Published in J Struct Biol on June 01, 2000
Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils. Proc Natl Acad Sci U S A (2008) 4.84
Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR. Biochemistry (2007) 3.57
Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane. Proc Natl Acad Sci U S A (2008) 2.25
Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence? Diabetologia (2010) 2.21
Two-dimensional IR spectroscopy and isotope labeling defines the pathway of amyloid formation with residue-specific resolution. Proc Natl Acad Sci U S A (2009) 2.02
Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). Protein Sci (2008) 1.89
Molecular basis for amyloid-beta polymorphism. Proc Natl Acad Sci U S A (2011) 1.76
Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape. Chem Rev (2010) 1.62
Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide. J Am Chem Soc (2008) 1.56
A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils. PLoS Biol (2007) 1.56
A role for helical intermediates in amyloid formation by natively unfolded polypeptides? Phys Biol (2009) 1.49
The structural biology of protein aggregation diseases: Fundamental questions and some answers. Acc Chem Res (2006) 1.47
Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process. Protein Sci (2009) 1.46
Human islet amyloid polypeptide monomers form ordered beta-hairpins: a possible direct amyloidogenic precursor. J Am Chem Soc (2009) 1.46
A critical assessment of the role of helical intermediates in amyloid formation by natively unfolded proteins and polypeptides. Protein Eng Des Sel (2009) 1.38
Prediction of "hot spots" of aggregation in disease-linked polypeptides. BMC Struct Biol (2005) 1.34
The amyloid formation mechanism in human IAPP: dimers have β-strand monomer-monomer interfaces. J Am Chem Soc (2011) 1.22
Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid. Biochem J (2003) 1.20
2DIR spectroscopy of human amylin fibrils reflects stable β-sheet structure. J Am Chem Soc (2011) 1.20
Recent insights in islet amyloid polypeptide-induced membrane disruption and its role in beta-cell death in type 2 diabetes mellitus. Exp Diabetes Res (2008) 1.15
Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4. Diabetologia (2008) 1.14
Contribution of the intrinsic disulfide to the assembly mechanism of islet amyloid. Protein Sci (2004) 1.09
Molecular alignment within beta-sheets in Abeta(14-23) fibrils: solid-state NMR experiments and theoretical predictions. Biophys J (2006) 1.09
Amyloidogenesis of natively unfolded proteins. Curr Alzheimer Res (2008) 1.08
Two-dimensional infrared spectroscopy provides evidence of an intermediate in the membrane-catalyzed assembly of diabetic amyloid. J Phys Chem B (2009) 1.07
Model discrimination and mechanistic interpretation of kinetic data in protein aggregation studies. Biophys J (2009) 1.02
Solution state structures of human pancreatic amylin and pramlintide. Protein Eng Des Sel (2009) 1.00
Amyloid structure and assembly: insights from scanning transmission electron microscopy. J Struct Biol (2010) 0.98
Self-assembly of functional, amphipathic amyloid monolayers by the fungal hydrophobin EAS. Proc Natl Acad Sci U S A (2012) 0.94
Micelle formation by a fragment of human islet amyloid polypeptide. Biophys J (2003) 0.94
Amylin uncovered: a review on the polypeptide responsible for type II diabetes. Biomed Res Int (2013) 0.89
Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice. Diabetes (2009) 0.87
Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFM. J Struct Biol (2012) 0.86
Structural similarities and differences between amyloidogenic and non-amyloidogenic islet amyloid polypeptide (IAPP) sequences and implications for the dual physiological and pathological activities of these peptides. PLoS Comput Biol (2013) 0.86
Defining the molecular basis of amyloid inhibitors: human islet amyloid polypeptide-insulin interactions. J Am Chem Soc (2014) 0.86
Designed hairpin peptides interfere with amyloidogenesis pathways: fibril formation and cytotoxicity inhibition, interception of the preamyloid state. Biochemistry (2011) 0.86
Lipid interaction and membrane perturbation of human islet amyloid polypeptide monomer and dimer by molecular dynamics simulations. PLoS One (2012) 0.85
Computational assembly of polymorphic amyloid fibrils reveals stable aggregates. Biophys J (2013) 0.85
