Published in Nature on August 17, 2000
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet (2007) 5.68
Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc Natl Acad Sci U S A (2003) 3.75
Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood. J Clin Invest (2003) 2.37
Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol (2007) 2.28
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med (2005) 2.05
Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. J Clin Invest (2006) 1.88
Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. Proc Natl Acad Sci U S A (2003) 1.75
Beta-cell mass and type 1 diabetes: going, going, gone? Diabetes (2008) 1.69
A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice. J Exp Med (2003) 1.62
Autoimmune polyglandular syndromes. Nat Rev Endocrinol (2010) 1.60
Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2001) 1.56
Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation. Diabetes (2011) 1.52
Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8(+) T cells by enhancing T cell receptor signaling. Immunity (2012) 1.50
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol (2017) 1.43
Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes. J Clin Invest (2005) 1.42
Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proc Natl Acad Sci U S A (2002) 1.40
Functional avidity directs T-cell fate in autoreactive CD4+ T cells. Blood (2005) 1.39
Identification of novel IGRP epitopes targeted in type 1 diabetes patients. Clin Immunol (2008) 1.38
Monitoring of antigen-specific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies. Clin Immunol (2010) 1.22
Prevention of autoimmune diabetes by ectopic pancreatic β-cell expression of interleukin-35. Diabetes (2012) 1.21
CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice. J Exp Med (2004) 1.20
Retrogenic modeling of experimental allergic encephalomyelitis associates T cell frequency but not TCR functional affinity with pathogenicity. J Immunol (2008) 1.17
CD103 expression is required for destruction of pancreatic islet allografts by CD8(+) T cells. J Exp Med (2002) 1.16
In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8+ T cell inflammation. Proc Natl Acad Sci U S A (2010) 1.08
Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4. Proc Natl Acad Sci U S A (2004) 1.08
Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice. J Immunol (2010) 1.07
RAG-dependent peripheral T cell receptor diversification in CD8+ T lymphocytes. Proc Natl Acad Sci U S A (2002) 1.06
Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes. Diabetes (2009) 1.04
Breakdown in peripheral tolerance in type 1 diabetes in mice and humans. Cold Spring Harb Perspect Med (2012) 1.00
Viral triggers for autoimmunity: is the 'glass of molecular mimicry' half full or half empty? J Autoimmun (2009) 0.98
Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cells. Diabetes (2009) 0.94
The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity. J Clin Invest (2010) 0.93
Antigen-based immune therapeutics for type 1 diabetes: magic bullets or ordinary blanks? Clin Dev Immunol (2011) 0.90
Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach. Diabetes (2011) 0.88
T-cell promiscuity in autoimmune diabetes. Diabetes (2008) 0.88
T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity. Int Rev Immunol (2006) 0.88
Enumerating autoreactive T cells in peripheral blood: a big step in diabetes prediction. J Clin Invest (2003) 0.88
Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice. J Exp Med (2016) 0.87
A pancreatic beta-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes. Proc Natl Acad Sci U S A (2003) 0.86
Targeting T lymphocytes for immune monitoring and intervention in autoimmune diabetes. Am J Ther (2005) 0.86
Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented. J Immunol (2009) 0.86
Theranostic magnetic resonance imaging of type 1 diabetes and pancreatic islet transplantation. Quant Imaging Med Surg (2012) 0.85
