TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation.

PubWeight™: 2.28‹?› | Rank: Top 2%

🔗 View Article (PMID 11389444)

Published in Nat Cell Biol on June 01, 2001

Authors

S Bonni1, H R Wang, C G Causing, P Kavsak, S L Stroschein, K Luo, J L Wrana

Author Affiliations

1: Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

Articles citing this

Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol (2009) 5.43

TGF-β and BMP signaling in osteoblast differentiation and bone formation. Int J Biol Sci (2012) 3.49

Ski and SnoN, potent negative regulators of TGF-beta signaling. Cell Res (2009) 2.07

Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes Dev (2001) 1.91

Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. Proc Natl Acad Sci U S A (2002) 1.89

Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo. J Biol Chem (2003) 1.81

Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. Mol Biol Cell (2003) 1.78

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7. EMBO J (2003) 1.68

Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Mol Cell Biol (2007) 1.65

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. Biochem J (2005) 1.50

Dual role of SnoN in mammalian tumorigenesis. Mol Cell Biol (2006) 1.47

Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation. J Biol Chem (2005) 1.44

Regulation of Smad activities. Biochim Biophys Acta (2006) 1.41

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. EMBO J (2004) 1.41

Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice. Proc Natl Acad Sci U S A (2004) 1.41

Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation. J Bone Miner Res (2005) 1.39

AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PLoS One (2008) 1.35

Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation. J Biol Chem (2003) 1.31

Smurf2 up-regulation activates telomere-dependent senescence. Genes Dev (2004) 1.23

Post-translational regulation of TGF-β receptor and Smad signaling. FEBS Lett (2012) 1.21

Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. Nat Commun (2013) 1.19

HECT E3s and human disease. BMC Biochem (2007) 1.19

Ubiquitin-dependent regulation of TGFbeta signaling in cancer. Neoplasia (2006) 1.14

Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins. Proc Natl Acad Sci U S A (2005) 1.14

The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. Br J Cancer (2003) 1.14

Multiple transcription factor families regulate axon growth and regeneration. Dev Neurobiol (2011) 1.13

Downregulation of MMP-2 and -9 by proteasome inhibition: a possible mechanism to decrease LEC migration and prevent posterior capsular opacification. Invest Ophthalmol Vis Sci (2008) 1.12

CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription. Mol Cell Biol (2004) 1.11

Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype. J Biol Chem (2011) 1.10

SnoN functions as a tumour suppressor by inducing premature senescence. EMBO J (2009) 1.09

The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein. Genomics (2002) 1.09

Requirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogenic transformation of fibroblast cells. Mol Cell Biol (2005) 1.08

ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells. J Biol Chem (2008) 1.08

TGF-beta signaling in chondrocytes. Front Biosci (2005) 1.08

TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation. J Biol Chem (2007) 1.08

Molecular mechanism of the negative regulation of Smad1/5 protein by carboxyl terminus of Hsc70-interacting protein (CHIP). J Biol Chem (2011) 1.06

Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis. Am J Pathol (2008) 1.03

Smurf control in bone cells. J Cell Biochem (2010) 1.03

The Smads. Genome Biol (2001) 1.03

The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint. J Cell Biol (2008) 1.01

Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formation. Mol Biol Cell (2009) 0.99

The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2). J Biol Chem (2010) 0.99

Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT. Oncogene (2011) 0.99

Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells. PLoS One (2009) 0.99

To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications. Cell Signal (2008) 0.97

The tale of transforming growth factor-beta (TGFbeta) signaling: a soigné enigma. IUBMB Life (2009) 0.96

Dual effects of TGF-beta on ERalpha-mediated estrogenic transcriptional activity in breast cancer. Mol Cancer (2009) 0.95

The role of SnoN in transforming growth factor beta1-induced expression of metalloprotease-disintegrin ADAM12. J Biol Chem (2010) 0.93

Transforming growth factor-beta regulator SnoN modulates mammary gland branching morphogenesis, postlactational involution, and mammary tumorigenesis. Cancer Res (2010) 0.93

Transforming growth factor-beta signaling and ubiquitinators in cancer. Endocr Relat Cancer (2008) 0.93

Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Liver Transpl (2010) 0.91

Arkadia regulates tumor metastasis by modulation of the TGF-β pathway. Cancer Res (2013) 0.91

Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1. J Cell Biochem (2008) 0.90

