Published in J Cell Biol on October 02, 2000
One step at a time: endoplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol (2008) 8.68
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat Cell Biol (2008) 4.54
AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation. Mol Cell Biol (2002) 3.77
The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2001) 3.39
Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science (2011) 3.19
The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulum. Traffic (2008) 3.07
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A (2005) 3.01
For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection. EMBO J (2003) 2.82
HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins. Mol Biol Cell (2001) 2.65
Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J Virol (2004) 2.63
Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates. Mol Cell (2011) 2.36
Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast. Mol Biol Cell (2001) 2.34
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell (2010) 2.33
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J Clin Invest (2010) 2.22
SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. J Cell Biol (2006) 2.13
Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation. Semin Cell Dev Biol (2007) 2.13
Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Mol Cell (2009) 1.94
Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum. J Cell Biol (2009) 1.93
Defining the glycan destruction signal for endoplasmic reticulum-associated degradation. Mol Cell (2008) 1.86
The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment. EMBO J (2006) 1.83
Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. J Biol Chem (2008) 1.77
The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation. Nat Rev Mol Cell Biol (2011) 1.73
Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol. Mol Biol Cell (2001) 1.69
The mammalian endoplasmic reticulum-associated degradation system. Cold Spring Harb Perspect Biol (2013) 1.50
An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport. J Cell Biol (2002) 1.49
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol (2011) 1.48
In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. Mol Cell Biol (2001) 1.47
ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis. J Clin Invest (2017) 1.44
ER-golgi traffic is a prerequisite for efficient ER degradation. Mol Biol Cell (2002) 1.42
Key steps in ERAD of luminal ER proteins reconstituted with purified components. Cell (2014) 1.35
In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase. J Biol Chem (2009) 1.31
Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo. J Biol Chem (2008) 1.29
Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase. Crit Rev Biochem Mol Biol (2010) 1.29
A nucleus-based quality control mechanism for cytosolic proteins. Mol Biol Cell (2010) 1.28
Sel1 repeat protein LpnE is a Legionella pneumophila virulence determinant that influences vacuolar trafficking. Infect Immun (2007) 1.26
The proinflammatory cytokines IL-1beta and TNF-alpha induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway. Arthritis Res Ther (2006) 1.26
INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. EMBO J (2005) 1.25
Conserved endoplasmic reticulum-associated degradation system to eliminate mutated receptor-like kinases in Arabidopsis. Proc Natl Acad Sci U S A (2010) 1.22
Misfolded proteins traffic from the endoplasmic reticulum (ER) due to ER export signals. Mol Biol Cell (2006) 1.20
Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. EMBO J (2005) 1.17
Exposed hydrophobicity is a key determinant of nuclear quality control degradation. Mol Biol Cell (2011) 1.16
SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates. J Biol Chem (2011) 1.16
Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality. J Biol Chem (2010) 1.14
Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis. EMBO Rep (2008) 1.11
Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase. J Biol Chem (2009) 1.08
Sec61p is part of the endoplasmic reticulum-associated degradation machinery. EMBO J (2009) 1.07
Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. Proc Natl Acad Sci U S A (2014) 1.06
Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. J Biol Chem (2008) 1.05
Intrinsic conformational determinants signal protein misfolding to the Hrd1/Htm1 endoplasmic reticulum-associated degradation system. Mol Biol Cell (2009) 1.05
