Published in RNA on March 01, 2001
The mechanism of eukaryotic translation initiation and principles of its regulation. Nat Rev Mol Cell Biol (2010) 11.19
Untranslated regions of mRNAs. Genome Biol (2002) 8.03
The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection. Genes Dev (2002) 4.96
Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms. Genes Dev (2005) 3.92
The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol Cell Biol (2003) 3.90
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. EMBO J (2004) 3.29
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Molecular mechanism of scanning and start codon selection in eukaryotes. Microbiol Mol Biol Rev (2011) 2.51
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. J Clin Invest (2008) 2.40
A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Mol Cell Biol (2004) 2.38
The mechanism of eukaryotic translation initiation: new insights and challenges. Cold Spring Harb Perspect Biol (2012) 2.21
The major mRNA-associated protein YB-1 is a potent 5' cap-dependent mRNA stabilizer. EMBO J (2001) 2.15
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Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29. Cell (2008) 2.11
Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proc Natl Acad Sci U S A (2005) 2.00
Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation. Mol Cell Biol (2005) 1.99
A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proc Natl Acad Sci U S A (2004) 1.97
Poly(A)-binding protein interaction with elF4G stimulates picornavirus IRES-dependent translation. RNA (2001) 1.89
Structural basis for the enhancement of eIF4A helicase activity by eIF4G. Genes Dev (2005) 1.83
Prp43p is a DEAH-box spliceosome disassembly factor essential for ribosome biogenesis. Mol Cell Biol (2006) 1.64
Bridging IRES elements in mRNAs to the eukaryotic translation apparatus. Biochim Biophys Acta (2009) 1.62
Escherichia coli DbpA is an RNA helicase that requires hairpin 92 of 23S rRNA. EMBO J (2001) 1.58
mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. J Virol (2005) 1.56
Selective pharmacological targeting of a DEAD box RNA helicase. PLoS One (2008) 1.49
Folding free energies of 5'-UTRs impact post-transcriptional regulation on a genomic scale in yeast. PLoS Comput Biol (2005) 1.46
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Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI. RNA (2005) 1.40
Eukaryotic initiation factors 4G and 4A mediate conformational changes downstream of the initiation codon of the encephalomyocarditis virus internal ribosomal entry site. Mol Cell Biol (2003) 1.40
Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation. Am J Hum Genet (2007) 1.39
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Eukaryotic protein synthesis: still a mystery. J Biol Chem (2010) 1.36
The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway. Mol Cell (2010) 1.35
Efficient translation initiation directed by the 900-nucleotide-long and GC-rich 5' untranslated region of the human retrotransposon LINE-1 mRNA is strictly cap dependent rather than internal ribosome entry site mediated. Mol Cell Biol (2007) 1.33
DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs. EMBO J (2012) 1.31
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc Natl Acad Sci U S A (2010) 1.30
Translational control by a small RNA: dendritic BC1 RNA targets the eukaryotic initiation factor 4A helicase mechanism. Mol Cell Biol (2008) 1.28
Probing the mechanisms of DEAD-box proteins as general RNA chaperones: the C-terminal domain of CYT-19 mediates general recognition of RNA. Biochemistry (2007) 1.27
Differential contribution of the m7G-cap to the 5' end-dependent translation initiation of mammalian mRNAs. Nucleic Acids Res (2009) 1.25
RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis. RNA (2003) 1.23
Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity. Proc Natl Acad Sci U S A (2013) 1.23
Targeting the eIF4F translation initiation complex: a critical nexus for cancer development. Cancer Res (2015) 1.23
Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation. Proc Natl Acad Sci U S A (2011) 1.22
Mechanism of ATP turnover inhibition in the EJC. RNA (2008) 1.21
eIF4G stimulates the activity of the DEAD box protein eIF4A by a conformational guidance mechanism. Nucleic Acids Res (2010) 1.21
New ways of initiating translation in eukaryotes. Mol Cell Biol (2001) 1.20
