Published in J Biol Chem on June 08, 2001
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways. Nat Rev Mol Cell Biol (2009) 3.95
Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. J Virol (2005) 3.10
A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. EMBO J (2003) 2.73
Ubiquitin interactions of NZF zinc fingers. EMBO J (2004) 2.72
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A role for ubiquitin in the spliceosome assembly pathway. Nat Struct Mol Biol (2008) 2.12
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Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4. J Biol Chem (2003) 1.72
Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47. EMBO J (2004) 1.68
Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase. EMBO J (2006) 1.64
STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif. Mol Biol Cell (2003) 1.63
Late assembly domain function can exhibit context dependence and involves ubiquitin residues implicated in endocytosis. J Virol (2002) 1.61
Analyses of the effects of all ubiquitin point mutants on yeast growth rate. J Mol Biol (2013) 1.59
VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments. J Cell Biol (2004) 1.55
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Substrate degradation by the proteasome: a single-molecule kinetic analysis. Science (2015) 1.47
APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1. Nat Cell Biol (2012) 1.46
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Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site. J Biol Chem (2009) 1.42
A small conserved surface in SUMO is the critical structural determinant of its transcriptional inhibitory properties. Mol Cell Biol (2005) 1.40
Dissecting the ubiquitin pathway by mass spectrometry. Biochim Biophys Acta (2006) 1.32
Assembly, analysis and architecture of atypical ubiquitin chains. Nat Struct Mol Biol (2013) 1.27
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The ubiquitination code: a signalling problem. Cell Div (2007) 1.25
Molecular mechanisms of ubiquitin-dependent membrane traffic. Annu Rev Biophys (2011) 1.19
Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins. Proc Natl Acad Sci U S A (2005) 1.16
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Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control. J Cell Sci (2012) 1.06
Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34. Mol Cell Biol (2010) 1.05
The Colossus of ubiquitylation: decrypting a cellular code. Mol Cell (2013) 0.96
Structural determinants of ubiquitin-CXC chemokine receptor 4 interaction. J Biol Chem (2011) 0.96
Membrane protein targeting to the MVB/lysosome. Chem Rev (2009) 0.95
Structural and dynamic characteristics of a partially folded state of ubiquitin revealed by hydrogen exchange mass spectrometry. Biochemistry (2005) 0.95
Amyloidogenic regions and interaction surfaces overlap in globular proteins related to conformational diseases. PLoS Comput Biol (2009) 0.94
Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates. PLoS Genet (2009) 0.94
The ubiquitination machinery of the ubiquitin system. Arabidopsis Book (2014) 0.93
Role of the Zn(2+) motif of E1 in SUMO adenylation. J Biol Chem (2010) 0.91
Specificity of the E1-E2-E3 enzymatic cascade for ubiquitin C-terminal sequences identified by phage display. ACS Chem Biol (2012) 0.91
Structural analysis of the conserved ubiquitin-binding motifs (UBMs) of the translesion polymerase iota in complex with ubiquitin. J Biol Chem (2010) 0.91
Copper: from neurotransmission to neuroproteostasis. Front Aging Neurosci (2014) 0.89
Conformational dynamics and structural plasticity play critical roles in the ubiquitin recognition of a UIM domain. J Mol Biol (2010) 0.89
DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells. Cell Rep (2013) 0.88
Sequence and structure evolved separately in a ribosomal ubiquitin variant. EMBO J (2007) 0.86
Using Protein Motion to Read, Write, and Erase Ubiquitin Signals. J Biol Chem (2015) 0.86
Arabidopsis membrane-anchored ubiquitin-fold (MUB) proteins localize a specific subset of ubiquitin-conjugating (E2) enzymes to the plasma membrane. J Biol Chem (2011) 0.86
HyperISGylation of Old World monkey ISG15 in human cells. PLoS One (2008) 0.86
Ubiquitin interacts with the Tollip C2 and CUE domains and inhibits binding of Tollip to phosphoinositides. J Biol Chem (2013) 0.84
Alanine scan of core positions in ubiquitin reveals links between dynamics, stability, and function. J Mol Biol (2013) 0.84
Mechanisms of generating polyubiquitin chains of different topology. Cells (2014) 0.84
Orthogonal ubiquitin transfer through engineered E1-E2 cascades for protein ubiquitination. Chem Biol (2012) 0.84
Specificity and disease in the ubiquitin system. Biochem Soc Trans (2016) 0.82
Phosphorylation of ubiquitin at Ser65 affects its polymerization, targets, and proteome-wide turnover. EMBO Rep (2015) 0.82
The hydrophobic patch of ubiquitin is required to protect transactivator-promoter complexes from destabilization by the proteasomal ATPases. Nucleic Acids Res (2009) 0.80
Substrate specificity of the ubiquitin and Ubl proteases. Cell Res (2016) 0.80
Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin. Proc Natl Acad Sci U S A (2015) 0.80
The essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in Schizosaccharomyces pombe. PLoS One (2011) 0.80
Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting. Elife (2016) 0.79
Structural insight into effector proteins of Gram-negative bacterial pathogens that modulate the phosphoproteome of their host. Protein Sci (2015) 0.78
Counterbalance of ligand- and self-coupled motions characterizes multispecificity of ubiquitin. Protein Sci (2012) 0.78
Crystal structure of a complex of NOD1 CARD and ubiquitin. PLoS One (2014) 0.78
