Telomerase and cancer.

PubWeight™: 2.28‹?› | Rank: Top 2%

🔗 View Article (PMID 11257099)

Published in Hum Mol Genet on April 01, 2001

Authors

J W Shay1, Y Zou, E Hiyama, W E Wright

Author Affiliations

1: The University of Texas Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA. jerry.shay@utsouthwestern.edu

Associated clinical trials:

Telomere Associated Variables (TAVs) in Prostate Cancer | NCT04124900

Articles citing this

TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. Am J Hum Genet (2008) 4.12

The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev (2011) 3.29

Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes. Nat Genet (2014) 2.91

History of the Baylor Charles A. Sammons Cancer Center. Proc (Bayl Univ Med Cent) (2003) 2.15

TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements. Blood (2008) 1.99

Telomerase reverse-transcriptase homozygous mutations in autosomal recessive dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome. Blood (2007) 1.93

The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation. Nucleic Acids Res (2006) 1.71

Differential regulation and predictive potential of MacroH2A1 isoforms in colon cancer. Am J Pathol (2012) 1.71

The role of telomere biology in bone marrow failure and other disorders. Mech Ageing Dev (2007) 1.56

A phase I study of telomerase-specific replication competent oncolytic adenovirus (telomelysin) for various solid tumors. Mol Ther (2009) 1.50

Do you know the sex of your cells? Am J Physiol Cell Physiol (2013) 1.49

Antitumor compounds from marine actinomycetes. Mar Drugs (2009) 1.44

Dyskeratosis congenita. FEBS Lett (2010) 1.36

How to track cellular aging of mesenchymal stromal cells? Aging (Albany NY) (2010) 1.34

Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort. EBioMedicine (2015) 1.27

Molecular characterization of spontaneous mesenchymal stem cell transformation. PLoS One (2008) 1.26

Involvement of replicative polymerases, Tel1p, Mec1p, Cdc13p, and the Ku complex in telomere-telomere recombination. Mol Cell Biol (2002) 1.23

Tiny telomere DNA. Nucleic Acids Res (2002) 1.20

Clinical implications of quantitative real-time RT-PCR analysis of hTERT gene expression in human gliomas. Br J Cancer (2003) 1.15

Telomeres, telomerase, and tumorigenesis--a review. MedGenMed (2004) 1.11

Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1. J Cell Biol (2012) 1.09

Pathophysiology and biology of peritoneal carcinomatosis. World J Gastrointest Oncol (2010) 1.07

Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13. Nucleic Acids Res (2009) 1.01

Expression profile of a gamma-deletion variant of the human telomerase reverse transcriptase gene. Neoplasia (2003) 1.01

Toxin-based therapeutic approaches. Toxins (Basel) (2010) 1.00

Extrachromosomal telomeric circles contribute to Rad52-, Rad50-, and polymerase delta-mediated telomere-telomere recombination in Saccharomyces cerevisiae. Eukaryot Cell (2005) 0.99

Imatinib mesylate (Gleevec) downregulates telomerase activity and inhibits proliferation in telomerase-expressing cell lines. Br J Cancer (2005) 0.97

Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis. BMC Cancer (2010) 0.96

Orthotopic injection of breast cancer cells into the mammary fat pad of mice to study tumor growth. J Vis Exp (2015) 0.93

Gene signatures in hepatocellular carcinoma (HCC). Semin Cancer Biol (2010) 0.93

High-mobility group A2 protein modulates hTERT transcription to promote tumorigenesis. Mol Cell Biol (2011) 0.92

Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines. Int J Biochem Cell Biol (2010) 0.91

5-aza-2'-deoxycytidine-mediated c-myc Down-regulation triggers telomere-dependent senescence by regulating human telomerase reverse transcriptase in chronic myeloid leukemia. Neoplasia (2014) 0.91

TERT promoter mutations lead to high transcriptional activity under hypoxia and temozolomide treatment and predict poor prognosis in gliomas. PLoS One (2014) 0.91

Senescence in Human Mesenchymal Stem Cells: Functional Changes and Implications in Stem Cell-Based Therapy. Int J Mol Sci (2016) 0.91

Alternative splicing regulation of telomerase: a new paradigm? Trends Genet (2014) 0.90

