Published in Angew Chem Int Ed Engl on September 15, 2000
New chemistry with old functional groups: on the reaction of isonitriles with carboxylic acids--a route to various amide types. J Am Chem Soc (2008) 2.61
Evolution of multi-component anion relay chemistry (ARC): construction of architecturally complex natural and unnatural products. Chem Commun (Camb) (2008) 2.06
Addressing mechanistic issues in the coupling of isonitriles and carboxylic acids: potential routes to peptidic constructs. J Am Chem Soc (2008) 1.97
On the two-component microwave-mediated reaction of isonitriles with carboxylic acids: regarding alleged formimidate carboxylate mixed anhydrides. J Am Chem Soc (2008) 1.96
Applications of multicomponent reactions to the synthesis of diverse heterocyclic scaffolds. Chemistry (2009) 1.60
Strategies for innovation in multicomponent reaction design. Acc Chem Res (2009) 1.34
Ortho-TMS benzaldehyde: an effective linchpin for type II anion relay chemistry (ARC). Angew Chem Int Ed Engl (2008) 1.34
Reaction of isonitriles with carboxylic acids in a cavitand: observation of elusive isoimide intermediates. J Am Chem Soc (2008) 1.29
Noncatalytic reaction of isonitriles and carboxylic acids en route to amide-type linkages. Nat Protoc (2008) 1.21
Microwave-assisted synthesis of a 3-aminoimidazo[1,2-a]-pyridine/pyrazine library by fluorous multicomponent reactions and subsequent cross-coupling reactions. QSAR Comb Sci (2004) 1.18
N-[(2-Hydr-oxy-1-naphthyl)(3-nitro-phenyl)meth-yl]acetamide. Acta Crystallogr Sect E Struct Rep Online (2009) 1.17
Synthesizing our future. Nat Chem (2009) 1.04
Efficient assembly of iminodicarboxamides by a "truly" four-component reaction. Angew Chem Int Ed Engl (2012) 1.03
Stereochemical control of the Passerini reaction. Org Lett (2004) 1.03
Chemistry and catalysis in functional cavitands. Chem Biol (2009) 1.02
Allenamides: a powerful and versatile building block in organic synthesis. Chem Rev (2013) 1.02
Monamphilectine A, a potent antimalarial β-lactam from marine sponge Hymeniacidon sp: isolation, structure, semisynthesis, and bioactivity. Org Lett (2010) 0.99
Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation. J Comb Chem (2006) 0.95
MCR synthesis of praziquantel derivatives. Chem Biol Drug Des (2012) 0.94
General one-pot, two-step protocol accessing a range of novel polycyclic heterocycles with high skeletal diversity. ACS Comb Sci (2012) 0.93
Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity. Proc Natl Acad Sci U S A (2011) 0.92
A fascinating journey into history: exploration of the world of isonitriles en route to complex amides. Angew Chem Int Ed Engl (2012) 0.91
Applications of the Ugi reaction with ketones. Tetrahedron Lett (2008) 0.90
Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP. ACS Chem Biol (2013) 0.89
Concise route to a series of novel 3-(tetrazol-5-yl)quinoxalin-2(1H)-ones. Tetrahedron Lett (2012) 0.88
Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. ACS Chem Biol (2014) 0.87
Syntheses of isochromenes and naphthalenes by electrophilic cyclization of acetylenic arenecarboxaldehydes. J Org Chem (2006) 0.87
Two step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines. Tetrahedron Lett (2010) 0.87
An interrupted Ugi reaction enables the preparation of substituted indoxyls and aminoindoles. Tetrahedron (2009) 0.87
1-{Phen-yl[1-(p-tol-yl)ethyl-amino]meth-yl}-2-naphthol. Acta Crystallogr Sect E Struct Rep Online (2008) 0.87
4-[(2-Hy-droxy-naphthalen-1-yl)(morpholin-4-yl)meth-yl]benzonitrile. Acta Crystallogr Sect E Struct Rep Online (2011) 0.87
Enantioselective synthesis of cyclic carbamimidates via a three-component reaction of imines, terminal alkynes, and p-toluenesulfonylisocyanate using a monophosphine gold(I) catalyst(). Chem Sci (2011) 0.86
Development of a 2-aza-Cope-[3 + 2] dipolar cycloaddition strategy for the synthesis of quaternary proline scaffolds. Org Lett (2010) 0.85
Formation of diverse polycyclic spirooxindoles via three-component reaction of isoquinolinium salts, isatins and malononitrile. Sci Rep (2017) 0.85
Optimization of the Ugi reaction using parallel synthesis and automated liquid handling. J Vis Exp (2008) 0.84
