Published in Am J Physiol Cell Physiol on July 01, 2000
Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PLoS Pathog (2009) 4.12
Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest (2003) 4.08
Arginase: a critical regulator of nitric oxide synthesis and vascular function. Clin Exp Pharmacol Physiol (2007) 2.67
Recent advances in arginine metabolism: roles and regulation of the arginases. Br J Pharmacol (2009) 2.24
Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox. Proc Natl Acad Sci U S A (2003) 1.92
Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc Natl Acad Sci U S A (2001) 1.76
Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma. Curr Mol Med (2008) 1.64
Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation. Proc Natl Acad Sci U S A (2001) 1.58
Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness. Br J Pharmacol (2002) 1.44
Arginase and vascular aging. J Appl Physiol (1985) (2008) 1.33
Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway. Br J Pharmacol (2012) 1.31
Arginase: marker, effector, or candidate gene for asthma? J Clin Invest (2003) 1.24
Arginase and pulmonary diseases. Naunyn Schmiedebergs Arch Pharmacol (2008) 1.16
Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives. Br J Pharmacol (2009) 1.16
Arginase: the emerging therapeutic target for vascular oxidative stress and inflammation. Front Immunol (2013) 1.03
Roles of arginase variants, atopy, and ozone in childhood asthma. J Allergy Clin Immunol (2009) 1.03
Arginase promotes neointima formation in rat injured carotid arteries. Arterioscler Thromb Vasc Biol (2009) 0.99
Glucocorticoids inhibit lipopolysaccharide-induced up-regulation of arginase in rat alveolar macrophages. Br J Pharmacol (2001) 0.99
Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling? Transl Res (2010) 0.99
Arginase in retinopathy. Prog Retin Eye Res (2013) 0.94
Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties. Proc Natl Acad Sci U S A (2004) 0.94
Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness. J Med Genet (2007) 0.94
Role of p42/p44 mitogen-activated-protein kinase and p21waf1/cip1 in the regulation of vascular smooth muscle cell proliferation by nitric oxide. Proc Natl Acad Sci U S A (2001) 0.92
Role of arginase in vessel wall remodeling. Front Immunol (2013) 0.90
Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets. PLoS One (2010) 0.90
Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.88
Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice. BMC Immunol (2009) 0.88
IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2012) 0.87
Pharmacologic agents elevating cAMP prevent arginase II expression and proliferation of pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol (2012) 0.86
Vasomotor regulation of coronary microcirculation by oxidative stress: role of arginase. Front Immunol (2013) 0.83
Molecular mechanisms of induction of antigen-specific allograft tolerance by intranasal peptide administration. J Immunol (2011) 0.83
Double positive CD4CD8 alphabeta T cells: a new tumor-reactive population in human melanomas. PLoS One (2010) 0.82
Regulation of avoidant behaviors and pain by the anti-inflammatory tyrosine phosphatase SHP-1. Neuron Glia Biol (2006) 0.82
Identification of 9 uterine genes that are regulated during mouse pregnancy and exhibit abnormal levels in the cyclooxygenase-1 knockout mouse. Reprod Biol Endocrinol (2007) 0.81
Acellular pertussis vaccine protects against exacerbation of allergic asthma due to Bordetella pertussis in a murine model. Clin Diagn Lab Immunol (2005) 0.81
Oxidized low-density lipoprotein inhibits nitric oxide-mediated coronary arteriolar dilation by up-regulating endothelial arginase I. Microcirculation (2011) 0.80
Expression profiles in surgically-induced carotid stenosis: a combined transcriptomic and proteomic investigation. J Cell Mol Med (2008) 0.79
The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis. Respir Res (2010) 0.78
A₁ adenosine receptor deficiency or inhibition reduces atherosclerotic lesions in apolipoprotein E deficient mice. Cardiovasc Res (2014) 0.77
Chronic oral administration of the arginase inhibitor 2(S)-amino-6-boronohexanoic acid (ABH) improves erectile function in aged rats. J Androl (2012) 0.77
Agmatine induced NO dependent rat mesenteric artery relaxation and its impairment in salt-sensitive hypertension. Nitric Oxide (2013) 0.76
Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency. Immunology (2015) 0.75
The function of cancer-shed gangliosides in macrophage phenotype: involvement with angiogenesis. Oncotarget (2016) 0.75
From inflammation to wound healing: using a simple model to understand the functional versatility of murine macrophages. Bull Math Biol (2011) 0.75
Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury. PLoS One (2017) 0.75
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther (1981) 6.71
Arginine metabolism: nitric oxide and beyond. Biochem J (1998) 6.44
The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. Annu Rev Pharmacol Toxicol (1985) 3.29
Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin. J Pharmacol Exp Ther (1981) 3.14
Place of death: preferences among cancer patients and their carers. Soc Sci Med (2004) 2.87
Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. J Pharmacol Exp Ther (1986) 2.64
Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med (1992) 2.56
Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J Immunol (1993) 2.53
Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells. Am J Physiol Endocrinol Metab (2001) 2.50
Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene. J Biol Chem (1998) 2.35
The diversion of mentally ill persons from jails to community-based services: a profile of programs. Am J Public Health (1995) 2.08
Activation of purified guanylate cyclase by nitric oxide requires heme. Comparison of heme-deficient, heme-reconstituted and heme-containing forms of soluble enzyme from bovine lung. Biochim Biophys Acta (1982) 2.00
Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme forms. J Biol Chem (1986) 1.86
Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery. J Pharmacol Exp Ther (1984) 1.85
Shear stress-induced release of nitric oxide from endothelial cells grown on beads. Hypertension (1991) 1.77
Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite. Can J Physiol Pharmacol (1981) 1.74
Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: possible involvement of S-nitrosothiols. Biochim Biophys Acta (1980) 1.74
Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase. Proc Natl Acad Sci U S A (1994) 1.71
Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter. Proc Natl Acad Sci U S A (1996) 1.71
Inhibition of human platelet aggregation by S-nitrosothiols. Heme-dependent activation of soluble guanylate cyclase and stimulation of cyclic GMP accumulation. Mol Pharmacol (1983) 1.68
Bioregulation of lysosomal enzyme secretion from human neutrophils: roles of guanosine 3':5'-monophosphate and calcium in stimulus-secretion coupling. Proc Natl Acad Sci U S A (1975) 1.65
Activation of purified soluble guanylate cyclase by protoporphyrin IX. Proc Natl Acad Sci U S A (1982) 1.64
Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene. Mol Cell Biol (2001) 1.63
Hormonal control of lysosomal enzyme release from human neutrophils. Effects of autonomic agents on enzyme release, phagocytosis, and cylic nucleotide levels. J Exp Med (1974) 1.58
Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation. Proc Natl Acad Sci U S A (2001) 1.58
Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysaccharide. Biochem Biophys Res Commun (1995) 1.57
Nitric oxide and atherosclerosis. Nitric Oxide (2001) 1.57
Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J (2003) 1.57
Repair of elastase-digested elastic fibers in acellular matrices by replating with neonatal rat-lung lipid interstitial fibroblasts or other elastogenic cell types. Am J Respir Cell Mol Biol (1997) 1.56
Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins. J Biol Chem (1984) 1.55
Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry (2001) 1.51
The significant unmet needs of cancer patients: probing psychosocial concerns. Support Care Cancer (2001) 1.51
Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production. Am J Physiol (1996) 1.50
Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine. Biochem Biophys Res Commun (1992) 1.50
Negative feedback regulation of endothelial cell function by nitric oxide. Circ Res (1993) 1.48
Hormonal control of lysosomal enzyme release from human neutrophils: elevation of cyclic nucleotide levels by autonomic neurohormones. Proc Natl Acad Sci U S A (1974) 1.48
Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine. Biochem Biophys Res Commun (1992) 1.46
Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO. Biochem Biophys Res Commun (1993) 1.44
Microvascular pedal bypass for salvage of the severely ischemic limb. Mayo Clin Proc (1991) 1.42
Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury. Am J Physiol (1992) 1.41
Vascular smooth muscle-derived relaxing factor (MDRF) and its close similarity to nitric oxide. Biochem Biophys Res Commun (1990) 1.41
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. Proc Natl Acad Sci U S A (2001) 1.39
Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis. Proc Natl Acad Sci U S A (1992) 1.39
Purification and properties of heme-deficient hepatic soluble guanylate cyclase: effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX. Arch Biochem Biophys (1982) 1.38
Nitric oxide as a potential pathological mechanism in demyelination: its differential effects on primary glial cells in vitro. Neuroscience (1994) 1.36
Possible involvement of S-nitrosothiols in the activation of guanylate cyclase by nitroso compounds. FEBS Lett (1980) 1.36
Enzyme release from polymorphonuclear leukocyte lysosomes: regulation by autonomic drugs and cyclic nucleotides. Science (1973) 1.34
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B. Proc Natl Acad Sci U S A (1996) 1.32
Improved methods to measure end products of nitric oxide in biological fluids: nitrite, nitrate, and S-nitrosothiols. Nitric Oxide (1997) 1.31
Coronary arterial relaxation and guanylate cyclase activation by cigarette smoke, N'-nitrosonornicotine and nitric oxide. J Pharmacol Exp Ther (1980) 1.31
Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide. J Immunol (1993) 1.30
Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation. Biochem Biophys Res Commun (1989) 1.29
Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. Biochem Biophys Res Commun (1993) 1.29
A spectrophotometric assay for nitrate using NADPH oxidation by Aspergillus nitrate reductase. Anal Biochem (1993) 1.29
Endothelium-derived nitric oxide relaxes nonvascular smooth muscle. Eur J Pharmacol (1989) 1.27
