The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2.

PubWeight™: 2.36‹?› | Rank: Top 2%

🔗 View Article (PMID 11056537)

Published in Nat Cell Biol on November 01, 2000

Authors

P M Ojala1, K Yamamoto, E Castaños-Vélez, P Biberfeld, S J Korsmeyer, T P Mäkelä

Author Affiliations

1: Haartman Institute & Biocentrum Helsinki, University of Helsinki, PO Box 21, Haartmaninkatu 3, 00014 Helsinki, Finland. Paivi.Ojala@helsinki.fi

Articles citing this

The importance of intrinsic disorder for protein phosphorylation. Nucleic Acids Res (2004) 8.23

Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J Clin Invest (2004) 4.97

Kaposi's sarcoma and its associated herpesvirus. Nat Rev Cancer (2010) 3.55

Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis. Microbiol Mol Biol Rev (2003) 2.90

Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J (2004) 2.77

TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression. Proc Natl Acad Sci U S A (2008) 2.58

Role of glycogen synthase kinase-3beta in cardioprotection. Circ Res (2009) 2.10

Kaposi's sarcoma-associated herpesvirus immunoevasion and tumorigenesis: two sides of the same coin? Annu Rev Microbiol (2003) 2.07

Nuclear export of phosphorylated galectin-3 regulates its antiapoptotic activity in response to chemotherapeutic drugs. Mol Cell Biol (2004) 1.63

Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus. Proc Natl Acad Sci U S A (2002) 1.52

Transcripts encoding K12, v-FLIP, v-cyclin, and the microRNA cluster of Kaposi's sarcoma-associated herpesvirus originate from a common promoter. J Virol (2005) 1.50

Molecular biology of KSHV in relation to AIDS-associated oncogenesis. Cancer Treat Res (2007) 1.47

Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. J Virol (2002) 1.33

A surface groove essential for viral Bcl-2 function during chronic infection in vivo. PLoS Pathog (2005) 1.30

Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen prolongs the life span of primary human umbilical vein endothelial cells. J Virol (2003) 1.28

Intracellular localization map of human herpesvirus 8 proteins. J Virol (2007) 1.16

Protection against ischemic brain injury by protein therapeutics. Proc Natl Acad Sci U S A (2002) 1.11

Glycyrrhizic acid alters Kaposi sarcoma-associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytes. J Clin Invest (2005) 1.11

Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Sci (2007) 1.11

Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization. Proc Natl Acad Sci U S A (2009) 1.05

Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1. Neoplasia (2002) 1.04

Induction of p53-independent apoptosis by simian virus 40 small t antigen. J Virol (2001) 1.01

KSHV: pathways to tumorigenesis and persistent infection. Adv Virus Res (2014) 0.99

Tissue specificity of the Kaposi's sarcoma-associated herpesvirus latent nuclear antigen (LANA/orf73) promoter in transgenic mice. J Virol (2002) 0.98

Kaposi's sarcoma-associated herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor. J Virol (2007) 0.97

Fowlpox virus encodes a Bcl-2 homologue that protects cells from apoptotic death through interaction with the proapoptotic protein Bak. J Virol (2007) 0.96

Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression. PLoS One (2012) 0.93

Characterization of the interaction between human respiratory syncytial virus and the cell cycle in continuous cell culture and primary human airway epithelial cells. J Virol (2011) 0.92

Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1. Neoplasia (2001) 0.91

Connective tissue growth factor (CTGF) promotes activated mesangial cell survival via up-regulation of mitogen-activated protein kinase phosphatase-1 (MKP-1). Biochem J (2007) 0.89

The modulation of apoptosis by oncogenic viruses. Virol J (2013) 0.89

KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo. Cell Cycle (2014) 0.87

KSHV downregulation of galectin-3 in Kaposi's sarcoma. Glycobiology (2009) 0.85

Why anti-Bcl-2 clinical trials fail: a solution. Cancer Metastasis Rev (2014) 0.84

Inhibition of apoptosis in Cryptosporidium parvum-infected intestinal epithelial cells is dependent on survivin. Infect Immun (2008) 0.84

CAK-independent activation of CDK6 by a viral cyclin. Mol Biol Cell (2001) 0.84

GLTSCR2/PICT-1, a putative tumor suppressor gene product, induces the nucleolar targeting of the Kaposi's sarcoma-associated herpesvirus KS-Bcl-2 protein. J Virol (2009) 0.83

