Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture--primary culture cells markedly differ from fourth-passage cells.

PubWeight™: 1.62‹?› | Rank: Top 4%

🔗 View Article (PMC 17827)

Published in Arthritis Res on November 21, 2000

Authors

T Zimmermann1, E Kunisch, R Pfeiffer, A Hirth, H D Stahl, U Sack, A Laube, E Liesaus, A Roth, E Palombo-Kinne, F Emmrich, R W Kinne

Author Affiliations

1: Experimental Rheumatology Unit, Friedrich Schiller University Jena, Jena, Germany.

Articles citing this

Macrophage specificity of three anti-CD68 monoclonal antibodies (KP1, EBM11, and PGM1) widely used for immunohistochemistry and flow cytometry. Ann Rheum Dis (2004) 2.09

Angiopoietin-1 is expressed in the synovium of patients with rheumatoid arthritis and is induced by tumour necrosis factor alpha. Ann Rheum Dis (2003) 1.74

Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells. Arthritis Res Ther (2005) 1.37

Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther (2007) 1.29

Synovium-derived stem cell-based chondrogenesis. Differentiation (2008) 1.18

The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis. Arthritis Res Ther (2011) 1.05

Synovial biology and T cells in rheumatoid arthritis. Pathophysiology (2005) 1.05

Cytokine mRNA and protein expression in primary-culture and repeated-passage synovial fibroblasts from patients with rheumatoid arthritis. Arthritis Res (2001) 1.01

The production of CXCR3-agonistic chemokines by synovial fibroblasts from patients with rheumatoid arthritis. Rheumatol Int (2004) 0.99

Molecular interactions between T cells and fibroblast-like synoviocytes: role of membrane tumor necrosis factor-alpha on cytokine-activated T cells. Am J Pathol (2007) 0.98

Relevance of the stroma and epithelial-mesenchymal transition (EMT) for the rheumatic diseases. Arthritis Res Ther (2006) 0.97

Identification of genomic targets downstream of p38 mitogen-activated protein kinase pathway mediating tumor necrosis factor-alpha signaling. Physiol Genomics (2007) 0.97

Cia5d regulates a new fibroblast-like synoviocyte invasion-associated gene expression signature. Arthritis Res Ther (2008) 0.95

Batch correction of microarray data substantially improves the identification of genes differentially expressed in rheumatoid arthritis and osteoarthritis. BMC Med Genomics (2012) 0.95

IL-33 regulates TNF-α dependent effects in synovial fibroblasts. Int J Mol Med (2012) 0.95

Detection of oncofetal h19 RNA in rheumatoid arthritis synovial tissue. Am J Pathol (2003) 0.94

The synovial proteome: analysis of fibroblast-like synoviocytes. Arthritis Res Ther (2004) 0.94

In vitro model for the analysis of synovial fibroblast-mediated degradation of intact cartilage. Arthritis Res Ther (2009) 0.93

Taurine chloramine differentially inhibits matrix metalloproteinase 1 and 13 synthesis in interleukin-1beta stimulated fibroblast-like synoviocytes. Arthritis Res Ther (2007) 0.92

Prostaglandin E2 differentially modulates proinflammatory/prodestructive effects of TNF-alpha on synovial fibroblasts via specific E prostanoid receptors/cAMP. J Immunol (2009) 0.91

Robust computational reconstitution - a new method for the comparative analysis of gene expression in tissues and isolated cell fractions. BMC Bioinformatics (2006) 0.89

Predominant activation of MAP kinases and pro-destructive/pro-inflammatory features by TNF alpha in early-passage synovial fibroblasts via TNF receptor-1: failure of p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis. Ann Rheum Dis (2007) 0.89

CD14-negative isolation enhances chondrogenesis in synovial fibroblasts. Tissue Eng Part A (2009) 0.87

Mosaic chromosomal aberrations in synovial fibroblasts of patients with rheumatoid arthritis, osteoarthritis, and other inflammatory joint diseases. Arthritis Res (2001) 0.86

The roles of IFN-γ versus IL-17 in pathogenic effects of human Th17 cells on synovial fibroblasts. Mod Rheumatol (2013) 0.84

Enhancing and maintaining chondrogenesis of synovial fibroblasts by cartilage extracellular matrix protein matrilins. Osteoarthritis Cartilage (2008) 0.84

Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells. Arthritis Res Ther (2009) 0.84

Adapted Boolean network models for extracellular matrix formation. BMC Syst Biol (2009) 0.84

Nicotine inhibits tumor necrosis factor-α induced IL-6 and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Rheumatol Int (2010) 0.83

Expression of interleukin-18 receptor in fibroblast-like synoviocytes. Arthritis Res (2001) 0.83

A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis. Arthritis Res Ther (2010) 0.81

Thermally responsive polymeric hydrogel brushes: synthesis, physical properties and use for the culture of chondrocytes. J R Soc Interface (2007) 0.80

Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation. Arthritis Res Ther (2013) 0.79

Effect of taurine chloramine on the production of matrix metalloproteinases (MMPs) in adiponectin- or IL-1beta-stimulated fibroblast-like synoviocytes. J Biomed Sci (2010) 0.78

Investigation of the cytokine response to NF-κB decoy oligonucleotide coated polysaccharide based nanoparticles in rheumatoid arthritis in vitro models. Arthritis Res Ther (2015) 0.78

Novel application of multi-stimuli network inference to synovial fibroblasts of rheumatoid arthritis patients. BMC Med Genomics (2014) 0.77

Evaluation of SV40-transformed synovial fibroblasts in the study of rheumatoid arthritis pathogenesis. Rheumatol Int (2011) 0.77

Effects of CD14 macrophages and proinflammatory cytokines on chondrogenesis in osteoarthritic synovium-derived stem cells. Tissue Eng Part A (2014) 0.77

Ameliorative effect of ozone on cytokine production in mice injected with human rheumatoid arthritis synovial fibroblast cells. Rheumatol Int (2004) 0.77

Molecular basis of oxidative stress in gouty arthropathy. Clin Rheumatol (2015) 0.77

Zebrafish keratocyte explants to study collective cell migration and reepithelialization in cutaneous wound healing. J Vis Exp (2015) 0.77

Phenotypic characterization and invasive properties of synovial fluid-derived adherent cells in rheumatoid arthritis. Inflammation (2008) 0.76

Cellular electrophysiological principles that modulate secretion from synovial fibroblasts. J Physiol (2017) 0.75

Tryptase is a candidate autoantigen in rheumatoid arthritis. Immunology (2014) 0.75

A protocol for the culture and isolation of murine synovial fibroblasts. Biomed Rep (2016) 0.75

Localization, Shedding, Regulation and Function of Aminopeptidase N/CD13 on Fibroblast like Synoviocytes. PLoS One (2016) 0.75

Effect of serial cell passaging in the retention of fiber type and mitochondrial content in primary human myotubes. Obesity (Silver Spring) (2015) 0.75

Prostaglandin E(2) binding peptide screened by phage displaying: a new therapeutic strategy in rheumatoid arthritis. Lipids Health Dis (2011) 0.75

Suppression of the inflammatory response by disease-inducible interleukin-10 gene therapy in a three-dimensional micromass model of the human synovial membrane. Arthritis Res Ther (2016) 0.75

Human Dermal Fibroblasts Demonstrate Positive Immunostaining for Neuron- and Glia- Specific Proteins. PLoS One (2015) 0.75

Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis. Sci Rep (2017) 0.75

Corticosterone suppresses IL-1β-induced mPGE2 expression through regulation of the 11β-HSD1 bioactivity of synovial fibroblasts in vitro. Exp Ther Med (2017) 0.75

Thy1 (CD90) Expression Is Elevated in Radiation-Induced Periprosthetic Capsular Contracture: Implication for Novel Therapeutics. Plast Reconstr Surg (2017) 0.75

Obesity-associated metabolic syndrome spontaneously induces infiltration of pro-inflammatory macrophage in synovium and promotes osteoarthritis. PLoS One (2017) 0.75

Peri-prosthetic tissue cells show osteogenic capacity to differentiate into the osteoblastic lineage. J Orthop Res (2016) 0.75

Articles cited by this

The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum (1988) 111.05

Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? Arthritis Rheum (1996) 3.74

Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol (1996) 3.59

Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol (1990) 3.57

Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum (1996) 2.77

Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium. Quantitative analysis and effect of intraarticular corticosteroids. Arthritis Rheum (1991) 2.28

Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. J Clin Invest (1989) 2.28

Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia. Results of proliferating cell nuclear antigen/cyclin, c-myc, and nucleolar organizer region staining. Arthritis Rheum (1994) 2.19

Alpha 4/beta 1 integrin (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes. J Immunol (1992) 2.08

Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis? Arthritis Rheum (1997) 1.89

PG-M1: a new monoclonal antibody directed against a fixative-resistant epitope on the macrophage-restricted form of the CD68 molecule. Am J Pathol (1993) 1.81

Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key! Blood (1993) 1.77

Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis. J Exp Med (1989) 1.75

Expression of metalloproteinases and metalloproteinase inhibitor in human arthritic synovium. Arthritis Rheum (1991) 1.73

Influences of gamma interferon on synovial fibroblast-like cells. Ia induction and inhibition of collagen synthesis. J Clin Invest (1985) 1.71

In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium. Arthritis Rheum (1991) 1.66

Histomorphological basis of articular cartilage destruction in rheumatoid arthritis. Coll Relat Res (1983) 1.61

Pannus and pannocytes. Alternative models of joint destruction in rheumatoid arthritis. Arthritis Rheum (1994) 1.61

Light microscopic characterization of the fibroblast-like synovial intimal cell (synoviocyte). Arthritis Rheum (1992) 1.60

Transin/stromelysin expression in rheumatoid synovium. A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes. Am J Pathol (1989) 1.50

Cytokines in osteoarthritis: mediators or markers of joint destruction? Semin Arthritis Rheum (1996) 1.44

Evidence for cellular heterogeneity in primary cultures of human orbital fibroblasts. J Clin Endocrinol Metab (1995) 1.41

Antibodies to cytoplasmic intermediate filaments in rheumatic diseases. J Rheumatol (1983) 1.41

Methotrexate reduces inflammatory cell numbers, expression of monokines and of adhesion molecules in synovial tissue of patients with rheumatoid arthritis. Br J Rheumatol (1998) 1.38

The tissue architecture of synovial membranes in inflammatory and non-inflammatory joint diseases. I. The localization of the major synovial cell populations as detected by monoclonal reagents directed towards Ia and monocyte-macrophage antigens. Rheumatol Int (1983) 1.32

Monocyte activation in patients with Wegener's granulomatosis. Ann Rheum Dis (1999) 1.31

Characteristics of human "fibroblasts" cultivated in vitro from different anatomical sites. Lab Invest (1962) 1.30

Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis. Matrix (1990) 1.30

Overexpression of zinc-finger transcription factor Z-225/Egr-1 in synoviocytes from rheumatoid arthritis patients. J Immunol (1994) 1.23

Interleukin-4 and interferon-gamma discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets. J Cell Physiol (1996) 1.21

Sustained elevated levels of VCAM-1 in cultured fibroblast-like synoviocytes can be achieved by TNF-alpha in combination with either IL-4 or IL-13 through increased mRNA stability. Am J Pathol (1999) 1.21

Expression of vascular cell adhesion molecule-1 mRNA and protein in rheumatoid synovium demonstrated by in situ hybridization and immunohistochemistry. Lab Invest (1995) 1.20

Characterization of human renal fibroblasts in health and disease: II. In vitro growth, differentiation, and collagen synthesis of fibroblasts from kidneys with interstitial fibrosis. Am J Kidney Dis (1991) 1.19

Detection of human soluble Thy-1 in serum by ELISA. Fibroblasts and activated endothelial cells are a possible source of soluble Thy-1 in serum. Cell Tissue Res (1999) 1.18

Differential expression of Ia antigens by rheumatoid synovial lining cells. J Clin Invest (1987) 1.18

Differential Thy-1 expression by splenic fibroblasts defines functionally distinct subsets. Cell Immunol (1996) 1.18

Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts. Rheumatol Int (1992) 1.17

Characterization of human renal fibroblasts in health and disease: I. Immunophenotyping of cultured tubular epithelial cells and fibroblasts derived from kidneys with histologically proven interstitial fibrosis. Am J Kidney Dis (1991) 1.15

Down regulation of human monocyte differentiation antigens by interferon gamma. Cell Immunol (1987) 1.13