Nonphagocytic release of neutral protease and beta-glucuronidase from human neutrophils. Regulation by autonomic neurohormones and cyclic nucleotides. Arthritis Rheum (1974) 1.27
Correlation between specific DNA-methylation products and mutation induction at the HGPRT locus in Chinese hamster ovary cells. Mutat Res (1983) 1.27
Nitric oxide-cyclic GMP signal transduction system. Methods Enzymol (1996) 1.23
Relaxation of intrapulmonary artery and vein by nitrogen oxide-containing vasodilators and cyclic GMP. J Pharmacol Exp Ther (1984) 1.23
Cholinergic-adrenergic interactions on intestinal ion transport. Am J Physiol (1978) 1.23
Mutually dependent localization of megalin and Dab2 in the renal proximal tubule. Am J Physiol Renal Physiol (2005) 1.23
Informal carers of cancer patients: what are their unmet psychosocial needs? Health Soc Care Community (2001) 1.23
Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages. J Biol Chem (2001) 1.22
Differences in responsiveness of intrapulmonary artery and vein to arachidonic acid: mechanism of arterial relaxation involves cyclic guanosine 3':5'-monophosphate and cyclic adenosine 3':5'-monophosphate. J Pharmacol Exp Ther (1985) 1.20
Complement-mediated solubilization in patients with systemic lupus erythematosus, nephritis or vasculitis. Clin Exp Immunol (1981) 1.19
Breakdown of noncollagenous chondromucoprotein matrix by leukocyte lysosome granule lysates from guinea pig, rabbit, and human. Clin Immunol Immunopathol (1973) 1.18
NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein. Proc Natl Acad Sci U S A (1990) 1.17
Neutral protease release from human leukocytes regulated by neurohormones and cyclic nucleotides. Nat New Biol (1973) 1.16
Regulation of mRNA levels for five urea cycle enzymes in rat liver by diet, cyclic AMP, and glucocorticoids. Arch Biochem Biophys (1987) 1.16
Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat. Proc Natl Acad Sci U S A (1999) 1.16
Neutrophil deactivation by influenza A viruses: mechanisms of protection after viral opsonization with collectins and hemagglutination-inhibiting antibodies. Blood (1996) 1.16
Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production. J Biol Chem (1994) 1.15
Mediation of immunologic discharge of lysosomal enzymes from human neutrophils by guanosine 3',5'-monophosphate. Requirement of calcium, and inhibition by adenosine 3',5'-monophosphate. J Exp Med (1974) 1.15
An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity. Proc Natl Acad Sci U S A (2001) 1.14
Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis. J Biol Chem (1995) 1.13
Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme. J Biol Chem (1982) 1.12
Intraoperative topical tetracycline sclerotherapy following mastectomy: a prospective, randomized trial. J Surg Oncol (2000) 1.12
Effect of aspirin on normal and cholera toxin-stimulated intestinal electrolyte transport. J Clin Invest (1976) 1.11
L-arginine inhibits balloon catheter-induced intimal hyperplasia. Biochem Biophys Res Commun (1993) 1.11
Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart. Proc Natl Acad Sci U S A (2000) 1.11
Guanylate cyclase from bovine lung. Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes. J Biol Chem (1984) 1.11
Effects of anti-inflammatory drugs on the stability of rat liver lysosomes in vitro. Biochem Pharmacol (1971) 1.10
Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice. J Immunol (1998) 1.10
Changes in liver lysosome fragility, erythrocyte membrane stability, and local and systemic lysosomal enzyme levels in adjuvant-induced polyarthritis. Biochem Pharmacol (1972) 1.10
Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension. Am Heart J (2004) 1.10
Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice. Proc Natl Acad Sci U S A (2001) 1.09
Regulation of messenger ribonucleic acid levels for five urea cycle enzymes in cultured rat hepatocytes. Requirements for cyclic adenosine monophosphate, glucocorticoids, and ongoing protein synthesis. Mol Endocrinol (1988) 1.09
Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro- and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release. J Pharmacol Exp Ther (1991) 1.08
Induction of mutations and sister-chromatid exchanges in Chinese hamster ovary cells by ethylating agents. Mutat Res (1982) 1.08
Release of neutral protease and beta-glucuronidase from human neutrophils in the presence of cartilage treated with various immunologic reactants. J Immunol (1974) 1.08
Blue-phase templated fabrication of three-dimensional nanostructures for photonic applications. Nat Mater (2012) 1.06
Regulation of purified soluble guanylate cyclase by porphyrins and metalloporphyrins: a unifying concept. Adv Cyclic Nucleotide Protein Phosphorylation Res (1984) 1.06
Microcirculation and oxidative stress. Free Radic Res (2007) 1.06
Endothelium-dependent modulation of cGMP levels and intrinsic smooth muscle tone in isolated bovine intrapulmonary artery and vein. Circ Res (1987) 1.05
NG-amino-L-arginine: a new potent antagonist of L-arginine-mediated endothelium-dependent relaxation. Biochem Biophys Res Commun (1990) 1.05
Arginase I: a limiting factor for nitric oxide and polyamine synthesis by activated macrophages? Am J Physiol Regul Integr Comp Physiol (2000) 1.04
Condensed expirate nitrite as a home marker for acute asthma. Lancet (1995) 1.04
Ultrastructural changes in hamster lung four hours to twenty-four days after exposure to elastase. Anat Rec (1981) 1.03