Key role for ubiquitin protein modification in TGFβ signal transduction. Ups J Med Sci (2012) 0.90

Ubiquitin-dependent degradation of Smad2 is increased in the glomeruli of rats with anti-thymocyte serum nephritis. Am J Pathol (2003) 0.90

Regulation of the transforming growth factor β pathway by reversible ubiquitylation. Open Biol (2012) 0.90

Smad ubiquitination regulatory factor 2 expression is enhanced in hypertrophic scar fibroblasts from burned children. Burns (2011) 0.90

The regulation of TGF-β/SMAD signaling by protein deubiquitination. Protein Cell (2014) 0.88

Increased proteasome-dependent degradation of estrogen receptor-alpha by TGF-beta1 in breast cancer cell lines. J Cell Biochem (2003) 0.88

Defective T-cell activation is associated with augmented transforming growth factor Beta sensitivity in mice with mutations in the Sno gene. Mol Cell Biol (2003) 0.88

SMAD1 deficiency in either endothelial or smooth muscle cells can predispose mice to pulmonary hypertension. Hypertension (2013) 0.88

The phosphatidylinositol 3-kinase/Akt pathway regulates transforming growth factor-{beta} signaling by destabilizing ski and inducing Smad7. J Biol Chem (2009) 0.87

Identification of a Novel Link between the Protein Kinase NDR1 and TGFβ Signaling in Epithelial Cells. PLoS One (2013) 0.86

A decade of the anaphase-promoting complex in the nervous system. Genes Dev (2016) 0.86

Transforming growth factor-β/SMAD Target gene SKIL is negatively regulated by the transcriptional cofactor complex SNON-SMAD4. J Biol Chem (2012) 0.86

The role of the ubiquitin-proteasome system in kidney diseases. Clin Exp Nephrol (2012) 0.85

Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase. Mol Cell Proteomics (2012) 0.85

Cooperative involvement of NFAT and SnoN mediates transforming growth factor-β (TGF-β) induced EMT in metastatic breast cancer (MDA-MB 231) cells. Clin Exp Metastasis (2013) 0.84

Oxidative exposure impairs TGF-β pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts. Age (Dordr) (2014) 0.83

TIF1γ protein regulates epithelial-mesenchymal transition by operating as a small ubiquitin-like modifier (SUMO) E3 ligase for the transcriptional regulator SnoN1. J Biol Chem (2014) 0.83

The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1. Genes Dev (2013) 0.83

SnoN signaling in proliferating cells and postmitotic neurons. FEBS Lett (2012) 0.83

SnoN in regulation of embryonic development and tissue morphogenesis. FEBS Lett (2012) 0.81

SnoN oncoprotein enhances estrogen receptor-α transcriptional activity. Cell Signal (2011) 0.80

The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation. Cell Div (2010) 0.79

Evidence Supporting a Role for SMAD2/3 in Bovine Early Embryonic Development: Potential Implications for Embryotropic Actions of Follistatin. Biol Reprod (2015) 0.79

ZAS3 accentuates transforming growth factor β signaling in epithelial cells. Cell Signal (2010) 0.79

The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial-mesenchymal transition in a sumoylation-regulated manner. Cell Death Differ (2015) 0.78

Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis. BMC Cancer (2014) 0.78

Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis. Cell Div (2009) 0.78

The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells. Genes Dev (2012) 0.78

SnoN facilitates axonal regeneration after spinal cord injury. PLoS One (2013) 0.77

PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism. Cell Signal (2014) 0.77

Regulation of early xenopus embryogenesis by Smad ubiquitination regulatory factor 2. Dev Dyn (2012) 0.76

WW Domain Containing Transcription Regulator regulates human conjunctiva epithelial cell proliferation via inhibiting TGFβ signaling pathway [corrected]. Mol Vis (2012) 0.75

Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. PLoS Genet (2016) 0.75

The PIAS3-Smurf2 sumoylation pathway suppresses breast cancer organoid invasiveness. Oncotarget (2017) 0.75

The influence of SnoN gene silencing by siRNA on the cell proliferation and apoptosis of human pancreatic cancer cells. Diagn Pathol (2015) 0.75

Articles by these authors

SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast. Genes Dev (1997) 7.81

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Science (1999) 7.51

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol Cell (2000) 6.69

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell (1997) 6.34

The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription. Nature (2001) 5.14