Modularity of the Hrd1 ERAD complex underlies its diverse client range. J Cell Biol (2010) 1.02
The binary switch between life and death of endoplasmic reticulum-stressed beta cells. Curr Opin Endocrinol Diabetes Obes (2010) 0.99
Effects of a defective ERAD pathway on growth and heterologous protein production in Aspergillus niger. Appl Microbiol Biotechnol (2010) 0.95
Identification of an Htm1 (EDEM)-dependent, Mns1-independent Endoplasmic Reticulum-associated Degradation (ERAD) pathway in Saccharomyces cerevisiae: application of a novel assay for glycoprotein ERAD. J Biol Chem (2010) 0.95
Regulation of Endoplasmic Reticulum-Associated Protein Degradation (ERAD) by Ubiquitin. Cells (2014) 0.95
The endoplasmic reticulum-associated degradation pathways of budding yeast. Cold Spring Harb Perspect Biol (2012) 0.95
Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD. Cell (2016) 0.94
Transcriptional activation and increased mRNA stability contribute to overexpression of CDR1 in azole-resistant Candida albicans. Antimicrob Agents Chemother (2008) 0.94
Mutant membrane protein of the budding yeast spindle pole body is targeted to the endoplasmic reticulum degradation pathway. Genetics (2002) 0.94
Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. Crit Rev Biochem Mol Biol (2014) 0.92
Mechanisms for quality control of misfolded transmembrane proteins. Biochim Biophys Acta (2011) 0.92
Ubiquitin chain elongation enzyme Ufd2 regulates a subset of Doa10 substrates. J Biol Chem (2010) 0.92
Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes. Circ Res (2015) 0.92
The ERdj5-Sel1L complex facilitates cholera toxin retrotranslocation. Mol Biol Cell (2013) 0.92
Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast. PLoS One (2011) 0.91
Sorting things out through endoplasmic reticulum quality control. Mol Membr Biol (2010) 0.91
Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking. FEBS Lett (2011) 0.88
Transient arrest in proteasomal degradation during inhibition of translation in the unfolded protein response. Biochem J (2007) 0.88
Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation. Semin Cell Dev Biol (2012) 0.88
Selective targeting of proteins within secretory pathway for endoplasmic reticulum-associated degradation. J Biol Chem (2012) 0.87
Yos9p and Hrd1p mediate ER retention of misfolded proteins for ER-associated degradation. Mol Biol Cell (2012) 0.87
Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum. J Biol Chem (2013) 0.87
A switch from life to death in endoplasmic reticulum stressed β-cells. Diabetes Obes Metab (2010) 0.86
The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism. Cell Metab (2014) 0.86
Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells. J Biol Chem (2009) 0.86
Characterization of the ubiquitylating components of the human malaria parasite's protein degradation pathway. PLoS One (2012) 0.86
The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2. J Biol Chem (2011) 0.86
Usa1 protein facilitates substrate ubiquitylation through two separate domains. PLoS One (2009) 0.84
Endoplasmic reticulum-associated degradation is required for cold adaptation and regulation of sterol biosynthesis in the yeast Saccharomyces cerevisiae. Eukaryot Cell (2006) 0.84
Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p. PLoS One (2012) 0.84
IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol (2015) 0.84
Defective ER associated degradation of a model luminal substrate in yeast carrying a mutation in the 4th ER luminal loop of Sec61p. Biochem Biophys Res Commun (2012) 0.83
A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation. Mol Biol Cell (2013) 0.83
Endoplasmic reticulum quality control in cancer: Friend or foe. Semin Cancer Biol (2015) 0.83
Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions. J Biol Chem (2016) 0.82
Structural and biochemical basis of Yos9 protein dimerization and possible contribution to self-association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation ubiquitin-ligase complex. J Biol Chem (2012) 0.82
New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation. Trends Cell Biol (2017) 0.81
The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins. Mol Biol Cell (2014) 0.80
Recent technical developments in the study of ER-associated degradation. Curr Opin Cell Biol (2014) 0.80
The protein translocation systems in plants - composition and variability on the example of Solanum lycopersicum. BMC Genomics (2013) 0.80
