PubRank

C D Poulter

Author PubWeight™ 98.16‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Creating isoprenoid diversity. Science 1997 3.78
2 Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther 2001 3.59
3 Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution. Biochemistry 1994 3.10
4 Synthesis of allylic and homoallylic isoprenoid pyrophosphates. Methods Enzymol 1985 2.18
5 Regulation of product chain length by isoprenyl diphosphate synthases. Proc Natl Acad Sci U S A 1996 2.13
6 Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein. Science 1990 2.04
7 Isoprenyl diphosphate synthases: protein sequence comparisons, a phylogenetic tree, and predictions of secondary structure. Protein Sci 1994 1.82
8 Chain elongation in the isoprenoid biosynthetic pathway. Curr Opin Chem Biol 1997 1.78
9 Yeast farnesyl-diphosphate synthase: site-directed mutagenesis of residues in highly conserved prenyltransferase domains I and II. Proc Natl Acad Sci U S A 1994 1.69
10 Escherichia coli open reading frame 696 is idi, a nonessential gene encoding isopentenyl diphosphate isomerase. J Bacteriol 1999 1.64
11 Isopentenyl diphosphate:dimethylallyl diphosphate isomerase. An improved purification of the enzyme and isolation of the gene from Saccharomyces cerevisiae. J Biol Chem 1989 1.56
12 The Claviceps purpurea gene encoding dimethylallyltryptophan synthase, the committed step for ergot alkaloid biosynthesis. Biochem Biophys Res Commun 1995 1.51
13 Farnesyl diphosphate synthetase. Molecular cloning, sequence, and expression of an essential gene from Saccharomyces cerevisiae. J Biol Chem 1989 1.48
14 The crtE gene in Erwinia herbicola encodes geranylgeranyl diphosphate synthase. Proc Natl Acad Sci U S A 1992 1.42
15 1H-15N NMR studies of Escherichia coli tRNA(Phe) from hisT mutants: a structural role for pseudouridine. Biochemistry 1991 1.38
16 Effects of site-directed mutagenesis of the highly conserved aspartate residues in domain II of farnesyl diphosphate synthase activity. J Biol Chem 1992 1.35
17 E. coli MEP synthase: steady-state kinetic analysis and substrate binding. Biochemistry 2002 1.32
18 Isopentenyl-diphosphate isomerase: inactivation of the enzyme with active-site-directed irreversible inhibitors and transition-state analogues. Biochemistry 1988 1.32
19 Continuous fluorescence assay for protein prenyltransferases. Methods Enzymol 1995 1.27
20 15N-labeled Escherichia coli tRNAfMet, tRNAGlu, tRNATyr, and tRNAPhe. Double resonance and two-dimensional NMR of N1-labeled pseudouridine. J Biol Chem 1985 1.27
21 The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities. Mol Cell Biol 2000 1.22
22 Pre-steady-state study of recombinant sesquiterpene cyclases. Biochemistry 1997 1.22
23 1-Deoxy-D-xylulose 5-phosphate synthase, the gene product of open reading frame (ORF) 2816 and ORF 2895 in Rhodobacter capsulatus. J Bacteriol 2001 1.19
24 Studies with recombinant Saccharomyces cerevisiae CaaX prenyl protease Rce1p. Biochemistry 2000 1.18
25 A mechanism for posttranslational modifications of proteins by yeast protein farnesyltransferase. Proc Natl Acad Sci U S A 1995 1.18
26 Isopentenyldiphosphate:dimethylallyldiphosphate isomerase: construction of a high-level heterologous expression system for the gene from Saccharomyces cerevisiae and identification of an active-site nucleophile. Biochemistry 1990 1.17
27 Prenyltransferase; determination of the binding mechanism and individual kinetic constants for farnesylpyrophosphate synthetase by rapid quench and isotope partitioning experiments. Biochemistry 1981 1.14
28 Purification and characterization of farnesyl diphosphate/geranylgeranyl diphosphate synthase. A thermostable bifunctional enzyme from Methanobacterium thermoautotrophicum. J Biol Chem 1993 1.14
29 Identification of Cys139 and Glu207 as catalytically important groups in the active site of isopentenyl diphosphate:dimethylallyl diphosphate isomerase. Biochemistry 1994 1.13
30 Isolation and characterization of isoprene mutants of Escherichia coli. J Bacteriol 1989 1.13
31 Farnesyl pyrophosphate synthetase. Mechanistic studies of the 1'-4 coupling reaction with 2-fluorogeranyl pyrophosphate. J Biol Chem 1978 1.11
