Published in Blood on February 01, 2001
The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway. EMBO Rep (2002) 4.76
Pannexin 1 in erythrocytes: function without a gap. Proc Natl Acad Sci U S A (2006) 4.03
Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes. Proc Natl Acad Sci U S A (2004) 3.05
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The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn. J Immunol (2006) 1.94
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A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion. Mol Biol Cell (2005) 1.80
Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts. J Bone Miner Res (2004) 1.69
Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transcription of IL-6 in macrophages. Proc Natl Acad Sci U S A (2004) 1.65
Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. FASEB J (2009) 1.61
Extracellular ATP induces the accumulation of superoxide via NADPH oxidases in Arabidopsis. Plant Physiol (2006) 1.58
Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth. Mol Biol Cell (2005) 1.58
Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse. Blood (2010) 1.56
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Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules. Blood (2006) 1.48
Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation. Am J Physiol Cell Physiol (2009) 1.46
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A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases. Expert Opin Investig Drugs (2011) 1.39
P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells. BMC Immunol (2004) 1.35
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Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R. Proc Natl Acad Sci U S A (2003) 1.30
A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice. J Biol Chem (2009) 1.29
P2 receptors: new potential players in atherosclerosis. Br J Pharmacol (2002) 1.27
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Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. Proc Natl Acad Sci U S A (2012) 1.25
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The role of transcription-independent damage signals in the initiation of epithelial wound healing. Nat Rev Mol Cell Biol (2013) 1.23
Self-regulation of inflammatory cell trafficking in mice by the leukocyte surface apyrase CD39. J Clin Invest (2009) 1.22
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Extracellular purines are biomarkers of neutrophilic airway inflammation. Eur Respir J (2008) 1.17
Leflunomide prevents alveolar fluid clearance inhibition by respiratory syncytial virus. Am J Respir Crit Care Med (2005) 1.16
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. J Exp Med (2010) 1.13
Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor. J Immunol (2007) 1.12
ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor. Am J Physiol Cell Physiol (2005) 1.08
The detection of micromolar pericellular ATP pool on lymphocyte surface by using lymphoid ecto-adenylate kinase as intrinsic ATP sensor. Mol Biol Cell (2006) 1.08
Inflammasomes bridge signaling between pathogen identification and the immune response. Drugs Today (Barc) (2009) 1.08
Activation of ERK1/2 by extracellular nucleotides in macrophages is mediated by multiple P2 receptors independently of P2X7-associated pore or channel formation. Br J Pharmacol (2006) 1.08
Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis. J Biol Chem (2009) 1.07
Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils. Br J Pharmacol (2003) 1.06
Both sides now: multiple interactions of ATP with pannexin-1 hemichannels. Focus on "A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP". Am J Physiol Cell Physiol (2009) 1.06
Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation. Free Radic Biol Med (2007) 1.05
Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo. J Leukoc Biol (2007) 1.05
Purinergic regulation of neutrophil chemotaxis. Cell Mol Life Sci (2008) 1.04
In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain. Brain Behav Immun (2007) 1.04
Chemotactic activity of extracellular nucleotideson human immune cells. Purinergic Signal (2007) 1.02
Human eosinophils recognize endogenous danger signal crystalline uric acid and produce proinflammatory cytokines mediated by autocrine ATP. J Immunol (2010) 1.02
The evidence for two opposite, ATP-generating and ATP-consuming, extracellular pathways on endothelial and lymphoid cells. Biochem J (2002) 1.02
Extracellular NAD+ regulates intracellular calcium levels and induces activation of human granulocytes. Biochem J (2006) 1.02
Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus. Mol Pain (2010) 1.01
Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells. Br J Pharmacol (2009) 0.99
Pulmonary infection with hypervirulent Mycobacteria reveals a crucial role for the P2X7 receptor in aggressive forms of tuberculosis. PLoS Pathog (2014) 0.98
AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2. Am J Respir Cell Mol Biol (2006) 0.98
