Hedgehog signals regulate multiple aspects of gastrointestinal development.

PubWeight™: 3.77‹?› | Rank: Top 1%

🔗 View Article (PMID 10821773)

Published in Development on June 01, 2000

Authors

M Ramalho-Santos1, D A Melton, A P McMahon

Author Affiliations

1: Department of Molecular and Cellular Biology, and Howard Hughes Medical Institute, Harvard University, Divinity Avenue, Cambridge, Massachusetts 02138, USA.

Articles citing this

(truncated to the top 100)

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature (2003) 10.33

Inflammation, atrophy, and gastric cancer. J Clin Invest (2007) 4.29

Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development (2007) 3.56

Villification: how the gut gets its villi. Science (2013) 2.94

Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology (2008) 2.71

Primary cilia are specialized calcium signalling organelles. Nature (2013) 2.63

Oesophageal atresia, tracheo-oesophageal fistula, and the VACTERL association: review of genetics and epidemiology. J Med Genet (2005) 2.28

Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology (2006) 2.04

Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol Med (2010) 1.82

Development and differentiation of the intestinal epithelium. Cell Mol Life Sci (2003) 1.80

Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome. Proc Natl Acad Sci U S A (2008) 1.78

Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning. Gastroenterology (2009) 1.76

Anorectal malformations caused by defects in sonic hedgehog signaling. Am J Pathol (2001) 1.72

Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis. Dev Cell (2009) 1.61

Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog. Gastroenterology (2009) 1.58

Enteric nervous system development: migration, differentiation, and disease. Am J Physiol Gastrointest Liver Physiol (2013) 1.46

Stomach Organ and Cell Lineage Differentiation: from Embryogenesis to Adult Homeostasis. Cell Mol Gastroenterol Hepatol (2016) 1.46

Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification. Genes Dev (2002) 1.46

Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut (2002) 1.46

Coup d'Etat: an orphan takes control. Endocr Rev (2011) 1.45

Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality. J Cell Biol (2006) 1.44

FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine. J Biol Chem (2008) 1.44

Vertebrate intestinal endoderm development. Dev Dyn (2011) 1.41

Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development. Gastroenterology (2010) 1.38

Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development (2010) 1.37

Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. PLoS One (2011) 1.37

Development and developmental disorders of the enteric nervous system. Nat Rev Gastroenterol Hepatol (2012) 1.36

Development of enteric neuron diversity. J Cell Mol Med (2009) 1.31

Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut. J Cell Biol (2004) 1.27

Pulmonary-intestinal cross-talk in mucosal inflammatory disease. Mucosal Immunol (2011) 1.26

Genetic factors in esophageal atresia, tracheo-esophageal fistula and the VACTERL association: roles for FOXF1 and the 16q24.1 FOX transcription factor gene cluster, and review of the literature. Eur J Med Genet (2009) 1.26

Genetic basis of Hirschsprung's disease. Pediatr Surg Int (2009) 1.25

The progesterone receptor regulates implantation, decidualization, and glandular development via a complex paracrine signaling network. Mol Cell Endocrinol (2011) 1.23

Multiphasic and tissue-specific roles of sonic hedgehog in cloacal septation and external genitalia development. Development (2009) 1.23

The contribution of associated congenital anomalies in understanding Hirschsprung's disease. Pediatr Surg Int (2006) 1.22

Building a brain in the gut: development of the enteric nervous system. Clin Genet (2012) 1.21

Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria. Gastroenterology (2010) 1.17

Roles for Hedgehog signaling in adult organ homeostasis and repair. Development (2014) 1.17

Anomalies of intestinal rotation and fixation: consequences of late diagnosis beyond two years of age. Pediatr Surg Int (2007) 1.16

A novel association of duodenal atresia, malrotation, segmental dilatation of the colon, and anorectal malformation. Pediatr Surg Int (2009) 1.16

Fgf9 signaling regulates small intestinal elongation and mesenchymal development. Development (2008) 1.15

