Published in J Biol Chem on December 08, 2000
G protein-coupled receptor sorting to endosomes and lysosomes. Annu Rev Pharmacol Toxicol (2008) 3.49
Clathrin-dependent endocytosis. Biochem J (2004) 1.89
EP1- and FP-mediated cross-desensitization of the alpha (alpha) and beta (beta) isoforms of the human thromboxane A2 receptor. Br J Pharmacol (2004) 1.50
Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. Mol Cell Biol (2006) 1.46
Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF. Biochem J (2003) 1.12
Visualizing odorant receptor trafficking in living cells down to the single-molecule level. Proc Natl Acad Sci U S A (2006) 1.04
Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway. J Biol Chem (2011) 1.02
Functional roles of short sequence motifs in the endocytosis of membrane receptors. Front Biosci (Landmark Ed) (2009) 0.94
EBV BILF1 evolved to downregulate cell surface display of a wide range of HLA class I molecules through their cytoplasmic tail. J Immunol (2013) 0.93
The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis. Cancer Metastasis Rev (2011) 0.91
Small peptide recognition sequence for intracellular sorting. Curr Opin Biotechnol (2010) 0.87
Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. PLoS One (2013) 0.87
Thromboxane and the thromboxane receptor in cardiovascular disease. Clin Lipidol (2010) 0.86
Palmitoylation of the TPbeta isoform of the human thromboxane A2 receptor. Modulation of G protein: effector coupling and modes of receptor internalization. Cell Signal (2006) 0.84
Heterodimerization of the alpha and beta isoforms of the human thromboxane receptor enhances isoprostane signaling. Biochem Biophys Res Commun (2006) 0.84
Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle. FASEB J (2013) 0.84
Homologous desensitization of signalling by the alpha (alpha) isoform of the human thromboxane A2 receptor: a specific role for nitric oxide signalling. Biochim Biophys Acta (2007) 0.81
Regulation of thromboxane receptor signaling at multiple levels by oxidative stress-induced stabilization, relocation and enhanced responsiveness. PLoS One (2010) 0.81
Biased suppression of TP homodimerization and signaling through disruption of a TM GxxxGxxxL helical interaction motif. J Lipid Res (2013) 0.80
Palmitoylation of protease-activated receptor-1 regulates adaptor protein complex-2 and -3 interaction with tyrosine-based motifs and endocytic sorting. J Biol Chem (2013) 0.80
Niacin activates the PI3K/Akt cascade via PKC- and EGFR-transactivation-dependent pathways through hydroxyl-carboxylic acid receptor 2. PLoS One (2014) 0.78
Regulation of the tumor suppressor FOXO3 by the thromboxane-A2 receptors in urothelial cancer. PLoS One (2014) 0.78
Mutation in the V2 vasopressin receptor gene, AVPR2, causes nephrogenic syndrome of inappropriate diuresis. Kidney Int (2015) 0.78
Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins. J Biol Chem (2016) 0.75
Endocytosis and Trafficking of Natriuretic Peptide Receptor-A: Potential Role of Short Sequence Motifs. Membranes (Basel) (2015) 0.75
The unanticipated difficult airway with recommendations for management. Can J Anaesth (1998) 7.35
Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature (1986) 7.06
Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature (1996) 6.32
beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science (1990) 4.53
The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol (1998) 3.87
Yeast Ku as a regulator of chromosomal DNA end structure. Science (1998) 3.86
Regulation of transmembrane signaling by receptor phosphorylation. Cell (1987) 3.74
Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. Science (1992) 3.45
Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A (1986) 3.38
Evidence for a new step in telomere maintenance. Cell (1996) 3.03
Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting. J Biol Chem (2001) 2.72
Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors. J Biol Chem (1995) 2.55
Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem (2000) 2.47
Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. J Biol Chem (1990) 2.42
Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem (2000) 2.19
G-protein-coupled receptor kinase activity is increased in hypertension. J Clin Invest (1997) 2.16
Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin. J Biol Chem (1993) 2.14
Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization. J Biol Chem (1999) 2.05
Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain. J Biol Chem (1997) 1.94
Arrestin/clathrin interaction. Localization of the clathrin binding domain of nonvisual arrestins to the carboxy terminus. J Biol Chem (1997) 1.88
Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding. EMBO J (1999) 1.86
Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2. J Biol Chem (1999) 1.82
The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system. Biochemistry (1984) 1.77
Role of clathrin-mediated endocytosis in agonist-induced down-regulation of the beta2-adrenergic receptor. J Biol Chem (1998) 1.71
Agonist-receptor-arrestin, an alternative ternary complex with high agonist affinity. J Biol Chem (1997) 1.70
Modulation of the arrestin-clathrin interaction in cells. Characterization of beta-arrestin dominant-negative mutants. J Biol Chem (1997) 1.69
G-protein-coupled receptor kinases. Trends Biochem Sci (1991) 1.62
Inflammatory and contractile agents sensitize specific adenylyl cyclase isoforms in human airway smooth muscle. Am J Respir Cell Mol Biol (1999) 1.62
Visual arrestin binding to rhodopsin. Intramolecular interaction between the basic N terminus and acidic C terminus of arrestin may regulate binding selectivity. J Biol Chem (1994) 1.59
G-protein-coupled receptors: turn-ons and turn-offs. Curr Opin Neurobiol (1998) 1.54
Regulation of G protein-coupled receptor kinases. Trends Cardiovasc Med (2000) 1.53
Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. J Biol Chem (1985) 1.52
A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor. J Biol Chem (1994) 1.51
Visualization of agonist-induced sequestration and down-regulation of a green fluorescent protein-tagged beta2-adrenergic receptor. J Biol Chem (1998) 1.49
Arrestin with a single amino acid substitution quenches light-activated rhodopsin in a phosphorylation-independent fashion. Biochemistry (1997) 1.49
Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. Proc Natl Acad Sci U S A (1986) 1.46
Mechanism of quenching of phototransduction. Binding competition between arrestin and transducin for phosphorhodopsin. J Biol Chem (1997) 1.46
The mammalian beta 2-adrenergic receptor: purification and characterization. Biochemistry (1984) 1.45
Arrestin: mutagenesis, expression, purification, and functional characterization. Methods Enzymol (2000) 1.45
Visual arrestin binding to rhodopsin. Diverse functional roles of positively charged residues within the phosphorylation-recognition region of arrestin. J Biol Chem (1995) 1.44
Purification and characterization of the beta-adrenergic receptor kinase. J Biol Chem (1987) 1.43
Regulation of G protein-coupled receptor kinases by caveolin. J Biol Chem (1999) 1.42
Cell-free expression of visual arrestin. Truncation mutagenesis identifies multiple domains involved in rhodopsin interaction. J Biol Chem (1992) 1.41
Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. J Biol Chem (2000) 1.41
The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2. J Biol Chem (1993) 1.34
Binding and phosphorylation of tubulin by G protein-coupled receptor kinases. J Biol Chem (1998) 1.32
Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor. J Biol Chem (1996) 1.32
The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis. J Biol Chem (1987) 1.30
MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation. Am J Physiol (1999) 1.29
Interaction of arrestins with intracellular domains of muscarinic and alpha2-adrenergic receptors. J Biol Chem (1997) 1.29
Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development. Neuroscience (2002) 1.28
Pharmacological inhibition of protein kinases in intact cells: antagonism of beta adrenergic receptor ligand binding by H-89 reveals limitations of usefulness. J Pharmacol Exp Ther (1999) 1.27
Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. J Biol Chem (1986) 1.27
Internalization of the m2 muscarinic acetylcholine receptor. Arrestin-independent and -dependent pathways. J Biol Chem (1997) 1.27
Polypeptide variants of beta-arrestin and arrestin3. J Biol Chem (1993) 1.27
Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors. Proc Natl Acad Sci U S A (1986) 1.27
Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C. J Biol Chem (1997) 1.26
Mechanism of phosphorylation-recognition by visual arrestin and the transition of arrestin into a high affinity binding state. Mol Pharmacol (1997) 1.25
Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. Biochemistry (1991) 1.23
The determination of the free magnesium level in the human red blood cell by 31P NMR. J Biol Chem (1978) 1.23
G-Protein-coupled receptor kinase activity in hypertension : increased vascular and lymphocyte G-protein receptor kinase-2 protein expression. Hypertension (2000) 1.22
Regulation of G protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain. J Biol Chem (1997) 1.22
Arrestin specificity for G protein-coupled receptors in human airway smooth muscle. J Biol Chem (2001) 1.20
Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family. Proc Natl Acad Sci U S A (1993) 1.19
Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells. Mol Pharmacol (2001) 1.18
Mechanisms of acute desensitization of the beta2AR-adenylyl cyclase pathway in human airway smooth muscle. Am J Respir Cell Mol Biol (1998) 1.18
Selective regulation of endogenous G protein-coupled receptors by arrestins in HEK293 cells. J Biol Chem (2000) 1.16
Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2. J Biol Chem (1995) 1.15
Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase. Biochemistry (1989) 1.15
Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms. J Biol Chem (1995) 1.15
Sequestration of a G-protein beta gamma subunit or ADP-ribosylation of Rho can inhibit thrombin-induced activation of platelet phosphoinositide 3-kinases. J Biol Chem (1995) 1.14
Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. Proc Natl Acad Sci U S A (1989) 1.14
Characterization of G protein-coupled receptor regulation in antisense mRNA-expressing cells with reduced arrestin levels. Biochemistry (1999) 1.13
Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5. J Biol Chem (1994) 1.13
Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors. Parkinsonism Relat Disord (2005) 1.13
Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes. J Biol Chem (1999) 1.13
Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression system. Receptor (1993) 1.13
Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase. Nature (1986) 1.12
Internalization of the TXA2 receptor alpha and beta isoforms. Role of the differentially spliced cooh terminus in agonist-promoted receptor internalization. J Biol Chem (1999) 1.12
Receptor docking sites for G-protein betagamma subunits. Implications for signal regulation. J Biol Chem (1998) 1.12
Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. Circ Res (2000) 1.11
Using green fluorescent proteins to study G-protein-coupled receptor localization and trafficking. Trends Pharmacol Sci (2000) 1.11
Insulin-dependent phosphorylation of GTP-binding proteins in phospholipid vesicles. J Biol Chem (1988) 1.11
Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation. J Biol Chem (1998) 1.10
The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. J Biol Chem (2000) 1.10
L-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain. Neurobiol Dis (2005) 1.10
Photoaffinity labelling of mammalian beta-adrenergic receptors: metal-dependent proteolysis explains apparent heterogeneity. Biochem Biophys Res Commun (1983) 1.09
Identification of Gbetagamma binding sites in the third intracellular loop of the M(3)-muscarinic receptor and their role in receptor regulation. J Biol Chem (2000) 1.07
Characterization of dominant negative arrestins that inhibit beta2-adrenergic receptor internalization by distinct mechanisms. J Biol Chem (1998) 1.07
Beta-adrenergic receptor kinase. Agonist-dependent receptor binding promotes kinase activation. J Biol Chem (1993) 1.06
G protein-coupled receptor kinase GRK2 is a phospholipid-dependent enzyme that can be conditionally activated by G protein betagamma subunits. J Biol Chem (1996) 1.05
Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5. J Biol Chem (1994) 1.05
Binding of wild type and chimeric arrestins to the m2 muscarinic cholinergic receptor. J Biol Chem (1993) 1.05
G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells. Proc Natl Acad Sci U S A (2000) 1.05
Magnetic resonance studies of the binding of ATP and cations to human hemoglobin. J Biol Chem (1978) 1.04