Identification of a novel structural variant of the alpha 6 integrin.

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMC 2824502)

Published in J Biol Chem on May 18, 2001

Authors

T L Davis1, I Rabinovitz, B W Futscher, M Schnölzer, F Burger, Y Liu, M Kulesz-Martin, A E Cress

Author Affiliations

1: Department of Radiation Oncology, University of Arizona Cancer Center, Tucson, Arizona 85724, USA.

Articles citing this

The role of alpha 6 integrin in prostate cancer migration and bone pain in a novel xenograft model. PLoS One (2008) 1.31

Integrin clipping: a novel adhesion switch? J Cell Biochem (2004) 1.19

Extracellular engagement of alpha6 integrin inhibited urokinase-type plasminogen activator-mediated cleavage and delayed human prostate bone metastasis. Cancer Res (2009) 1.18

Extracellular alpha 6 integrin cleavage by urokinase-type plasminogen activator in human prostate cancer. Exp Cell Res (2004) 1.16

Integrin alpha6 cleavage: a novel modification to modulate cell migration. Exp Cell Res (2007) 1.14

Different phenotypes in human prostate cancer: alpha6 or alpha3 integrin in cell-extracellular adhesion sites. Neoplasia (2002) 1.13

Temporal and spatial regulation of integrins during development. Curr Opin Cell Biol (2008) 1.03

Epigenetic regulation of the cell type-specific gene 14-3-3sigma. Neoplasia (2005) 0.92

alpha6 integrin cleavage: sensitizing human prostate cancer to ionizing radiation. Int J Radiat Biol (2007) 0.88

RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis. Cancers (Basel) (2012) 0.87

Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function. J Biol Chem (2008) 0.86

Human Cell Surface Receptors as Molecular Imaging Candidates for Metastatic Prostate Cancer. Open Prost Cancer J (2009) 0.82

Androgen control of cell proliferation and cytoskeletal reorganization in human fibrosarcoma cells: role of RhoB signaling. J Biol Chem (2003) 0.82

Differential regulation of a novel variant of the alpha(6) integrin, alpha(6p). Cell Growth Differ (2002) 0.82

Spatially and temporally regulated alpha6 integrin cleavage during Xenopus laevis development. Biochem Biophys Res Commun (2007) 0.81

Intracellular modifiers of integrin alpha 6p production in aggressive prostate and breast cancer cell lines. Biochem Biophys Res Commun (2014) 0.79

Integrin A6 Cleavage in Mouse Skin Tumors. Open Cancer J (2008) 0.77

Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers. Am J Transl Res (2016) 0.75

Integrin involvement in freeze resistance of androgen-insensitive prostate cancer. Prostate Cancer Prostatic Dis (2010) 0.75

Articles cited by this

Improved tools for biological sequence comparison. Proc Natl Acad Sci U S A (1988) 193.60

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95

Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem (1996) 45.70

Integrin signaling. Science (1999) 16.44

Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells. Cell (1990) 8.41

Laminin receptor on platelets is the integrin VLA-6. Nature (1988) 4.91

The role of integrins alpha 2 beta 1 and alpha 3 beta 1 in cell-cell and cell-substrate adhesion of human epidermal cells. J Cell Biol (1990) 3.82

The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platelet glycoproteins Ic-IIa. J Cell Biol (1988) 3.67

Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Nat Genet (1996) 3.42

A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody. J Biol Chem (1987) 2.94

N-hydroxysulfosuccinimide active esters: bis(N-hydroxysulfosuccinimide) esters of two dicarboxylic acids are hydrophilic, membrane-impermeant, protein cross-linkers. Biochemistry (1982) 2.63

Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain. Proc Natl Acad Sci U S A (1997) 2.27

Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4. J Cell Biol (1990) 2.24

Integrin switching regulates normal trophoblast invasion. Development (1994) 2.23

Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures. J Biol Chem (1988) 2.20

Characterization of integrin-tetraspanin adhesion complexes: role of tetraspanins in integrin signaling. J Cell Biol (1999) 2.18

Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis. Cell (1998) 2.08

The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes. J Cell Biol (2000) 2.00

Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins). Mol Biol Cell (1996) 1.94