Gene targeting reveals a crucial role for MTG8 in the gut. Mol Cell Biol (2001) 1.14

A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus. Hum Mol Genet (2011) 1.13

Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin development. Dev Biol (2006) 1.09

Hedgehog signalling in gut development, physiology and cancer. J Physiol (2011) 1.09

The developmental etiology and pathogenesis of Hirschsprung disease. Transl Res (2013) 1.09

Epithelial lineages of the small intestine have unique patterns of GATA expression. J Mol Histol (2005) 1.08

Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease. Neurogastroenterol Motil (2009) 1.07

Sonic hedgehog induces angiogenesis via Rho kinase-dependent signaling in endothelial cells. J Mol Cell Cardiol (2010) 1.07

Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta (2010) 1.07

The Hedgehog gene family of the cnidarian, Nematostella vectensis, and implications for understanding metazoan Hedgehog pathway evolution. Dev Biol (2007) 1.06

Sonic hedgehog is associated with H+-K+-ATPase-containing membranes in gastric parietal cells and secreted with histamine stimulation. Am J Physiol Gastrointest Liver Physiol (2008) 1.05

The intestinal stem cell niche: there grows the neighborhood. Proc Natl Acad Sci U S A (2001) 1.05

A multicellular approach forms a significant amount of tissue-engineered small intestine in the mouse. Tissue Eng Part A (2011) 1.04

Expression of hedgehog proteins in the human thymus. J Histochem Cytochem (2003) 1.04

lessen encodes a zebrafish trap100 required for enteric nervous system development. Development (2006) 1.03

SOX9 specifies the pyloric sphincter epithelium through mesenchymal-epithelial signals. Development (2004) 1.03

The role of hedgehog signaling during gastric regeneration. J Gastroenterol (2009) 1.02

Loss of genes implicated in gastric function during platypus evolution. Genome Biol (2008) 1.02

Hedgehog signaling controls homeostasis of adult intestinal smooth muscle. Dev Biol (2011) 1.01

Inflammatory pathways in the early steps of colorectal cancer development. World J Gastroenterol (2014) 1.00

Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis. J Clin Invest (2002) 0.99

BMP signaling regulates murine enteric nervous system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition. Dev Biol (2006) 0.99

Cell-cell interactions during remodeling of the intestine at metamorphosis in Xenopus laevis. Dev Biol (2009) 0.99

pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development. BMC Dev Biol (2007) 0.99

Prenatal diagnosis of annular pancreas: reliability of the double bubble sign with periduodenal hyperechogenic band. Fetal Diagn Ther (2008) 0.99

Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish. Dev Biol (2008) 0.98

Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation. Virchows Arch (2009) 0.97

Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway. J Biol Chem (2009) 0.96

Expression and regulation of hedgehog signaling pathway in pancreatic cancer. Langenbecks Arch Surg (2009) 0.96

Thyroid hormone-induced cell-cell interactions are required for the development of adult intestinal stem cells. Cell Biosci (2013) 0.95

Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer. Br J Cancer (2010) 0.94

Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice. Genes Dev (2006) 0.94

Associations of anorectal malformations and related syndromes. Pediatr Surg Int (2013) 0.93

Genetic control of intestinal stem cell specification and development: a comparative view. Stem Cell Rev (2012) 0.93

Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans. J Clin Invest (2011) 0.93

Animal models in pediatric surgery. Pediatr Surg Int (2005) 0.92

Molecular mechanisms involved in progesterone receptor regulation of uterine function. J Steroid Biochem Mol Biol (2006) 0.92

Wnt5a knock-out mouse as a new model of anorectal malformation. J Surg Res (2009) 0.92

Immunological and morphogenic basis of gastric mucosa atrophy and metaplasia. Virchows Arch (2004) 0.90

Localized rbp4 expression in the yolk syncytial layer plays a role in yolk cell extension and early liver development. BMC Dev Biol (2007) 0.90