Antigen-specific therapeutic approaches in Type 1 diabetes. Cold Spring Harb Perspect Med (2012) 0.85
TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential. J Immunol (2014) 0.84
The immunotherapeutic potential of dendritic cells in type 1 diabetes. Clin Exp Immunol (2010) 0.84
Pre-existing autoimmunity determines type 1 diabetes outcome after Flt3-ligand treatment. J Autoimmun (2009) 0.84
Mechanistic basis of immunotherapies for type 1 diabetes mellitus. Transl Res (2013) 0.84
Approaches to reduce false positives and false negatives in the analysis of microarray data: applications in type 1 diabetes research. BMC Genomics (2008) 0.83
Endoplasmic reticulum stress caused by overexpression of islet-specific glucose-6-phosphatase catalytic subunit-related protein in pancreatic Beta-cells. Rev Diabet Stud (2007) 0.83
Therapeutic regulatory T cells subvert effector T cell function in inflamed islets to halt autoimmune diabetes. J Immunol (2015) 0.82
The pathogenicity of self-antigen decreases at high levels of autoantigenicity: a computational approach. Int Immunol (2010) 0.82
Altered differentiation, diminished pathogenicity, and regulatory activity of myelin-specific T cells expressing an enhanced affinity TCR. J Immunol (2011) 0.82
Antibody-validated proteins in inflamed islets of fulminant type 1 diabetes profiled by laser-capture microdissection followed by mass spectrometry. PLoS One (2014) 0.81
Crystallization and preliminary X-ray structural studies of a high-affinity CD8alphaalpha co-receptor to pMHC. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.81
Autoimmune responses in T1DM: quantitative methods to understand onset, progression, and prevention of disease. Pediatr Diabetes (2014) 0.80
DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8⁺ T cells independently of PD-1 and PD-L1. Int Immunol (2013) 0.79
Local autoantigen expression as essential gatekeeper of memory T-cell recruitment to islet grafts in diabetic hosts. Diabetes (2012) 0.79
Rebalancing immune specificity and function in cancer by T-cell receptor gene therapy. Arch Immunol Ther Exp (Warsz) (2010) 0.78
EphA2 targeting peptide tethered bioreducible poly(cystamine bisacrylamide-diamino hexane) for the delivery of therapeutic pCMV-RAE-1γ to pancreatic islets. J Control Release (2011) 0.78
The use of peptide-major-histocompatibility-complex multimers in type 1 diabetes mellitus. J Diabetes Sci Technol (2012) 0.77
T cells recognizing a peptide contaminant undetectable by mass spectrometry. PLoS One (2011) 0.77
Functional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands. Eur J Immunol (2008) 0.77
Age-related accumulation of T cells with markers of relatively stronger autoreactivity leads to functional erosion of T cells. BMC Immunol (2012) 0.77
Continuum model of T-cell avidity: Understanding autoreactive and regulatory T-cell responses in type 1 diabetes. J Theor Biol (2015) 0.77
Polymeric delivery of therapeutic RAE-1 plasmid to the pancreatic islets for the prevention of type 1 diabetes. J Control Release (2012) 0.77
Targeted immune interventions for type 1 diabetes: not as easy as it looks! Curr Opin Endocrinol Diabetes Obes (2014) 0.77
Characterization of Diabetogenic CD8+ T Cells: IMMUNE THERAPY WITH METABOLIC BLOCKADE. J Biol Chem (2016) 0.76
Making the most of major histocompatibility complex molecule multimers: applications in type 1 diabetes. Clin Dev Immunol (2012) 0.76
Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes. J Immunol (2012) 0.76
Mechanisms of autoimmunity in the non-obese diabetic mouse: effector/regulatory cell equilibrium during peak inflammation. Immunology (2016) 0.76
Mapping I-A(g7) restricted epitopes in murine G6PC2. Immunol Res (2013) 0.75
Adoptive Transfer of mRNA-Transfected T Cells Redirected against Diabetogenic CD8 T Cells Can Prevent Diabetes. Mol Ther (2017) 0.75
