Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase.

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Published in J Biol Chem on July 30, 2001

Authors

T Saric1, J Beninga, C I Graef, T N Akopian, K L Rock, A L Goldberg

Author Affiliations

1: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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Degradation of abnormal proteins in Escherichia coli (protein breakdown-protein structure-mistranslation-amino acid analogs-puromycin). Proc Natl Acad Sci U S A (1972) 3.53

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Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc Natl Acad Sci U S A (1993) 3.27

Sequence of the lon gene in Escherichia coli. A heat-shock gene which encodes the ATP-dependent protease La. J Biol Chem (1988) 3.21

Proteolysis, proteasomes and antigen presentation. Nature (1992) 3.15

Subcellular distribution of various proteases in Escherichia coli. J Bacteriol (1982) 3.10

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Origin and possible significance of alanine production by skeletal muscle. J Biol Chem (1974) 2.49

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Effects of food deprivation on protein synthesis and degradation in rat skeletal muscles. Am J Physiol (1976) 2.42

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Evidence for a role of cyclic AMP in neuromuscular transmission. Proc Natl Acad Sci U S A (1969) 2.32

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Involvement of the chaperonin dnaK in the rapid degradation of a mutant protein in Escherichia coli. EMBO J (1992) 2.29

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What do we really know about the ubiquitin-proteasome pathway in muscle atrophy? Curr Opin Clin Nutr Metab Care (2001) 2.18

Work-induced growth of skeletal muscle in normal and hypophysectomized rats. Am J Physiol (1967) 2.15

Identity of the 19S 'prosome' particle with the large multifunctional protease complex of mammalian cells (the proteasome). Nature (1988) 2.15

Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy. J Biol Chem (1990) 2.14

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A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation. Nature (1993) 2.11

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The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins. J Biol Chem (1990) 2.06

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Degradation of abnormal proteins in Escherichia coli. Formation of protein inclusions in cells exposed to amino acid analogs. J Biol Chem (1975) 2.03

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Effects of protease inhibitors on protein breakdown in Escherichia coli. J Biol Chem (1972) 1.97

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HslV-HslU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome. Proc Natl Acad Sci U S A (1996) 1.94

Leupeptin, a protease inhibitor, decreases protein degradation in normal and diseased muscles. Science (1978) 1.93

Demonstration of an ATP-dependent, vanadate-sensitive endoprotease in the matrix of rat liver mitochondria. J Biol Chem (1982) 1.92

The heat-shock protein ClpB in Escherichia coli is a protein-activated ATPase. J Biol Chem (1992) 1.92

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A high molecular weight protease in the cytosol of rat liver. I. Purification, enzymological properties, and tissue distribution. J Biol Chem (1986) 1.86

P504S: a new molecular marker for the detection of prostate carcinoma. Am J Surg Pathol (2001) 1.86

Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes. J Clin Invest (1994) 1.83

A set of endoplasmic reticulum proteins possessing properties of molecular chaperones includes Ca(2+)-binding proteins and members of the thioredoxin superfamily. J Biol Chem (1994) 1.83

Proteins are unfolded on the surface of the ATPase ring before transport into the proteasome. Mol Cell (2001) 1.81

The ATP-dependent HslVU protease from Escherichia coli is a four-ring structure resembling the proteasome. Nat Struct Biol (1997) 1.81

Further evidence for the involvement of charged tRNA and guanosine tetraphosphate in the control of protein degradation in Escherichia coli. J Biol Chem (1978) 1.78

A role of aminoacyl-tRNA in the regulation of protein breakdown in Escherichia coli. Proc Natl Acad Sci U S A (1971) 1.77

Structural characterization of the TAP molecule: a phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1. Cell (1986) 1.77

Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A (1996) 1.76

Energy requirement for degradation of tumor-associated protein p53. Mol Cell Biol (1984) 1.73

Proteases in Escherichia coli. Methods Enzymol (1981) 1.72

Leucine degradation in cell-free extracts of skeletal muscle. Biochem J (1979) 1.71

Oxidation of leucine by rat skeletal muscle. Am J Physiol (1972) 1.70

Regulation and significance of amino acid metabolism in skeletal muscle. Fed Proc (1978) 1.70

The stimulation of protein degradation in muscle by Ca2+ is mediated by prostaglandin E2 and does not require the calcium-activated protease. J Biol Chem (1982) 1.70

Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae. Mol Cell Biol (1996) 1.69

Oxidation of amino acids by diaphragms from fed and fasted rats. Am J Physiol (1972) 1.67