Elevated human telomerase reverse transcriptase gene expression in blood cells associated with chronic arsenic exposure in Inner Mongolia, China. Environ Health Perspect (2008) 0.88

Degradation of p53, not telomerase activation, by E6 is required for bypass of crisis and immortalization by human papillomavirus type 16 E6/E7. J Virol (2004) 0.87

Prodrug applications for targeted cancer therapy. AAPS J (2014) 0.87

Theranostic nanoparticles based on bioreducible polyethylenimine-coated iron oxide for reduction-responsive gene delivery and magnetic resonance imaging. Int J Nanomedicine (2014) 0.86

Over-expression of LPTS-L in hepatocellular carcinoma cell line SMMC-7721 induces crisis. World J Gastroenterol (2002) 0.86

Telomerase-dependent and independent telomere maintenance and its clinical implications in medullary thyroid carcinoma. J Clin Endocrinol Metab (2014) 0.86

Nanopore detection of 8-oxoguanine in the human telomere repeat sequence. ACS Nano (2015) 0.86

BamHI-A rightward frame 1, an Epstein-Barr virus-encoded oncogene and immune modulator. Rev Med Virol (2013) 0.85

Inhibition of telomerase by linear-chain fatty acids: a structural analysis. Biochem J (2002) 0.84

Inhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instability. Genome Integr (2010) 0.84

Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells. Oncotarget (2016) 0.83

Experience with peritoneal mesothelioma at the Milan National Cancer Institute. World J Gastrointest Oncol (2010) 0.81

Telomere length in peripheral blood leukocytes is associated with risk of colorectal cancer in Chinese population. PLoS One (2014) 0.81

Telomeres and telomerase: from discovery to clinical trials. Chem Biol (2009) 0.80

Selective increase in subtelomeric DNA methylation: an epigenetic biomarker for malignant glioma. Clin Epigenetics (2015) 0.80

Examining the pathogenesis of breast cancer using a novel agent-based model of mammary ductal epithelium dynamics. PLoS One (2013) 0.79

Effects of treatment with platinum azidothymidine and azidothymidine on telomerase activity and bcl-2 concentration in hepatocellular carcinoma- induced rats. Avicenna J Med Biotechnol (2014) 0.79

Altered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma. Mol Med (2010) 0.79

Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. PLoS One (2012) 0.79

Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy. Mol Ther Nucleic Acids (2015) 0.78

Regulation of hTERT transcription: a target of cellular and viral mechanisms for immortalization and carcinogenesis. Cytotechnology (2004) 0.78

OX26/CTX-conjugated PEGylated liposome as a dual-targeting gene delivery system for brain glioma. Mol Cancer (2014) 0.78

In silico evaluation of TERT inhibition by anticancer drugs. J Mol Model (2012) 0.77

Effective antitumor immunity against murine gliomas using dendritic cells transduced with hTERTC27 recombinant adenovirus. Oncol Rep (2011) 0.77

BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo. Oncotarget (2016) 0.77

Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology. Philos Trans R Soc Lond B Biol Sci (2002) 0.77

Genome-wide prediction of cancer driver genes based on SNP and cancer SNV data. Am J Cancer Res (2014) 0.77

Detection of cell carcinogenic transformation by a quadruplex DNA binding fluorescent probe. PLoS One (2014) 0.76

Influence of the hTERT rs2736100 polymorphism on telomere length in gastric cancer. World J Gastroenterol (2015) 0.76

Telomere dynamics and homeostasis in a transmissible cancer. PLoS One (2012) 0.76

Virus and host genomic, molecular, and cellular interactions during Marek's disease pathogenesis and oncogenesis. Poult Sci (2016) 0.76

Single cell measurement of telomerase expression and splicing using microfluidic emulsion cultures. Nucleic Acids Res (2015) 0.75

Expression of phosphorylated Akt and hTERT is associated with prognosis of epithelial ovarian carcinoma. Int J Clin Exp Pathol (2015) 0.75

RNA interference mediated downregulation of human telomerase reverse transcriptase (hTERT) in LN18 cells. Cytotechnology (2016) 0.75

Genome-wide identification of expression quantitative trait loci for human telomerase. Medicine (Baltimore) (2016) 0.75

The status of telomerase enzyme activity in benign and malignant gynaecologic pathologies. Balkan Med J (2013) 0.75

Balancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too? Cell Mol Life Sci (2016) 0.75

Suppressing tumor growth of nasopharyngeal carcinoma by hTERTC27 polypeptide delivered through adeno-associated virus plus adenovirus vector cocktail. Chin J Cancer (2012) 0.75

Inhibition of hepatocellular carcinoma growth by adenovirus-mediated expression of human telomerase reverse transcriptase COOH-27 terminal polypeptide in mice. Oncol Lett (2013) 0.75

Telomerase activity and the risk of lung cancer. J Korean Med Sci (2012) 0.75

Telomere Length, TERT, and miRNA Expression. PLoS One (2016) 0.75

Telomeres and telomerase in prostate cancer development and therapy. Nat Rev Urol (2017) 0.75

Reconstruction of enhancer-target networks in 935 samples of human primary cells, tissues and cell lines. Nat Genet (2017) 0.75

Oligonucleotide-based theranostic nanoparticles in cancer therapy. Nanomedicine (Lond) (2016) 0.75

Articles by these authors

Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20

Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet (1997) 6.69

A transcriptionally active DNA-binding site for human p53 protein complexes. Mol Cell Biol (1992) 6.56

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell (1991) 6.48

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol (2001) 5.82

Positive autoregulation of the myogenic determination gene MyoD1. Cell (1989) 4.28

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet (1999) 4.22

A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res (1991) 4.07

Defining the molecular mechanisms of human cell immortalization. Biochim Biophys Acta (1991) 3.73

Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis. Nature (1989) 3.73

Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol (1995) 3.20

Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev (1999) 3.19

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev (2001) 3.16

Telomere position effect in human cells. Science (2001) 2.61

Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest (1997) 2.44

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci U S A (1999) 2.36

Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill (2013) 2.34

E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene (1993) 2.25

Telomerase activity in small-cell and non-small-cell lung cancers. J Natl Cancer Inst (1995) 2.18

Hayflick, his limit, and cellular ageing. Nat Rev Mol Cell Biol (2000) 2.15

Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation. Science (2001) 2.14

Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J Biol Chem (2000) 2.14

Combinatorial signaling in the specification of unique cell fates. Cell (2000) 2.13

Telomerase activity in human cancer. Curr Opin Oncol (1996) 2.13

Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins. Mol Cell Biol (1994) 2.00

Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen. Exp Cell Res (1989) 1.96

Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Mol Cell Biol (1999) 1.96

The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes. Hum Mol Genet (2000) 1.93

Regulation of telomerase activity in immortal cell lines. Mol Cell Biol (1996) 1.82

Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections. Neuron (2000) 1.76

Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells. Nucleic Acids Res (2001) 1.73

Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang. J Biol Chem (2000) 1.73

Identification of skeletal muscle precursor cells in vivo by use of MyoD1 and myogenin probes. Cell Tissue Res (1992) 1.67

Biliary excretion of cephalosporins in rats: influence of molecular weight. Antimicrob Agents Chemother (1980) 1.63

Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences. Oncogene (1993) 1.59

Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy. J Biol Chem (1996) 1.57

Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels. Mol Cell Biol (1999) 1.55

Transient expression of human telomerase extends the life span of normal human fibroblasts. Biochem Biophys Res Commun (2000) 1.54

Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers. Proc Natl Acad Sci U S A (1985) 1.54

Formation of anucleate and multinucleate cells in normal and SV 40 transformed WI-38 by cytochalasin B. Exp Cell Res (1972) 1.50

An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity. Neoplasia (2001) 1.48

Telomerase immortalization of human myometrial cells. Biol Reprod (2002) 1.48

Natural IgG antibodies in normal rabbit serum are involved in killing of the ompP2 mutant of Haemophilus parasuis SC096 strain via the classical complement pathway. Vet J (2012) 1.45

Increasing trends in the use of breast-conserving surgery in California. Am J Public Health (2000) 1.44

Leukaemia in workers exposed to electrical and magnetic fields. Lancet (1982) 1.43

Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy. J Biol Chem (2000) 1.43

Telomeres and telomerase: a simple picture becomes complex. Cell (1996) 1.41

Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor. Proc Natl Acad Sci U S A (1992) 1.41