The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1. J Immunol (1997) 1.93

Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia. Nat Genet (1995) 1.90

The alpha 6 beta 1 and alpha 6 beta 4 integrins in human prostate cancer progression. Cancer Metastasis Rev (1995) 1.84

The alpha 6 beta 1 (VLA-6) and alpha 6 beta 4 protein complexes: tissue distribution and biochemical properties. J Cell Sci (1990) 1.83

Axonal regulation of Schwann cell integrin expression suggests a role for alpha 6 beta 4 in myelination. J Cell Biol (1993) 1.74

Basement membrane diversity detected by monoclonal antibodies. Differentiation (1984) 1.72

Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. J Exp Med (1993) 1.70

N-Cadherin expression in human prostate carcinoma cell lines. An epithelial-mesenchymal transformation mediating adhesion withStromal cells. Am J Pathol (1999) 1.70

High expression level of alpha 6 integrin in human breast carcinoma is correlated with reduced survival. Cancer Res (1995) 1.65

Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains. Proc Natl Acad Sci U S A (1991) 1.61

Differential expression of extracellular matrix molecules and the alpha 6-integrins in the normal and neoplastic prostate. Am J Pathol (1994) 1.57

Integrin activation: the link between ligand binding and signal transduction. Curr Opin Cell Biol (1996) 1.54

The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis. Cell Mol Life Sci (1998) 1.52

Localization of integrin receptors for fibronectin, collagen, and laminin in human skin. Variable expression in basal and squamous cell carcinomas. J Clin Invest (1989) 1.52

Expression of hemidesmosomal and extracellular matrix proteins by normal and malignant human prostate tissue. Am J Pathol (1995) 1.49

The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin alpha 6 beta 4. Cancer Res (1991) 1.49

The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin. J Cell Biol (1991) 1.45

Phenotypic characteristics of cell lines derived from disseminated cancer cells in bone marrow of patients with solid epithelial tumors: establishment of working models for human micrometastases. Cancer Res (1999) 1.43

Crystal structure of hemopexin reveals a novel high-affinity heme site formed between two beta-propeller domains. Nat Struct Biol (1999) 1.42

Ribosomal scanning past the primary initiation codon as a mechanism for expression of CTL epitopes encoded in alternative reading frames. J Exp Med (1996) 1.39

Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes. Eur J Biochem (1991) 1.38

Quantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal. J Cell Biol (1999) 1.38

Deficiency of the integrin beta 4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion properties. J Cell Sci (1996) 1.37

Characterization of integrin subunits, cellular adhesion and tumorgenicity of four human prostate cell lines. J Cancer Res Clin Oncol (1993) 1.35

Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit. J Cell Biol (1993) 1.34

Alpha 6 integrins are required for Langerhans cell migration from the epidermis. J Exp Med (1997) 1.32

Molecular basis of ligand recognition by integrin alpha 5beta 1. I. Specificity of ligand binding is determined by amino acid sequences in the second and third NH2-terminal repeats of the alpha subunit. J Biol Chem (2000) 1.29

Rapid disruption of an astrocyte interaction with the extracellular matrix mediated by integrin alpha 6 beta 4 during focal cerebral ischemia/reperfusion. Stroke (1997) 1.28

Integrin alpha 6 expression in human prostate carcinoma cells is associated with a migratory and invasive phenotype in vitro and in vivo. Clin Exp Metastasis (1995) 1.26

Integrins and their ligands. Curr Top Microbiol Immunol (1993) 1.20

Monoclonal antibody to human carcinoma-associated protein complex: quantitation in normal and tumor tissue. Cancer Res (1988) 1.20

Epidermal differentiation and basement membrane formation by HaCaT cells in surface transplants. Eur J Cell Biol (1998) 1.20

Quantitative assay for carcinogen altered differentiation in mouse epidermal cells. Carcinogenesis (1980) 1.17

Expression and function of VLA-alpha 2, -alpha 3, -alpha 5 and -alpha 6-integrin receptors in pancreatic carcinoma. Int J Cancer (1992) 1.13

Role of the alpha subunit cytoplasmic domain in regulation of adhesive activity mediated by the integrin VLA-2. J Biol Chem (1993) 1.08

Expression and function of the keratinocyte integrins. Dev Suppl (1993) 1.04

Regulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunit. J Cell Biol (1993) 1.04