The role of sonic hedgehog reemergence during gastric cancer. Dig Dis Sci (2010) 0.90

Comprehensive timeline of mesodermal development in the quail small intestine. Dev Dyn (2012) 0.90

Injury-stimulated Hedgehog signaling promotes regenerative proliferation of Drosophila intestinal stem cells. J Cell Biol (2015) 0.90

Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling. Development (2014) 0.90

Genome-wide copy number analysis uncovers a new HSCR gene: NRG3. PLoS Genet (2012) 0.90

Transcriptional networks in liver and intestinal development. Cold Spring Harb Perspect Biol (2012) 0.89

Fibroblast growth factor 10 represses premature cell differentiation during establishment of the intestinal progenitor niche. Dev Biol (2010) 0.89

Pleiotropic beneficial effects of sonic hedgehog gene therapy in an experimental model of peripheral limb ischemia. Mol Ther (2011) 0.88

Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev Biol (2012) 0.88

Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients. Chin J Cancer Res (2012) 0.88

Thyroid hormone-up-regulated hedgehog interacting protein is involved in larval-to-adult intestinal remodeling by regulating sonic hedgehog signaling pathway in Xenopus laevis. Dev Dyn (2008) 0.88

Stem cells in the adult pancreas and liver. Biochem J (2007) 0.88

Morphological changes of cell proliferation and apoptosis in rat jejunal mucosa at different ages. World J Gastroenterol (2003) 0.88

Urothelium-derived Sonic hedgehog promotes mesenchymal proliferation and induces bladder smooth muscle differentiation. Differentiation (2010) 0.88

Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy. Expert Rev Mol Med (2015) 0.87

Smooth muscle fascicular reorientation is required for esophageal morphogenesis and dependent on Cdo. J Cell Biol (2013) 0.87

Distraction induced enterogenesis: a unique mouse model using polyethylene glycol. J Surg Res (2011) 0.87

Hypospadias and anorectal malformations mediated by Eph/ephrin signaling. J Pediatr Urol (2007) 0.86

Generation of stomach tissue from mouse embryonic stem cells. Nat Cell Biol (2015) 0.86

Articles by these authors

Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res (1984) 86.56

Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs. Nucleic Acids Res (1984) 14.92

Hedgehog signaling in animal development: paradigms and principles. Genes Dev (2001) 14.75

A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci U S A (1996) 11.37

Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol (1998) 10.58

Human beta-globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei. Cell (1983) 9.77

Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development (2001) 9.00

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev (1999) 8.43

Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development (2000) 8.07

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell (1993) 7.41

Fate of the mammalian cardiac neural crest. Development (2000) 6.79

In vitro RNA synthesis with SP6 RNA polymerase. Methods Enzymol (1987) 6.68

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature (1994) 6.57

Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science (2003) 6.35

A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development (1999) 5.85

Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58

Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol (1995) 5.36

Injected anti-sense RNAs specifically block messenger RNA translation in vivo. Proc Natl Acad Sci U S A (1985) 5.09

Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development (2001) 4.89

Formation of the 3' end of histone mRNA by post-transcriptional processing. Nature (1984) 4.75

Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science (1998) 4.72

Sonic hedgehog regulates growth and morphogenesis of the tooth. Development (2000) 4.71

Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron (2000) 4.17

Female development in mammals is regulated by Wnt-4 signalling. Nature (1999) 4.13

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature (1999) 3.87

Antisense RNA injections in fertilized frog eggs reveal an RNA duplex unwinding activity. Cell (1987) 3.81

Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev (1994) 3.77

Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development (1993) 3.66

Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A (2000) 3.62

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev (1998) 3.46

Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev (2000) 3.30

Identification and cloning of localized maternal RNAs from Xenopus eggs. Cell (1985) 3.30

Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol (1998) 3.29

Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell (1987) 3.29

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature (1992) 3.23

T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev (1999) 3.13

Wnt signalling required for expansion of neural crest and CNS progenitors. Nature (1997) 3.11

