Published in Proc Natl Acad Sci U S A on November 21, 2000
Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag). Proc Natl Acad Sci U S A (2001) 5.83
Persistent and transient replication of full-length hepatitis C virus genomes in cell culture. J Virol (2002) 5.21
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell (2007) 5.20
Viral late domains. J Virol (2002) 4.51
Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2. Proc Natl Acad Sci U S A (2000) 4.31
Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. Proc Natl Acad Sci U S A (2003) 4.21
Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function. Proc Natl Acad Sci U S A (2002) 4.14
Ubiquitin is part of the retrovirus budding machinery. Proc Natl Acad Sci U S A (2000) 3.83
The Trojan exosome hypothesis. Proc Natl Acad Sci U S A (2003) 3.45
Role of ESCRT-I in retroviral budding. J Virol (2003) 3.36
APOBEC3G incorporation into human immunodeficiency virus type 1 particles. J Virol (2004) 3.17
Overlapping motifs (PTAP and PPEY) within the Ebola virus VP40 protein function independently as late budding domains: involvement of host proteins TSG101 and VPS-4. J Virol (2003) 3.05
Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells. Proc Natl Acad Sci U S A (2001) 3.04
Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. J Cell Biol (2002) 2.94
The late domain of human immunodeficiency virus type 1 p6 promotes virus release in a cell type-dependent manner. J Virol (2002) 2.66
Rhabdoviruses and the cellular ubiquitin-proteasome system: a budding interaction. J Virol (2001) 2.66
ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity. Proc Natl Acad Sci U S A (2008) 2.48
Binding and susceptibility to postentry restriction factors in monkey cells are specified by distinct regions of the human immunodeficiency virus type 1 capsid. J Virol (2004) 2.41
Structure and functional interactions of the Tsg101 UEV domain. EMBO J (2002) 2.40
HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. J Cell Biol (2003) 2.38
HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway. J Cell Biol (2004) 2.34
Functional involvement of a novel Nedd4-like ubiquitin ligase on retrovirus budding. EMBO Rep (2002) 2.22
The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release. J Virol (2003) 2.19
Distinct domains of the influenza a virus M2 protein cytoplasmic tail mediate binding to the M1 protein and facilitate infectious virus production. J Virol (2006) 2.18
The ubiquitin-proteasome pathway and proteasome inhibitors. Med Res Rev (2001) 2.18
Ubiquitin in retrovirus assembly: actor or bystander? Proc Natl Acad Sci U S A (2000) 2.08
Inhibition of lysosome and proteasome function enhances human immunodeficiency virus type 1 infection. J Virol (2005) 2.05
Requirements for budding of paramyxovirus simian virus 5 virus-like particles. J Virol (2002) 2.02
Ebola virus VP40 late domains are not essential for viral replication in cell culture. J Virol (2005) 1.97
Context-dependent effects of L domains and ubiquitination on viral budding. J Virol (2004) 1.92
PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101 [corrected]. J Virol (2003) 1.80
Defects in human immunodeficiency virus budding and endosomal sorting induced by TSG101 overexpression. J Virol (2003) 1.79
Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions. Cell Death Differ (2010) 1.77
Virus budding and the ESCRT pathway. Cell Host Microbe (2013) 1.70
Structural basis for viral late-domain binding to Alix. Nat Struct Mol Biol (2007) 1.69
Budding of equine infectious anemia virus is insensitive to proteasome inhibitors. J Virol (2002) 1.67
Budding of PPxY-containing rhabdoviruses is not dependent on host proteins TGS101 and VPS4A. J Virol (2004) 1.64
Equine infectious anemia virus and the ubiquitin-proteasome system. J Virol (2002) 1.63
The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis. Proc Natl Acad Sci U S A (2008) 1.63