The monoclonal antibody AS02 recognizes a protein on human fibroblasts being highly homologous to Thy-1. Arch Dermatol Res (1998) 1.12

DNA synthesis in prolyl 4-hydroxylase positive fibroblasts in situ in synovial tissue. An autoradiography-immunoperoxidase double labeling study. J Rheumatol (1989) 1.08

Novel fibroblast-specific monoclonal antibodies: properties and specificities. J Invest Dermatol (1996) 1.07

Activation of synovial fibroblasts in rheumatoid arthritis. Ann Rheum Dis (1995) 1.03

Responsiveness of human T lymphocytes to bacterial superantigens presented by cultured rheumatoid arthritis synoviocytes. Arthritis Rheum (1996) 1.02

Depletion of gamma/delta T cells does not prevent or ameliorate, but rather aggravates, rat adjuvant arthritis. Arthritis Rheum (1996) 1.02

Rheumatoid arthritis synovial fibroblast and U937 macrophage/monocyte cell line interaction in cartilage degradation. Arthritis Rheum (1997) 1.02

Antigen-presenting capacity of rheumatoid synovial fibroblasts. Immunology (1994) 1.01

Potential mechanisms for coordinate gene activation in the rheumatoid synoviocyte: implications and hypotheses. Springer Semin Immunopathol (1989) 1.01

Contribution of IL-1, CD14, and CD13 in the increased IL-6 production induced by in vitro monocyte-synoviocyte interactions. J Immunol (1995) 0.98

Effect of human endopeptidase 24.11 ("enkephalinase") on IL-1-induced thymocyte proliferation activity. J Immunol (1988) 0.98

Characterization of the immunophenotype and functional properties of fibroblast-like synoviocytes in comparison to skin fibroblasts and umbilical vein endothelial cells. Immunobiology (1994) 0.98

Constitutive expression of c-fos and c-jun, overexpression of ets-2, and reduced expression of metastasis suppressor gene nm23-H1 in rheumatoid arthritis. Ann Rheum Dis (1996) 0.96

Synovial tissue implants from patients with rheumatoid arthritis cause cartilage destruction in knee joints of SCID.bg mice. J Rheumatol (1994) 0.96

Human Thy-1 is cytokine-inducible on vascular endothelial cells and is a signaling molecule regulated by protein kinase C. J Immunol (1996) 0.95

NF-kappa B regulates VCAM-1 expression on fibroblast-like synoviocytes. J Immunol (2000) 0.95

Proliferation enhancement by spontaneous multiplication of chromosome 7 in rheumatic synovial cells in vitro. Hum Genet (1995) 0.94

Up-regulation of class II major histocompatibility complex and intercellular adhesion molecule 1 expression on scleroderma fibroblasts and endothelial cells by interferon-gamma and tumor necrosis factor alpha in the early disease stage. Arthritis Rheum (1997) 0.92

Regulation of synovial cell growth. Coexpression of transforming growth factor beta and basic fibroblast growth factor by cultured synovial cells. Arthritis Rheum (1992) 0.91

Activation pathways of synovial T lymphocytes. Expression and function of the UM4D4/CDw60 antigen. J Clin Invest (1990) 0.88

Synovial distribution of alpha d/CD18, a novel leukointegrin. Comparison with other integrins and their ligands. Arthritis Rheum (1996) 0.86

MRP8/MRP14, CD11b and HLA-DR expression of alveolar macrophages in pneumonia. Immunol Lett (2000) 0.84

Cultured human synovial fibroblasts rapidly metabolize kinins and neuropeptides. J Clin Invest (1992) 0.84

Aminopeptidase N: a constitutive cell-surface protein on human dermal fibroblasts. Cell Immunol (1995) 0.84

Development of in vitro model systems for destructive joint diseases: novel strategies for establishing inflammatory pannus. Arthritis Rheum (1997) 0.84

Synovial fibroblast-like cells strongly express jun-B and C-fos proto-oncogenes in rheumatoid- and osteoarthritis. Scand J Rheumatol Suppl (1995) 0.83

Evidence for the expression of a second CD6 ligand by synovial fibroblasts. Arthritis Rheum (2000) 0.83

