Published in Genetics on July 01, 2001
Human non-synonymous SNPs: server and survey. Nucleic Acids Res (2002) 50.45
Accounting for human polymorphisms predicted to affect protein function. Genome Res (2002) 14.10
Most rare missense alleles are deleterious in humans: implications for complex disease and association studies. Am J Hum Genet (2007) 10.92
Interrogating a high-density SNP map for signatures of natural selection. Genome Res (2002) 10.33
Assessing the evolutionary impact of amino acid mutations in the human genome. PLoS Genet (2008) 8.92
Proportionally more deleterious genetic variation in European than in African populations. Nature (2008) 6.61
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77
Identification of deleterious mutations within three human genomes. Genome Res (2009) 5.42
Localizing recent adaptive evolution in the human genome. PLoS Genet (2007) 5.11
Exome sequencing and the genetic basis of complex traits. Nat Genet (2012) 4.11
Maximum-likelihood estimation of demographic parameters using the frequency spectrum of unlinked single-nucleotide polymorphisms. Genetics (2004) 4.02
Pervasive hitchhiking at coding and regulatory sites in humans. PLoS Genet (2009) 4.02
The distribution of fitness effects of new deleterious amino acid mutations in humans. Genetics (2006) 3.63
Linkage disequilibrium as a signature of selective sweeps. Genetics (2004) 3.52
Evidence for widespread degradation of gene control regions in hominid genomes. PLoS Biol (2005) 3.47
Pervasive natural selection in the Drosophila genome? PLoS Genet (2009) 3.27
Patterns of intra- and interhost nonsynonymous variation reveal strong purifying selection in dengue virus. J Virol (2003) 2.98
Adaptive genic evolution in the Drosophila genomes. Proc Natl Acad Sci U S A (2007) 2.56
The amino-acid mutational spectrum of human genetic disease. Genome Biol (2003) 2.55
Selection on human genes as revealed by comparisons to chimpanzee cDNA. Genome Res (2003) 2.48
A microsatellite variability screen for positive selection associated with the "out of Africa" habitat expansion of Drosophila melanogaster. Genetics (2003) 2.39
Changing effective population size and the McDonald-Kreitman test. Genetics (2002) 2.38
Genomic variation in natural populations of Drosophila melanogaster. Genetics (2012) 2.33
Computational and statistical approaches to analyzing variants identified by exome sequencing. Genome Biol (2011) 2.32
A catalog of neutral and deleterious polymorphism in yeast. PLoS Genet (2008) 2.28
Effects of inbreeding on the genetic diversity of populations. Philos Trans R Soc Lond B Biol Sci (2003) 2.26
Estimating selection on nonsynonymous mutations. Genetics (2005) 2.19
Subfunctionalization of duplicated genes as a transition state to neofunctionalization. BMC Evol Biol (2005) 2.19
Homotypic clusters of transcription factor binding sites are a key component of human promoters and enhancers. Genome Res (2010) 2.12
Genome-wide inference of natural selection on human transcription factor binding sites. Nat Genet (2013) 2.03
Estimating the distribution of fitness effects from DNA sequence data: implications for the molecular clock. Proc Natl Acad Sci U S A (2003) 2.01
Understanding the evolutionary fate of finite populations: the dynamics of mutational effects. PLoS Biol (2007) 1.95
Reference-free population genomics from next-generation transcriptome data and the vertebrate-invertebrate gap. PLoS Genet (2013) 1.91
Implications of natural selection in shaping 99.4% nonsynonymous DNA identity between humans and chimpanzees: enlarging genus Homo. Proc Natl Acad Sci U S A (2003) 1.83
Estimating the genomewide rate of adaptive protein evolution in Drosophila. Genetics (2006) 1.76
Genome wide analyses reveal little evidence for adaptive evolution in many plant species. Mol Biol Evol (2010) 1.76
Quantifying adaptive evolution in the Drosophila immune system. PLoS Genet (2009) 1.74