Means of self-preservation: how an intrinsically disordered ubiquitin-protein ligase averts self-destruction. Mol Biol Cell (2013) 0.80
Role of HERP and a HERP-related protein in HRD1-dependent protein degradation at the endoplasmic reticulum. J Biol Chem (2013) 0.80
Crystal structure of SEL1L: Insight into the roles of SLR motifs in ERAD pathway. Sci Rep (2016) 0.78
Direct and essential function for Hrd3 in ER-associated degradation. Proc Natl Acad Sci U S A (2016) 0.77
OsHrd3 is necessary for maintaining the quality of endoplasmic reticulum-derived protein bodies in rice endosperm. J Exp Bot (2015) 0.76
Whole Blood Gene Expression Profiling in Preclinical and Clinical Cattle Infected with Atypical Bovine Spongiform Encephalopathy. PLoS One (2016) 0.76
EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog. PLoS One (2014) 0.76
Misfolded proteins induce aggregation of the lectin Yos9. J Biol Chem (2014) 0.76
The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity. Nat Commun (2016) 0.75
Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae. J Vis Exp (2016) 0.75
How Polyomaviruses Exploit the ERAD Machinery to Cause Infection. Viruses (2016) 0.75
Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene (1989) 23.74
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell (2000) 13.44
Degradation of CFTR by the ubiquitin-proteasome pathway. Cell (1995) 7.88
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science (1999) 7.60
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc Natl Acad Sci U S A (1999) 7.32
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem (2000) 6.92
ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway. Science (1996) 5.13
The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell (1994) 5.10
Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. Science (1999) 4.65
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol Cell (1999) 4.53
Degradation from the endoplasmic reticulum: disposing of newly synthesized proteins. Cell (1988) 4.42
Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell (1996) 4.19
Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34. Genes Dev (1999) 4.17
A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol (2000) 3.65
A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole. EMBO J (1993) 3.49
Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast. EMBO J (1996) 3.34
Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell (1998) 3.33
Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism. Proc Natl Acad Sci U S A (1999) 3.17
Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway. EMBO J (1996) 2.72
Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast. Eur J Biochem (1993) 2.55
Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast. J Cell Biol (1994) 2.23
The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain. EMBO J (1999) 2.00
The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J Biol Chem (1997) 1.87
Subunits and substrates of the anaphase-promoting complex. Exp Cell Res (1999) 1.87
The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. Proc Natl Acad Sci U S A (1998) 1.86
HRD gene dependence of endoplasmic reticulum-associated degradation. Mol Biol Cell (2000) 1.84
Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme. J Biol Chem (1988) 1.82
Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation. J Cell Sci (1999) 1.62
Saccharomyces cerevisiae CNE1 encodes an endoplasmic reticulum (ER) membrane protein with sequence similarity to calnexin and calreticulin and functions as a constituent of the ER quality control apparatus. J Biol Chem (1995) 1.62
Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome. J Biol Chem (1998) 1.61
In vivo examination of membrane protein localization and degradation with green fluorescent protein. Proc Natl Acad Sci U S A (1996) 1.59
The engagement of Sec61p in the ER dislocation process. Mol Cell (1999) 1.57
Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase. Proc Natl Acad Sci U S A (1997) 1.56
Mevalonolactone inhibits the rate of synthesis and enhances the rate of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat hepatocytes. J Biol Chem (1983) 1.51
Expression of heterologous genes in Saccharomyces cerevisiae from vectors utilizing the glyceraldehyde-3-phosphate dehydrogenase gene promoter. Gene (1984) 1.51
