Published in EMBO Rep on July 03, 2001
Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol (2008) 4.95
Causes and consequences of aneuploidy in cancer. Nat Rev Genet (2012) 4.08
Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer (2010) 3.95
Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proc Natl Acad Sci U S A (2004) 3.69
Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS One (2009) 3.36
Mechanisms of chromosomal instability. Curr Biol (2010) 3.21
Distinct chromosome segregation roles for spindle checkpoint proteins. Mol Biol Cell (2002) 2.29
Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. Cancer Cell (2011) 2.29
Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC. J Cell Biol (2003) 2.13
Chromosomal instability determines taxane response. Proc Natl Acad Sci U S A (2009) 2.12
The ins and outs of APC and beta-catenin nuclear transport. EMBO Rep (2002) 1.93
Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes. J Cell Sci (2004) 1.83
Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep (2012) 1.81
Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells. Curr Biol (2012) 1.78
5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint. Gastroenterology (2006) 1.62
Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis. Mol Biol Cell (2003) 1.62
Merotelic kinetochore attachment: causes and effects. Trends Cell Biol (2011) 1.60
The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation. Chromosome Res (2004) 1.60
Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC. Nat Rev Cancer (2006) 1.53
Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells. Proc Natl Acad Sci U S A (2002) 1.50
GSK-3 inhibitors induce chromosome instability. BMC Cell Biol (2007) 1.48
When 2+2=5: the origins and fates of aneuploid and tetraploid cells. Biochim Biophys Acta (2008) 1.42
Translating tumor biology into personalized treatment planning: analytical performance characteristics of the Oncotype DX Colon Cancer Assay. BMC Cancer (2010) 1.38
The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells. Cell Motil Cytoskeleton (2009) 1.32
Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis. Mol Biol Cell (2008) 1.31
Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation. Mol Biol Cell (2008) 1.26
The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts. Mol Biol Cell (2004) 1.25
Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest. Exp Cell Res (2006) 1.22
Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons. Proc Natl Acad Sci U S A (2012) 1.19
Studying chromosome instability in the mouse. Biochim Biophys Acta (2008) 1.17
Original CIN: reviewing roles for APC in chromosome instability. J Cell Biol (2008) 1.10
Ase1/Prc1-dependent spindle elongation corrects merotely during anaphase in fission yeast. J Cell Biol (2009) 1.08
The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores. Structure (2009) 1.05
Substrate degradation by the anaphase promoting complex occurs during mitotic slippage. Cell Cycle (2010) 1.03
Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy. PLoS One (2013) 1.03
A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability. Front Oncol (2013) 1.00
Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment. J Biol Chem (2010) 0.94
Examination of actin and microtubule dependent APC localisations in living mammalian cells. BMC Cell Biol (2006) 0.94
Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation. Cell Cycle (2011) 0.94
The wages of CIN. J Cell Biol (2008) 0.92
Cancer karyotypes: survival of the fittest. Front Oncol (2013) 0.90
Targeting the mitotic checkpoint to kill tumor cells. Horm Cancer (2010) 0.89
Oncogenic Adenomatous polyposis coli mutants impair the mitotic checkpoint through direct interaction with Mad2. Mol Biol Cell (2009) 0.87
Elevated level of spindle checkprotein MAD2 correlates with cellular mitotic arrest, but not with aneuploidy and clinicopathological characteristics in gastric cancer. World J Gastroenterol (2004) 0.86
Cre recombinase induces DNA damage and tetraploidy in the absence of loxP sites. Cell Cycle (2013) 0.85
Mitotic Origins of Chromosomal Instability in Colorectal Cancer. Curr Colorectal Cancer Rep (2007) 0.84
Role of APC and its binding partners in regulating microtubules in mitosis. Adv Exp Med Biol (2009) 0.83
A Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly Checkpoint. Biology (Basel) (2016) 0.83
Human T Lymphotropic Virus Type I (HTLV-I) Oncogenesis: Molecular Aspects of Virus and Host Interactions in Pathogenesis of Adult T cell Leukemia/Lymphoma (ATL). Iran J Basic Med Sci (2013) 0.81
Centrosome amplification, chromosomal instability and cancer: mechanistic, clinical and therapeutic issues. Chromosome Res (2016) 0.79
Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression. Semin Cell Dev Biol (2011) 0.79
Aurea mediocritas: the importance of a balanced genome. Cold Spring Harb Perspect Biol (2014) 0.79
Overexpression of the E2F target gene CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer. Oncotarget (2017) 0.75
Spindle checkpoint and apoptotic response in alpha-particle transformed human bronchial epithelial cells. Radiat Environ Biophys (2004) 0.75
Lessons from hereditary colorectal cancer. Cell (1996) 25.73
Genetic instabilities in human cancers. Nature (1998) 22.76
Genetic instability in colorectal cancers. Nature (1997) 12.51
Mutations of mitotic checkpoint genes in human cancers. Nature (1998) 11.20
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J (1998) 7.39
How cells get the right chromosomes. Science (1997) 6.88
Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell (1997) 6.36
MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature (2001) 6.36
Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell (2000) 4.91
The ABC of APC. Hum Mol Genet (2001) 4.16
Genetic instability and darwinian selection in tumours. Trends Cell Biol (1999) 4.12
APC binds to the novel protein EB1. Cancer Res (1995) 3.98
APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits". Proc Natl Acad Sci U S A (2000) 3.41
Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase. J Cell Biol (1998) 3.37
Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr Biol (2001) 3.13
EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability. J Cell Biol (2000) 2.76
Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. Genes Dev (2000) 2.53
A molecular marker for centriole maturation in the mammalian cell cycle. J Cell Biol (1995) 2.28
Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics (1999) 2.01
Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement. Proc Natl Acad Sci U S A (2001) 1.85
Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidy. Proc Natl Acad Sci U S A (2000) 1.54
Colorectal cancer with and without microsatellite instability involves different genes. Genes Chromosomes Cancer (1999) 1.44
APC mutations are sufficient for the growth of early colorectal adenomas. Proc Natl Acad Sci U S A (2000) 1.41
Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours. Hum Mutat (1998) 1.41
Heterogeneity studies identify a subset of sporadic colorectal cancers without evidence for chromosomal or microsatellite instability. Oncogene (1999) 1.32
The many faces of the tumor suppressor gene APC. Exp Cell Res (2001) 1.19
Chromosome segregation: dual control ensures fidelity. Curr Biol (1999) 1.07
Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines. Cancer Lett (1999) 1.06
Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers. Jpn J Cancer Res (1999) 1.04
Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines. Cancer Lett (2000) 1.03
Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer. Jpn J Cancer Res (2000) 0.97
Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science (1991) 13.85
Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science (1991) 9.99
Identification of a signal for rapid export of proteins from the nucleus. Cell (1995) 9.92
Fluorescence ratio imaging of cyclic AMP in single cells. Nature (1991) 4.45
Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. J Biol Chem (1984) 4.20
Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites. Nature (1984) 3.91
Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry (1993) 3.88
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proc Natl Acad Sci U S A (2001) 3.77
Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell (1999) 3.46
Dynamics of cAMP-dependent protein kinase. Chem Rev (2001) 3.18
Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains. Science (1995) 3.18
A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates. J Biol Chem (1994) 3.08
A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. J Cell Biol (1999) 2.69
2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor. Acta Crystallogr D Biol Crystallogr (1993) 2.66
cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer. Protein Sci (1994) 2.62
Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria. Proc Natl Acad Sci U S A (1990) 2.61
Affinity labeling of cAMP-dependent protein kinase with p-fluorosulfonylbenzoyl adenosine. Covalent modification of lysine 71. J Biol Chem (1981) 2.48
Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations. Protein Sci (1993) 2.44
A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nat Cell Biol (2000) 2.34
Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence. Nature (1986) 2.32
Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated. J Bacteriol (1995) 2.26
Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. J Biol Chem (1997) 2.10
Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. Proc Natl Acad Sci U S A (1998) 2.09
Structural adaptations of lactate dehydrogenase isozymes. Proc Natl Acad Sci U S A (1977) 1.88
Structure-function relationships in lactate dehydrogenase. Proc Natl Acad Sci U S A (1973) 1.87
The protein kinase resource. Trends Biochem Sci (1997) 1.85
Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli. J Biol Chem (1989) 1.85
Climate change and the integrity of science. Science (2010) 1.80
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc Natl Acad Sci U S A (1997) 1.79
Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion. Mol Biol Cell (1993) 1.71
Energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments. Biochemistry (1992) 1.64
Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit. Structure (2001) 1.59
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem (1990) 1.57
Role of the glycine triad in the ATP-binding site of cAMP-dependent protein kinase. J Biol Chem (1997) 1.55
Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase. Biochemistry (1995) 1.55
Phosphorylation of histones 1 and 3 and nonhistone high mobility group 14 by an endogenous kinase in HeLa metaphase chromosomes. J Biol Chem (1982) 1.54
Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor. Proc Natl Acad Sci U S A (1993) 1.53
Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli: multiple isozymes reflect different phosphorylation states. Protein Eng (1993) 1.52
A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility. Structure (1997) 1.51
Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. Biochemistry (1997) 1.50
Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase. Biochemistry (1996) 1.48
Domain movements in protein kinases. Curr Opin Struct Biol (1994) 1.47
NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. J Cell Biol (1999) 1.46
Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal. J Biol Chem (1994) 1.43
N-myristylation of the catalytic subunit of cAMP-dependent protein kinase conveys structural stability. J Biol Chem (1993) 1.42
Profile of the disulfide bonds in acetylcholinesterase. J Biol Chem (1986) 1.42
Ribitol dehydrogenase from Klebsiella aerogenes. Purification and subunit structure. Biochem J (1974) 1.39
Serum protein electrophoresis in 147 dogs. Vet Rec (2011) 1.38
Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit. J Biol Chem (1992) 1.37
The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication. Prog Biophys Mol Biol (1999) 1.36
Structural comparisons of cAMP-dependent protein kinases I and II from porcine skeletal muscle. J Biol Chem (1979) 1.36
Dissecting cAMP binding domain A in the RIalpha subunit of cAMP-dependent protein kinase. Distinct subsites for recognition of cAMP and the catalytic subunit. J Biol Chem (1998) 1.34
Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: effect of MgATP on protein-protein interactions. Biochemistry (1993) 1.33
600 ps molecular dynamics reveals stable substructures and flexible hinge points in cAMP dependent protein kinase. Biopolymers (1999) 1.32
Structural basis of the intrasteric regulation of myosin light chain kinases. Science (1992) 1.31
Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase. Biochemistry (1999) 1.29
MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly. EMBO J (2000) 1.28
Identification of a partially rate-determining step in the catalytic mechanism of cAMP-dependent protein kinase: a transient kinetic study using stopped-flow fluorescence spectroscopy. Biochemistry (1997) 1.27
Phosphorylation of peptide substrates for the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem (1993) 1.27
Signal transduction through the cAMP-dependent protein kinase. Mol Cell Biochem (1993) 1.27
Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli. Protein Eng (1997) 1.26
Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells. Proc Natl Acad Sci U S A (1990) 1.26
Identification of phosphorylation sites in the recombinant catalytic subunit of cAMP-dependent protein kinase. J Biol Chem (1993) 1.26
Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation. Acta Crystallogr D Biol Crystallogr (1993) 1.24
Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain. J Biol Chem (1996) 1.23
Serine-53 at the tip of the glycine-rich loop of cAMP-dependent protein kinase: role in catalysis, P-site specificity, and interaction with inhibitors. Biochemistry (2000) 1.23
