CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo.

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Published in J Exp Med on December 18, 2000

Authors

J M den Haan1, S M Lehar, M J Bevan

Author Affiliations

1: Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA.

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Properties and applications of monoclonal antibodies directed against determinants of they Thy-1 locus. J Immunol (1979) 7.79

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J Exp Med (1976) 6.33

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Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J Exp Med (2000) 5.07

In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature (1977) 4.76

Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity (1999) 4.61

Interaction antigens detected by cytotoxic T cells with the major histocompatibility complex as modifier. Nature (1975) 4.27

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Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes. Nature (1991) 3.80

Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo. J Exp Med (1990) 3.73

Positive selection of thymocytes. Annu Rev Immunol (1995) 3.68

Specific immunity to Listeria monocytogenes in the absence of IFN gamma. Immunity (1995) 3.54

Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens? Cell Immunol (1977) 3.13

Induction of cytotoxic T lymphocytes by primary in vitro stimulation with peptides. J Exp Med (1988) 2.82

Correlating notch signaling with thymocyte maturation. Immunity (1998) 2.82

Cytotoxic effects of antigen- and mitogen-induced T cells on various targets. J Immunol (1975) 2.80

Differences in the surface proteins of mouse B and T cells. Proc Natl Acad Sci U S A (1975) 2.78

Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization. J Exp Med (1989) 2.74

H-2M3 presents a Listeria monocytogenes peptide to cytotoxic T lymphocytes. Cell (1992) 2.70

CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo. J Exp Med (1992) 2.62

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Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J Exp Med (1993) 2.57

Expression and functional significance of the J11d marker on mouse thymocytes. J Immunol (1987) 2.56

Role of self-peptides in positively selecting the T-cell repertoire. Nature (1990) 2.47

Protective cytotoxic T lymphocytes are induced during murine infection with Chlamydia trachomatis. J Immunol (1994) 2.41

Hybrid antibodies can target sites for attack by T cells. Nature (1985) 2.36

Killer cells reactive to altered-self antigens can also be alloreactive. Proc Natl Acad Sci U S A (1977) 2.35

The influence of thymus H-2 antigens on the specificity of maturing killer and helper cells. Immunol Rev (1978) 2.34

Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Nature (1992) 2.27

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Defective presentation of endogenous antigen by a cell line expressing class I molecules. Science (1990) 2.25

RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity (1998) 2.15

Antigen recognition. Class discrimination in the world of immunology. Nature (1987) 2.10

Specificity of cytotoxic T cells from athymic mice. J Exp Med (1980) 2.07

N protein is the predominant antigen recognized by vesicular stomatitis virus-specific cytotoxic T cells. J Virol (1986) 2.01

Differentiation potential of subsets of CD4-8- thymocytes. Nature (1987) 2.00

Minor H antigens introduced on H-2 different stimulating cells cross-react at the cytotoxic T cell level during in vivo priming. J Immunol (1976) 1.95

H-2 antigen-specific cytotoxic T cells induced by concanavalin A: estimation of their relative frequency. Eur J Immunol (1976) 1.95

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T cell receptor antagonists and partial agonists. Immunity (1995) 1.83

Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered-self hypothesis. J Exp Med (1982) 1.80

Presentation of exogenous protein antigens on major histocompatibility complex class I molecules by dendritic cells: pathway of presentation and regulation by cytokines. Blood (1997) 1.80

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Cytotoxic T lymphocytes produce immune interferon in response to antigen or mitogen. J Exp Med (1982) 1.76

Specificity and flexibility in thymic selection. Nature (1994) 1.72

Identification of an H2-M3-restricted Listeria epitope: implications for antigen presentation by M3. Immunity (1996) 1.70

Coordinate production by a T cell hybridoma of gamma interferon and three other lymphokine activities: multiple activities of a single lymphokine? J Immunol (1983) 1.67

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A differentiation factor required for the expression of cytotoxic T-cell function. Nature (1982) 1.56

Veto cells. Annu Rev Immunol (1988) 1.56

Evidence from in vitro studies that tolerance to self antigens is MHC-restricted. Nature (1984) 1.54

The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway. Dev Biol (2001) 1.54

Positive selection of thymocytes. Adv Immunol (1995) 1.53

Antigen presentation to CD8+ T cells: cross-priming in infectious diseases. Curr Opin Immunol (2001) 1.53

The effect of 2-mercaptoethanol on murine mixed lymphocyte cultures. J Exp Med (1974) 1.52