Regulated Co-translational ubiquitination of apolipoprotein B100. A new paradigm for proteasomal degradation of a secretory protein. J Biol Chem (1998) 1.44
The regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase requires a short-lived protein and occurs in the endoplasmic reticulum. J Biol Chem (1990) 1.43
Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell (1998) 1.25
Mutations in PEX10 is the cause of Zellweger peroxisome deficiency syndrome of complementation group B. Hum Mol Genet (1998) 1.22
Ubiquitin-proteasome pathway mediates intracellular degradation of apolipoprotein B. Biochemistry (1996) 1.19
Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans. Development (1997) 1.10
A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae. FEBS Lett (1999) 1.10
Association with cullin partners protects ROC proteins from proteasome-dependent degradation. Oncogene (1999) 1.09
Associations between subunit ectodomains promote T cell antigen receptor assembly and protect against degradation in the ER. J Cell Biol (1993) 1.08
Identification of SEC12, SED4, truncated SEC16, and EKS1/HRD3 as multicopy suppressors of ts mutants of Sar1 GTPase. J Biochem (1999) 0.95
Intracellular retention and degradation of human mutant variant of a alpha 1-antitrypsin in stably transfected Chinese hamster ovary cell lines. Eur J Biochem (1993) 0.91
Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene. Mech Dev (1998) 0.88
Resolution of recent evolutionary divergence among Escherichia coli from related lineages: the application of pulsed field electrophoresis to molecular epidemiology. J Infect Dis (1990) 8.33
Adjunctive subconjunctival mitomycin C in glaucoma triple procedure. Ophthalmology (1995) 5.35
The Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative Na+/H+ antiporter. Proc Natl Acad Sci U S A (2000) 5.08
Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat Cell Biol (2001) 4.28
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity (1999) 3.84
Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes. Mol Psychiatry (2009) 3.56
Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. Science (1992) 3.45
Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes. J Biol Chem (1991) 3.41
Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am J Respir Crit Care Med (2000) 3.25
T-DNA insertional mutagenesis for functional genomics in rice. Plant J (2000) 3.25
Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA. Antimicrob Agents Chemother (1998) 3.01
HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins. Mol Biol Cell (2001) 2.65
Novel Jeff=1/2 Mott state induced by relativistic spin-orbit coupling in Sr2IrO4. Phys Rev Lett (2008) 2.38
Marital conflict in older adults: endocrinological and immunological correlates. Psychosom Med (1997) 2.34
Optimized THP-1 differentiation is required for the detection of responses to weak stimuli. Inflamm Res (2007) 2.21
Meta-analysis of exercise testing to detect coronary artery disease in women. Am J Cardiol (1999) 2.20
Toward an explanation of the power law artifact: insights from response surface analysis. Mem Cognit (2000) 2.15
Key role for sulfur in peptide metabolism and in regulation of three hydrogenases in the hyperthermophilic archaeon Pyrococcus furiosus. J Bacteriol (2001) 2.12
Evaluation of pulsed-field gel electrophoresis in epidemiological investigations of meningococcal disease outbreaks caused by Neisseria meningitidis serogroup C. J Clin Microbiol (2001) 2.12
Molecular epidemiology of adhesin and hemolysin virulence factors among uropathogenic Escherichia coli. Infect Immun (1989) 2.12
Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. Blood (2000) 2.08
Risk factors for retinal vein occlusions. A case-control study. Ophthalmology (1992) 2.06
Restriction fragment length polymorphisms among uropathogenic Escherichia coli isolates: pap-related sequences compared with rrn operons. Infect Immun (1990) 1.95
Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells. Immunity (2000) 1.87
Nosocomial clonal dissemination of methicillin-resistant Staphylococcus aureus. Elucidation by plasmid analysis. Arch Intern Med (1987) 1.86
Primary glaucoma triple procedure with or without adjunctive mitomycin. Prognostic factors for filtration failure. Ophthalmology (1996) 1.67
Transmembrane signalling by a hybrid protein: communication from the domain of chemoreceptor Trg that recognizes sugar-binding proteins to the kinase/phosphatase domain of osmosensor EnvZ. J Bacteriol (1994) 1.66