CD8(+) T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage. Sci Rep (2017) 0.75
Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses. Vaccines (Basel) (2014) 0.75
Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes. Front Physiol (2016) 0.75
Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells. Diabetes (2016) 0.75
Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice. J Diabetes Res (2016) 0.75
Cumulative autoimmunity: T cell clones recognizing several self-epitopes exhibit enhanced pathogenicity. Front Immunol (2011) 0.75
Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes. Nat Immunol (2017) 0.75
Conformation of the TAR RNA-arginine complex by NMR spectroscopy. Science (1992) 5.08
Alpha helix-RNA major groove recognition in an HIV-1 rev peptide-RRE RNA complex. Science (1996) 3.39
Retroviruses in invertebrates: the gypsy retrotransposon is apparently an infectious retrovirus of Drosophila melanogaster. Proc Natl Acad Sci U S A (1994) 3.03
Viraemia in patients with naturally acquired dengue infection. Bull World Health Organ (1981) 2.99
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice. J Exp Med (1997) 2.94
A prospective seroepidemiologic study on dengue in children four to nine years of age in Yogyakarta, Indonesia I. studies in 1995-1996. Am J Trop Med Hyg (1999) 2.78
Variation in susceptibility to oral infection with dengue viruses among geographic strains of Aedes aegypti. Am J Trop Med Hyg (1979) 2.64
Developmental Analysis of the Achaete-Scute System of DROSOPHILA MELANOGASTER. Genetics (1978) 2.29
[The spread of oxacillin-resistant Staphylococcus aureus]. Recenti Prog Med (1995) 2.01
A complex genetic locus, polyhomeotic, is required for segmental specification and epidermal development in D. melanogaster. Cell (1987) 1.81
Cardiovascular effects of hydrocortisone in preterm infants with pressor-resistant hypotension. Pediatrics (2001) 1.78
Developmental analysis of the wing disc in the mutant engrailed of Drosophila melanogaster. Genetics (1972) 1.68
A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J Exp Med (1997) 1.67
Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice. J Immunol (1994) 1.63
Polyhomeotic: a gene of Drosophila melanogaster required for correct expression of segmental identity. Mol Gen Genet (1985) 1.62
Prevalent CD8(+) T cell response against one peptide/MHC complex in autoimmune diabetes. Proc Natl Acad Sci U S A (1999) 1.61
LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing. Proc Natl Acad Sci U S A (1997) 1.58
Influenza virus lung infection protects from respiratory syncytial virus-induced immunopathology. J Exp Med (2000) 1.57
Oxygen effect on O2 deficit and VO2 kinetics during exercise in obstructive pulmonary disease. J Appl Physiol (1985) (1995) 1.55
Acceleration of spontaneous diabetes in TCR-beta-transgenic nonobese diabetic mice by beta-cell cytotoxic CD8+ T cells expressing identical endogenous TCR-alpha chains. J Immunol (1996) 1.54
Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice. J Clin Invest (1999) 1.53
Nutritional state and exercise tolerance in patients with COPD. Chest (1995) 1.52
Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells. J Exp Med (1997) 1.52
Role of cellular immunity in protection against HIV infection. Adv Immunol (1997) 1.51
Lymphocytic vasculitis in X-linked lymphoproliferative disease. Blood (2001) 1.49
Proviral amplification of the Gypsy endogenous retrovirus of Drosophila melanogaster involves env-independent invasion of the female germline. EMBO J (1999) 1.48
Binding of an HIV Rev peptide to Rev responsive element RNA induces formation of purine-purine base pairs. Biochemistry (1994) 1.47
Antimicrobial susceptibilities of Streptococcus species that cause septicemia in neutropenic patients. Antimicrob Agents Chemother (1989) 1.44
[Idiopathic CD4+ T-lymphocyte deficiency: the clinical evolution of a case]. Ann Ital Med Int (1998) 1.41