The population genomics of a fast evolver: high levels of diversity, functional constraint, and molecular adaptation in the tunicate Ciona intestinalis. Genome Biol Evol (2012) 1.71
"Reverse ecology" and the power of population genomics. Evolution (2008) 1.69
Evolution of the human ASPM gene, a major determinant of brain size. Genetics (2003) 1.69
Weak selection revealed by the whole-genome comparison of the X chromosome and autosomes of human and chimpanzee. Proc Natl Acad Sci U S A (2005) 1.67
Prevalence of positive selection among nearly neutral amino acid replacements in Drosophila. Proc Natl Acad Sci U S A (2007) 1.63
Impact of mating systems on patterns of sequence polymorphism in flowering plants. Proc Biol Sci (2006) 1.62
Comparative population genetics of the panicoid grasses: sequence polymorphism, linkage disequilibrium and selection in a diverse sample of sorghum bicolor. Genetics (2004) 1.58
Evidence for balancing selection from nucleotide sequence analyses of human G6PD. Am J Hum Genet (2002) 1.58
Relaxation of selective constraint on dog mitochondrial DNA following domestication. Genome Res (2006) 1.56
Evolutionary evidence of the effect of rare variants on disease etiology. Clin Genet (2010) 1.54
A population threshold for functional polymorphisms. Genome Res (2003) 1.52
The genomic rate of molecular adaptation of the human influenza A virus. Mol Biol Evol (2011) 1.48
Positive and negative selection on noncoding DNA in Drosophila simulans. Mol Biol Evol (2008) 1.47
Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutation-selection models. Genetics (2011) 1.45
Variation resources at UC Santa Cruz. Nucleic Acids Res (2006) 1.42
Molecular basis of adaptive convergence in experimental populations of RNA viruses. Genetics (2002) 1.41
Fundamental concepts in genetics: genetics and the understanding of selection. Nat Rev Genet (2009) 1.41
Relaxed purifying selection and possibly high rate of adaptation in primate lineage-specific genes. Genome Biol Evol (2010) 1.40
The matrix coalescent and an application to human single-nucleotide polymorphisms. Genetics (2002) 1.39
Evidence for pervasive adaptive protein evolution in wild mice. PLoS Genet (2010) 1.39
Does positive selection drive transcription factor binding site turnover? A test with Drosophila cis-regulatory modules. PLoS Genet (2011) 1.39
Frequent adaptation and the McDonald-Kreitman test. Proc Natl Acad Sci U S A (2013) 1.37
Standard and generalized McDonald-Kreitman test: a website to detect selection by comparing different classes of DNA sites. Nucleic Acids Res (2008) 1.34
Long runs of homozygosity are enriched for deleterious variation. Am J Hum Genet (2013) 1.32
Measuring the rates of spontaneous mutation from deep and large-scale polymorphism data. Genetics (2009) 1.31
The evolution of gene expression QTL in Saccharomyces cerevisiae. PLoS One (2007) 1.29
Patterns of coding variation in the complete exomes of three Neandertals. Proc Natl Acad Sci U S A (2014) 1.29
A method for calculating probabilities of fitness consequences for point mutations across the human genome. Nat Genet (2015) 1.27
Functional genomics of membrane transporters in human populations. Genome Res (2005) 1.27
Synonymous SNPs provide evidence for selective constraint on human exonic splicing enhancers. J Mol Evol (2005) 1.26
On the utility of short intron sequences as a reference for the detection of positive and negative selection in Drosophila. Mol Biol Evol (2010) 1.26
Shifts in the intensity of purifying selection: an analysis of genome-wide polymorphism data from two closely related yeast species. Genome Res (2010) 1.25
Selection, recombination and demographic history in Drosophila miranda. Genetics (2006) 1.24
Selection on amino acid substitutions in Arabidopsis. Mol Biol Evol (2008) 1.23
Integrating evolutionary and functional approaches to infer adaptation at specific loci. Evolution (2010) 1.21