Site-specific deoxyribonucleases in Bacillus subtilis and other Bacillus strains. J Bacteriol (1976) 1.65
Use of molecular subtyping to document long-term persistence of Corynebacterium diphtheriae in South Dakota. J Clin Microbiol (1999) 1.64
Outbreak of neonatal listeriosis associated with mineral oil. Pediatr Infect Dis J (1991) 1.64
leafy hull sterile1 is a homeotic mutation in a rice MADS box gene affecting rice flower development. Plant Cell (2000) 1.62
An increased estimate of the merger rate of double neutron stars from observations of a highly relativistic system. Nature (2003) 1.62
Detection and identification of mycobacteria by amplification of the internal transcribed spacer regions with genus- and species-specific PCR primers. J Clin Microbiol (2000) 1.60
Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells. Biochem Biophys Res Commun (1999) 1.56
A 'distributed degron' allows regulated entry into the ER degradation pathway. EMBO J (1999) 1.55
Use of insulin pump therapy at nighttime only for children 7-10 years of age with type 1 diabetes. Diabetes Care (2000) 1.51
Regional deposition and retention of particles in shallow, inhaled boluses: effect of lung volume. J Appl Physiol (1985) (1999) 1.51
In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. Mol Cell Biol (2001) 1.47
Medical student radiology teaching in Australia and New Zealand. Australas Radiol (2007) 1.46
Distinguishing optimism from pessimism in older adults: is it more important to be optimistic or not to be pessimistic? J Pers Soc Psychol (1997) 1.44
Correlation between evoked motor response of the sciatic nerve and sensory blockade. Anesthesiology (1997) 1.44
Primary glaucoma triple procedure in patients with primary open-angle glaucoma: the effect of mitomycin C in patients with and without prognostic factors for filtration failure. Am J Ophthalmol (1998) 1.44
Atracurium and vecuronium block nicotine-induced carotid body chemoreceptor responses. Acta Anaesthesiol Scand (2002) 1.44
A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes. J Biol Chem (1999) 1.44
Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. J Cell Biol (2000) 1.43
Medical therapy or coronary artery bypass graft surgery for chronic stable angina: an update using decision analysis. Am J Med (2001) 1.43
Use of spirometry for case finding, diagnosis, and management of chronic obstructive pulmonary disease (COPD). Evid Rep Technol Assess (Summ) (2005) 1.42
Coronary AVE micro stents: serial quantitative angiography and histology in a canine model. Cathet Cardiovasc Diagn (1997) 1.39
Milrinone improves lung compliance in patients receiving mechanical ventilation for cardiogenic pulmonary edema. Acta Anaesthesiol Scand (2003) 1.39
Intraocular pressure-dependent retinal vascular change in adult chronic open-angle glaucoma patients. Ophthalmology (1991) 1.39
Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma. Oncogene (2009) 1.37
Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway. Proc Natl Acad Sci U S A (2001) 1.35
Anisotropic Dirac fermions in a Bi square net of SrMnBi2. Phys Rev Lett (2011) 1.33
Response to bronchodilator drug administration by a new reservoir aerosol delivery system and a review of other auxiliary delivery systems. Am Rev Respir Dis (1982) 1.33
The relationship of cigarette prices and no-smoking bylaws to the prevalence of smoking in Canada. Am J Public Health (1997) 1.32
Syndecans-1 and -4 are induced during wound repair of neonatal but not fetal skin. J Invest Dermatol (1996) 1.32
Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon! Cell Mol Life Sci (2005) 1.31
The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan. Proc Natl Acad Sci U S A (2001) 1.30
Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress. Mucosal Immunol (2012) 1.29
Experimental induction of cerebral aneurysms in monkeys. J Neurosurg (1987) 1.28
Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae. Appl Environ Microbiol (1997) 1.22
Antibodies to cell envelope proteins of Pseudomonas aeruginosa in cystic fibrosis patients. Infect Immun (1981) 1.21
Tissue-preferential expression of a rice alpha-tubulin gene, OsTubA1, mediated by the first intron. Plant Physiol (2000) 1.20
N-terminal processing is essential for release of epithin, a mouse type II membrane serine protease. J Biol Chem (2001) 1.20