DABCO Catalyzed Synthesis of Xanthene Derivatives in Aqueous Media. ISRN Org Chem (2013) 0.84
Synthesis and Biological Evaluation of Muraymycin Analogues Active against Anti-Drug-Resistant Bacteria. ACS Med Chem Lett (2010) 0.83
A Synthesis of the Tricyclic Core Structure of FR901483 Featuring an Ugi Four-Component Coupling and a Remarkably Selective Elimination Reaction. Synlett (2008) 0.83
Three-component reaction discovery enabled by mass spectrometry of self-assembled monolayers. Nat Chem (2011) 0.83
An Efficient Boric Acid Mediated Preparation of α-Hydroxyamides. Tetrahedron Lett (2010) 0.82
Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays. PLoS One (2009) 0.81
Synthetic studies toward lapidilectine-type Kopsia alkaloids. Org Lett (2012) 0.81
Synthesis of peptide macrocycles using unprotected amino aldehydes. Nat Protoc (2010) 0.81
Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines. Mol Divers (2012) 0.81
Synthesis and preliminary biological evaluation of a small library of hybrid compounds based on Ugi isocyanide multicomponent reactions with a marine natural product scaffold. Bioorg Med Chem Lett (2015) 0.80
Structures, semisyntheses, and absolute configurations of the antiplasmodial α-substituted β-lactam monamphilectines B and C from the sponge Svenzea flava. Tetrahedron (2015) 0.80
Efficient and General Synthesis of 3-Aminoindolines and 3-Aminoindoles via Copper-Catalyzed Three Component Coupling Reaction. Adv Synth Catal (2010) 0.80
1,4-Thienodiazepine-2,5-diones via MCR (II): scaffold hopping by Gewald and Ugi-deprotection-cyclization strategy. Chem Biol Drug Des (2010) 0.80
Straightforward assembly of phenylimidazoquinoxalines via a one-pot two-step MCR process. Org Lett (2012) 0.80
Identification of two novel RET kinase inhibitors through MCR-based drug discovery: design, synthesis and evaluation. Eur J Med Chem (2014) 0.80
Fluorous parallel synthesis of a piperazinedione-fused tricyclic compound library. J Comb Chem (2009) 0.79
Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives. Beilstein J Org Chem (2014) 0.79
Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis. Tetrahedron (2013) 0.78
Diastereoselective three-component synthesis of β-amino carbonyl compounds using diazo compounds, boranes, and acyl imines under catalyst-free conditions. J Org Chem (2014) 0.78
Ugi post-condensation copper-triggered oxidative cascade towards pyrazoles. Beilstein J Org Chem (2011) 0.78
Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase. Virol J (2012) 0.78
An Ugi Reaction Incorporating a Redox-Neutral Amine C-H Functionalization Step. Org Lett (2016) 0.78
Site-specific C-functionalization of free-(NH) peptides and glycine derivatives via direct C-H bond functionalization. Proc Natl Acad Sci U S A (2009) 0.78
Selective N-alkylation of β-alanine facilitates the synthesis of a poly(amino acid)-based theranostic nanoagent. Biomacromolecules (2011) 0.78
Studies toward a library of tetrahydrofurans: click and MCR products of mono- and bis-tetrahydrofurans. J Comb Chem (2010) 0.77
Peptide-cleaving catalyst selective for melanin-concentrating hormone: Oxidative decarboxylation of N-terminal aspartate catalyzed by Co(III)cyclen. J Biol Inorg Chem (2006) 0.77
Diversity oriented one-pot three-component sequential synthesis of annulated benzothiazoloquinazolines. Org Med Chem Lett (2012) 0.77
Isocyanide-Based Multicomponent Reactions for the Synthesis of Heterocycles. Molecules (2015) 0.76
The Ugi four-component reaction as a concise modular synthetic tool for photo-induced electron transfer donor-anthraquinone dyads. Beilstein J Org Chem (2014) 0.76
A Simple, General Synthesis of Carbonimidic Dichlorides. Tetrahedron Lett (2012) 0.76
Studies on the chemistry and reactivity of alpha-substituted ketones in isonitrile-based multicomponent reactions. J Org Chem (2008) 0.75
PEG-embedded KBr(3): A recyclable catalyst for multicomponent coupling reaction for the efficient synthesis of functionalized piperidines. Beilstein J Org Chem (2011) 0.75
N-Hydroxyimide Ugi Reaction toward α-Hydrazino Amides. Org Lett (2017) 0.75