Thermostable inhibitor of cAMP-dependent protein kinase enhances the rate of export of the kinase catalytic subunit from the nucleus. J Biol Chem (1994) 1.22
Correlation of the cAMP binding domain with a site of autophosphorylation on the regulatory subunit of cAMP-dependent protein kinase II from porcine skeletal muscle. J Biol Chem (1979) 1.21
Divalent metal ions influence catalysis and active-site accessibility in the cAMP-dependent protein kinase. Protein Sci (1993) 1.19
Identification of aspartate-184 as an essential residue in the catalytic subunit of cAMP-dependent protein kinase. Biochemistry (1988) 1.19
Kinetic analyses of mutations in the glycine-rich loop of cAMP-dependent protein kinase. Biochemistry (1998) 1.19
Importance of the A-helix of the catalytic subunit of cAMP-dependent protein kinase for stability and for orienting subdomains at the cleft interface. Protein Sci (1997) 1.19
A point mutation abolishes binding of cAMP to site A in the regulatory subunit of cAMP-dependent protein kinase. J Biol Chem (1988) 1.18
Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch. Proc Natl Acad Sci U S A (1999) 1.18
Conserved water molecules contribute to the extensive network of interactions at the active site of protein kinase A. Proc Natl Acad Sci U S A (1998) 1.18
Affinity labeling of the nucleotide binding site of the catalytic subunit of cAMP-dependent protein kinase using p-fluorosulfonyl-[14C]benzoyl 5'-adenosine. Identification of a modified lysine residue. J Biol Chem (1979) 1.15
Relationships between structural domains and function in the regulatory subunit of cAMP-dependent protein kinases I and II from porcine skeletal muscle. J Biol Chem (1979) 1.14
DdPK3, which plays essential roles during Dictyostelium development, encodes the catalytic subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1992) 1.13
Cowpea mosaic virus: from the presentation of antigenic peptides to the display of active biomaterials. Intervirology (2002) 1.12
Differential binding of cAMP-dependent protein kinase regulatory subunit isoforms Ialpha and IIbeta to the catalytic subunit. J Biol Chem (2000) 1.11
Inhibition of mitogen-activated kinase signaling sensitizes HeLa cells to Fas receptor-mediated apoptosis. Mol Cell Biol (1999) 1.11
Specificity of LIM domain interactions with receptor tyrosine kinases. J Biol Chem (1996) 1.11
Divergence in primary structure between the molecular forms of acetylcholinesterase. J Biol Chem (1988) 1.10
Predicted structures of cAMP binding domains of type I and II regulatory subunits of cAMP-dependent protein kinase. Biochemistry (1987) 1.10
Prokaryotic expression of catalytic subunit of adenosine cyclic monophosphate-dependent protein kinase. Methods Enzymol (1991) 1.10
A conserved helix motif complements the protein kinase core. Proc Natl Acad Sci U S A (1993) 1.10
Protein kinases: a diverse family of related proteins. Bioessays (1987) 1.09
Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. Proc Natl Acad Sci U S A (2001) 1.08
A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites. Mol Cell Biol (1993) 1.08
Crosstalk between domains in the regulatory subunit of cAMP-dependent protein kinase: influence of amino terminus on cAMP binding and holoenzyme formation. Biochemistry (1994) 1.07
Isoform-specific differences between the type Ialpha and IIalpha cyclic AMP-dependent protein kinase anchoring domains revealed by solution NMR. J Biol Chem (2000) 1.07
Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. Biochemistry (1999) 1.06
Interaction of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Electrostatic sites on the type Ialpha regulatory subunit. J Biol Chem (1997) 1.05
2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent. Acta Crystallogr D Biol Crystallogr (1993) 1.05
The structural domains of cAMP-dependent protein kinase I. Characterization of two sites of proteolytic cleavage and homologies to cAMP-dependent protein kinase II. J Biol Chem (1980) 1.05
Differential labeling of the catalytic subunit of cAMP-dependent protein kinase with acetic anhydride: substrate-induced conformational changes. Biochemistry (1989) 1.05
Modification of the catalytic subunit of bovine heart cAMP-dependent protein kinase with affinity labels related to peptide substrates. J Biol Chem (1982) 1.04
2H NMR studies of a myristoylated peptide in neutral and acidic phospholipid bicelles. Biochemistry (1998) 1.03
Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem (1992) 1.01
Consequences of cAMP-binding site mutations on the structural stability of the type I regulatory subunit of cAMP-dependent protein kinase. Biochemistry (2000) 1.00