Biology and disease associations of Epstein-Barr virus.

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Published in Philos Trans R Soc Lond B Biol Sci on April 29, 2001

Authors

D H Crawford1

Author Affiliations

1: Division of Biomedical and Clinical Laboratory Sciences, Edinburgh University Medical School, Teviot Place, Edinburgh EH8 9AG, UK. d.crawford@ed.ac.uk

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Germinal centers. Annu Rev Immunol (1994) 10.85

A sarcoma involving the jaws in African children. Br J Surg (1958) 10.60

Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N Engl J Med (1983) 10.09

Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature (1988) 6.38

Transformation of foetal human keukocytes in vitro by filtrates of a human leukaemic cell line containing herpes-like virus. Int J Cancer (1968) 6.29

Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet (1984) 5.74

Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo. J Exp Med (1998) 5.33

The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Cell (1986) 5.13

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EB viral genomes in epithelial nasopharyngeal carcinoma cells. Nat New Biol (1973) 2.71

T-cell lymphomas containing Epstein-Barr viral DNA in patients with chronic Epstein-Barr virus infections. N Engl J Med (1988) 2.63

Epstein-Barr virus in AIDS-related primary central nervous system lymphoma. Lancet (1991) 2.60

Outbreak of Burkitt's-like lymphoma in homosexual men. Lancet (1982) 2.58

Identification of the site of Epstein-Barr virus persistence in vivo as a resting B cell. J Virol (1997) 2.53

Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein. Proc Natl Acad Sci U S A (1994) 2.49

The pathogenesis of Burkitt's lymphoma. Adv Cancer Res (1990) 2.35

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Detection of EBV gene expression in Reed-Sternberg cells of Hodgkin's disease. Int J Cancer (1990) 2.28

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Hodgkin's disease and Epstein-Barr virus. Altered antibody pattern before diagnosis. N Engl J Med (1989) 2.25

Evidence for a malaria mitogen in human malaria. Nature (1975) 2.25

The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA. Int J Cancer (1987) 2.16

Morphology, immunophenotype, and distribution of latently and/or productively Epstein-Barr virus-infected cells in acute infectious mononucleosis: implications for the interindividual infection route of Epstein-Barr virus. Blood (1995) 2.15

Immunohistology of Epstein-Barr virus-associated antigens in B cell disorders from immunocompromised individuals. Transplantation (1990) 2.13

Etiology of Burkitt's lymphoma--an alternative hypothesis to a vectored virus. J Natl Cancer Inst (1969) 1.95

p53 is frequently mutated in Burkitt's lymphoma cell lines. EMBO J (1991) 1.91

Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region. Nature (1990) 1.87

Oncogenic role of Epstein-Barr virus-encoded RNAs in Burkitt's lymphoma cell line Akata. J Virol (1999) 1.86

Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice. EMBO J (1996) 1.80

Identification of a human epithelial cell surface protein sharing an epitope with the C3d/Epstein-Barr virus receptor molecule of B lymphocytes. Int J Cancer (1989) 1.76

T-cell control of Epstein-Barr virus-infected B cells is lost during P. falciparum malaria. Nature (1985) 1.69

A model for persistent infection with Epstein-Barr virus: the stealth virus of human B cells. Life Sci (1999) 1.64

A second site for Epstein-Barr virus shedding: the uterine cervix. Lancet (1986) 1.61

Epstein Barr virus nuclear antigen positive lymphoma after cyclosporin A treatment in patient with renal allograft. Lancet (1980) 1.60

Episomal and integrated copies of Epstein-Barr virus coexist in Burkitt lymphoma cell lines. J Virol (1993) 1.56

Posttransplant lymphoproliferative disease in thoracic organ transplant patients: ten years of cyclosporine-based immunosuppression. J Heart Lung Transplant (1992) 1.54

Treatment of post-transplant lymphoproliferative disease with rituximab monoclonal antibody after lung transplantation. Lancet (1999) 1.46

EB virus induction is associated with B-cell maturation. Immunology (1986) 1.45

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Nasopharyngeal carcinoma in Malaysian Chinese: salted fish and other dietary exposures. Int J Cancer (1998) 1.41

Epstein-Barr virus-associated lymphoproliferative disorders in immunocompromised individuals. Adv Cancer Res (1991) 1.36

Circulating Epstein-Barr virus-carrying B cells in acute malaria. Lancet (1991) 1.35

Epidemiology of Hodgkin's disease. Semin Oncol (1980) 1.33

Epstein-Barr virus and nasopharyngeal carcinoma. Semin Cancer Biol (1992) 1.27

Expression of Epstein-Barr virus BamHI-A rightward transcripts in latently infected B cells from peripheral blood. Blood (1999) 1.24

Strict lymphotropism of Epstein-Barr virus during acute infectious mononucleosis in nonimmunocompromised individuals. Blood (1997) 1.23

Qualitative analysis of the expression of Epstein-Barr virus lytic genes in nasopharyngeal carcinoma biopsies. J Gen Virol (1995) 1.20

The biology of the SCID mutation. Immunol Today (1989) 1.19

Anti-B-cell monoclonal antibodies in the treatment of severe B-cell lymphoproliferative syndrome following bone marrow and organ transplantation. N Engl J Med (1991) 1.18

An Epstein-Barr virus-associated superantigen. J Exp Med (1996) 1.17

X-Linked agammaglobulinemia patients are not infected with Epstein-Barr virus: implications for the biology of the virus. J Virol (1999) 1.15

Infection of human thymocytes by Epstein-Barr virus. J Exp Med (1991) 1.15

Evidence for restricted Epstein-Barr virus latent gene expression and anti-EBNA antibody response in solid organ transplant recipients with posttransplant lymphoproliferative disorders. Blood (1993) 1.12

Excretion of the Epstein-Barr virus from the genital tract of men. J Infect Dis (1991) 1.10

Characterization of a T-lymphocyte Epstein-Barr virus/C3d receptor (CD21). J Virol (1988) 1.08

Epstein-Barr virus induction of recombinase-activating genes RAG1 and RAG2. J Virol (1995) 1.05

The ins and outs of EBV infection. Trends Microbiol (2000) 1.05

The role of EBV in post-transplant malignancies: a review. J Clin Pathol (2000) 1.02

Patterns of cytokine gene expression in infectious mononucleosis. Blood (1994) 0.99

A prospective study in heart and lung transplant recipients correlating persistent Epstein-Barr virus infection with clinical events. Transplantation (1997) 0.97

Transmission of donor Epstein-Barr virus (EBV) in transplanted organs causes lymphoproliferative disease in EBV-seronegative recipients. J Gen Virol (1996) 0.96

Epstein-Barr virus gene expression and epithelial cell differentiation in oral hairy leukoplakia. Am J Pathol (1991) 0.95

Epstein-Barr virus latent membrane protein does not inhibit differentiation and induces tumorigenicity of human epithelial cells. Oncogene (1997) 0.92

T-cell memory: lessons from Epstein-Barr virus infection in man. Philos Trans R Soc Lond B Biol Sci (2000) 0.92

Essential role for T cells in human B-cell lymphoproliferative disease development in severe combined immunodeficient mice. Br J Haematol (2000) 0.89

The gene defective in X-linked lymphoproliferative disease controls T cell dependent immune surveillance against Epstein-Barr virus. Curr Opin Immunol (2000) 0.87

Analysis of the T-cell micro-environment in Epstein-Barr virus-related post-transplantation B lymphoproliferative disease. J Pathol (1998) 0.83

Epstein-Barr virus associated Burkitt lymphoma in a heart transplant recipient. Transplantation (1996) 0.78