32 Open reading frame 176 in the photosynthesis gene cluster of Rhodobacter capsulatus encodes idi, a gene for isopentenyl diphosphate isomerase. J Bacteriol 1996 1.08
33 Yeast squalene synthase: expression, purification, and characterization of soluble recombinant enzyme. Arch Biochem Biophys 1993 1.08
34 Chrysanthemyl diphosphate synthase: isolation of the gene and characterization of the recombinant non-head-to-tail monoterpene synthase from Chrysanthemum cinerariaefolium. Proc Natl Acad Sci U S A 2001 1.06
35 Analysis of the isopentenyl diphosphate isomerase gene family from Arabidopsis thaliana. Plant Mol Biol 1998 1.04
36 Purification and characterization of dimethylallyl tryptophan synthase from Claviceps purpurea. Arch Biochem Biophys 1992 1.03
37 Multiple quantum two-dimensional 1H--15N nuclear magnetic resonance spectroscopy: chemical shift correlation maps for exchangeable imino protons of Escherichia coli tRNAMetf in water. Proc Natl Acad Sci U S A 1983 1.03
38 Analysis and purification of phosphorylated isoprenoids by reversed-phase HPLC. Anal Biochem 1993 1.03
39 Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization. Arch Biochem Biophys 1996 1.02
40 Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: essential elements for recognition of tRNA substrates within the anticodon stem-loop. Biochemistry 2000 1.01
41 Synthesis of (S)-isoprenoid thiodiphosphates as substrates and inhibitors. J Org Chem 2001 0.99
42 Mechanism of the prenyl-transfer reaction. Studies with (E)- and (Z)-3-trifluoromethyl-2-buten-1-yl pyrophosphate. Biochemistry 1977 0.98
43 Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: site-directed mutagenesis of highly conserved residues. Biochemistry 2001 0.97
44 Protein farnesyltransferase: production in Escherichia coli and immunoaffinity purification of the heterodimer from Saccharomyces cerevisiae. Gene 1993 0.97
45 Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: a binding mechanism for recombinant enzyme. Biochemistry 1997 0.96
46 Squalene synthase: steady-state, pre-steady-state, and isotope-trapping studies. Biochemistry 2000 0.95
47 Stereostructure of the archaebacterial C40 diol. Science 1985 0.95
48 Disruption and mapping of IDI1, the gene for isopentenyl diphosphate isomerase in Saccharomyces cerevisiae. Yeast 1992 0.95
49 Geranylgeranylglyceryl phosphate synthase. Characterization of the recombinant enzyme from Methanobacterium thermoautotrophicum. Biochemistry 2001 0.94
50 Crystal structure of the C67A mutant of isopentenyl diphosphate isomerase complexed with a mechanism-based irreversible inhibitor. Proteins 2004 0.94
51 Farnesyl protein transferase: identification of K164 alpha and Y300 beta as catalytic residues by mutagenesis and kinetic studies. Biochemistry 1999 0.93
52 Isolation and characterization of idsA: the gene for the short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrophicum. Arch Biochem Biophys 1994 0.93
53 Isopentenyl-diphosphate isomerase: irreversible inhibition by 3-methyl-3,4-epoxybutyl diphosphate. Biochemistry 1992 0.93
54 Prenyltransferase: the mechanism of the reaction. Biochemistry 1976 0.92
55 Yeast protein farnesyltransferase: steady-state kinetic studies of substrate binding. Biochemistry 1995 0.90
56 Purification of farnesylpyrophosphate synthetase by affinity chromatography. Methods Enzymol 1985 0.90
57 Isolation of Schizosaccharomyces pombe isopentenyl diphosphate isomerase cDNA clones by complementation and synthesis of the enzyme in Escherichia coli. J Biol Chem 1995 0.90
58 Yeast protein farnesyltransferase. pKas of peptide substrates bound as zinc thiolates. Biochemistry 1999 0.89
59 Biosynthesis of isoprenoids in Escherichia coli: stereochemistry of the reaction catalyzed by farnesyl diphosphate synthase. Org Lett 1999 0.88
60 Prenyltransferase. Kinetic studies of the 1'-4 coupling reaction with avian liver enzyme. J Biol Chem 1979 0.87
61 Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway. Biochemistry 2006 0.87
62 Synthesis of 2-C-methyl-D-erythritol 4-phosphate: the first pathway-specific intermediate in the methylerythritol phosphate route to isoprenoids. Org Lett 2000 0.87