Cleavage of beta 4 integrin by matrilysin. Exp Cell Res (1997) 1.04

Growth and differentiation of mouse epidermal cells in culture: effects of extracellular calcium. Curr Probl Dermatol (1980) 1.00

Extracellular matrix receptors in the kidney cortex. Am J Physiol (1990) 0.98

Junctional epidermolysis bullosis: defects in expression of epiligrin/nicein/kalinin and integrin beta 4 that inhibit hemidesmosome formation. J Invest Dermatol (1994) 0.98

Genomic organization of the integrin beta 4 gene (ITGB4): a homozygous splice-site mutation in a patient with junctional epidermolysis bullosa associated with pyloric atresia. Lab Invest (1997) 0.97

Defective integrin alpha 6 beta 4 expression in the skin of patients with junctional epidermolysis bullosa and pyloric atresia. J Invest Dermatol (1996) 0.95

A beta turn in the cytoplasmic tail of the integrin alpha v subunit influences conformation and ligand binding of alpha v beta 3. J Biol Chem (1994) 0.95

Alpha 4/180, a novel form of the integrin alpha 4 subunit. J Biol Chem (1993) 0.94

Multiple loop structures critical for ligand binding of the integrin alpha4 subunit in the upper face of the beta-propeller mode 1. Proc Natl Acad Sci U S A (1997) 0.93

Benign and malignant tumor stages in a mouse keratinocyte line treated with 7,12-dimethylbenz[a]anthracene in vitro. Carcinogenesis (1988) 0.92

Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface. Proc Natl Acad Sci U S A (1998) 0.90

The monoclonal antibody BQ16 identifies the alpha 6 beta 4 integrin on bladder cancer. Hybridoma (1993) 0.90

Distribution of integrin subunits in normal human kidney. Cell Adhes Commun (1994) 0.90

The alpha 6-integrin receptor in pancreatic carcinoma. Gastroenterology (1995) 0.89

Quantitative measurement of alpha 6 beta 1 and alpha 6 beta 4 integrin internalization under cross-linking conditions: a possible role for alpha 6 cytoplasmic domains. J Cell Sci (1994) 0.88

A novel recognition site on laminin for the alpha 3 beta 1 integrin. Exp Cell Res (1996) 0.88

Identification of the cleavage sites in the alpha6A integrin subunit: structural requirements for cleavage and functional analysis of the uncleaved alpha6Abeta1 integrin. Biochem J (1997) 0.88

Distribution of integrin cell adhesion molecules in endometrial cancer. Am J Pathol (1995) 0.88

Distribution of VLA integrins in solid tumors. Emergence of tumor-type-related expression. Patterns in carcinomas and sarcomas. Am J Pathol (1993) 0.88

Absence of detectable alpha 6 integrin in pyloric atresia-junctional epidermolysis bullosa syndrome. Application for prenatal diagnosis in a family at risk for recurrence. Arch Dermatol (1996) 0.88

Post-translational processing of the leukocyte integrin alpha 4 beta 1. J Biol Chem (1992) 0.86

Alpha 6 integrin distribution in human embryonic and adult tissues. Histochemistry (1994) 0.86

Role of endoproteolytic processing in the adhesive and signaling functions of alphavbeta5 integrin. J Biol Chem (2000) 0.86

Composition of extracellular matrix and distribution of cell adhesion molecules in renal cell tumors. Lab Invest (1994) 0.84

Integrin alpha 6 is a differentiation antigen of human granulosa cells. J Clin Endocrinol Metab (1995) 0.83

Expression of beta 1 integrins in non-neoplastic mammary epithelium, fibroadenoma and carcinoma of the breast. Virchows Arch A Pathol Anat Histopathol (1993) 0.82

Altered surface expression and increased turnover of the alpha6beta4 integrin in an undifferentiated carcinoma. Carcinogenesis (2000) 0.81

Quantitation of phosphotyrosine signals in human prostate cell adhesion sites. Biotechniques (2000) 0.81

Immunolocalization of integrins in the normal and neoplastic colonic epithelium. Virchows Arch B Cell Pathol Incl Mol Pathol (1993) 0.80

A quantitative immunohistochemical study of the expression of integrins by nerves in psoriatic and normal skin. Br J Dermatol (1992) 0.77