Nonpathological extracellular amyloid is present during normal epididymal sperm maturation. PLoS One (2012) 0.85
Amphiphilic adsorption of human islet amyloid polypeptide aggregates to lipid/aqueous interfaces. J Mol Biol (2011) 0.83
Structural basis of infectious and non-infectious amyloids. Curr Alzheimer Res (2008) 0.83
Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAAS. FEBS Lett (2013) 0.81
Solid-state NMR as a probe of amyloid structure. Protein Pept Lett (2006) 0.81
The role of aromatic side-chains in amyloid growth and membrane interaction of the islet amyloid polypeptide fragment LANFLVH. Eur Biophys J (2010) 0.81
Dehydration stability of amyloid fibrils studied by AFM. Eur Biophys J (2009) 0.81
Butyrylcholinesterase interactions with amylin may protect pancreatic cells in metabolic syndrome. J Cell Mol Med (2011) 0.80
α-helix to β-hairpin transition of human amylin monomer. J Chem Phys (2013) 0.80
Membrane permeation induced by aggregates of human islet amyloid polypeptides. Biophys J (2013) 0.80
Nucleobindin 1 caps human islet amyloid polypeptide protofibrils to prevent amyloid fibril formation. J Mol Biol (2012) 0.79
Inhibitory effects of choline-O-sulfate on amyloid formation of human islet amyloid polypeptide. FEBS Open Bio (2012) 0.79
Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core. PLoS One (2016) 0.77
Evidence of π-stacking interactions in the self-assembly of hIAPP(22-29). Proteins (2013) 0.77
Secondary Structure of Rat and Human Amylin across Force Fields. PLoS One (2015) 0.76
Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus. J Diabetes Res (2015) 0.76
Cyclic N-terminal loop of amylin forms non amyloid fibers. Biophys J (2013) 0.76
Structural transitions and interactions in the early stages of human glucagon amyloid fibrillation. Biophys J (2015) 0.75
Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate. PLoS One (2016) 0.75
Novel insights into amylin aggregation. Biotechnol Biotechnol Equip (2014) 0.75
New Insights from Sum Frequency Generation Vibrational Spectroscopy into the Interactions of Islet Amyloid Polypeptides with Lipid Membranes. J Diabetes Res (2015) 0.75
Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus. Clin Interv Aging (2015) 0.75
Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity. Elife (2017) 0.75
The Effects of Lipid Membranes, Crowding and Osmolytes on the Aggregation, and Fibrillation Propensity of Human IAPP. J Diabetes Res (2015) 0.75
MpUL-multi: Software for Calculation of Amyloid Fibril Mass per Unit Length from TB-TEM Images. Sci Rep (2016) 0.75
Electrochemical Assay of Human Islet Amyloid Polypeptide and Its Aggregation. Sensors (Basel) (2008) 0.75
Development of proteolytically stable N-methylated peptide inhibitors of aggregation of the amylin peptide implicated in type 2 diabetes. Interface Focus (2017) 0.75
The dynamic structure of fatty acyl chains in a phospholipid bilayer measured by deuterium magnetic resonance. Biochemistry (1974) 7.10
Lipid conformation in model membranes and biological membranes. Q Rev Biophys (1980) 6.44
The nuclear lamina is a meshwork of intermediate-type filaments. Nature (1986) 5.69
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci U S A (1997) 5.66
Identification of different roles for RanGDP and RanGTP in nuclear protein import. EMBO J (1996) 5.53
Deuterium magnetic resonance: theory and application to lipid membranes. Q Rev Biophys (1977) 5.48
Neutron diffraction studies on phosphatidylcholine model membranes. I. Head group conformation. J Mol Biol (1979) 5.27
Neutron diffraction studies on selectively deuterated phospholipid bilayers. Nature (1978) 5.16
Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore complex components. J Cell Biol (1990) 4.52
A giant nucleopore protein that binds Ran/TC4. Nature (1995) 4.36
Neutron diffraction studies on phosphatidylcholine model membranes. II. Chain conformation and segmental disorder. J Mol Biol (1979) 4.27
31P nuclear magnetic resonance and the head group structure of phospholipids in membranes. Biochim Biophys Acta (1978) 4.11
Deuterium order parameters in relation to thermodynamic properties of a phospholiped bilayer. A statistical mechanical interpretation. Biochemistry (1975) 3.92
Nuclear lamins: their structure, assembly, and interactions. J Struct Biol (1998) 3.54