HIV-1 expression induces cyclin D1 expression and pRb phosphorylation in infected podocytes: cell-cycle mechanisms contributing to the proliferative phenotype in HIV-associated nephropathy. BMC Microbiol (2002) 0.83

Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins. J Mol Biol (2015) 0.82

Viral cyclin promotes KSHV-induced cellular transformation and tumorigenesis by overriding contact inhibition. Cell Cycle (2014) 0.81

Viral Bcl-2 Encoded by the Kaposi's Sarcoma-Associated Herpesvirus Is Vital for Virus Reactivation. J Virol (2015) 0.80

Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak. Cell Death Discov (2016) 0.79

Detrimental effects of antiapoptotic treatments in spinal cord injury. Exp Neurol (2007) 0.79

Regulation of growth signalling and cell cycle by Kaposi's sarcoma-associated herpesvirus genes. Int J Exp Pathol (2004) 0.79

Cyclin' on the viral path to destruction. Nat Cell Biol (2000) 0.79

Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer. Infect Agent Cancer (2014) 0.77

The Viral Bcl-2 Homologs of Kaposi's Sarcoma-Associated Herpesvirus and Rhesus Rhadinovirus Share an Essential Role for Viral Replication. J Virol (2017) 0.76

The Modulation of Apoptotic Pathways by Gammaherpesviruses. Front Microbiol (2016) 0.76

Pre-ischemia electro-acupuncture potentiates the expression of Bcl-2 and transforming growth factor-beta 1 in rat brains. Neural Regen Res (2012) 0.75

Verifying the stability of selected genes for normalization in Q PCR experiments of Spodoptera frugiperda cells during AcMNPV infection. PLoS One (2014) 0.75

Cyclin-cyclin-dependent kinase regulatory response is linked to substrate recognition. J Biol Chem (2011) 0.75

Preparation and application of polyclonal antibodiesagainst KSHV v-cyclin. J Biomed Res (2013) 0.75

Articles by these authors

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell (1993) 20.72

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature (1990) 14.46

BCL-2 family members and the mitochondria in apoptosis. Genes Dev (1999) 13.52

Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins. Proc Natl Acad Sci U S A (2000) 10.98

Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell (1993) 10.83

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) Cell (1996) 10.83

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell (2001) 9.33

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell (1995) 8.75

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev (2000) 8.35

Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science (1986) 8.15

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell (1991) 8.13

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell (1985) 7.29

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell (1993) 7.25

Hd1, a major photoperiod sensitivity quantitative trait locus in rice, is closely related to the Arabidopsis flowering time gene CONSTANS. Plant Cell (2000) 6.93

Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science (1995) 6.84

A high-density rice genetic linkage map with 2275 markers using a single F2 population. Genetics (1998) 6.82

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature (1994) 6.69

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell (1989) 6.66

Altered Hox expression and segmental identity in Mll-mutant mice. Nature (1995) 6.60

BCL-2 family: regulators of cell death. Annu Rev Immunol (1998) 6.41

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature (1999) 6.37

Cell death in development. Cell (1999) 6.01

BID: a novel BH3 domain-only death agonist. Genes Dev (1996) 5.90

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J (1998) 5.78

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci U S A (1991) 5.50

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature (1996) 5.45

Isolation of single-copy human genes from a library of yeast artificial chromosome clones. Science (1989) 5.29

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J Immunol (1990) 5.26

Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes. Virology (1992) 5.16

Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood (1996) 5.13

A 300 kilobase interval genetic map of rice including 883 expressed sequences. Nat Genet (1994) 5.08

Clustered arrangement of immunoglobulin lambda constant region genes in man. Nature (1981) 4.87

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem (1999) 4.56

Culture conditions for stimulating cholera toxin production by Vibrio cholerae O1 El Tor. Microbiol Immunol (1986) 4.38

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci U S A (1995) 4.22

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Proc Natl Acad Sci U S A (1996) 4.20

Regulated targeting of BAX to mitochondria. J Cell Biol (1998) 4.17

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18). Nature (1991) 4.06

BAX is required for neuronal death after trophic factor deprivation and during development. Neuron (1996) 4.02