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell (1996) 4.70

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. EMBO J (1995) 4.63

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell (1998) 4.51

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature (1999) 4.17

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell (1996) 4.13

MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell (1996) 3.87

Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. Cell (1993) 3.51

Betaglycan presents ligand to the TGF beta signaling receptor. Cell (1993) 3.48

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature (1993) 3.45

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol Cell (1998) 3.36

TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. J Biol Chem (1997) 3.03

Smads as transcriptional co-modulators. Curr Opin Cell Biol (2000) 2.92

Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol Cell Biol (2003) 2.90

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. J Biol Chem (1999) 2.77

MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. Genomics (2000) 2.75

Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J Biol Chem (1998) 2.72

Reversal of resistance to Bacillus thuringiensis in Plutella xylostella. Proc Natl Acad Sci U S A (1994) 2.68

Infection with HIV and hepatitis C virus among injecting drug users in a prevention setting: retrospective cohort study. BMJ (1998) 2.64

Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell (1998) 2.60

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. Mol Cell Biol (1994) 2.59

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes Dev (1999) 2.52

Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages. EMBO J (1998) 2.45

Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors. Cell (1992) 2.40

The TGF-beta family and its composite receptors. Trends Cell Biol (1994) 2.36

Development of Bacillus thuringiensis CryIC Resistance by Spodoptera exigua (Hubner) (Lepidoptera: Noctuidae). Appl Environ Microbiol (1995) 2.36

Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J Biol Chem (1989) 2.05

MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing. J Biomed Mater Res A (2004) 2.03

Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region. Mol Cell Biol (1993) 1.98

Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila. Cell (1994) 1.94

Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes Dev (2001) 1.91

The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. J Cell Biol (1998) 1.90

Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression. J Biol Chem (1991) 1.81

Activation of signalling by the activin receptor complex. Mol Cell Biol (1996) 1.79

TGF-beta receptors and actions. Biochim Biophys Acta (1994) 1.78

Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Cell (1994) 1.76

Geographic distribution, virologic and clinical characteristics of hepatitis B virus genotypes in China. J Viral Hepat (2005) 1.74

Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF beta receptor family. Cell (1995) 1.68

Structural basis of Smad2 recognition by the Smad anchor for receptor activation. Science (2000) 1.66

The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor. Cell (1996) 1.64

Prevalence of naturally occurring surface gene variants of hepatitis B virus in nonimmunized surface antigen-negative Chinese carriers. Hepatology (2001) 1.61

The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes Dev (1999) 1.60

Mads and Smads in TGF beta signalling. Curr Opin Cell Biol (1998) 1.57

FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev (2001) 1.47

Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor beta-induced smad-dependent transcriptional activation. J Biol Chem (1999) 1.47

Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling. J Biol Chem (2000) 1.43

Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Mol Cell Biol (2000) 1.37

Post-translational control of the MEF2A transcriptional regulatory protein. Nucleic Acids Res (1999) 1.37

Activators of protein kinase C induce dissociation of CD4, but not CD8, from p56lck. Science (1989) 1.34

Reconstitution and transphosphorylation of TGF-beta receptor complexes. EMBO J (1994) 1.30

The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development (1998) 1.29

BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis. Am J Physiol (1997) 1.29

Mutational analysis suggests that activation of the yeast pheromone response mitogen-activated protein kinase pathway involves conformational changes in the Ste5 scaffold protein. Mol Biol Cell (2000) 1.25

Signal transduction by members of the transforming growth factor-beta superfamily. Cytokine Growth Factor Rev (1996) 1.25

Mothers against dpp participates in a DDP/TGF-beta responsive serine-threonine kinase signal transduction cascade. Development (1997) 1.24

Characterization of fetal porcine bone sialoproteins, secreted phosphoprotein I (SPPI, osteopontin), bone sialoprotein, and a 23-kDa glycoprotein. Demonstration that the 23-kDa glycoprotein is derived from the carboxyl terminus of SPPI. J Biol Chem (1990) 1.24

Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative. J Clin Invest (1997) 1.24

Mechanism and function of signaling by the TGF beta superfamily. Curr Top Microbiol Immunol (1998) 1.24

Identification of a Drosophila activin receptor. Proc Natl Acad Sci U S A (1993) 1.23

Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals. Diabetologia (2012) 1.17

Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-beta-induced transcription of the Smad7 gene. J Biol Chem (2000) 1.15

Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus. Dev Biol (1999) 1.14

A unique insertion in the S gene of surface antigen--negative hepatitis B virus Chinese carriers. Hepatology (1995) 1.14

Extracellular matrix-induced transforming growth factor-beta receptor signaling dynamics. Oncogene (2010) 1.12

Binding of Bacillus thuringiensis Cry1Ac Toxin to Aminopeptidase in Susceptible and Resistant Diamondback Moths (Plutella xylostella). Appl Environ Microbiol (1997) 1.09

Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation. Oncogene (2012) 1.07

Localization of bone sialoprotein (BSP) expression to sites of mineralized tissue formation in fetal rat tissues by in situ hybridization. Matrix (1991) 1.06

Functional evidence that BDNF is an anterograde neuronal trophic factor in the CNS. J Neurosci (1998) 1.05

T1762/A1764 variants of the basal core promoter of hepatitis B virus; serological and clinical correlations in Chinese patients. Liver (1999) 1.04

Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins. Nucleic Acids Res (2001) 1.04

TGF-beta receptors. Mol Reprod Dev (1992) 1.03

Multiple forms of SppI (secreted phosphoprotein, osteopontin) synthesized by normal and transformed rat bone cell populations: regulation by TGF-beta. Biochem Biophys Res Commun (1989) 1.03

Nuclear localization signals of human and Thermoplasma proteasomal alpha subunits are functional in vitro. Proc Natl Acad Sci U S A (1995) 1.03

Signaling activity of homologous and heterologous transforming growth factor-beta receptor kinase complexes. J Biol Chem (1995) 1.01

The effects of platelet-derived transforming growth factor beta on normal human diploid gingival fibroblasts. Eur J Biochem (1986) 0.99

Protein kinase A is a negative regulator of renal branching morphogenesis and modulates inhibitory and stimulatory bone morphogenetic proteins. J Biol Chem (1999) 0.99

Characterization of the promoter region of the porcine opn (osteopontin, secreted phosphoprotein 1) gene. Identification of positive and negative regulatory elements and a 'silent' second promoter. Eur J Biochem (1992) 0.96

Transforming growth factor-beta regulation of collagenase, 72 kDa-progelatinase, TIMP and PAI-1 expression in rat bone cell populations and human fibroblasts. Connect Tissue Res (1989) 0.95

Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. Proc Natl Acad Sci U S A (2000) 0.94

Characterization of porcine bone sialoprotein: primary structure and cellular expression. Matrix (1993) 0.94

Establishment of a highly efficient transformation system for pepper (Capsicum annuum L.). Plant Cell Rep (2003) 0.92

HIV infection in recipients of blood products from donors with known duration of infection. Lancet (1994) 0.92

Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic osteosarcoma ROS17/2.8 cells and primary rat calvaria cells. J Biol Chem (1998) 0.92

Strain differences in the ontogeny of estrogen receptors in murine uterine epithelium. Endocrinology (1990) 0.90

The composition and structure of Pd-Au surfaces. J Phys Chem B (2005) 0.88

Antiproliferative effect of baicalein, a flavonoid from a Chinese herb, on vascular smooth muscle cell. Eur J Pharmacol (1994) 0.88

Differential regulation of the 55 and 44 kDa forms of secreted phosphoprotein 1 (SPP-1, osteopontin) in normal and transformed rat bone cells by osteotropic hormones, growth factors and a tumor promoter. Bone Miner (1991) 0.88

Characterization of the human bone sialoprotein (BSP) gene and its promoter sequence. Matrix Biol (1994) 0.88

Transforming growth factor-beta signaling and cirrhosis. Hepatology (1999) 0.87

Kinetics of inactivation of aminoacylase by 2-chloromercuri-4-nitrophenol: a new type of complexing inhibitor. Biochemistry (1995) 0.87

1,25-Dihydroxyvitamin D3 increases epidermal growth factor receptors and transforming growth factor beta-like activity in a bone-derived cell line. J Biol Chem (1987) 0.85

BMP-2/ALK3 and HGF signal in parallel to regulate renal collecting duct morphogenesis. J Cell Sci (2000) 0.85

Antiproliferative effect of esculetin on vascular smooth muscle cells: possible roles of signal transduction pathways. Eur J Pharmacol (1993) 0.84