The nuclear pore complex: from molecular architecture to functional dynamics. Curr Opin Cell Biol (1999) 3.30
Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res (1988) 3.10
An actin-binding protein from Acanthamoeba regulates actin filament polymerization and interactions. Nature (1980) 3.04
Structure and function of an acetylcholine receptor. Biophys J (1982) 2.92
Ultrastructure of a periodic protein layer in the outer membrane of Escherichia coli. J Cell Biol (1977) 2.89
Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues. J Cell Biol (1989) 2.66
Interactions and three-dimensional localization of a group of nuclear pore complex proteins. J Cell Biol (1994) 2.63
Toward a more complete 3-D structure of the nuclear pore complex. J Struct Biol (1991) 2.62
Severe osteolysis after third-body wear due to hydroxyapatite particles from acetabular cup coating. J Bone Joint Surg Br (1998) 2.59
Utility values and age-related macular degeneration. Arch Ophthalmol (2000) 2.48
Molecular order in cis and trans unsaturated phospholipid bilayers. Biochemistry (1978) 2.47
Effect of a single cis double bond on the structures of a phospholipid bilayer. Biochemistry (1977) 2.42
A study of the structure of the T-layer of Bacillus brevis. J Supramol Struct (1973) 2.32
Fatigue testing median sternotomy closures. Eur J Cardiothorac Surg (2001) 2.27
Polymorphic fibrillar assembly of human amylin. J Struct Biol (1997) 2.26
Structure and assembly of the Nup84p complex. J Cell Biol (2000) 2.22
Studies on the in vitro assembly of a beta 1-40: implications for the search for a beta fibril formation inhibitors. J Struct Biol (2000) 2.19
Electric charge effects on phospholipid headgroups. Phosphatidylcholine in mixtures with cationic and anionic amphiphiles. Biochemistry (1989) 2.16
Islet amyloid formed from diabetes-associated peptide may be pathogenic in type-2 diabetes. Lancet (1987) 2.15
Structure and assembly properties of the intermediate filament protein vimentin: the role of its head, rod and tail domains. J Mol Biol (1996) 2.13
Progressive Muscular Dystrophy. V. The Identification of the Carrier State in the Duchenne Type by Serum Creatine Kinase Determination. Am J Hum Genet (1963) 2.12
Bilayers of dipalmitoyl-3-sn-phosphatidylcholine. Conformational differences between the fatty acyl chains. Biochim Biophys Acta (1975) 2.12
Intermediate filaments and their associates: multi-talented structural elements specifying cytoarchitecture and cytodynamics. Curr Opin Cell Biol (2000) 2.08
Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins. J Biol Chem (1994) 2.07
Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex. Mol Biol Cell (1995) 2.04
The role of keratin subfamilies and keratin pairs in the formation of human epidermal intermediate filaments. J Cell Biol (1986) 2.04
Conformation and motion of the choline head group in bilayers of dipalmitoyl-3-sn-phosphatidylcholine. Biochemistry (1975) 2.00
Cortexillins, major determinants of cell shape and size, are actin-bundling proteins with a parallel coiled-coil tail. Cell (1996) 1.98
The nuclear pore complex. J Cell Biol (1993) 1.98
2D crystallization: from art to science. Ultramicroscopy (1992) 1.97
Casualties from terrorist bombings. J Trauma (1983) 1.95
Bundling of actin filaments by alpha-actinin depends on its molecular length. J Cell Biol (1990) 1.93
Electrostatically balanced subnanometer imaging of biological specimens by atomic force microscope. Biophys J (1999) 1.91
Melittin binding to mixed phosphatidylglycerol/phosphatidylcholine membranes. Biochemistry (1990) 1.91
Experimental experience with a temporary intraluminal heparin-bonded polyurethane arterial shunt. Br J Surg (1994) 1.86
Conformational changes of the phosphatidylcholine headgroup due to membrane dehydration. A 2H-NMR study. Chem Phys Lipids (1991) 1.85
Cerebral metabolism of [1,2-13C2]acetate as detected by in vivo and in vitro 13C NMR. J Biol Chem (1990) 1.83
Watching amyloid fibrils grow by time-lapse atomic force microscopy. J Mol Biol (1999) 1.82
The ATP-dependent HslVU protease from Escherichia coli is a four-ring structure resembling the proteasome. Nat Struct Biol (1997) 1.81
Utility values associated with blindness in an adult population. Br J Ophthalmol (2001) 1.79
The structural basis for the intrinsic disorder of the actin filament: the "lateral slipping" model. J Cell Biol (1991) 1.77