Synthesis of structurally diverse 3,4-dihydropyrimidin-2(1H)-ones via sequential Biginelli and Passerini reactions. Beilstein J Org Chem (2017) 0.75
A Rh(II)-catalyzed multicomponent reaction by trapping an α-amino enol intermediate in a traditional two-component reaction pathway. Sci Adv (2017) 0.75
N-[2-(N-Cyclo-hexyl-carbamo-yl)propan-2-yl]-N-(2-iodo-phen-yl)prop-2-ynamide. Acta Crystallogr Sect E Struct Rep Online (2012) 0.75
Copper Perchlorate Hexahydrate: An Efficient Catalyst for the Green Synthesis of Polyhydroquinolines under Ultrasonication. ISRN Org Chem (2011) 0.75
Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines - sequential versus multicomponent reaction approach. Beilstein J Org Chem (2014) 0.75
Ruthenium-Catalyzed Multicomponent Reactions: Access to α-Silyl-β-Hydroxy Vinylsilanes, Stereodefined 1,3-Dienes, and Cyclohexenes. Chemistry (2016) 0.75
Concise Synthesis of Spergualin-Inspired Molecules With Broad-Spectrum Antibiotic Activity. Medchemcomm (2015) 0.75
Exploiting the Divalent Nature of Isonitriles: a novel Pictet-Spengler Amidination process. Tetrahedron Lett (2014) 0.75
A palladium-catalysed multicomponent coupling approach to conjugated poly(1,3-dipoles) and polyheterocycles. Nat Commun (2015) 0.75
Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization. Beilstein J Org Chem (2012) 0.75
Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues. Beilstein J Org Chem (2014) 0.75
One-pot synthesis of tetracyclic fused imidazo[1,2-a]pyridines via a three-component reaction. Beilstein J Org Chem (2016) 0.75
1-[(3-Chloro-phen-yl)(morpholin-4-yl)-meth-yl]naphthalen-2-ol. Acta Crystallogr Sect E Struct Rep Online (2011) 0.75
Solvent-Free Green and Efficient One-Pot Synthesis of Dihydropyrano[3,2-c]chromene Derivatives. ISRN Org Chem (2013) 0.75
Benzyl 5-phenyl-pyrazolo-[5,1-a]isoquino-line-1-carboxyl-ate. Acta Crystallogr Sect E Struct Rep Online (2011) 0.75
Application of heterocyclic aldehydes as components in Ugi-Smiles couplings. Beilstein J Org Chem (2016) 0.75
Dipyrazolo[1,5-a:4',3'-c]pyridines - a new heterocyclic system accessed via multicomponent reaction. Beilstein J Org Chem (2012) 0.75
Focusing on shared subpockets - new developments in fragment-based drug discovery. Expert Opin Drug Discov (2015) 0.75
Synthesis of acylhydrazino-peptomers, a new class of peptidomimetics, by consecutive Ugi and hydrazino-Ugi reactions. Beilstein J Org Chem (2016) 0.75
Regioselectivity in the multicomponent reaction of 5-aminopyrazoles, cyclic 1,3-diketones and dimethylformamide dimethylacetal under controlled microwave heating. Beilstein J Org Chem (2012) 0.75
Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods. Angew Chem Int Ed Engl (2015) 0.75
Metal-free [3 + 2 + 1]/[2 + 2 + 1] biscyclization: stereospecific construction with concomitant functionalization of indolizin-5(1H)-one. J Org Chem (2013) 0.75
ZnO Catalyzed Efficient Synthesis of Some New 2-Substituted-4,6-diarylpyrimidines. ISRN Org Chem (2012) 0.75
Facile synthesis of 1H-imidazo[1,2-b]pyrazoles via a sequential one-pot synthetic approach. Beilstein J Org Chem (2014) 0.75
Post-Ugi gold-catalyzed diastereoselective domino cyclization for the synthesis of diversely substituted spiroindolines. Beilstein J Org Chem (2013) 0.75
Expanding the substrate scope of Ugi five-center, four-component reaction U-5C-4CR): ketones as coupling partners for secondary amino acids. Mol Divers (2013) 0.75
Solid-phase synthesis of N-substituted pyrrolidinone-tethered N-substituted piperidines via Ugi reaction. J Comb Chem (2010) 0.75
One-pot synthesis of β-acetamido ketones using boric acid at room temperature. ScientificWorldJournal (2012) 0.75
Features of the behavior of 4-amino-5-carboxamido-1,2,3-triazole in multicomponent heterocyclizations with carbonyl compounds. Beilstein J Org Chem (2012) 0.75
Cysteine isocyanide in multicomponent reaction: Synthesis of peptido-mimetic 1,3-azoles. J Org Chem (2017) 0.75
Angiotensin-cleaving catalysts: conversion of N-terminal aspartate to pyruvate through oxidative decarboxylation catalyzed by Co(III)cyclen. J Biol Inorg Chem (2005) 0.75