Heritabilities, apolipoprotein E, and effects of inbreeding on plasma lipids in a genetically isolated population: the Erasmus Rucphen Family Study. Eur J Epidemiol (2007) 1.20
A population genetics-phylogenetics approach to inferring natural selection in coding sequences. PLoS Genet (2011) 1.19
Estimating the frequency of events that cause multiple-nucleotide changes. Genetics (2004) 1.18
Genomic patterns of adaptive divergence between chromosomally differentiated sunflower species. Mol Biol Evol (2009) 1.17
Effective population size is positively correlated with levels of adaptive divergence among annual sunflowers. Mol Biol Evol (2010) 1.16
Nonlinear dynamics of nonsynonymous (dN) and synonymous (dS) substitution rates affects inference of selection. Genome Biol Evol (2009) 1.15
SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex. Immunogenetics (2004) 1.15
Effective population size and the efficacy of selection on the X chromosomes of two closely related Drosophila species. Genome Biol Evol (2010) 1.14
The Hill-Robertson effect and the evolution of recombination. Genetics (2006) 1.14
Evidence for widespread positive and purifying selection across the European rabbit (Oryctolagus cuniculus) genome. Mol Biol Evol (2012) 1.13
A covarion-based method for detecting molecular adaptation: application to the evolution of primate mitochondrial genomes. Proc Biol Sci (2002) 1.12
Hypervariable noncoding sequences in Saccharomyces cerevisiae. Genetics (2005) 1.12
Inference of natural selection from interspersed genomic elements based on polymorphism and divergence. Mol Biol Evol (2013) 1.10
Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease. J Clin Invest (2009) 1.10
Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency. PLoS Genet (2013) 1.10
Weak selection and protein evolution. Genetics (2012) 1.09
Evidence for hitchhiking of deleterious mutations within the human genome. PLoS Genet (2011) 1.08
Natural selection of protein structural and functional properties: a single nucleotide polymorphism perspective. Genome Biol (2008) 1.08
Genomic mutation rates: what high-throughput methods can tell us. Bioessays (2009) 1.08
Functional classification of proteins and protein variants. Proc Natl Acad Sci U S A (2004) 1.07
Signatures of selection and gene conversion associated with human color vision variation. Am J Hum Genet (2004) 1.06
Role of duplicate genes in robustness against deleterious human mutations. PLoS Genet (2008) 1.06
Variation in constraint versus positive selection as an explanation for evolutionary rate variation among anthocyanin genes. J Mol Evol (2008) 1.06
Recombination yet inefficient selection along the Drosophila melanogaster subgroup's fourth chromosome. Mol Biol Evol (2009) 1.05
Lethal mutagenesis: targeting the mutator phenotype in cancer. Semin Cancer Biol (2010) 1.05
High nucleotide divergence in developmental regulatory genes contrasts with the structural elements of olfactory pathways in caenorhabditis. Genetics (2008) 1.04
Proteome-wide evidence for enhanced positive Darwinian selection within intrinsically disordered regions in proteins. Genome Biol (2011) 1.04
DNA sequence variation in a 3.7-kb noncoding sequence 5' of the CYP1A2 gene: implications for human population history and natural selection. Am J Hum Genet (2002) 1.03
On the number of segregating sites in genetical models without recombination. Theor Popul Biol (1975) 60.96
Adaptive protein evolution at the Adh locus in Drosophila. Nature (1991) 31.65
Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet (1999) 24.24
Our load of mutations. Am J Hum Genet (1950) 24.01
AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES. Proc Natl Acad Sci U S A (1956) 23.27
Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet (1999) 17.09
Amino acid difference formula to help explain protein evolution. Science (1974) 15.19
Hitchhiking under positive Darwinian selection. Genetics (2000) 14.72
Statistical properties of segregating sites. Theor Popul Biol (1995) 6.58