Late assembly domain function can exhibit context dependence and involves ubiquitin residues implicated in endocytosis. J Virol (2002) 1.61
Functional replacement and positional dependence of homologous and heterologous L domains in equine infectious anemia virus replication. J Virol (2002) 1.60
NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and YPXL late domains. J Virol (2008) 1.60
Late domain-dependent inhibition of equine infectious anemia virus budding. J Virol (2004) 1.57
The genome of canarypox virus. J Virol (2004) 1.56
How ubiquitin functions with ESCRTs. Traffic (2011) 1.51
Ubiquitin-dependent virus particle budding without viral protein ubiquitination. Proc Natl Acad Sci U S A (2007) 1.51
Pyrrolidine dithiocarbamate reduces coxsackievirus B3 replication through inhibition of the ubiquitin-proteasome pathway. J Virol (2005) 1.50
No strings attached: the ESCRT machinery in viral budding and cytokinesis. J Cell Sci (2009) 1.50
The PPPY motif of human T-cell leukemia virus type 1 Gag protein is required early in the budding process. J Virol (2002) 1.45
Mammalian Orc1 protein is selectively released from chromatin and ubiquitinated during the S-to-M transition in the cell division cycle. Mol Cell Biol (2002) 1.44
Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway. Mol Cell Biol (2008) 1.41
Efficient and specific rescue of human immunodeficiency virus type 1 budding defects by a Nedd4-like ubiquitin ligase. J Virol (2008) 1.41
Kaposi's sarcoma-associated herpesvirus K3 utilizes the ubiquitin-proteasome system in routing class major histocompatibility complexes to late endocytic compartments. J Virol (2002) 1.36
Late assembly motifs of human T-cell leukemia virus type 1 and their relative roles in particle release. J Virol (2004) 1.34
Retroviruses have differing requirements for proteasome function in the budding process. J Virol (2003) 1.34
Intracellular trafficking and maturation of herpes simplex virus type 1 gB and virus egress require functional biogenesis of multivesicular bodies. J Virol (2007) 1.33
Human immunodeficiency virus type 1 Gag contains a dileucine-like motif that regulates association with multivesicular bodies. J Virol (2004) 1.32
Ebola virus matrix protein VP40 uses the COPII transport system for its intracellular transport. Cell Host Microbe (2008) 1.31
The clathrin adaptor complex AP-1 binds HIV-1 and MLV Gag and facilitates their budding. Mol Biol Cell (2007) 1.30
Nonstructural protein 3 of bluetongue virus assists virus release by recruiting ESCRT-I protein Tsg101. J Virol (2006) 1.30
Equine infectious anemia virus utilizes host vesicular protein sorting machinery during particle release. J Virol (2003) 1.27
Role of Nedd4 and ubiquitination of Rous sarcoma virus Gag in budding of virus-like particles from cells. J Virol (2004) 1.27
Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding. J Virol (2010) 1.27
Efficient assembly of an HIV-1/MLV Gag-chimeric virus in murine cells. Proc Natl Acad Sci U S A (2001) 1.26
A bipartite late-budding domain in human immunodeficiency virus type 1. J Virol (2003) 1.25
Antiviral activity of innate immune protein ISG15. J Innate Immun (2009) 1.25
Functional roles of equine infectious anemia virus Gag p9 in viral budding and infection. J Virol (2001) 1.24
Resistance to nucleoside analog reverse transcriptase inhibitors mediated by human immunodeficiency virus type 1 p6 protein. J Virol (2001) 1.22
Autographa californica multiple nucleopolyhedrovirus exon0 (orf141), which encodes a RING finger protein, is required for efficient production of budded virus. J Virol (2004) 1.20
HECT E3s and human disease. BMC Biochem (2007) 1.19
Proteasome inhibition reduces coxsackievirus B3 replication in murine cardiomyocytes. Am J Pathol (2003) 1.19
Both the PPPY and PTAP motifs are involved in human T-cell leukemia virus type 1 particle release. J Virol (2004) 1.17