Antigen-specific release of beta-chemokines by anti-HIV-1 cytotoxic T lymphocytes. Curr Biol (1998) 1.41
Severe plasmalogen deficiency in tissues of infants without peroxisomes (Zellweger syndrome). Nature (1983) 1.35
Blastoschizomyces capitatus: an emerging cause of invasive fungal disease in leukemia patients. Rev Infect Dis (1990) 1.34
Dengue virus isolation in Indonesia, 1975-1978. Asian J Infect Dis (1979) 1.32
Immunogenicities of intravenous and intramuscular administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for human immunodeficiency virus type 1 in mice. J Gen Virol (1998) 1.32
Defective NK cell activation in X-linked lymphoproliferative disease. J Immunol (2000) 1.31
Lymphocyte immunophenotyping by flow cytometry in normal adults. Comparison of fresh whole blood lysis technique, Ficoll-Paque separation and cryopreservation. J Immunol Methods (1992) 1.28
Long-term prevalence of oropharyngeal dysphagia in head and neck cancer patients: Impact on quality of life. Clin Nutr (2007) 1.25
Evidence of a dual function in fl(2)d, a gene needed for Sex-lethal expression in Drosophila melanogaster. Genetics (1992) 1.22
Major histocompatibility complex class I-restricted infiltration and destruction of pancreatic islets by NOD mouse-derived beta-cell cytotoxic CD8+ T-cell clones in vivo. Diabetes (1996) 1.20
Teicoplanin in the treatment of gram-positive-bacterial endocarditis. Antimicrob Agents Chemother (1989) 1.19
Expansion of the antigenic repertoire of a single T cell receptor upon T cell activation. J Immunol (2001) 1.19
Cellular and molecular mechanisms for the initiation and progression of beta cell destruction resulting from the collaboration between macrophages and T cells. Autoimmunity (1998) 1.18
The measurement of chronic pain and health-related quality of life following inguinal hernia repair: a review of the literature. Hernia (2008) 1.16
A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex. Immunity (2001) 1.14
Localization and growth pattern of the tergite Anlage of Drosophila. J Embryol Exp Morphol (1972) 1.14
Subacute bacterial endocarditis due to Actinobacillus actinomycetemcomitans. Am J Med (1969) 1.10
Sex determination in the germ line of Drosophila melanogaster: activation of the gene Sex-lethal. Development (1993) 1.08
Gene expression profiles for the human pancreas and purified islets in type 1 diabetes: new findings at clinical onset and in long-standing diabetes. Clin Exp Immunol (2009) 1.07
Natural killer cells are required for accelerated type 1 diabetes driven by interferon-beta. Clin Exp Immunol (2008) 1.07
GABA(B) receptor 1 polymorphism (G1465A) is associated with temporal lobe epilepsy. Neurology (2003) 1.06
IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytes. J Clin Invest (2000) 1.06
Molding a peptide into an RNA site by in vivo peptide evolution. Proc Natl Acad Sci U S A (1997) 1.06
Antineoplastic agents. 398. Isolation and structure elucidation of cephalostatins 18 and 19. J Nat Prod (1998) 1.06
Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice. Diabetes (1999) 1.05
Two mechanisms for the non-MHC-linked resistance to spontaneous autoimmunity. J Immunol (1999) 1.04
Synergistic treatment of enterococcal endocarditis: in vitro and in vivo studies. Arch Intern Med (1977) 1.04
Ventilatory and metabolic adaptations to walking and cycling in patients with COPD. J Appl Physiol (1985) (2000) 1.04
The twin transfusion syndrome. Clinical observations on 35 affected pairs. Clin Pediatr (Phila) (1979) 1.04
Localization of the basement membrane heparan sulfate proteoglycan in islet amyloid deposits in type II diabetes mellitus. Arch Pathol Lab Med (1992) 1.04
Postoperative endophthalmitis caused by Stomatococcus mucilaginosus. Clin Infect Dis (1994) 1.03
Antimicrobial susceptibilities of Erysipelothrix rhusiopathiae. Antimicrob Agents Chemother (1990) 1.03
A technical note on diluting semen for the haemocytometric determination of sperm concentration. Hum Reprod (1989) 1.02