Distribution of laminin variants and their integrin receptors in human secondary lymphoid tissue. Colocalization suggests that the alpha 6 beta 4-integrin is a receptor for laminin-5 in lymphoid follicles. Cell Adhes Commun (1996) 0.77

Translational introns: an additional regulatory element in gene expression. Trends Biochem Sci (1993) 0.76

Articles by these authors

(truncated to the top 100)

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity (2000) 16.03

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (1997) 13.61

Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base. Pharmacogenomics J (2001) 5.94

Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes. Biophys J (2001) 5.28

HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol (2000) 4.96

The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med (1993) 4.88

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A (2001) 4.58

Diffusion of the Interspecies Electron Carriers H(2) and Formate in Methanogenic Ecosystems and Its Implications in the Measurement of K(m) for H(2) or Formate Uptake. Appl Environ Microbiol (1989) 4.53

The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-independent resistance. Plant Cell (1997) 4.47

Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity (2000) 4.44

Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol (2001) 4.39

Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques (1994) 4.24

Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood (1999) 4.13

Junction adhesion molecule is a receptor for reovirus. Cell (2001) 4.00

Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell (1997) 3.90

Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Genes Dev (1998) 3.84

Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. J Biol Chem (2000) 3.75

Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol (1985) (1999) 3.65

Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury. J Biol Chem (1996) 3.65

Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol (2001) 3.63

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. Proc Natl Acad Sci U S A (1997) 3.59

Response regulator output in bacterial chemotaxis. EMBO J (1998) 3.40

Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY. Cell (1997) 3.32

Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors. Mol Ther (2000) 3.32

Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature (2000) 3.26

Proto-oncogene PML controls genes devoted to MHC class I antigen presentation. Nature (1998) 3.22

Subsequent pulmonary embolism: risk after a negative helical CT pulmonary angiogram--prospective comparison with scintigraphy. Radiology (2000) 3.06

IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J (1998) 2.99

Activation of a mitogen-activated protein kinase pathway is involved in disease resistance in tobacco. Proc Natl Acad Sci U S A (2001) 2.98

Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest (1997) 2.93

Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. EMBO J (1993) 2.92

Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles. J Virol (1997) 2.91

Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export. EMBO J (1998) 2.90

Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem (2000) 2.89

Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene (2012) 2.82

Structure of the adenylyl cyclase catalytic core. Nature (1997) 2.81

Interlocked feedback loops contribute to the robustness of the Neurospora circadian clock. Proc Natl Acad Sci U S A (2001) 2.77

Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol (2001) 2.73

Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem (2000) 2.71

The regulation of reactive oxygen species production during programmed cell death. J Cell Biol (1998) 2.62

The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci (1998) 2.58

The C termini of Arabidopsis cryptochromes mediate a constitutive light response. Cell (2000) 2.53

Nitric oxide and cutaneous active vasodilation during heat stress in humans. J Appl Physiol (1985) (1998) 2.53

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J (1998) 2.50

Uncoupling PR gene expression from NPR1 and bacterial resistance: characterization of the dominant Arabidopsis cpr6-1 mutant. Plant Cell (1998) 2.48

On the use of thiol-modifying agents to determine channel topology. Neuropharmacology (1996) 2.47

Increased thermal stability of proteins in the presence of naturally occurring osmolytes. Biochemistry (1992) 2.47

Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cells. J Biol Chem (1997) 2.47

Profiling serine hydrolase activities in complex proteomes. Biochemistry (2001) 2.46

Molecular cloning of potato spindle tuber viroid (PSTV) cDNA synthesized by enzymatic elongation of PSTV-specific DNA primers: a general strategy for viroid cloning. Biosci Rep (1985) 2.44

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene (2012) 2.41

A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Neurology (2011) 2.39

Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37

Design of allele-specific inhibitors to probe protein kinase signaling. Curr Biol (1998) 2.36

Establishment, maintenance and description of cell lines from the tick Ixodes scapularis. J Parasitol (1994) 2.36

Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron (1997) 2.34

Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity. Curr Biol (2000) 2.30

The transcriptome of the arbuscular mycorrhizal fungus Glomus intraradices (DAOM 197198) reveals functional tradeoffs in an obligate symbiont. New Phytol (2011) 2.29