Ubiquitin-like domains can target to the proteasome but proteolysis requires a disordered region. EMBO J (2016) 0.78
Role of a non-canonical surface of Rad6 in ubiquitin conjugating activity. Nucleic Acids Res (2015) 0.77
Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity. Mol Ther (2015) 0.77
Simultaneous detection of distinct ubiquitin chain topologies by 19F NMR. ACS Chem Biol (2014) 0.77
Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis. Circ Res (2016) 0.77
Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination. Proc Natl Acad Sci U S A (2015) 0.76
Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog. Sci Rep (2016) 0.76
Guanine nucleotide-binding protein (Gα) endocytosis by a cascade of ubiquitin binding domain proteins is required for sustained morphogenesis and proper mating in yeast. J Biol Chem (2014) 0.76
Intrinsic site-selectivity of ubiquitin dimer formation. Protein Sci (2015) 0.76
Observing a late folding intermediate of Ubiquitin at atomic resolution by NMR. Protein Sci (2016) 0.75
Ubiquitin utilizes an acidic surface patch to alter chromatin structure. Nat Chem Biol (2016) 0.75
Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage. Nucleic Acids Res (2016) 0.75
A high throughput mutagenic analysis of yeast sumo structure and function. PLoS Genet (2017) 0.75
Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3. Biochem J (2016) 0.75
Ubiquitin is a versatile scaffold protein for the generation of molecules with de novo binding and advantageous drug-like properties. FEBS Open Bio (2015) 0.75
Recognition of the polyubiquitin proteolytic signal. EMBO J (2000) 10.12
Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell (1999) 6.56
Reconstitution of SEC gene product-dependent intercompartmental protein transport. Cell (1988) 4.66
Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer. Cell (2001) 3.09
A function for monoubiquitination in the internalization of a G protein-coupled receptor. Mol Cell (1998) 2.81
Monoubiquitin carries a novel internalization signal that is appended to activated receptors. EMBO J (2000) 2.54
Functional heterogeneity of ubiquitin carrier proteins. J Biol Chem (1985) 2.53
Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a. J Biol Chem (1998) 2.47
Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. J Biol Chem (1998) 2.44
In vitro assembly and recognition of Lys-63 polyubiquitin chains. J Biol Chem (2001) 2.42
A 25-kilodalton ubiquitin carrier protein (E2) catalyzes multi-ubiquitin chain synthesis via lysine 48 of ubiquitin. J Biol Chem (1990) 2.31
Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T. Biochemistry (1995) 2.31
Mammalian Sec23p homologue is restricted to the endoplasmic reticulum transitional cytoplasm. Proc Natl Acad Sci U S A (1991) 2.27
Inhibition of the 26 S proteasome by polyubiquitin chains synthesized to have defined lengths. J Biol Chem (1997) 2.14
Ubiquitin carboxyl-terminal hydrolase acts on ubiquitin carboxyl-terminal amides. J Biol Chem (1985) 2.08
Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (E2). J Biol Chem (1992) 2.08
End4p/Sla2p interacts with actin-associated proteins for endocytosis in Saccharomyces cerevisiae. Mol Biol Cell (1997) 2.07
Structure of tetraubiquitin shows how multiubiquitin chains can be formed. J Mol Biol (1994) 1.76
The hydrophobic effect contributes to polyubiquitin chain recognition. Biochemistry (1998) 1.68
Multiple roles for Rsp5p-dependent ubiquitination at the internalization step of endocytosis. J Biol Chem (2001) 1.68
Structure and function of ubiquitin conjugating enzyme E2-25K: the tail is a core-dependent activity element. Biochemistry (1997) 1.66
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Specificity of the ubiquitin isopeptidase in the PA700 regulatory complex of 26 S proteasomes. J Biol Chem (1997) 1.56
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. Proc Natl Acad Sci U S A (2000) 1.52
Domains of the Rsp5 ubiquitin-protein ligase required for receptor-mediated and fluid-phase endocytosis. Mol Biol Cell (2001) 1.50
Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. J Biol Chem (1996) 1.47
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Actin-, myosin- and ubiquitin-dependent endocytosis. Experientia (1996) 1.39
A HECT domain E3 enzyme assembles novel polyubiquitin chains. J Biol Chem (2001) 1.30
Structure of a new crystal form of tetraubiquitin. Acta Crystallogr D Biol Crystallogr (2001) 1.28
Construct for high-level expression and low misincorporation of lysine for arginine during expression of pET-encoded eukaryotic proteins in Escherichia coli. Biotechniques (1999) 1.06
E2/E3-mediated assembly of lysine 29-linked polyubiquitin chains. J Biol Chem (1999) 1.05
Inactivation of arginyl-tRNA protein transferase by a bifunctional arsenoxide: identification of residues proximal to the arsenoxide site. Biochemistry (1995) 0.98
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Arsenite inhibits two steps in the ubiquitin-dependent proteolytic pathway. J Biol Chem (1989) 0.94
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Several mammalian ubiquitin carrier proteins, but not E2(20K), are related to the 20-kDa yeast E2, RAD6. Biochem Biophys Res Commun (1990) 0.89
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Core domain mutation (S86Y) selectively inactivates polyubiquitin chain synthesis catalyzed by E2-25K. Biochemistry (1998) 0.83
Opening doors into the proteasome. Nat Struct Biol (2000) 0.81
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Dihydroorotate dehydrogenase from Clostridium oroticum is a class 1B enzyme and utilizes a concerted mechanism of catalysis. Biochemistry (2000) 0.80
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