High genomic deleterious mutation rates in hominids. Nature (1999) 6.23
Linkage and the limits to natural selection. Genetics (1995) 5.49
Rapid evolution of male reproductive genes in the descent of man. Nature (2000) 5.33
SNP frequencies in human genes an excess of rare alleles and differing modes of selection. Trends Genet (2000) 3.78
The costs of human inbreeding and their implications for variations at the DNA level. Nat Genet (1994) 3.69
The effects of Hill-Robertson interference between weakly selected mutations on patterns of molecular evolution and variation. Genetics (2000) 3.24
Pattern of selective constraint in C. elegans and C. briggsae genomes. Genet Res (1999) 2.40
Evidence of selection on silent site base composition in mammals: potential implications for the evolution of isochores and junk DNA. Genetics (1999) 2.29
Within- and between-species DNA sequence variation and the 'footprint' of natural selection. Gene (1999) 2.06
Contingency tests of neutrality using intra/interspecific gene trees: the rejection of neutrality for the evolution of the mitochondrial cytochrome oxidase II gene in the hominoid primates. Genetics (1996) 1.94
Estimating the proportion of neutral mutants. Genet Res (1987) 1.17
Hitchhiking under positive Darwinian selection. Genetics (2000) 14.72
A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes. Mol Biol Evol (1985) 10.67
Evidence for higher rates of nucleotide substitution in rodents than in man. Proc Natl Acad Sci U S A (1985) 8.18
A rapidly evolving homeobox at the site of a hybrid sterility gene. Science (1998) 5.40
Rapid evolution of male reproductive genes in the descent of man. Nature (2000) 5.33
Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications. J Mol Evol (1984) 4.42
Genetics of reproductive isolation in the Drosophila simulans clade: complex epistasis underlying hybrid male sterility. Genetics (1994) 3.68
Genetics of hybrid male sterility between drosophila sibling species: a complex web of epistasis is revealed in interspecific studies. Genetics (1994) 3.03
A human population bottleneck can account for the discordance between patterns of mitochondrial versus nuclear DNA variation. Mol Biol Evol (1999) 2.81
Positive selection and the molecular evolution of a gene of male reproduction, Acp26Aa of Drosophila. Mol Biol Evol (1997) 2.58
Models of evolution of reproductive isolation. Genetics (1983) 2.58
The phylogeny of closely related species as revealed by the genealogy of a speciation gene, Odysseus. Proc Natl Acad Sci U S A (2000) 2.52
Positive selection driving the evolution of a gene of male reproduction, Acp26Aa, of Drosophila: II. Divergence versus polymorphism. Mol Biol Evol (1998) 2.42
Evolution of postmating reproductive isolation: the composite nature of Haldane's rule and its genetic bases. Am Nat (1993) 2.35
The genetics of reproductive isolation in the Drosophila simulans clade: X vs. autosomal effects and male vs. female effects. Genetics (1996) 2.27
Evidence for complex genic interactions between conspecific chromosomes underlying hybrid female sterility in the Drosophila simulans clade. Genetics (1994) 1.97
A test of reciprocal X-Y interactions as a cause of hybrid sterility in Drosophila. Nature (1992) 1.93
The broom of the sorcerer's apprentice: the fine structure of a chromosomal region causing reproductive isolation between two sibling species of Drosophila. Genetics (1996) 1.91
Genetics of reproductive isolation in the Drosophila simulans clade: DNA marker-assisted mapping and characterization of a hybrid-male sterility gene, Odysseus (Ods). Genetics (1993) 1.88
The nucleotide changes governing cuticular hydrocarbon variation and their evolution in Drosophila melanogaster. Proc Natl Acad Sci U S A (2001) 1.88
Further characterization of the Odysseus locus of hybrid sterility in Drosophila: one gene is not enough. Genetics (1995) 1.86