The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nat Med (2000) 1.39

Pulmonary effects of exposures in silicon carbide manufacturing. Br J Ind Med (1984) 1.39

Multiple myeloma in cosmetologists. Am J Ind Med (1982) 1.38

A QTL located on chromosome 4A associated with dormancy in white- and red-grained wheats of diverse origin. Theor Appl Genet (2005) 1.38

Induction of muscle genes in neural cells. J Cell Biol (1984) 1.36

High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer. Clin Cancer Res (2000) 1.36

Rho family small G proteins play critical roles in mechanical stress-induced hypertrophic responses in cardiac myocytes. Circ Res (1999) 1.35

Telomeres and telomerase: implications for cancer and aging. Radiat Res (2001) 1.34

Malignant mesothelioma: incidence, asbestos exposure, and reclassification of histopathology. Br J Ind Med (1984) 1.34

Cephaloglycin and its biologically active metabolite desacetylcephaloglycin. Appl Microbiol (1971) 1.34

Hallmarks of telomeres in ageing research. J Pathol (2007) 1.33

Molecular inflammation as an underlying mechanism of the aging process and age-related diseases. J Dent Res (2011) 1.32

A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1. Nucleic Acids Res (1999) 1.32

The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen. Exp Cell Res (1993) 1.32

Inhibition of human telomerase activity by peptide nucleic acids. Nat Biotechnol (1996) 1.30

Lack of cell cycle regulation of telomerase activity in human cells. Proc Natl Acad Sci U S A (1997) 1.30

Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cells. J Biol Chem (2001) 1.28

Recent trends in mesothelioma incidence in the United States. Am J Ind Med (1986) 1.28

Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy. Circulation (1999) 1.26

Biomechanical stress-induced apoptosis in vein grafts involves p38 mitogen-activated protein kinases. FASEB J (2000) 1.26

Telomerase activity concentrates in the mitotically active segments of human hair follicles. J Invest Dermatol (1997) 1.25

Telomerase activity does not always imply telomere maintenance. Biochem Biophys Res Commun (1999) 1.25

The isolation of heterokaryons and hybrids by a selective system using irreversible biochemical inhibitors. Exp Cell Res (1978) 1.25

Expression of differentiated functions in heterokaryons between skeletal myocytes, adrenal cells, fibroblasts and glial cells. Exp Cell Res (1984) 1.24

Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy. Circ Res (1995) 1.24

Breast cancer stage at diagnosis in relation to duration of medicaid enrollment. Med Care (2001) 1.23

Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci (1998) 1.23

Is telomerase a viable target in cancer? Mutat Res (2011) 1.23

Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase. Mol Cell Biol (2000) 1.22

Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis. Development (1999) 1.21

ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation. Oncogene (2006) 1.20

Exon skipping mutations in collagen VI are common and are predictive for severity and inheritance. Hum Mutat (2008) 1.18

Identification of MICA as a new polymorphic alloantigen recognized by antibodies in sera of organ transplant recipients. Hum Immunol (2000) 1.18

Telomerase inhibitors. Trends Biotechnol (2001) 1.18

Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression. Oncogene (2001) 1.18

Angiotensin II stimulates c-Jun NH2-terminal kinase in cultured cardiac myocytes of neonatal rats. Circ Res (1997) 1.18

MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytes. Circulation (1999) 1.18

Use of reiterative selection for defining protein-nucleic acid interactions. Curr Opin Biotechnol (1995) 1.17

Organic chemicals and malignant melanoma. Am J Ind Med (1983) 1.17

Telomerase activity in human acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agents. Clin Cancer Res (1996) 1.17

Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes. J Clin Invest (1995) 1.16

Novel DNA binding of p53 mutants and their role in transcriptional activation. Oncogene (1993) 1.16

Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation. J Biol Chem (1997) 1.16

Mechanical stretch activates the stress-activated protein kinases in cardiac myocytes. FASEB J (1996) 1.16

SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene (2012) 1.16

Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney. Inflamm Res (2009) 1.14

Refining the telomere-telomerase hypothesis of aging and cancer. Nat Biotechnol (1996) 1.14

Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system. Mol Cell (2000) 1.13

Telomerase activity in ordinary meningiomas predicts poor outcome. Hum Pathol (1997) 1.13