Functional modifications of cytotoxic T-lymphocyte T200 glycoprotein recognized by monoclonal antibodies. Nature (1985) 1.51

Specificity of T-cell cones illustrates altered self hypothesis. Nature (1981) 1.50

Class I-restricted presentation occurs without internalization or processing of exogenous antigenic peptides. J Immunol (1989) 1.49

Transient expression of IL-2 receptor precedes the differentiation of immature thymocytes. Nature (1987) 1.48

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells. Immunity (1995) 1.47

The CD8 response on autopilot. Nat Immunol (2001) 1.45

Dissection of major histocompatibility complex (MHC) and T cell receptor contact residues in a Kb-restricted ovalbumin peptide and an assessment of the predictive power of MHC-binding motifs. Eur J Immunol (1992) 1.42

T-cell selection. Curr Opin Immunol (1998) 1.42

Hybrid hybridoma producing a bispecific monoclonal antibody that can focus effector T-cell activity. Proc Natl Acad Sci U S A (1986) 1.40

Self H-2 antigens influence the specificity of alloreactive cells. J Exp Med (1980) 1.40

Requirements for bone marrow-derived antigen-presenting cells in priming cytotoxic T cell responses to intracellular pathogens. J Exp Med (2000) 1.39

Induction of H-2-restricted cytotoxic T cells: in vivo induction has the appearance of being unrestricted. Cell Immunol (1977) 1.39

Different classes of T lymphocytes have different mRNAs for the leukocyte-common antigen, T200. J Exp Med (1986) 1.39

Identification of a natural T cell epitope presented by Salmonella-infected macrophages and recognized by T cells from orally immunized mice. J Immunol (1997) 1.38

Cells infected with Yersinia present an epitope to class I MHC-restricted CTL. J Immunol (1994) 1.38

Selective activation of Lyt 2+ precursor T cells by ligation of the antigen receptor. Nature (1985) 1.38

Cooperation between helper T cells and cytotoxic T lymphocyte precursors. Ann N Y Acad Sci (1988) 1.38

Characterization of dual-reactive H-2Kb-restricted anti-vesicular stomatitus virus and alloreactive cytotoxic T cells. J Immunol (1987) 1.35

Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire. Immunity (1995) 1.34

Notch signaling in T cell development. Curr Opin Immunol (2000) 1.32

Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection. Eur J Immunol (1997) 1.31

Haplotype-specific suppression of cytotoxic T cell induction by antigen inappropriately presented on T cells. J Exp Med (1983) 1.31

Thymocytes expressing CD8 differentiate into CD4+ cells following intrathymic injection. Proc Natl Acad Sci U S A (1988) 1.31

Virus-mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL. J Immunol (1997) 1.30

Gamma interferon production by cytotoxic T lymphocytes is required for resolution of Chlamydia trachomatis infection. Infect Immun (1998) 1.26

Secretion of immune interferon and generation of cytotoxic T cell activity in nude mice are dependent on interleukin 2: age-associated endogenous production of interleukin 2 in nude mice. J Immunol (1983) 1.24

Monoclonal antibodies specific for a murine cytotoxic T-lymphocyte clone. Proc Natl Acad Sci U S A (1984) 1.24

An endogenous antigenic peptide bypasses the class I antigen presentation defect in RMA-S. J Exp Med (1992) 1.24

Mouse T-cell surface glycoprotein recognised by heterologous anti-thymocyte sera and its relationship to Thy-1 antigen. Nature (1975) 1.23

Cytotoxic t-cell response to histocompatibility antigens: the role of H-2. Cold Spring Harb Symp Quant Biol (1977) 1.21

Murine cytotoxic T lymphocytes induced following Chlamydia trachomatis intraperitoneal or genital tract infection respond to cells infected with multiple serovars. Infect Immun (1995) 1.20

Alloimmune cytotoxic T cells: Evidence that they recognize serologically defined antigens and bear clonally restricted receptors. J Immunol (1975) 1.20

Primary and secondary immune responses to Listeria monocytogenes. Curr Opin Immunol (1996) 1.19

A reexamination of the role of LYT-2-positive T cells in murine skin graft rejection. J Exp Med (1984) 1.17

Acquisition of cytotoxic T lymphocyte-specific carbohydrate differentiation antigens. J Exp Med (1985) 1.16

H2-M3 restricted presentation of a Listeria-derived leader peptide. J Exp Med (1998) 1.16