Transforming growth factor-beta induces airway smooth muscle hypertrophy. Am J Respir Cell Mol Biol (2005) 1.20
Depletion of eIF4G from yeast cells narrows the range of translational efficiencies genome-wide. BMC Genomics (2011) 1.19
RNA helicase proteins as chaperones and remodelers. Annu Rev Biochem (2014) 1.17
A cellular response linking eIF4AI activity to eIF4AII transcription. RNA (2012) 1.13
Regulation of mRNA translation by signaling pathways. Cold Spring Harb Perspect Biol (2012) 1.13
Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated. Mol Biol Cell (2011) 1.13
Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay. RNA (2006) 1.13
Unique translation initiation of mRNAs-containing TISU element. Nucleic Acids Res (2011) 1.12
mTOR coordinates protein synthesis, mitochondrial activity and proliferation. Cell Cycle (2015) 1.11
Characterization of the ATPase and unwinding activities of the yeast DEAD-box protein Has1p and the analysis of the roles of the conserved motifs. Nucleic Acids Res (2005) 1.09
The herpes simplex virus 1 vhs protein enhances translation of viral true late mRNAs and virus production in a cell type-dependent manner. J Virol (2011) 1.08
eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways. Cell Cycle (2010) 1.07
The virion host shutoff endonuclease (UL41) of herpes simplex virus interacts with the cellular cap-binding complex eIF4F. J Virol (2010) 1.07
General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation. EMBO J (2008) 1.06
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Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance. Mol Cell Biol (2008) 1.05
The DEAD-box RNA helicase-like Utp25 is an SSU processome component. RNA (2010) 1.04
Synergistic activation of eIF4A by eIF4B and eIF4G. Nucleic Acids Res (2010) 1.04
Plakophilin 1 stimulates translation by promoting eIF4A1 activity. J Cell Biol (2010) 1.04
PKR-dependent mechanisms of gene expression from a subgenomic hepatitis C virus clone. J Virol (2002) 1.04
Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A. Genome Res (2015) 1.03
Transcriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation. Genome Biol (2014) 1.02
Small interfering RNAs that deplete the cellular translation factor eIF4H impede mRNA degradation by the virion host shutoff protein of herpes simplex virus. J Virol (2008) 1.01
Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation. Carcinogenesis (2011) 1.01
Functional analyses of RNA structures shared between the internal ribosome entry sites of hepatitis C virus and the picornavirus porcine teschovirus 1 Talfan. J Virol (2006) 1.01
eIF4B, eIF4G and RNA regulate eIF4A activity in translation initiation by modulating the eIF4A conformational cycle. Nucleic Acids Res (2014) 1.01
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The picornavirus avian encephalomyelitis virus possesses a hepatitis C virus-like internal ribosome entry site element. J Virol (2007) 1.00
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4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy. Am J Respir Cell Mol Biol (2005) 0.98
The two eIF4A helicases in Trypanosoma brucei are functionally distinct. Nucleic Acids Res (2006) 0.98
Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B. RNA (2006) 0.96
Cap-dependent eukaryotic initiation factor-mRNA interactions probed by cross-linking. RNA (2008) 0.96
RNA aptamers to mammalian initiation factor 4G inhibit cap-dependent translation by blocking the formation of initiation factor complexes. RNA (2006) 0.96
The DEAD-box helicase eIF4A: paradigm or the odd one out? RNA Biol (2012) 0.95
Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species. Nat Prod Rep (2014) 0.95
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Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells. Proc Natl Acad Sci U S A (2014) 0.93
New frontiers in translational control of the cancer genome. Nat Rev Cancer (2016) 0.92
The herpes simplex virus 1 virion host shutoff protein enhances translation of viral late mRNAs by preventing mRNA overload. J Virol (2014) 0.89
Signalling to eIF4E in cancer. Biochem Soc Trans (2015) 0.86
Duck Hepatitis A virus possesses a distinct type IV internal ribosome entry site element of picornavirus. J Virol (2011) 0.86
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A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1. Open Biol (2014) 0.84
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