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol (1999) 4.00

Ultrastructural features of Mycoplasma pneumoniae. J Bacteriol (1970) 3.84

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma. EMBO J (1988) 3.77

Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proc Natl Acad Sci U S A (1981) 3.73

Experimental transmission of Bartonella henselae by the cat flea. J Clin Microbiol (1996) 3.67

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc Natl Acad Sci U S A (1997) 3.66

Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells. Nature (1981) 3.64

BAX-dependent transport of cytochrome c reconstituted in pure liposomes. Nat Cell Biol (2000) 3.53

Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci U S A (1999) 3.46

Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell (1999) 3.46

Checkpoints of dueling dimers foil death wishes. Cell (1994) 3.45

Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Biochem Sci (1994) 3.36

Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci U S A (1999) 3.35

A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma. Nat Med (1995) 3.30

Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J Immunol (1993) 3.28

Expression of interleukin 2 receptors on activated human B cells. J Exp Med (1984) 3.27

Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence. J Biol Chem (1993) 3.21

Production of cholera-like enterotoxin by a Vibrio cholerae non-O1 strain isolated from the environment. Infect Immun (1981) 3.21

Mcl-1 deficiency results in peri-implantation embryonic lethality. Genes Dev (2000) 3.21

FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. EMBO J (1991) 3.19

Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners. Proc Natl Acad Sci U S A (1987) 3.18

Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol Cell Biol (1996) 3.15

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci U S A (2001) 3.11

Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature (1997) 3.10

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science (2000) 3.06

Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science (2001) 2.99

Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Blood (1996) 2.98

Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms. N Engl J Med (1983) 2.96

Bcl-XL and Bcl-2 repress a common pathway of cell death. J Exp Med (1995) 2.94

AIDS-Kaposi's sarcoma-derived cells express cytokines with autocrine and paracrine growth effects. Science (1989) 2.93

Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol (1999) 2.92

Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. J Clin Invest (1983) 2.91

Association of Cdk-activating kinase subunits with transcription factor TFIIH. Nature (1995) 2.87

Widespread elimination of naturally occurring neuronal death in Bax-deficient mice. J Neurosci (1998) 2.80

Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nat Genet (2001) 2.79

Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proc Natl Acad Sci U S A (1999) 2.76

Similarity among the Drosophila (6-4)photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family. Science (1996) 2.74

Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia. Proc Natl Acad Sci U S A (1983) 2.73

Non-O1 Vibrio cholerae hemolysin: purification, partial characterization, and immunological relatedness to El Tor hemolysin. Infect Immun (1984) 2.72

The NPH4 locus encodes the auxin response factor ARF7, a conditional regulator of differential growth in aerial Arabidopsis tissue. Plant Cell (2000) 2.68

MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis. Proc Natl Acad Sci U S A (1998) 2.65

A uniform deleting element mediates the loss of kappa genes in human B cells. Nature (1985) 2.65

Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest (1993) 2.64

Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. Science (1991) 2.64

Bcl-2 and Bax function independently to regulate cell death. Nat Genet (1997) 2.64

Purification and some properties of a non-o1 Vibrio cholerae enterotoxin that is identical to cholera enterotoxin. Infect Immun (1983) 2.62

Signaling through the hematopoietic cytokine receptors. Annu Rev Immunol (1995) 2.61

BRCT domain-containing protein TopBP1 functions in DNA replication and damage response. J Biol Chem (2001) 2.60

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc Natl Acad Sci U S A (1997) 2.59

Outbreak of Burkitt's-like lymphoma in homosexual men. Lancet (1982) 2.58

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Mol Cell Biol (2001) 2.58

Purification and partial characterization of heat-stable enterotoxin of enterotoxigenic Escherichia coli. Infect Immun (1979) 2.55

Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J Biol Chem (1999) 2.52

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists. Cell (1999) 2.51

Enterotoxicity of El Tor-like hemolysin of non-O1 Vibrio cholerae. Infect Immun (1987) 2.46

Association of amino acid substitutions in penicillin-binding protein 3 with beta-lactam resistance in beta-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob Agents Chemother (2001) 2.46

A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c. EMBO J (2001) 2.44

Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an enterohemorrhagic Escherichia coli O157:H7 derived from Sakai outbreak. DNA Res (1998) 2.43