Spontaneous and cytokine regulated c-fos gene expression in rheumatoid synovial cells: resistance to cytokine stimulation when the c-fos gene is overexpressed. Ann Rheum Dis (2000) 0.80

Proto-oncogene expression in cultured synovial fibroblasts of patients with rheumatoid arthritis. Mol Cell Probes (1991) 0.80

Synthesis of interleukin-1 receptor antagonist by Thy-1+ and Thy-1- murine lung fibroblast subsets. J Interferon Cytokine Res (1995) 0.78

Interleukin-1alpha regulates Thy-1 expression on rat vascular endothelial cells. Microvasc Res (1997) 0.77

Articles by these authors

Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex. J Physiol (1997) 5.94

eggNOG v2.0: extending the evolutionary genealogy of genes with enhanced non-supervised orthologous groups, species and functional annotations. Nucleic Acids Res (2009) 4.55

A recombinant 64 kilodalton protein of Mycobacterium bovis bacillus Calmette-Guerin specifically stimulates human T4 clones reactive to mycobacterial antigens. J Exp Med (1986) 3.92

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci U S A (1999) 3.85

The Memorial Delirium Assessment Scale. J Pain Symptom Manage (1997) 3.55

Macrophages in rheumatoid arthritis. Arthritis Res (2000) 3.40

Propagation of action potentials in dendrites depends on dendritic morphology. J Neurophysiol (2001) 3.05

Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64-kDa protein. Eur J Immunol (1987) 2.45

On meta-analytic assessment of surrogate outcomes. Biostatistics (2000) 2.41

Size variation in chromosomes from independent cultured isolates of Plasmodium falciparum. Nature (1985) 2.33

Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Nature (1998) 2.28

Cognitive performance of GBA mutation carriers with early-onset PD: the CORE-PD study. Neurology (2012) 2.26

Synovitis score: discrimination between chronic low-grade and high-grade synovitis. Histopathology (2006) 2.24

Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. Neuron (1997) 2.14

Chemical characterization of element 112. Nature (2007) 2.12

Synergism in the activation of human CD8 T cells by cross-linking the T-cell receptor complex with the CD8 differentiation antigen. Proc Natl Acad Sci U S A (1986) 2.10

Macrophage specificity of three anti-CD68 monoclonal antibodies (KP1, EBM11, and PGM1) widely used for immunohistochemistry and flow cytometry. Ann Rheum Dis (2004) 2.09

Is trauma in Switzerland any different? epidemiology and patterns of injury in major trauma - a 5-year review from a Swiss trauma centre. Swiss Med Wkly (2014) 2.07

Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis. Ann Rheum Dis (1999) 2.06

A versatile plasmid vector system for the regulated expression of genes in Escherichia coli. Biotechniques (1994) 2.02

The FIS protein binds and bends the origin of chromosomal DNA replication, oriC, of Escherichia coli. Nucleic Acids Res (1991) 2.02

Adding cetuximab to capecitabine plus oxaliplatin (XELOX) in first-line treatment of metastatic colorectal cancer: a randomized phase II trial of the Swiss Group for Clinical Cancer Research SAKK. Ann Oncol (2008) 1.99

Localization of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum in merozoites and ring-infected erythrocytes. J Exp Med (1985) 1.97

Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis. Rheumatol Int (1993) 1.96

Characteristics of respondents and non-respondents to a mailed questionnaire. Am J Public Health (1980) 1.94

Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis? Arthritis Rheum (1997) 1.89

Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. Allergy (2012) 1.88

Serum IgE levels in healthy children quantified by a sandwich technique (PRIST). Clin Allergy (1976) 1.83

A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease. Neurology (2012) 1.77

Angiogenic and angiostatic factors in the molecular control of angiogenesis. Q J Nucl Med (2003) 1.71

Plasmid-encoded outer membrane protein YadA mediates specific binding of enteropathogenic yersiniae to various types of collagen. Infect Immun (1992) 1.68

Adjuvant treatment of colorectal cancer (current expert opinion derived from the Third International Conference: Perspectives in Colorectal Cancer, Dublin, 2001). Eur J Cancer (2002) 1.66

The product of the Herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p56lck in transformed cells. J Biol Chem (1995) 1.65

Interspersed blocks of repetitive and charged amino acids in a dominant immunogen of Plasmodium falciparum. Proc Natl Acad Sci U S A (1985) 1.64

