C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue.

PubWeight™: 1.49‹?› | Rank: Top 4%

🔗 View Article (PMC 86283)

Published in Mol Cell Biol on October 01, 2000

Authors

S S Chen1, J F Chen, P F Johnson, V Muppala, Y H Lee

Author Affiliations

1: Laboratory of Molecular Pathology, Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan.

Articles citing this

C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev (2002) 6.46

Regulatory circuits controlling white versus brown adipocyte differentiation. Biochem J (2006) 2.23

Cooperation between C/EBPalpha TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation. Genes Dev (2001) 2.00

Mitochondrial dysfunction in obesity. Curr Opin Endocrinol Diabetes Obes (2010) 1.42

CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. J Biol Chem (2007) 1.35

Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations. Am J Pathol (2009) 1.33

Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells. Genes Dev (2004) 1.26

Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction. Exp Gerontol (2007) 1.07

Essential requirement of CCAAT/enhancer binding proteins in embryogenesis. Mol Cell Biol (2004) 1.07

Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis. J Biol Chem (2007) 1.06

Genetic ablation of CCAAT/enhancer binding protein alpha in epidermis reveals its role in suppression of epithelial tumorigenesis. Cancer Res (2007) 1.04

Androgen effects on adipose tissue architecture and function in nonhuman primates. Endocrinology (2012) 0.95

CCAAT/enhancer-binding protein delta (C/EBPdelta) maintains amelogenin expression in the absence of C/EBPalpha in vivo. J Biol Chem (2007) 0.95

Hzf regulates adipogenesis through translational control of C/EBPalpha. EMBO J (2008) 0.94

Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα. PLoS One (2012) 0.90

In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response. PLoS One (2010) 0.89

C/EBPalpha and C/EBPbeta are required for Sebocyte differentiation and stratified squamous differentiation in adult mouse skin. PLoS One (2010) 0.87

Transcriptional regulation of fatty acid translocase/CD36 expression by CCAAT/enhancer-binding protein alpha. J Biol Chem (2008) 0.84

C/EBPα is required for development of dendritic cell progenitors. Blood (2013) 0.83

Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. Mol Cell Biol (2010) 0.82

Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs. Transcription (2012) 0.82

3T3-L1 adipocytes and rat adipose tissue have a high capacity for taurine synthesis by the cysteine dioxygenase/cysteinesulfinate decarboxylase and cysteamine dioxygenase pathways. J Nutr (2008) 0.80

Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: crosstalk through C/EBPs. Drug Metab Rev (2007) 0.76

Polyunsaturated fatty acids augment tumoricidal action of 5-fluorouracil on gastric cancer cells by their action on vascular endothelial growth factor, tumor necrosis factor-α and lipid metabolism related factors. Arch Med Sci (2015) 0.76

Prolonged induction activates Cebpα independent adipogenesis in NIH/3T3 cells. PLoS One (2013) 0.75

Recent advances in the understanding of how neuropeptide Y and α-melanocyte stimulating hormone function in adipose physiology. Adipocyte (2016) 0.75

C/EBP-Induced Transdifferentiation Reveals Granulocyte-Macrophage Precursor-like Plasticity of B Cells. Stem Cell Reports (2017) 0.75

A tumor suppressor role for C/EBPα in solid tumors: more than fat and blood. Oncogene (2017) 0.75

Articles cited by this

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A (1996) 12.92

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev (1991) 11.10

Understanding adipocyte differentiation. Physiol Rev (1998) 6.84

Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev (1995) 6.03

Impaired energy homeostasis in C/EBP alpha knockout mice. Science (1995) 5.68

Adipogenesis and obesity: rounding out the big picture. Cell (1996) 5.15

A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev (1991) 4.50

Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation. Genes Dev (1999) 3.19

An essential role for C/EBPbeta in female reproduction. Genes Dev (1997) 2.96

Adipsin and complement factor D activity: an immune-related defect in obesity. Science (1989) 1.87

Molecular regulation of adipocyte differentiation. Semin Cell Dev Biol (1999) 1.72

