells apoptosis via NF-κB/Bcl2-dependent mitochondrial pathway. J Cell Mol Med (2016) 0.75
Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory. Cancer Immunol Immunother (2011) 0.75
Transglutaminase is a Critical Link Between Inflammation and Hypertension. J Am Heart Assoc (2016) 0.75
Lentivirus-mediated LIGHT overexpression inhibits human colorectal carcinoma cell growth in vitro and in vivo. Oncol Lett (2013) 0.75
Axl acts as a tumor suppressor by regulating LIGHT expression in T lymphoma. Oncotarget (2017) 0.75
LIGHT Elevation Enhances Immune Eradication of Colon Cancer Metastases. Cancer Res (2017) 0.75
Protective effect of vitamin E against diabetes-induced oxidized LDL and aorta cell wall proliferation in rat. Iran Biomed J (2015) 0.75
Monoclonal antibodies to B and T lymphocyte attenuator (BTLA) have no effect on in vitro B cell proliferation and act to inhibit in vitro T cell proliferation when presented in a cis, but not trans, format relative to the activating stimulus. Clin Exp Immunol (2010) 0.75
Increased Serum LIGHT Levels Correlate with Disease Progression and Severity of Interstitial Pneumonia in Patients with Dermatomyositis: A Case Control Study. PLoS One (2015) 0.75
Generating Peripheral Blood Derived Lymphocytes Reacting Against Autologous Primary AML Blasts. J Immunother (2016) 0.75
Role of LIGHT in the pathogenesis of joint destruction in rheumatoid arthritis. World J Exp Med (2017) 0.75
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