The effects of interspecific Y chromosome replacements on hybrid sterility within the Drosophila simulans clade. Genetics (1993) 1.78
Incipient speciation by sexual isolation in Drosophila: concurrent evolution at multiple loci. Proc Natl Acad Sci U S A (2001) 1.52
The neutral theory in the genomic era. Curr Opin Genet Dev (2001) 1.52
Incipient speciation by sexual isolation in Drosophila melanogaster: extensive genetic divergence without reinforcement. Genetics (1997) 1.51
Inequality in mutation rates of the two strands of DNA. Nature (1987) 1.47
Molecular evolution of intergenic DNA in higher primates: pattern of DNA changes, molecular clock, and evolution of repetitive sequences. Mol Biol Evol (1988) 1.41
Genetic analysis of speciation by means of introgression into Drosophila melanogaster. Proc Natl Acad Sci U S A (2000) 1.27
An empirical test of the meiotic drive models of hybrid sterility: sex-ratio data from hybrids between Drosophila simulans and Drosophila sechellia. Genetics (1992) 1.25
Rapid evolution of a coadapted gene complex: evidence from the Segregation Distorter (SD) system of meiotic drive in Drosophila melanogaster. Genetics (1996) 1.24
The fate of autosomal modifiers of the sex-ratio trait in drosophila and other sex-linked meiotic drive systems. Theor Popul Biol (1983) 1.16
Population genetics of tandem repeats in centromeric heterochromatin: unequal crossing over and chromosomal divergence at the Responder locus of Drosophila melanogaster. Genetics (1993) 1.13
Gametic incompatibilities between races of Drosophila melanogaster. Proc Biol Sci (2001) 1.12
Sex in Drosophila mauritiana: a very high level of amino acid polymorphism in a male reproductive protein gene, Acp26Aa. Mol Biol Evol (2001) 1.00
Molecular analysis of the responder satellite DNA in Drosophila melanogaster: DNA bending, nucleosome structure, and Rsp-binding proteins. Mol Biol Evol (1991) 0.94
Discord between the phylogenies inferred from molecular versus functional data: uneven rates of functional evolution or low levels of gene flow? Genetics (1996) 0.93
Evolution of cytochrome c genes and pseudogenes. J Mol Evol (1986) 0.93
Selfish genetic elements. Trends Ecol Evol (1988) 0.90
Growth hormone secretion by pituitary grafts under the median eminence or renal capsule. Endocrinology (1969) 0.90
Modeling linkage disequilibrium between a polymorphic marker locus and a locus affecting complex dichotomous traits in natural populations. Genetics (2001) 0.82
Rates of nucleotide substitution are evidently higher in rodents than in man. Mol Biol Evol (1987) 0.81
Characterization of two Segregation distorter revertants: evidence that the tandem duplication is necessary for Sd activity in Drosophila melanogaster. Genetics (1994) 0.80
Support from spouse as mediator and moderator of the disruptive influence of economic strain on parenting. Child Dev (1992) 0.80
DNA strand asymmetry. Nature (1991) 0.79
Now blows the east wind. Nature (1996) 0.75
Epidural ketamine for postoperative pain relief. Ma Zui Xue Za Zhi (1986) 0.75
[Effect of increasing amounts of clonidine during hyperbaric tetracaine spinal anesthesia]. Ma Zui Xue Za Zhi (1989) 0.75
PE-PEG/LEH can reduce its interactions with plasma expanders indexed through viscosity measurements. Artif Cells Blood Substit Immobil Biotechnol (1999) 0.75
Group and allied therapies in China. Curr Psychiatr Ther (1983) 0.75
Evolution of postmating reproductive isolation: measuring the fitness effects of chromosomal regions containing hybrid male sterility factors. Am Nat (1993) 0.75
Evolutionary biology. Endless forms, several powers. Nature (1996) 0.75
[Intrathecal meperidine on the effects of anesthesia and postoperative pain relief]. Ma Zui Xue Za Zhi (1987) 0.75
Facilitation of rapid endotracheal intubation and neuromuscular effect with priming dose of atracurium in pediatrics. Ma Zui Xue Za Zhi (1985) 0.75
The adjuvant use of epidural butorphanol in caesarean section. Ma Zui Xue Za Zhi (1986) 0.75