Dissociation of rabies virus matrix protein functions in regulation of viral RNA synthesis and virus assembly. J Virol (2003) 1.17
Lysines close to the Rous sarcoma virus late domain critical for budding. J Virol (2004) 1.16
Analysis of human immunodeficiency virus type 1 Gag ubiquitination. J Virol (2005) 1.15
Functional replacement of a retroviral late domain by ubiquitin fusion. Traffic (2008) 1.14
The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production. Proc Natl Acad Sci U S A (2005) 1.14
Endophilins interact with Moloney murine leukemia virus Gag and modulate virion production. J Biol (2003) 1.14
Cumulative mutations of ubiquitin acceptor sites in human immunodeficiency virus type 1 gag cause a late budding defect. J Virol (2006) 1.11
Functional interchangeability of late domains, late domain cofactors and ubiquitin in viral budding. PLoS Pathog (2010) 1.10
Ubiquitination is required for effective replication of coxsackievirus B3. PLoS One (2008) 1.09
The late-domain-containing protein p6 is the predominant phosphoprotein of human immunodeficiency virus type 1 particles. J Virol (2002) 1.04
The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle. J Virol (2010) 1.04
Rescue of HIV-1 release by targeting widely divergent NEDD4-type ubiquitin ligases and isolated catalytic HECT domains to Gag. PLoS Pathog (2010) 1.03
GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation. J Neurochem (2008) 0.99
Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses. J Virol (2014) 0.99
Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding. Retrovirology (2013) 0.98
The deubiquitinating enzyme Ubp1 affects sorting of the ATP-binding cassette-transporter Ste6 in the endocytic pathway. Mol Biol Cell (2005) 0.97
Dysregulation of the ubiquitin-proteasome system by curcumin suppresses coxsackievirus B3 replication. J Virol (2007) 0.97
Heterologous late-domain sequences have various abilities to promote budding of human immunodeficiency virus type 1. J Virol (2005) 0.97
The role of WWP1-Gag interaction and Gag ubiquitination in assembly and release of human T-cell leukemia virus type 1. J Virol (2007) 0.96
In vivo interference of Rous sarcoma virus budding by cis expression of a WW domain. J Virol (2002) 0.95
Ubiquitination of human immunodeficiency virus type 1 Gag is highly dependent on Gag membrane association. J Virol (2007) 0.93
Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets. Cancer Biol Ther (2010) 0.93
Role of the feline immunodeficiency virus L-domain in the presence or absence of Gag processing: involvement of ubiquitin and Nedd4-2s ligase in viral egress. J Cell Physiol (2009) 0.92
Feline tetherin is characterized by a short N-terminal region and is counteracted by the feline immunodeficiency virus envelope glycoprotein. J Virol (2012) 0.92
Citron kinase, a RhoA effector, enhances HIV-1 virion production by modulating exocytosis. Traffic (2006) 0.91
The late stage of human immunodeficiency virus type 1 assembly is an energy-dependent process. J Virol (2001) 0.91
L-domain flanking sequences are important for host interactions and efficient budding of vesicular stomatitis virus recombinants. J Virol (2005) 0.90
Ubiquitin-dependent protein degradation. Annu Rev Genet (1996) 10.97
Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release. Proc Natl Acad Sci U S A (1991) 10.05
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell (1994) 8.65
p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease. J Virol (1995) 6.87
Functional association of cyclophilin A with HIV-1 virions. Nature (1994) 6.82
An assembly domain of the Rous sarcoma virus Gag protein required late in budding. J Virol (1994) 5.87
WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. EMBO J (1996) 5.24
Positionally independent and exchangeable late budding functions of the Rous sarcoma virus and human immunodeficiency virus Gag proteins. J Virol (1995) 4.92
Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2. Proc Natl Acad Sci U S A (2000) 4.31
Equine infectious anemia virus utilizes a YXXL motif within the late assembly domain of the Gag p9 protein. J Virol (1997) 4.08
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. EMBO J (1997) 4.01
Fine mapping and characterization of the Rous sarcoma virus Pr76gag late assembly domain. J Virol (1996) 3.97
A proline-rich motif within the matrix protein of vesicular stomatitis virus and rabies virus interacts with WW domains of cellular proteins: implications for viral budding. J Virol (1999) 3.92
Ubiquitin is part of the retrovirus budding machinery. Proc Natl Acad Sci U S A (2000) 3.83
Efficient particle production by minimal Gag constructs which retain the carboxy-terminal domain of human immunodeficiency virus type 1 capsid-p2 and a late assembly domain. J Virol (2000) 3.77
A proline-rich motif (PPPY) in the Gag polyprotein of Mason-Pfizer monkey virus plays a maturation-independent role in virion release. J Virol (1998) 3.69
Mutations altering the moloney murine leukemia virus p12 Gag protein affect virion production and early events of the virus life cycle. EMBO J (1999) 3.67
Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels. Trends Cell Biol (1999) 3.37
The intracisternal A-particle gene family: structure and functional aspects. Adv Cancer Res (1988) 3.26
WW domains and retrovirus budding. Nature (1996) 3.10
Late domain function identified in the vesicular stomatitis virus M protein by use of rhabdovirus-retrovirus chimeras. J Virol (1999) 2.90
A function for monoubiquitination in the internalization of a G protein-coupled receptor. Mol Cell (1998) 2.81
Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: effects on replication, transcription, translation, and the cellular stress response. Biochemistry (1997) 2.73
Equine infectious anemia virus Gag polyprotein late domain specifically recruits cellular AP-2 adapter protein complexes during virion assembly. J Virol (1998) 2.68
Monoubiquitin carries a novel internalization signal that is appended to activated receptors. EMBO J (2000) 2.54
Lactacystin, proteasome function, and cell fate. J Biol Chem (1998) 2.33
Ubiquitin in avian leukosis virus particles. Virology (1990) 2.13
Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions. Trends Cell Biol (1999) 2.03
The ubiquitin-proteasome system and endocytosis. J Cell Sci (1999) 1.87
Identification of novel human WW domain-containing proteins by cloning of ligand targets. J Biol Chem (1997) 1.78
Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination. Kidney Int (2000) 1.67
The gap junction protein connexin43 is degraded via the ubiquitin proteasome pathway. J Biol Chem (1995) 1.64
Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor. EMBO J (1999) 1.58
Release of bluetongue virus-like particles from insect cells is mediated by BTV nonstructural protein NS3/NS3A. Virology (1993) 1.39
Localization of the non-structural protein NS3 in bluetongue virus-infected cells. J Gen Virol (1991) 1.13
The release of bluetongue virus from infected cells and their superinfection by progeny virus. Virology (1989) 1.10
Membrane organization of bluetongue virus nonstructural glycoprotein NS3. J Virol (1998) 1.05
Structure of Broadhaven virus by cryoelectron microscopy: correlation of structural and antigenic properties of Broadhaven virus and bluetongue virus outer capsid proteins. Virology (1997) 1.03
Comparison of the nonstructural protein, NS3, of tick-borne and insect-borne orbiviruses. Virology (1992) 0.86
Metal ion measurement as a diagnostic tool to identify problems with metal-on-metal hip resurfacing. J Bone Joint Surg Am (2008) 1.85
Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence. Proc Natl Acad Sci U S A (1997) 1.68
6-Aminoquinolones as new potential anti-HIV agents. J Med Chem (2000) 1.05