Influence of cholesterol on the polar region of phosphatidylcholine and phosphatidylethanolamine bilayers. Biochemistry (1978) 1.76
The fibrillar substructure of keratin filaments unraveled. J Cell Biol (1983) 1.75
Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro. Nature (1988) 1.72
Exploring the mechanical behavior of single intermediate filaments. J Mol Biol (2005) 1.72
The coiled-coil trigger site of the rod domain of cortexillin I unveils a distinct network of interhelical and intrahelical salt bridges. Structure (2000) 1.71
Interaction of Alzheimer beta-amyloid peptide(1-40) with lipid membranes. Biochemistry (1997) 1.71
Characterization of distinct early assembly units of different intermediate filament proteins. J Mol Biol (1999) 1.69
Orientation and flexibility of the choline head group in phosphatidylcholine bilayers. Biochim Biophys Acta (1977) 1.66
The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme. J Cell Biol (2000) 1.66
Identification of a 70,000-D protein in lens membrane junctional domains. J Cell Biol (1985) 1.66
Field surgery on a future conventional battlefield: strategy and wound management. Ann R Coll Surg Engl (1991) 1.64
Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope. EMBO J (1995) 1.64
Toward the molecular dissection of protein import into nuclei. Curr Opin Cell Biol (1996) 1.64
Molecular solutions to mammalian lens transparency. News Physiol Sci (2001) 1.62
Assessment of the use of disposable skin staplers in bowel anastomoses to reduce laparotomy time in penetrating ballistic injury to the abdomen. Ann R Coll Surg Engl (1991) 1.61
A distinct 14 residue site triggers coiled-coil formation in cortexillin I. EMBO J (1998) 1.61
Interaction of metal ions with phosphatidylcholine bilayer membranes. Biochemistry (1981) 1.61
Structure of T4 polyheads. II. A pathway of polyhead transformation as a model for T4 capsid maturation. J Mol Biol (1976) 1.60
Preparation of single molecules and supramolecular complexes for high-resolution metal shadowing. J Ultrastruct Res (1983) 1.60
Molecular architecture of the yeast nuclear pore complex: localization of Nsp1p subcomplexes. J Cell Biol (1998) 1.57
Self-association of beta-amyloid peptide (1-40) in solution and binding to lipid membranes. J Mol Biol (1995) 1.57
Evidence that aquaporin 1 is a major pathway for CO2 transport across the human erythrocyte membrane. FASEB J (2006) 1.56
Comparative proteome analysis of the hippocampus implicates chromosome 6q in schizophrenia. Mol Psychiatry (2000) 1.54
An autonomous folding unit mediates the assembly of two-stranded coiled coils. Proc Natl Acad Sci U S A (1998) 1.54
Ca2+ binding to phosphatidylcholine bilayers as studied by deuterium magnetic resonance. Evidence for the formation of a Ca2+ complex with two phospholipid molecules. Biochemistry (1984) 1.54
The transformation of tau particles into T4 heads. II. Transformations of the surface lattice and related observations on form determination. J Supramol Struct (1974) 1.52
Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex. J Cell Biol (1994) 1.52
Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nat Med (2001) 1.51
A spin label study of sarcoplasmic vesicles. Eur J Biochem (1971) 1.51
Interaction of electric dipoles with phospholipid head groups. A 2H and 31P NMR study of phloretin and phloretin analogues in phosphatidylcholine membranes. Biochemistry (1991) 1.51
Assessing the flexibility of intermediate filaments by atomic force microscopy. J Mol Biol (2004) 1.49
Architecture and polymorphism of fibrillar supramolecular assemblies produced by in vitro aggregation of human calcitonin. J Struct Biol (1995) 1.47
Expression of chicken lamin B2 in Escherichia coli: characterization of its structure, assembly, and molecular interactions. J Cell Biol (1991) 1.47
Intermediate filament assembly: fibrillogenesis is driven by decisive dimer-dimer interactions. Curr Opin Struct Biol (1998) 1.47
Probing actin polymerization by intermolecular cross-linking. J Cell Biol (1988) 1.46
C-reactive protein as early predictor for infectious postoperative complications in rectal surgery. Int J Colorectal Dis (2007) 1.45
Oligomeric structure of the Bacillus subtilis cell division protein DivIVA determined by transmission electron microscopy. Mol Microbiol (2004) 1.45