P2 receptors and platelet function. Purinergic Signal (2011) 0.98
Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate. Am J Physiol Gastrointest Liver Physiol (2013) 0.98
P2 receptor-mediated signaling in mast cell biology. Purinergic Signal (2009) 0.98
Kinetics of P2X7 receptor-operated single channels currents. Biophys J (2006) 0.98
Activation of sickle red blood cell adhesion via integrin-associated protein/CD47-induced signal transduction. J Clin Invest (2001) 0.96
Extracellular NAD+ regulates intracellular free calcium concentration in human monocytes. Biochem J (2004) 0.96
Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response. Infect Immun (2006) 0.95
Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence. J Clin Invest (2014) 0.95
The P2X7 receptor is a key modulator of aerobic glycolysis. Cell Death Dis (2012) 0.95
Phospholipase A2 regulates eicosanoid class switching during inflammasome activation. Proc Natl Acad Sci U S A (2014) 0.95
Enteric P2X receptors as potential targets for drug treatment of the irritable bowel syndrome. Br J Pharmacol (2004) 0.94
Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection. PLoS One (2012) 0.94
ATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation. Glia (2012) 0.94
Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. J Biol Chem (2008) 0.94
Purinergic signalling and immune cells. Purinergic Signal (2014) 0.94
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P2 purinergic receptor modulation of cytokine production. Purinergic Signal (2007) 0.93
Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors. Stem Cells (2013) 0.92
Nucleotidase cascades are catalyzed by secreted proteins of the parasitic nematode Trichinella spiralis. Infect Immun (2002) 0.92
ATP release through pannexon channels. Philos Trans R Soc Lond B Biol Sci (2015) 0.92
Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses. Purinergic Signal (2013) 0.92
P2X(7) nucleotide receptors mediate caspase-8/9/3-dependent apoptosis in rat primary cortical neurons. Purinergic Signal (2005) 0.91
Cell signaling via the P2X(7) nucleotide receptor: linkage to ROS production, gene transcription, and receptor trafficking. Purinergic Signal (2009) 0.91
Uncoupling of ATP-mediated calcium signaling and dysregulated interleukin-6 secretion in dendritic cells by nanomolar thimerosal. Environ Health Perspect (2006) 0.90
Differential macrophage activation alters the expression profile of NTPDase and ecto-5'-nucleotidase. PLoS One (2012) 0.90
Oxidized ATP protection against anthrax lethal toxin. Infect Immun (2006) 0.90
Novel data point to a broader mechanism of action of oxidized ATP: the P2X7 receptor is not the only target. Br J Pharmacol (2003) 0.90
Ecto-5'-nucleotidase: a candidate virulence factor in Streptococcus sanguinis experimental endocarditis. PLoS One (2012) 0.90
Expression and function of the purinergic receptor P2X7 in patients with pulmonary tuberculosis. Clin Exp Immunol (2006) 0.89
Dexamethasone enhances ATP-induced inflammatory responses in endothelial cells. J Pharmacol Exp Ther (2010) 0.89
Influence of Ecto-nucleoside triphosphate diphosphohydrolase activity on Trypanosoma cruzi infectivity and virulence. PLoS Negl Trop Dis (2009) 0.89
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Large-conductance channel formation mediated by P2X7 receptor activation is regulated through distinct intracellular signaling pathways in peritoneal macrophages and 2BH4 cells. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.89
Dynamic purine signaling and metabolism during neutrophil-endothelial interactions. Purinergic Signal (2005) 0.88
Extracellular ATP reduces HIV-1 transfer from immature dendritic cells to CD4+ T lymphocytes. Retrovirology (2008) 0.87
Preservation of differentiation and clonogenic potential of human hematopoietic stem and progenitor cells during lyophilization and ambient storage. PLoS One (2010) 0.87
Similarities between UDP-glucose and adenine nucleotide release in yeast: involvement of the secretory pathway. Biochemistry (2008) 0.87
Purinergic modulation of microglial cell activation. Purinergic Signal (2006) 0.87
Modulation of P2X7 receptor functions by polymyxin B: crucial role of the hydrophobic tail of the antibiotic molecule. Br J Pharmacol (2007) 0.87
Modeling of eicosanoid fluxes reveals functional coupling between cyclooxygenases and terminal synthases. Biophys J (2014) 0.87
Differences in purinergic amplification of osmotic cell lysis by the pore-forming RTX toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: the role of pore size. Infect Immun (2013) 0.86
Extracellular ATP-stimulated macrophages produce macrophage inflammatory protein-2 which is important for neutrophil migration. Immunology (2012) 0.86
Toll-like receptor-triggered calcium mobilization protects mice against bacterial infection through extracellular ATP release. Infect Immun (2014) 0.86
The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal (2012) 0.86
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