63 (S)-geranylgeranylglyceryl phosphate synthase. Purification and characterization of the first pathway-specific enzyme in archaebacterial membrane lipid biosynthesis. J Biol Chem 1993 0.87
64 Solid-phase synthesis of a farnesylated CaaX peptide library: inhibitors of the Ras CaaX endoprotease. J Comb Chem 2000 0.87
65 Yeast protein farnesyltransferase: a pre-steady-state kinetic analysis. Biochemistry 1997 0.86
66 Farnesyl diphosphate synthase. Altering the catalytic site to select for geranyl diphosphate activity. Biochemistry 2000 0.85
67 Mechanistic studies with 2-C-methyl-D-erythritol 4-phosphate synthase from Escherichia coli. Biochemistry 2005 0.83
68 Efficient syntheses of [3-15N]uracil and [3-15N]thymine. Nucleic Acids Res 1983 0.82
69 Purification and characterization of recombinant human farnesyl diphosphate synthase expressed in Escherichia coli. Biochem J 1991 0.82
70 Letter: Prenyltransferase. New evidence for an ionization-condensation-elimination mechanism with 2-fluorogeranyl pyrophosphate. J Am Chem Soc 1977 0.81
71 Recent studies of the mechanism of protein prenylation. Nat Prod Rep 2000 0.81
72 Yeast protein geranylgeranyltransferase type-I: overproduction, purification, and characterization. Arch Biochem Biophys 1995 0.80
73 15N-labeled tRNA. Identification of 4-thiouridine in Escherichia coli tRNASer1 and tRNATyr2 by 1H-15N two-dimensional NMR spectroscopy. J Biol Chem 1986 0.80
74 Synthesis of (R)-[2-2H]isopentenyl diphosphate and determination of its enantiopurity by 2H NMR spectroscopy in a lyotropic medium. Org Lett 1999 0.79
75 Yeast squalene synthase. A mechanism for addition of substrates and activation by NADPH. J Biol Chem 1994 0.79
76 Yeast geranylgeranyltransferase type-II: steady state kinetic studies of the recombinant enzyme. Biochemistry 1996 0.79
77 Studies on the mechanism of squalene biosynthesis. Presqualene pyrophosphate, stereochemistry and a mechanism for its conversion to squalene. J Am Chem Soc 1971 0.79
78 Model studies in terpene biosynthesis. J Agric Food Chem 1974 0.78
79 Solid-phase synthesis of a radiolabeled, biotinylated, and farnesylated Ca(1)a(2)X peptide substrate for Ras- and a-mating factor converting enzyme. Bioconjug Chem 2001 0.78
80 Yeast protein geranylgeranyltransferase type-I: steady-state kinetics and substrate binding. Biochemistry 1997 0.78
81 An affinity column for the purification of prenyltransferases. Anal Biochem 1985 0.77
82 Enzymatic synthesis of isotopically labeled isoprenoid diphosphates. Bioorg Med Chem 1994 0.77
83 Synthesis of geranyl S-thiolodiphosphate. A new alternative substrate/inhibitor for prenyltransferases. Org Lett 2000 0.77
84 Yeast protein farnesyltransferase. Site-directed mutagenesis of conserved residues in the beta-subunit. Biochemistry 1997 0.77
85 Yeast protein farnesyltransferase. Binding of S-alkyl peptides and related analogues. Org Lett 1999 0.77
86 Biosynthesis of head-to-head terpenes. Carbonium ion rearrangements which lead to head-to-head terpenes. Biochemistry 1974 0.75
87 15N-labeled tRNA. Identification of dihydrouridine in Escherichia coli tRNAfMet, tRNALys, and tRNAPhe by 1H-15N two-dimensional NMR. J Biol Chem 1986 0.75
88 Identification of the gltX gene encoding glutamyl-tRNA synthetase from Methanobacterium thermoautotrophicum. Biochim Biophys Acta 1996 0.75
89 Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: pre-steady-state kinetic studies. Biochim Biophys Acta 2000 0.75
90 15N-labeled 5S RNA. Identification of uridine base pairs in Escherichia coli 5S RNA by 1H-15N multiple quantum NMR. Biochemistry 1989 0.75
91 Investigation of isoprenoid benzoates and naphthoates by reversed-phase liquid chromatography. Isocratic elution characteristics of benzoates and naphthoates of C5-C20 terpenoid alcohols. J Chromatogr 1984 0.75
92 Reversed-phase high-performance liquid chromatography of C5 to C20 isoprenoid benzoates and naphthoates. Methods Enzymol 1985 0.75
93 Model studies of terpene biosynthesis. Cationic rearrangements leading to head-to-head terpenes. J Am Chem Soc 1972 0.75
94 Letter: Prenyltransferase. The mechanism of the reaction. J Am Chem Soc 1976 0.75
95 Effect of zinc ions on farnesyl pyrophosphate synthetase activity. Biochem Int 1984 0.75
96 The addition of methanol to some bicyclobutanes. Tetrahedron Lett 1967 0.75