The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev (1997) 2.26

Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China. Ann Neurol (1993) 2.23

Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J Cell Biol (2001) 2.23

Odd-parity superconductivity in Sr2RuO4. Science (2004) 2.22

Systemic gene expression after intravenous DNA delivery into adult mice. Science (1993) 2.21

Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A (2001) 2.21

Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Proc Natl Acad Sci U S A (1999) 2.19

Coiled-coil domain-mediated FRQ-FRQ interaction is essential for its circadian clock function in Neurospora. EMBO J (2001) 2.19

Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity (1999) 2.18

Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. Oncogene (2012) 2.16

Human albumin therapy of acute ischemic stroke: marked neuroprotective efficacy at moderate doses and with a broad therapeutic window. Stroke (2001) 2.16

Characterization of apelin, the ligand for the APJ receptor. J Neurochem (2000) 2.11

Dissecting glycoprotein quality control in the secretory pathway. Trends Biochem Sci (2001) 2.08

Method for obtaining structure and interactions from oriented lipid bilayers. Phys Rev E Stat Nonlin Soft Matter Phys (2000) 2.08

Covalent catalysis in nucleotidyl transfer reactions: essential motifs in Saccharomyces cerevisiae RNA capping enzyme are conserved in Schizosaccharomyces pombe and viral capping enzymes and among polynucleotide ligases. Proc Natl Acad Sci U S A (1994) 2.07

PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. J Cell Biol (2000) 2.07

Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease. J Intern Med (2014) 2.06

Identification of a global repressor gene, rsmA, of Erwinia carotovora subsp. carotovora that controls extracellular enzymes, N-(3-oxohexanoyl)-L-homoserine lactone, and pathogenicity in soft-rotting Erwinia spp. J Bacteriol (1995) 2.06

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol Cell Biol (2000) 2.06

5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation. Oncogene (2006) 2.05

Preconditioning protects ischemic rabbit heart by protein kinase C activation. Am J Physiol (1994) 2.04

Discovery of a receptor related to the galanin receptors. FEBS Lett (1999) 2.01

Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channel. J Biol Chem (2000) 1.99

A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice. Carcinogenesis (2001) 1.99

Unnatural ligands for engineered proteins: new tools for chemical genetics. Annu Rev Biophys Biomol Struct (2000) 1.99

Investigating the hows and whys of DNA endoreduplication. J Exp Bot (2001) 1.97

Human hair follicle bulge cells are biochemically distinct and possess an epithelial stem cell phenotype. J Investig Dermatol Symp Proc (1999) 1.96

Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects. Proc Natl Acad Sci U S A (1999) 1.95

Programmed myocyte cell death affects the viable myocardium after infarction in rats. Exp Cell Res (1996) 1.95

Inactivation of rsmA leads to overproduction of extracellular pectinases, cellulases, and proteases in Erwinia carotovora subsp. carotovora in the absence of the starvation/cell density-sensing signal, N-(3-oxohexanoyl)-L-homoserine lactone. Appl Environ Microbiol (1995) 1.94

Exaggerated heart rate oscillations during two meditation techniques. Int J Cardiol (1999) 1.93

A receptor for interleukin 10 is related to interferon receptors. Proc Natl Acad Sci U S A (1993) 1.91

microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity. Br J Cancer (2010) 1.90

Response of MG63 osteoblast-like cells to titanium and titanium alloy is dependent on surface roughness and composition. Biomaterials (1998) 1.89

Malignant peritoneal mesothelioma-Results from the International Expanded Access Program using pemetrexed alone or in combination with a platinum agent. Lung Cancer (2008) 1.88

Structure of human chorionic gonadotropin at 2.6 A resolution from MAD analysis of the selenomethionyl protein. Structure (1994) 1.87

Breast-cancer diagnosis with nipple fluid bFGF. Lancet (2000) 1.86

Evidence for a zinc uptake transporter in human prostate cancer cells which is regulated by prolactin and testosterone. J Biol Chem (1999) 1.86

Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo. Genes Dev (1999) 1.86

The alpha 6 beta 1 and alpha 6 beta 4 integrins in human prostate cancer progression. Cancer Metastasis Rev (1995) 1.84

Fruiting body production in Basidiomycetes. Appl Microbiol Biotechnol (2000) 1.83