Order and intracellular location of the events involved in the maturation of a spliced tRNA. Nature (1980) 3.07

Nuclear reprogramming in cells. Science (2008) 3.04

Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol (1999) 2.99

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Cell (1994) 2.98

Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature (1996) 2.98

Promoter of a eukaryotic tRNAPro gene is composed of three noncontiguous regions. Proc Natl Acad Sci U S A (1982) 2.91

Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development (1998) 2.90

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell (2001) 2.84

The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature (2000) 2.78

A local Wnt-3a signal is required for development of the mammalian hippocampus. Development (2000) 2.75

Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell (1991) 2.75

Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature (1995) 2.73

Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS. Development (1994) 2.73

Vertebrate endoderm development. Annu Rev Cell Dev Biol (1999) 2.73

A two-step model for the localization of maternal mRNA in Xenopus oocytes: involvement of microtubules and microfilaments in the translocation and anchoring of Vg1 mRNA. Development (1990) 2.69

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature (1999) 2.69

Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev (1998) 2.66

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell (2001) 2.65

A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta. Cell (1987) 2.64

Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol (1996) 2.59

Vegetal messenger RNA localization directed by a 340-nt RNA sequence element in Xenopus oocytes. Science (1992) 2.57

Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily. Cell (1996) 2.56

Gene transfer in amphibian eggs and oocytes. Annu Rev Genet (1981) 2.52

The world according to hedgehog. Trends Genet (1997) 2.52

Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron (1999) 2.50

Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development (2000) 2.49

Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest (2001) 2.49

Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature (1995) 2.46

A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression. Development (1987) 2.44

Regulation of pancreas development by hedgehog signaling. Development (2000) 2.43

Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. Development (2000) 2.39

Differential transformation of mammary epithelial cells by Wnt genes. Mol Cell Biol (1994) 2.37

BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development (2001) 2.37

Notch gene expression during pancreatic organogenesis. Mech Dev (2000) 2.36

Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev (2001) 2.29

Introduction of cloned DNA into sea urchin egg cytoplasm: replication and persistence during embryogenesis. Dev Biol (1985) 2.23

Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev (1995) 2.22

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell (1990) 2.22

Processed Vg1 protein is an axial mesoderm inducer in Xenopus. Cell (1993) 2.12

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell (1994) 2.12

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse. EMBO J (1988) 2.08

The zebrafish organizer requires chordino. Nature (1997) 2.06

Synthesis of long, capped transcripts in vitro by SP6 and T7 RNA polymerases. Methods Enzymol (1989) 2.05

Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction. Development (1987) 2.04

Translocation of a localized maternal mRNA to the vegetal pole of Xenopus oocytes. Nature (1987) 2.03

Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Curr Biol (1994) 2.03

Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev (1998) 2.02

Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev Biol (1997) 2.02

Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci (1999) 2.02

Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. Development (1991) 2.02

Specificity of antisense oligonucleotides in vivo. Proc Natl Acad Sci U S A (1992) 2.00

Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Development (1996) 1.99

Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development (1992) 1.99

The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev Biol (2001) 1.98

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev (1990) 1.97

Inhibition of activin receptor signaling promotes neuralization in Xenopus. Cell (1994) 1.96

Notochord to endoderm signaling is required for pancreas development. Development (1997) 1.95

Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev (1996) 1.94

Xfin: an embryonic gene encoding a multifingered protein in Xenopus. EMBO J (1987) 1.94

The mRNA encoding elongation factor 1-alpha (EF-1 alpha) is a major transcript at the midblastula transition in Xenopus. Dev Biol (1989) 1.94

Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature (1998) 1.94

The stability, toxicity and effectiveness of unmodified and phosphorothioate antisense oligodeoxynucleotides in Xenopus oocytes and embryos. Nucleic Acids Res (1990) 1.93