Circadian variation of symptomatic paroxysmal atrial fibrillation. Data from almost 10 000 episodes. Eur Heart J (1999) 1.63

Nilotinib in the treatment of advanced gastrointestinal stromal tumours resistant to both imatinib and sunitinib. Eur J Cancer (2009) 1.62

Amelioration of rat experimental arthritides by treatment with the alkaloid sinomenine. Int J Immunopharmacol (1996) 1.61

Dopaminergic defect of enteric nervous system in Parkinson's disease patients with chronic constipation. Lancet (1995) 1.57

Olfaction in Parkin heterozygotes and compound heterozygotes: the CORE-PD study. Neurology (2010) 1.57

Apoptotic cell death in activated monocytes following incorporation of clodronate-liposomes. J Leukoc Biol (1996) 1.57

RAST, skin and nasal tests and the history in grass pollen allergy. Clin Allergy (1975) 1.56

[Development and implementation of integrated health care in pain medicine : the nationwide German headache treatment network]. Schmerz (2009) 1.56

Sequence of a cDNA encoding a small polymorphic histidine- and alanine-rich protein from Plasmodium falciparum. Nucleic Acids Res (1985) 1.55

Circulating adiponectin concentrations in patients with congestive heart failure. Heart (2006) 1.47

Analysis of coronary ultrasound thrombolysis endpoints in acute myocardial infarction (ACUTE trial). Results of the feasibility phase. Circulation (1997) 1.47

Treatment of rheumatoid arthritis with an anti-CD4 monoclonal antibody. Arthritis Rheum (1991) 1.45

The management of pancreatic cancer. Current expert opinion and recommendations derived from the 8th World Congress on Gastrointestinal Cancer, Barcelona, 2006. Ann Oncol (2007) 1.44

Effective activation of resting mouse T lymphocytes by cross-linking submitogenic concentrations of the T cell antigen receptor with either Lyt-2 or L3T4. Eur J Immunol (1987) 1.43

Affinity purification of human antibodies directed against cloned antigens of Plasmodium falciparum. J Immunol Methods (1986) 1.42

Outer membrane protein YadA of enteropathogenic yersiniae mediates specific binding to cellular but not plasma fibronectin. Infect Immun (1993) 1.41

Value of PCR for evaluating occurrence of parasitemia in immunocompromised patients with cerebral and extracerebral toxoplasmosis. J Clin Microbiol (1994) 1.41

Lassa fever encephalopathy: Lassa virus in cerebrospinal fluid but not in serum. J Infect Dis (2001) 1.40

Lymphocytes of healthy subjects and schizophrenic patients possess no high-affinity binding sites for spiroperidol. Pharmacopsychiatry (1990) 1.40

Aminophylline for bradyasystolic cardiac arrest refractory to atropine and epinephrine. Ann Intern Med (1993) 1.39

The Wellcome Trust lecture. Genes for antigens of Plasmodium falciparum. Parasitology (1986) 1.39

Estimating the time course of the excitatory synaptic conductance in neocortical pyramidal cells using a novel voltage jump method. J Neurosci (1997) 1.38

Mice transgenic for the human carcinoembryonic antigen gene maintain its spatiotemporal expression pattern. Cancer Res (1994) 1.35

Variable antigen associated with the surface of erythrocytes infected with mature stages of Plasmodium falciparum. Mol Biochem Parasitol (1986) 1.35

No impact of repeated endoscopic screens on gastric cancer mortality in a prospectively followed Chinese population at high risk. Prev Med (2002) 1.33

The ring-infected erythrocyte surface antigen (RESA) polypeptide of Plasmodium falciparum contains two separate blocks of tandem repeats encoding antigenic epitopes that are naturally immunogenic in man. Mol Biol Med (1984) 1.32

A comprehensive set of DnaA-box mutations in the replication origin, oriC, of Escherichia coli. Mol Microbiol (1996) 1.32

New glycoprotein-associated amino acid transporters. J Membr Biol (1999) 1.32

Pharmaceutical solids: a strategic approach to regulatory considerations. Pharm Res (1995) 1.32

Letter: Cardiotoxicity of 5-fluorouracil (NSC-19893) Cancer Chemother Rep (1976) 1.31