Disruption of the c/ebp alpha gene in adult mouse liver. Mol Cell Biol (1997) 1.72

Transcriptional control of adipogenesis. Curr Opin Cell Biol (1998) 1.52

The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis. J Clin Invest (1993) 1.25

The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression. Proc Natl Acad Sci U S A (1996) 1.23

The application of lipid-soluble stains in plastic-embedded sections. Histochemistry (1986) 1.02

Structural organization and tissue-specific expression of the gene encoding rat cysteine dioxygenase. Gene (1996) 1.01

C/EBPalpha is critical for the neonatal acute-phase response to inflammation. Mol Cell Biol (1998) 0.98

Modulating the transcriptional control of adipogenesis. Curr Opin Genet Dev (1997) 0.98

A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and Sertoli cells. J Biol Chem (1993) 0.94

Human cysteine dioxygenase gene: structural organization, tissue-specific expression and downregulation by phorbol 12-myristate 13-acetate. Biosci Biotechnol Biochem (1999) 0.93

Regulation of transferrin gene expression. FASEB J (1992) 0.87

Purification and partial characterization of rat factor D. Biochem J (1991) 0.82

Articles by these authors

(truncated to the top 100)

The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science (1988) 27.01

Isolation of a recombinant copy of the gene encoding C/EBP. Genes Dev (1988) 9.11

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol (2001) 8.95

In situ detection of sequence-specific DNA binding activity specified by a recombinant bacteriophage. Genes Dev (1988) 6.97

Directed deletion of a yeast transfer RNA intervening sequence. Science (1980) 6.67

The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite. Science (1989) 6.46

Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene. Cell (1986) 5.92

Transcription and processing of intervening sequences in yeast tRNA genes. Cell (1978) 5.07

A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev (1991) 4.50

An essential role for C/EBPbeta in female reproduction. Genes Dev (1997) 2.96

Jasmonic acid carboxyl methyltransferase: a key enzyme for jasmonate-regulated plant responses. Proc Natl Acad Sci U S A (2001) 2.84

Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities. J Biol Chem (2001) 2.74

Cloning of yeast transfer RNA genes in Escherichia coli. Science (1977) 2.73

Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanisms. FASEB J (2000) 2.53

Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP. Science (1989) 2.44

Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. J Biol Chem (1995) 2.43

Psychiatric epidemiology in Korea. Part I: Gender and age differences in Seoul. J Nerv Ment Dis (1990) 2.42

CRP2 (C/EBP beta) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity. EMBO J (1995) 2.28

The C/EBPbeta transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland. Genes Dev (1998) 2.25

The genital mycoplasmas. N Engl J Med (1973) 2.21

Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells. J Virol (1993) 2.16

The yeast tRNATyr gene intron is essential for correct modification of its tRNA product. Nature (1983) 2.11

Minocycline: Possible vestibular side-effects. Lancet (1974) 2.09

Methodologic investigations and prevalence of genital mycoplasmas in pregnancy. J Infect Dis (1970) 2.02

Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1. J Biol Chem (2001) 1.99

Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity. J Biol Chem (1998) 1.94

My children and me: midlife evaluations of grown children and of self. Psychol Aging (1994) 1.90

Toxoplasma gondii tachyzoites inhibit proinflammatory cytokine induction in infected macrophages by preventing nuclear translocation of the transcription factor NF-kappa B. J Immunol (2001) 1.76

Disruption of the c/ebp alpha gene in adult mouse liver. Mol Cell Biol (1997) 1.72

Genome scan meta-analysis of rheumatoid arthritis. Rheumatology (Oxford) (2005) 1.65

Hepatitis C virus core protein interacts with cellular putative RNA helicase. J Virol (1999) 1.63

leafy hull sterile1 is a homeotic mutation in a rice MADS box gene affecting rice flower development. Plant Cell (2000) 1.62

Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds. J Korean Med Sci (2001) 1.62

C/EBPbeta modulates the early events of keratinocyte differentiation involving growth arrest and keratin 1 and keratin 10 expression. Mol Cell Biol (1999) 1.61

Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein delta. Proc Natl Acad Sci U S A (1998) 1.59

Sexual activity and vaginal colonization with genital mycoplasmas. JAMA (1972) 1.57

Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene. J Biol Chem (1999) 1.54

Defective fatty acid-mediated beta-cell compensation in Zucker diabetic fatty rats. Pathogenic implications for obesity-dependent diabetes. J Biol Chem (1996) 1.53

Interleukin-6-specific activation of the C/EBPdelta gene in hepatocytes is mediated by Stat3 and Sp1. Mol Cell Biol (1998) 1.52

Agrobacterium tumefaciens-mediated transformation of the plant pathogenic fungus, Magnaporthe grisea. Mol Cells (2001) 1.51

Design of a C/EBP-specific, dominant-negative bZIP protein with both inhibitory and gain-of-function properties. J Biol Chem (1996) 1.51

Gene dose effect reveals no Gs-coupled A2A adenosine receptor reserve in murine T-lymphocytes: studies of cells from A2A-receptor-gene-deficient mice. Biochem J (2001) 1.49

Birth weight and genital mycoplasmas in pregnancy. N Engl J Med (1971) 1.48

The ability of C/EBP beta but not C/EBP alpha to synergize with an Sp1 protein is specified by the leucine zipper and activation domain. Mol Cell Biol (1997) 1.47

Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with non-obese Pima Indians. Diabetologia (2005) 1.47

Hepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha. J Virol (1999) 1.45

Analysis of genes expressed during rice-Magnaporthe grisea interactions. Mol Plant Microbe Interact (2001) 1.45

A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1. Blood (1997) 1.45

Paraffinoma of the penis. Yonsei Med J (1994) 1.45

Intradiverticular tumors of the bladder: surgical implications--an eleven-year review. Eur Urol (1993) 1.44

Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor. J Virol (1997) 1.42

Tumor necrosis factor alpha transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-kappaB p50. Mol Cell Biol (1998) 1.41

Complete membranous obstruction of the inferior vena cava treated successfully by King's bioptome and balloon angioplasty. Am J Cardiol (1993) 1.40

Inhibition of CCAAT/enhancer-binding protein alpha and beta translation by upstream open reading frames. J Biol Chem (1998) 1.40

Microbiological investigation of Bartholin's gland abscesses and cysts. Am J Obstet Gynecol (1977) 1.35

Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family. J Virol (1998) 1.32

Factors related to the survival of papillary and follicular thyroid carcinoma patients with distant metastases. Thyroid (1999) 1.30

CCAAT/enhancer binding protein beta is a neuronal transcriptional regulator activated by nerve growth factor receptor signaling. J Neurochem (1998) 1.29

Rupture of the rectosigmoid colon with evisceration of the small bowel through the anus. Yonsei Med J (2000) 1.29

Neoplastic transformation and tumorigenesis associated with overexpression of phospholipase D isozymes in cultured murine fibroblasts. Carcinogenesis (2001) 1.29

Fractional moving blood volume: estimation with power Doppler US. Radiology (1995) 1.29

Sexual experience and urethral colonization with genital mycoplasmas. A study in normal men. Ann Intern Med (1973) 1.28

Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor. Mol Cell Endocrinol (1997) 1.27

Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation. J Virol (1995) 1.27

Drugs derived from cannabinoids. 5. delta6a,10a-Tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains. J Med Chem (1976) 1.26

The C/EBP bZIP domain can mediate lipopolysaccharide induction of the proinflammatory cytokines interleukin-6 and monocyte chemoattractant protein-1. J Biol Chem (2000) 1.26

Cloning of genes for bacterial glycosyltransferases. II. Selection of a hybrid plasmid carrying the rfah gene. J Biol Chem (1979) 1.25

Structural modification of lignocellulosics by pretreatments to enhance enzymatic hydrolysis. Biotechnol Bioeng (1983) 1.23

Redundancy of C/EBP alpha, -beta, and -delta in supporting the lipopolysaccharide-induced transcription of IL-6 and monocyte chemoattractant protein-1. J Immunol (1998) 1.23