Isolation of a tetracycline-resistance plasmid excised from a chromosomal DNA sequence in Bacillus subtilis. Plasmid (1983) 1.19
Identification of the calcium binding sites in translationally controlled tumor protein. Arch Pharm Res (2000) 1.19
Human phagocytes have multiple lipid A-binding sites. Infect Immun (1990) 1.18
Kinetic analysis of the interaction of cidofovir diphosphate with human cytomegalovirus DNA polymerase. Biochem Pharmacol (1996) 1.16
Effects of changes in osmolality on the stability and function of cultured chromaffin cells and the possible role of osmotic forces in exocytosis. J Cell Biol (1983) 1.16
Genetic alterations and epithelial dysplasia in juvenile polyposis syndrome and sporadic juvenile polyps. Am J Pathol (1997) 1.15
Physicians' participatory decision-making and quality of diabetes care processes and outcomes: results from the triad study. Chronic Illn (2009) 1.11
Upper limits on a stochastic background of gravitational waves. Phys Rev Lett (2005) 1.11
Ionic interactions in the nitrogenase complex. Properties of Fe-protein containing substitutions for Arg-100. J Biol Chem (1992) 1.10
unc-45 gene of Caenorhabditis elegans encodes a muscle-specific tetratricopeptide repeat-containing protein. Cell Motil Cytoskeleton (1999) 1.10
Structure and copy number of gene clusters related to the pap P-adhesin operon of uropathogenic Escherichia coli. Infect Immun (1989) 1.09
Effects of selective type I and II adrenal steroid agonists on immune cell distribution. Endocrinology (1994) 1.08
Duodenal neoplasms: role of CT. Radiology (1987) 1.08
An oxysterol-derived positive signal for 3-hydroxy- 3-methylglutaryl-CoA reductase degradation in yeast. J Biol Chem (2000) 1.07
Transscleral suture fixation of posterior chamber lenses combined with trabeculectomy. Ophthalmology (2001) 1.07
Early changes of experimentally induced cerebral aneurysms in rats. Light-microscopic study. Am J Pathol (1986) 1.06
Prognostic significance of circulating tumour cells following surgical resection of colorectal cancers: a systematic review. Br J Cancer (2010) 1.05
Formulation and in vivo evaluation of omeprazole buccal adhesive tablet. J Control Release (2000) 1.05
Variability of fine particle deposition in healthy adults: effect of age and gender. Am J Respir Crit Care Med (1996) 1.04
Studies on avian erythrocyte metabolism. Inositol tetrakisphosphate: the major phosphate compound in the erythrocytes of the ostrich (Struthio camelus camelus). Eur J Biochem (1977) 1.04
Structure/function relationship of the cAMP response element in tyrosine hydroxylase gene transcription. J Biol Chem (1997) 1.03
Toxigenic Corynebacterium diphtheriae associated with an equine wound infection. J Vet Diagn Invest (2000) 1.02
Association between birth weight and insulin sensitivity in healthy young men in Korea: role of visceral adiposity. Diabetes Res Clin Pract (2000) 1.01
Induction of myelin basic protein-specific experimental autoimmune encephalomyelitis in C57BL/6 mice: mapping of T cell epitopes and T cell receptor V beta gene segment usage. J Neurosci Res (1996) 1.01
DNA damage in the kidneys of diabetic rats exhibiting microalbuminuria. Free Radic Biol Med (1994) 1.01
Telomere length changes in patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant (1999) 1.00
Stereospecific binding of 3H-phencyclidine in brain membranes. Life Sci (1982) 1.00
Measuring protein degradation with green fluorescent protein. Methods Enzymol (1999) 1.00
Risk factors for early filtration failure requiring suture release after primary glaucoma triple procedure with adjunctive mitomycin. Arch Ophthalmol (1999) 0.99
Homing of T cells to the central nervous system throughout the course of relapsing experimental autoimmune encephalomyelitis in Thy-1 congenic mice. J Neuroimmunol (1993) 0.99
Role of copper in the formation of elastin. Fed Proc (1967) 0.99
Functional analysis of aberrant behavior maintained by automatic reinforcement: assessments of specific sensory reinforcers. Res Dev Disabil (2001) 0.99
Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase. J Biol Chem (1993) 0.98
Photomovement of the gliding cyanobacterium Synechocystis sp. PCC 6803. Photochem Photobiol (1999) 0.98
K562 cells implicate increased chromatin accessibility in Alu transcriptional activation. Nucleic Acids Res (2000) 0.98
Bronchial airway deposition and retention of particles in inhaled boluses: effect of anatomic dead space. J Appl Physiol (1985) (1998) 0.98