The effect of the minor groove binding agent DAPI (4,6-diamidino-2-phenyl-indole) on DNA-directed enzymes: an attempt to explain inhibition of plasmid expression in Escherichia coli [corrected]. FEMS Microbiol Lett (1990) 1.03
Whole genome sequencing and phylogenetic analysis of West Nile virus lineage 1 and lineage 2 from human cases of infection, Italy, August 2013. Euro Surveill (2013) 1.03
Human cases of West Nile Virus infection in north-eastern Italy, 15 June to 15 November 2010. Euro Surveill (2011) 1.01
Molecular basis of the interactions between herpes simplex viruses and HIV-1. Herpes (2001) 1.01
West Nile virus infection in Veneto region, Italy, 2008-2009. Euro Surveill (2009) 0.97
Metal ion levels from well-functioning Birmingham Hip Resurfacings decline significantly at ten years. Bone Joint J (2013) 0.88
New endemic West Nile virus lineage 1a in northern Italy, July 2012. Euro Surveill (2012) 0.88
Prevalence of IgM and IgG antibodies to West Nile virus among blood donors in an affected area of north-eastern Italy, summer 2009. Euro Surveill (2011) 0.86
Oncolysis of pancreatic tumour cells by a gamma34.5-deleted HSV-1 does not rely upon Ras-activation, but on the PI 3-kinase pathway. Gene Ther (2006) 0.85
The nature of remission in acute myeloblastic leukaemia. Lancet (1979) 0.85
An evaluation of near patient tests for detecting herpes simplex virus type-2 antibody. Sex Transm Infect (2000) 0.85
Enhanced cytotoxicity against colon carcinoma by combinations of noncompeting monoclonal antibodies to the 17-1A antigen. Cancer Res (1988) 0.83
Back pain in pregnancy: 1-year follow-up of untreated cases. Eur Spine J (2004) 0.80
A new antisense tRNA construct for the genetic treatment of human immunodeficiency virus type 1 infection. J Virol (1996) 0.80
Evaluation of a near-patient test and 2 enzyme-linked immunosorbent assay-based assays for detecting anti-herpes simplex virus type-2 antibodies. Scand J Infect Dis (2001) 0.79
HIV-1-mediated delivery of a short hairpin RNA targeting vascular endothelial growth factor in human retinal pigment epithelium cells. Br J Ophthalmol (2009) 0.79
Asymptomatic herpes simplex type 1 virus infection of the mouse brain. J Neurovirol (2000) 0.79
Brain resistance to HSV-1 encephalitis in a mouse model. J Neurovirol (2002) 0.77
In vitro antiviral activity of hypothiocyanite against A/H1N1/2009 pandemic influenza virus. Int J Hyg Environ Health (2013) 0.77
Hip resurfacing: expectations and limitations. Acta Orthop (2009) 0.75
[Calcitonin in orthopedics and traumatology]. Clin Ter (1982) 0.75
N-methylmitomycin A cross-linking to nucleosomal structure. Anticancer Drug Des (1990) 0.75
[Surgical treatment of fractures of the tibial plate]. Chir Organi Mov (1983) 0.75
Photoreaction of psoralen derivatives with structurally organized DNA. Photochem Photobiol (1987) 0.75
[Salmon calcitonin in supportive therapy of neoplastic osteolysis. Preliminary report on a case of myeloma]. Clin Ter (1981) 0.75
ALEX (artificial liver for extracorporeal xenoassistance): a new bioreactor containing a porcine autologous biomatrix as hepatocyte support. Preliminary results in an ex vivo experimental model. Int J Artif Organs (2002) 0.75
Construction of a fusion protein between B subunit of E. coli heat-labile enterotoxin and the C-terminus of herpes simplex virus-DNA polymerase. Biochem Soc Trans (1995) 0.75
False positive bone scan in bone tumors of the lower limb. Eur J Nucl Med (1977) 0.75
DAPI-pUC8 complex: a tool to investigate biological effects of nucleic acid-drug interaction. Biochem Biophys Res Commun (1987) 0.75
Sphingomonas paucimobilis associated with localised calf myositis. J Neurol Neurosurg Psychiatry (2008) 0.75
Identification and characterization of an extracellular protease activity produced by the marine Vibrio sp. 60. FEMS Microbiol Lett (1996) 0.75
Analysis of human immunodeficiency virus type 1 vector cis- and trans-acting elements production by means of Semliki Forest virus. Gene Ther (2008) 0.75