An asparagine-rich protein from blood stages of Plasmodium falciparum shares determinants with sporozoites. Nucleic Acids Res (1986) 1.30

Cytomegalovirus infection in transplant recipients. The role of tumor necrosis factor. Transplantation (1994) 1.27

Diagnosis of penicillin allergy by means of Phadebas RAST penicilloyl G and V and skin tests. Clin Allergy (1981) 1.27

CD11c as a transcriptional biomarker to predict response to anti-TNF monotherapy with adalimumab in patients with rheumatoid arthritis. Clin Pharmacol Ther (2009) 1.25

Dendritic and somatic glutamate receptor channels in rat cerebellar Purkinje cells. J Physiol (1997) 1.24

Cross-linking of the T cell receptor complex with the subset-specific differentiation antigen stimulates interleukin 2 receptor expression in human CD4 and CD8 T cells. Eur J Immunol (1987) 1.23

Competitive calcium binding: implications for dendritic calcium signaling. J Comput Neurosci (1998) 1.23

Mass changes of inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate during cell cycle progression in rat thymocytes. J Biol Chem (1993) 1.21

Multicenter phase II trial of preoperative induction chemotherapy followed by chemoradiation with docetaxel and cisplatin for locally advanced esophageal carcinoma (SAKK 75/02). Ann Oncol (2009) 1.20

The complete sequence of the gene for the knob-associated histidine-rich protein from Plasmodium falciparum. EMBO J (1987) 1.18

A blood stage antigen of Plasmodium falciparum shares determinants with the sporozoite coat protein. Proc Natl Acad Sci U S A (1985) 1.17

Intracellular Ca2+ pools in Jurkat T-lymphocytes. Biochem J (1993) 1.15

A novel multispecific competitor fragment for quantitative PCR analysis of cytokine gene expression in rats. J Immunol Methods (1994) 1.14

Genetic parameters for clinical mastitis, somatic cell score, and production in the first three lactations of Swedish holstein cows. J Dairy Sci (2004) 1.13

Systemic macrophage activation in locally-induced experimental arthritis. J Autoimmun (2001) 1.13

Longitudinal outcome of Parkinson's disease patients with psychosis. Neurology (2003) 1.12

First- and second-line anti-tuberculosis drug resistance in Northwest Ethiopia. Int J Tuberc Lung Dis (2012) 1.11

Nonlinear anisotropic diffusion filtering of three-dimensional image data from two-photon microscopy. J Biomed Opt (2004) 1.11

Antigenic repeat structures in proteins of Plasmodium falciparum. Ciba Found Symp (1986) 1.10

Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis. Arthritis Rheum (2000) 1.10

Pause-dependent torsade de pointes following acute myocardial infarction: a variant of the acquired long QT syndrome. J Am Coll Cardiol (2001) 1.10

T-cell receptor-mediated metabolism of inositol polyphosphates in Jurkat T-lymphocytes. Identification of a D-myo-inositol 1,2,3,4,6-pentakisphosphate-2-phosphomonoesterase activity, a D-myo-inositol 1,3,4,5,6-pentakisphosphate-1/3-phosphatase activity and a D/L-myo-inositol 1,2,4,5,6-pentakisphosphate-1/3-kinase activity. J Biol Chem (1991) 1.10

Incidence of early tolerance to hemodynamic effects of continuous infusion of nitroglycerin in patients with coronary artery disease and heart failure. Circulation (1987) 1.10

The diagnosis and management of gastric cancer: expert discussion and recommendations from the 12th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2010. Ann Oncol (2011) 1.10

Immortalization of human T cell clones by Herpesvirus saimiri. Signal transduction analysis reveals functional CD3, CD4, and IL-2 receptors. J Immunol (1993) 1.10

Reduction of monocyte-macrophage activation markers upon anti-CD4 treatment. Decreased levels of IL-1, IL-6, neopterin and soluble CD14 in patients with rheumatoid arthritis. Clin Exp Immunol (1993) 1.08

T-cells in the pathogenesis of rheumatoid arthritis villains or accomplices? Biochim Biophys Acta (1997) 1.06

Occurrence of matrix metalloproteinases and tissue inhibitors of metalloproteinases in tuberculous pleuritis. Tuberculosis (Edinb) (2001) 1.06