Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway.

PubWeight™: 1.85‹?› | Rank: Top 3%

🔗 View Article (PMC 4381838)

Published in Nat Struct Biol on December 01, 2000

Authors

H C Wong1, J Mao, J T Nguyen, S Srinivas, W Zhang, B Liu, L Li, D Wu, J Zheng

Author Affiliations

1: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Articles citing this

Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell (2003) 3.06

Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling. Dev Cell (2007) 1.99

Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. Nat Cell Biol (2009) 1.80

Crystal structure of the multifunctional Gbeta5-RGS9 complex. Nat Struct Mol Biol (2008) 1.52

Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling. Cold Spring Harb Perspect Biol (2012) 1.43

Casein kinase Iepsilon modulates the signaling specificities of dishevelled. Mol Cell Biol (2004) 1.41

A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin. Genetics (2002) 1.39

Identification of four candidate cGMP targets in Dictyostelium. Proc Natl Acad Sci U S A (2002) 1.38

The way Wnt works: components and mechanism. Growth Factors (2012) 1.37

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. J Biol Chem (2009) 1.34

Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Biol Chem (2011) 1.32

Direct spatial control of Epac1 by cyclic AMP. Mol Cell Biol (2009) 1.17

Diversin regulates heart formation and gastrulation movements in development. Proc Natl Acad Sci U S A (2006) 1.16

Structural insight into the mechanisms of Wnt signaling antagonism by Dkk. J Biol Chem (2008) 1.16

The various roles of ubiquitin in Wnt pathway regulation. Cell Cycle (2010) 1.08

Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled. Proc Natl Acad Sci U S A (2012) 1.07

Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. J Biol Chem (2010) 1.06

Structural features of the focal adhesion kinase-paxillin complex give insight into the dynamics of focal adhesion assembly. Protein Sci (2005) 1.06

Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure (2010) 1.04

Beta-catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells. Proc Natl Acad Sci U S A (2005) 0.98

cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane. Proc Natl Acad Sci U S A (2012) 0.96

Planar cell polarity in Drosophila. Organogenesis (2011) 0.95

Functional dissection of phosphorylation of Disheveled in Drosophila. Dev Biol (2011) 0.93

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Protein Sci (2009) 0.92

Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o. Mol Pharmacol (2004) 0.90

Structural modification of acyl carrier protein by butyryl group. Protein Sci (2009) 0.90

Phosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase. Biochemistry (2007) 0.88

Identification of tripeptides recognized by the PDZ domain of Dishevelled. Bioorg Med Chem (2009) 0.88

Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts. J Cell Sci (2012) 0.87

Dishevelled-2 docks and activates Src in a Wnt-dependent manner. J Cell Sci (2009) 0.87

Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects. J Mol Neurosci (2012) 0.86

Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling. Nat Commun (2014) 0.82

A disorder-to-order structural transition in the COOH-tail of Fz4 determines misfolding of the L501fsX533-Fz4 mutant. Sci Rep (2013) 0.82

Identification of DEP domain-containing proteins by a machine learning method and experimental analysis of their expression in human HCC tissues. Sci Rep (2016) 0.80

Phosphoprotein phosphatase-2A docks to Dishevelled and counterregulates Wnt3a/beta-catenin signaling. J Mol Signal (2007) 0.79

Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled. Mol Cell (2016) 0.79

A novel Dictyostelium RasGEF required for chemotaxis and development. BMC Cell Biol (2005) 0.79

The DEP domain-containing protein TOE-2 promotes apoptosis in the Q lineage of C. elegans through two distinct mechanisms. Development (2014) 0.78

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. J Biol Chem (2015) 0.78

DEEP Insights through the DEP Domain. Structure (2010) 0.77

Pharmacological folding chaperones act as allosteric ligands of Frizzled4. Nat Chem Biol (2015) 0.77

A putative novel protein, DEPDC1B, is overexpressed in oral cancer patients, and enhanced anchorage-independent growth in oral cancer cells that is mediated by Rac1 and ERK. J Biomed Sci (2014) 0.77

Biophysical and molecular-dynamics studies of phosphatidic acid binding by the Dvl-2 DEP domain. Biophys J (2014) 0.77

When you are Dishevelled, fat is good and acid is bad! Nat Cell Biol (2009) 0.75

Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. J Biol Chem (2017) 0.75

1H, 15N and 13C assignments of the targeting (FAT) domain of focal adhesion kinase. J Biomol NMR (2002) 0.75

Simulations of a specific inhibitor of the dishevelled PDZ domain. J Mol Model (2008) 0.75

Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5. Sci Rep (2017) 0.75

Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination. Oncogene (2017) 0.75

Articles cited by this

MOLMOL: a program for display and analysis of macromolecular structures. J Mol Graph (1996) 39.73

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins (1991) 36.69

Protein structure comparison by alignment of distance matrices. J Mol Biol (1993) 34.74

Raster3D: photorealistic molecular graphics. Methods Enzymol (1997) 27.30

Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature (1999) 20.34

Classical electrostatics in biology and chemistry. Science (1995) 17.26

Torsion angle dynamics for NMR structure calculation with the new program DYANA. J Mol Biol (1997) 15.40

Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol (1998) 9.24

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J (1998) 7.59

Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature (2000) 5.52

Dishevelled controls cell polarity during Xenopus gastrulation. Nature (2000) 4.91

Crystal structure of globular domain of histone H5 and its implications for nucleosome binding. Nature (1993) 4.81

Electrostatic aspects of protein-protein interactions. Curr Opin Struct Biol (2000) 4.57

Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev (1998) 4.51

Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell (1998) 4.49

EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Cell (1996) 4.22

Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin. Mol Cell Biol (1998) 3.79

Multidimensional heteronuclear nuclear magnetic resonance of proteins. Methods Enzymol (1994) 3.45

Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J (1999) 3.18

Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. J Biol Chem (1999) 2.67

Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription. Proc Natl Acad Sci U S A (1998) 2.66

Signal transduction by the Wnt family of ligands. Biochem J (1998) 2.66

Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis. EMBO J (2000) 2.55

Dishevelled: at the crossroads of divergent intracellular signaling pathways. Mech Dev (1999) 2.51

The dishevelled protein is modified by wingless signaling in Drosophila. Genes Dev (1995) 2.46

Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription. EMBO J (1999) 2.43

dishevelled is required during wingless signaling to establish both cell polarity and cell identity. Development (1994) 2.35

Identification of the binding site for acidic phospholipids on the pH domain of dynamin: implications for stimulation of GTPase activity. J Mol Biol (1996) 2.23

Pleckstrin's repeat performance: a novel domain in G-protein signaling? Trends Biochem Sci (1996) 2.13

WNT targets. Repression and activation. Trends Genet (1999) 1.91

Electrostatic properties of membranes containing acidic lipids and adsorbed basic peptides: theory and experiment. Biophys J (1999) 1.77

Krüppel, a gene whose activity is required early in the zygotic genome for normal embryonic segmentation. Dev Biol (1984) 1.76

Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification. J Cell Biol (2000) 1.63

Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation. J Biol Chem (1999) 1.61

The wingless signaling pathway is directly involved in Drosophila heart development. Dev Biol (1996) 1.57

Cellular mechanisms of wingless/Wnt signal transduction. Curr Top Dev Biol (1999) 1.55

Dishevelled is a component of the frizzled signaling pathway in Drosophila. Development (1995) 1.41

Human dishevelled genes constitute a DHR-containing multigene family. Genomics (1997) 1.31

Wnt signaling: why is everything so negative? Curr Opin Cell Biol (1998) 1.28

Interfacial binding of secreted phospholipases A(2): more than electrostatics and a major role for tryptophan. Curr Opin Struct Biol (1999) 1.25

Increased sensitivity in HNCA and HN(CO)CA experiments by selective C beta decoupling. J Magn Reson B (1996) 1.23

Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction. Mol Cell Biol (2000) 1.23

The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains. J Biol Chem (1997) 1.10

Linking Frizzled and Wnt signaling in Drosophila development. Development (1997) 1.06

The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits. J Biol Chem (1998) 0.91

Conformational stability studies of the pleckstrin DEP domain: definition of the domain boundaries. Biochim Biophys Acta (1998) 0.89

Linker histones: paradigm lost but questions remain. FEBS Lett (1998) 0.86

Articles by these authors

The sequence of the human genome. Science (2001) 101.55

The genome sequence of Drosophila melanogaster. Science (2000) 74.32

Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays. Nat Biotechnol (2000) 15.79

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell (1993) 9.93

Activation tagging of the floral inducer FT. Science (1999) 7.87

Activation tagging in Arabidopsis. Plant Physiol (2000) 7.09

Role of LXRs in control of lipogenesis. Genes Dev (2000) 6.98

The molecular basis of Turcot's syndrome. N Engl J Med (1995) 6.65

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science (2000) 6.52

Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature (1994) 6.21

Epitaxial BiFeO3 multiferroic thin film heterostructures. Science (2003) 6.14

Evolution and phylogeny of Wolbachia: reproductive parasites of arthropods. Proc Biol Sci (1995) 5.70

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol (2001) 5.36

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res (1995) 5.26

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell (2001) 5.19

Localization of neuronal and glial glutamate transporters. Neuron (1994) 5.14

Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions. Cell (1991) 5.14

Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ Res (2001) 5.08

American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken) (2012) 4.82

The GA5 locus of Arabidopsis thaliana encodes a multifunctional gibberellin 20-oxidase: molecular cloning and functional expression. Proc Natl Acad Sci U S A (1995) 4.80

Specific inhibition of Stat3 signal transduction by PIAS3. Science (1997) 4.74

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science (2000) 4.61

Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography. Opt Lett (1997) 4.48

Microarrays: handling the deluge of data and extracting reliable information. Trends Biotechnol (2001) 4.38

Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs. Science (2013) 4.17

The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake. Cell (1994) 4.12

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A (2000) 4.08

Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Proc Natl Acad Sci U S A (1994) 4.07

From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor. Proc Natl Acad Sci U S A (1998) 3.99

Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation (2001) 3.98

Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol (2001) 3.97

Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67. Am J Pathol (1991) 3.82

The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron (2001) 3.68

Genome of Geobacter sulfurreducens: metal reduction in subsurface environments. Science (2003) 3.68

Y-Chromosome evidence for a northward migration of modern humans into Eastern Asia during the last Ice Age. Am J Hum Genet (1999) 3.60

CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization. J Virol (1998) 3.60

Mismatch repair deficiency in phenotypically normal human cells. Science (1995) 3.55

Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. J Med Genet (2004) 3.45

The weight-based heparin dosing nomogram compared with a "standard care" nomogram. A randomized controlled trial. Ann Intern Med (1993) 3.43

Cancer risk associated with germline DNA mismatch repair gene mutations. Hum Mol Genet (1997) 3.41

Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment. J Virol (2001) 3.40

Evidence-based recommendations for the role of exercise in the management of osteoarthritis of the hip or knee--the MOVE consensus. Rheumatology (Oxford) (2004) 3.38

Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation. Neuron (2001) 3.37

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity (1998) 3.36

Analysis of effects of salts and uncharged solutes on protein and nucleic acid equilibria and processes: a practical guide to recognizing and interpreting polyelectrolyte effects, Hofmeister effects, and osmotic effects of salts. Adv Protein Chem (1998) 3.30

Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity (2001) 3.29

Rapid elimination of low-copy DNA sequences in polyploid wheat: a possible mechanism for differentiation of homoeologous chromosomes. Genetics (1997) 3.28

Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases. Proc Natl Acad Sci U S A (2000) 3.24

Mutations of GTBP in genetically unstable cells. Science (1995) 3.23

Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J (1999) 3.18

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif (2012) 3.18

Determinants of car travel on daily journeys to school: cross sectional survey of primary school children. BMJ (1998) 3.11

'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737. Oncogene (2006) 3.10

Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. Exp Cell Res (2001) 3.06

Activity of neurons in anterior inferior temporal cortex during a short-term memory task. J Neurosci (1993) 3.04

Molecular basis of T cell inactivation by CTLA-4. Science (1998) 3.00

Arrhythmias documented by 24 hour continuous electrocardiographic monitoring in 50 male medical students without apparent heart disease. Am J Cardiol (1977) 2.99

Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects. Clin Pharmacol Ther (2009) 2.98

Rickettsial relative associated with male killing in the ladybird beetle (Adalia bipunctata). J Bacteriol (1994) 2.97

Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus. Clin Pharmacol Ther (2009) 2.96

Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma. Blood (1999) 2.95

Isolation of an efficient actin promoter for use in rice transformation. Plant Cell (1990) 2.94

New tricks for modelers from the crystallography toolkit: the particle mesh Ewald algorithm and its use in nucleic acid simulations. Structure (1999) 2.92

Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure. Biochemistry (1995) 2.90

Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. Proc Natl Acad Sci U S A (1999) 2.88

Aerobic walking or strengthening exercise for osteoarthritis of the knee? A systematic review. Ann Rheum Dis (2005) 2.88

A neural mechanism for working and recognition memory in inferior temporal cortex. Science (1991) 2.86

Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation (2009) 2.85

GRB 090423 at a redshift of z approximately 8.1. Nature (2009) 2.84

Support vector machines for spam categorization. IEEE Trans Neural Netw (1999) 2.83

Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83

Potent urea and carbamate inhibitors of soluble epoxide hydrolases. Proc Natl Acad Sci U S A (1999) 2.79

The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH. Cell (1995) 2.78

Global gene expression profiles of Bacillus subtilis grown under anaerobic conditions. J Bacteriol (2000) 2.77

Visualizing the kinetics of tumor-cell clearance in living animals. Proc Natl Acad Sci U S A (1999) 2.76

Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature (2001) 2.76

Automatic adjustment of pacemaker stimulation output correlated with continuously monitored capture thresholds: a multicenter study. European Microny Study Group. Pacing Clin Electrophysiol (1998) 2.76

Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J Neurosci (2000) 2.75

Structural framework for the protein kinase family. Annu Rev Cell Biol (1992) 2.74

Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect. Nature (1998) 2.74

Superconductivity at 41 K and its competition with spin-density-wave instability in layered CeO1-xFxFeAs. Phys Rev Lett (2008) 2.72

Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. J Biol Chem (1999) 2.67

A molecular, isozyme and morphological map of the barley (Hordeum vulgare) genome. Theor Appl Genet (1993) 2.66

From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci U S A (2001) 2.66

Site-directed alkylation and the alternating access model for LacY. Proc Natl Acad Sci U S A (2006) 2.65

Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature (1998) 2.65

The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila. Cell (2001) 2.64

A katanin-like protein regulates normal cell wall biosynthesis and cell elongation. Plant Cell (2001) 2.63

Multiple novel astrovirus species in human stool. J Gen Virol (2009) 2.63

Ultrastructural evidence for hair cell regeneration in the mammalian inner ear. Science (1993) 2.62

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol (1995) 2.62

Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers. Br J Cancer (2009) 2.58

HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death Differ (2005) 2.54

Regulation of cell migration by the calcium-dependent protease calpain. J Biol Chem (1997) 2.52