Dendritic cells pulsed with antigen-specific apoptotic bodies prevent experimental type 1 diabetes. Clin Exp Immunol (2009) 1.01
Detection of dengue viral RNA in Aedes aegypti (Diptera: Culicidae) exposed to sticky lures using reverse-transcriptase polymerase chain reaction. J Med Entomol (2001) 1.01
Prepuberal and puberal melanomas in ophthalmology. Am J Ophthalmol (1965) 1.00
A rapid procedure for the quantitation of low abundance RNAs by competitive reverse transcription-polymerase chain reaction. Nucleic Acids Res (1994) 1.00
Erysipelothrix rhusiopathiae endocarditis. Eur J Clin Microbiol Infect Dis (1990) 1.00
Juvenile retinal detachment. Pan American Association of Ophthalmology and American Journal of Ophthalmology Lecture. Am J Ophthalmol (1982) 0.99
Needs and targets for the multi sex combs gene product in Drosophila melanogaster. Genetics (1998) 0.99
Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts antiepileptic effects via the GABA/benzodiazepine receptor complex in mice. Br J Pharmacol (2011) 0.98
Direct evidence for circulating apoSAA as the precursor of tissue AA amyloid deposits. Scand J Immunol (1988) 0.98
Analysis of haploid mosaics in Drosophila. Dev Biol (1983) 0.98
A case of brain abscess due to Brucella melitensis. Clin Infect Dis (1994) 0.98
Autoantigen-independent deletion of diabetogenic CD4+ thymocytes by protective MHC class II molecules. J Immunol (1999) 0.97
Ly-49P activates NK-mediated lysis by recognizing H-2Dd. J Immunol (2000) 0.96
IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice. Diabetologia (2008) 0.95
polyhomeotic controls engrailed expression and the hedgehog signaling pathway in imaginal discs. Mech Dev (2000) 0.94
Some clinical and epidemiological observations on virologically confirmed dengue hemorrhagic fever. Paediatr Indones (1991) 0.93
Reproductive isolation and morphogenetic evolution in Drosophila analyzed by breakage of ethological barriers. Genetics (1997) 0.93
Successful treatment of disseminated cerebritis complicating methicillin-resistant Staphylococcus aureus Endocarditis unresponsive to vancomycin therapy with linezolid. Scand J Infect Dis (2004) 0.93
Conservative medical therapy of prosthetic joint infections: retrospective analysis of an 8-year experience. Clin Microbiol Infect (2004) 0.93
Variegation of retroviral vector gene expression in myeloid cells. Gene Ther (2000) 0.92
Multiple myeloma and work in agriculture: results of a case-control study in Forlì, Italy. Cancer Causes Control (1998) 0.92
Benefits of smart pumps for automated changeovers of vasoactive drug infusion pumps: a quasi-experimental study. Br J Anaesth (2013) 0.91
Ethylmalonic and methylsuccinic aciduria in ethylmalonic encephalopathy arise from abnormal isoleucine metabolism. Metabolism (1998) 0.91
Reg (regenerating) gene overexpression in islets from non-obese diabetic mice with accelerated diabetes: role of IFNbeta. Diabetologia (2006) 0.90
The first reported outbreak of dengue hemorrhagic fever in Irian Jaya, Indonesia. Am J Trop Med Hyg (1997) 0.90
The effect of the major components of Salvia Miltiorrhiza Bunge on bone marrow cells. J Ethnopharmacol (2007) 0.90
Assignment and modeling of the Rev Response Element RNA bound to a Rev peptide using 13C-heteronuclear NMR. J Biomol NMR (1995) 0.89
Comparative in vitro activities of new fluorinated quinolones and other antibiotics against coagulase-negative Staphylococcus blood isolates from neutropenic patients, and relationship between susceptibility and slime production. Antimicrob Agents Chemother (1989) 0.89
Obesity does not induce abnormal CSF pressure in subjects with normal cerebral MR venography. Neurology (2002) 0.89
Dissecting autoimmune diabetes through genetic manipulation of non-obese diabetic mice. Diabetologia (2003) 0.89
Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules. J Immunol (2000) 0.88