Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome.

PubWeight™: 1.54‹?› | Rank: Top 4%

🔗 View Article (PMID 10816576)

Published in J Biol Chem on August 25, 2000

Authors

J Bao1, I Alroy, H Waterman, E D Schejter, C Brodie, J Gruenberg, Y Yarden

Author Affiliations

1: Departments of Biological Regulation and Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel.

Articles citing this

A comprehensive pathway map of epidermal growth factor receptor signaling. Mol Syst Biol (2005) 5.68

The juxtamembrane region of the EGF receptor functions as an activation domain. Mol Cell (2009) 2.90

p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy. EMBO J (2006) 2.23

Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation. Proc Natl Acad Sci U S A (2007) 2.20

Epidermal growth factor receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking. FASEB J (2007) 1.87

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling. EMBO J (2002) 1.86

EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment. Cancer Res (2011) 1.66

Degradation of activated protein kinases by ubiquitination. Annu Rev Biochem (2009) 1.61

Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61

Endocytosis of receptor tyrosine kinases. Cold Spring Harb Perspect Biol (2013) 1.57

Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression. Biol Psychiatry (2010) 1.49

The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers. J Cell Biol (2000) 1.44

ERK-dependent threonine phosphorylation of EGF receptor modulates receptor downregulation and signaling. Cell Signal (2008) 1.27

CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases. PLoS One (2010) 1.25

Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A (2006) 1.20

Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway. Mol Biol Cell (2002) 1.05

Regulation of epidermal growth factor receptor degradation by heterotrimeric Galphas protein. Mol Biol Cell (2004) 1.05

Novel mechanism for regulation of epidermal growth factor receptor endocytosis revealed by protein kinase A inhibition. Mol Biol Cell (2002) 1.03

Mu opioid transactivation and down-regulation of the epidermal growth factor receptor in astrocytes: implications for mitogen-activated protein kinase signaling. Mol Pharmacol (2003) 1.02

The role of the ubiquitination-proteasome pathway in breast cancer: ubiquitin mediated degradation of growth factor receptors in the pathogenesis and treatment of cancer. Breast Cancer Res (2002) 0.99

Novel PKCeta is required to activate replicative functions of the major nonstructural protein NS1 of minute virus of mice. J Virol (2003) 0.96

Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner. J Biol Chem (2009) 0.96

Theaflavin-3, 3'-digallate induces epidermal growth factor receptor downregulation. Mol Carcinog (2006) 0.92

Endosomal ricin transport: involvement of Rab4- and Rab5-positive compartments. Histochem Cell Biol (2004) 0.91

Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V. Mol Biol Cell (2012) 0.91

Activation of protein kinase C alpha is necessary for sorting the PDGF beta-receptor to Rab4a-dependent recycling. Mol Biol Cell (2009) 0.91

Epidermal growth factor receptor downregulation by small heterodimeric binding proteins. Protein Eng Des Sel (2011) 0.91

The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization. J Biol Chem (2012) 0.90

Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes. Mol Biol Cell (2004) 0.89

Stress-Induced EGFR Trafficking: Mechanisms, Functions, and Therapeutic Implications. Trends Cell Biol (2016) 0.89

Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8. J Biol Chem (2010) 0.87

Effects of membrane trafficking on signaling by receptor tyrosine kinases. Cold Spring Harb Perspect Biol (2013) 0.87

A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells. J Biol Chem (2014) 0.87

PKC putative phosphorylation site Ser235 is required for MIP/AQP0 translocation to the plasma membrane. Mol Vis (2008) 0.85

Fates of neurotrophins after retrograde axonal transport: phosphorylation of p75NTR is a sorting signal for delayed degradation. J Neurosci (2009) 0.83

Metastasis suppressor tetraspanin CD82/KAI1 regulates ubiquitylation of epidermal growth factor receptor. J Biol Chem (2013) 0.82

Growth factor signaling and memory formation: temporal and spatial integration of a molecular network. Learn Mem (2013) 0.82

Molecular mechanisms of cigarette smoke-induced proliferation of lung cells and prevention by vitamin C. J Oncol (2011) 0.81

Basolateral EGF receptor sorting regulated by functionally distinct mechanisms in renal epithelial cells. Traffic (2012) 0.79

The Contribution of Spatial and Temporal Molecular Networks in the Induction of Long-term Memory and Its Underlying Synaptic Plasticity. AIMS Neurosci (2016) 0.75

Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor. PLoS One (2013) 0.75

Phylogenetic analysis of the neuraminidase gene reveals that the H5N1 strains prevalent in chickens during 2006 bird flu outbreaks in two regions of Maharashtra, India are genetically different. Genomics Proteomics Bioinformatics (2009) 0.75

Selective regulation of clathrin-mediated EGFR signaling and endocytosis by phospholipase C and calcium. Mol Biol Cell (2017) 0.75

Articles by these authors

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature (1984) 17.70

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature (1984) 14.21

rab5 controls early endosome fusion in vitro. Cell (1991) 8.31

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. EMBO J (1994) 8.02

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature (1986) 7.90

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell (1999) 6.79

A lipid associated with the antiphospholipid syndrome regulates endosome structure and function. Nature (1998) 5.62

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev (1998) 5.31

Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport. Nat Cell Biol (1999) 4.76

A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol (1996) 4.47

Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J (1996) 4.26

Cytoplasmic dynein-dependent vesicular transport from early to late endosomes. J Cell Biol (1993) 4.12

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor. Biochemistry (1987) 3.94

Vacuolar ATPase activity is required for endosomal carrier vesicle formation. J Biol Chem (1994) 3.40

The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett (1997) 3.23

ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J (1996) 3.22

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation. Biochemistry (1987) 3.20

Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest. J Cell Biol (2001) 3.14

Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. Oncogene (2000) 3.12

Microtubule- and motor-dependent fusion in vitro between apical and basolateral endocytic vesicles from MDCK cells. Cell (1990) 3.07

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. J Biol Chem (2000) 3.06

Hypervariable C-terminal domain of rab proteins acts as a targeting signal. Nature (1991) 3.03

Endosome-to-cytosol transport of viral nucleocapsids. Nat Cell Biol (2005) 2.98

An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes. J Cell Biol (1996) 2.94

Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies. J Biol Chem (1983) 2.94

Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes. Cell (1999) 2.89

Expression of epidermal growth factor receptors in human brain tumors. Cancer Res (1984) 2.83

Endocytosis in filter-grown Madin-Darby canine kidney cells. J Cell Biol (1989) 2.65

Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells. Cell (1992) 2.62

Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway. Mol Cell Biol (2000) 2.47

The avian beta-adrenergic receptor: primary structure and membrane topology. Proc Natl Acad Sci U S A (1986) 2.45

Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors. Adv Cancer Res (2000) 2.33

Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis. Neuron (1997) 2.33

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization. Mol Cell Biol (1991) 2.27

The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors. Proc Natl Acad Sci U S A (1999) 2.22

The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex. Mol Cell (2001) 2.19

Developmental expression of two murine fibroblast growth factor receptors, flg and bek. Development (1991) 2.16

Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases. FEBS Lett (2001) 2.15

The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor. J Biol Chem (1999) 2.13

The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells. Mol Biol Cell (2000) 2.12

The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components. Mol Biol Cell (2000) 2.11

Regulation of cell proliferation by epidermal growth factor. CRC Crit Rev Biochem (1983) 2.09

Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2. Cancer Res (2000) 2.07

Pain relief during panretinal photocoagulation for diabetic retinopathy: a national survey. Eye (Lond) (2009) 2.05

Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J (1998) 2.04

Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors. Neuron (1995) 2.02

Neu and its ligands: from an oncogene to neural factors. Bioessays (1993) 2.00

Involvement of the transmembrane protein p23 in biosynthetic protein transport. J Cell Biol (1997) 2.00

Annexin II is a major component of fusogenic endosomal vesicles. J Cell Biol (1993) 1.99

Developmental expression of c-kit, a proto-oncogene encoded by the W locus. Development (1990) 1.99

The basic biology of HER2. Ann Oncol (2001) 1.97

Epidermal growth factor induces electrically silent Na+ influx in human fibroblasts. J Biol Chem (1982) 1.96

Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene (2001) 1.95

A confined variable region confers ligand specificity on fibroblast growth factor receptors: implications for the origin of the immunoglobulin fold. EMBO J (1992) 1.93

PI3P signaling regulates receptor sorting but not transport in the endosomal pathway. J Cell Biol (2003) 1.90

Mutations in centrosomin reveal requirements for centrosomal function during early Drosophila embryogenesis. Curr Biol (1999) 1.89

Functional dissection of COP-I subunits in the biogenesis of multivesicular endosomes. J Cell Biol (1997) 1.89

Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal growth factor. Proc Natl Acad Sci U S A (1981) 1.87

Jamming the endosomal system: lipid rafts and lysosomal storage diseases. Trends Cell Biol (2000) 1.85

Specific release of membrane-bound annexin II and cortical cytoskeletal elements by sequestration of membrane cholesterol. Mol Biol Cell (1997) 1.84

Inhibition of endocytic vesicle fusion in vitro by the cell-cycle control protein kinase cdc2. Nature (1990) 1.82

Epiregulin is a potent pan-ErbB ligand that preferentially activates heterodimeric receptor complexes. J Biol Chem (1998) 1.81

Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation. Biochemistry (1990) 1.81

Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling. Oncogene (2007) 1.79

Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth. Proc Natl Acad Sci U S A (1991) 1.78

A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Oncogene (2006) 1.78

Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling. J Cell Biol (2001) 1.77

Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships. EMBO J (1993) 1.74

Rotational diffusion of epidermal growth factor complexed to cell surface receptors reflects rapid microaggregation and endocytosis of occupied receptors. Proc Natl Acad Sci U S A (1981) 1.72

Two threshold values of low pH block endocytosis at different stages. EMBO J (1987) 1.69

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway. EMBO J (1994) 1.68

A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors. Oncogene (1997) 1.64

Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2. Mol Cell Biol (1995) 1.63

Circadian variation of symptomatic paroxysmal atrial fibrillation. Data from almost 10 000 episodes. Eur Heart J (1999) 1.63

Alternative intracellular routing of ErbB receptors may determine signaling potency. J Biol Chem (1998) 1.62

Purification of an active EGF receptor kinase with monoclonal antireceptor antibodies. J Biol Chem (1985) 1.61

ARF1 regulates pH-dependent COP functions in the early endocytic pathway. J Biol Chem (2000) 1.60

Bivalence of EGF-like ligands drives the ErbB signaling network. EMBO J (1997) 1.58

The arguments for pre-existing early and late endosomes. Trends Cell Biol (1991) 1.52

The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands. Biochim Biophys Acta (1998) 1.51

c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas. Mol Biol Cell (1992) 1.50

Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex. J Biol Chem (2001) 1.50

Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network. EMBO J (1998) 1.49

Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins. Oncogene (1996) 1.48

An immunological approach reveals biological differences between the two NDF/heregulin receptors, ErbB-3 and ErbB-4. J Biol Chem (1996) 1.43

A specific combination of substrates is involved in signal transduction by the kit-encoded receptor. EMBO J (1991) 1.39

Neu differentiation factor/neuregulin isoforms activate distinct receptor combinations. J Biol Chem (1996) 1.38

Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma. Eur J Immunol (1998) 1.37