Ginsenoside Rh4, a genuine dammarane glycoside from Korean red ginseng. Planta Med (1996) 1.22

Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma. Arthritis Rheum (2006) 1.22

Silica stone--development due to long time oral trisilicate intake. Scand J Urol Nephrol (1993) 1.22

Community study of depression in old age in Taiwan: prevalence, life events and socio-demographic correlates. Br J Psychiatry (2001) 1.22

Generation of truncated C/EBPbeta isoforms by in vitro proteolysis. J Biol Chem (2000) 1.21

Acute pelvic inflammatory disease: characteristics of patients with gonococcal and nongonococcal infection and evaluation of their response to treatment with aqueous procaine penicillin G and spectinomycin hydrochloride. Sex Transm Dis (1978) 1.19

A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Sp1 factor. Mol Cell Biol (1994) 1.19

In vitro and in vivo antitumoral phenanthrenes from the aerial parts of Dendrobium nobile. Planta Med (1995) 1.17

Abalone sperm lysin: unusual mode of evolution of a gamete recognition protein. Zygote (1993) 1.16

Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. Int J Oncol (2000) 1.15

Medullary nephrocalcinosis associated with long-term furosemide abuse in adults. Nephrol Dial Transplant (2001) 1.14

Angiopoietin-1 inhibits irradiation- and mannitol-induced apoptosis in endothelial cells. Circulation (2000) 1.14

Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPbeta). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPbeta. J Biol Chem (2000) 1.14

Caspase 3-mediated cleavage of p21WAF1/CIP1 associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells. J Biol Chem (2000) 1.13

Large scale isolation of human erythrocyte membranes by high volume molecular filtration. J Biochem Biophys Methods (1981) 1.13

Three-vessel view of the fetal upper mediastinum: an easy means of detecting abnormalities of the ventricular outflow tracts and great arteries during obstetric screening. Ultrasound Obstet Gynecol (1997) 1.12

The nucleolar phosphoprotein B23 interacts with hepatitis delta antigens and modulates the hepatitis delta virus RNA replication. J Biol Chem (2001) 1.12

Familial aggregation of blood pressures of newborn infants and their mother. Pediatrics (1976) 1.11

Prenatal diagnosis of placenta previa accreta by transabdominal color Doppler ultrasound. Ultrasound Obstet Gynecol (2000) 1.11

Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity. Carcinogenesis (2001) 1.11

Phospholipase C-delta1 is activated by capacitative calcium entry that follows phospholipase C-beta activation upon bradykinin stimulation. J Biol Chem (1999) 1.10

Bovine spongiform encephalopathy: the effect of oral exposure dose on attack rate and incubation period in cattle. J Gen Virol (2007) 1.10

Side-branching in the mammary gland: the progesterone-Wnt connection. Genes Dev (2000) 1.09

Susceptibility of Enterobacter aerogenes and Enterobacter cloacae to 19 antimicrobial agents in vitro. Am J Med Sci (1970) 1.09

DNA-binding specificity of the PAR basic leucine zipper protein VBP partially overlaps those of the C/EBP and CREB/ATF families and is influenced by domains that flank the core basic region. Mol Cell Biol (1995) 1.09

Fibrovascular polyp of the esophagus in infant. Yonsei Med J (2001) 1.09

Comparison of methods for the isolation of genital mycoplasmas from men. J Infect Dis (1976) 1.09

Plasma secretin concentrations in fasting and postprandial state in man. Am J Dig Dis (1978) 1.09

Cytochrome P450 family 4 in a cockroach: molecular cloning and regulation by regulation by hypertrehalosemic hormone. Proc Natl Acad Sci U S A (1991) 1.08

Nonenhancing intramedullary astrocytomas and other MR imaging features: a retrospective study and systematic review. AJNR Am J Neuroradiol (2009) 1.06

A study of purified montmorillonite intercalated with 5-fluorouracil as drug carrier. Biomaterials (2002) 1.06