Published in J Mol Biol on July 27, 2001
Predicting the energetics of osmolyte-induced protein folding/unfolding. Proc Natl Acad Sci U S A (2005) 2.85
A molecular mechanism for osmolyte-induced protein stability. Proc Natl Acad Sci U S A (2006) 2.36
Organic compatible solutes of halotolerant and halophilic microorganisms. Saline Systems (2005) 2.22
Protein stability in mixed solvents: a balance of contact interaction and excluded volume. Biophys J (2003) 2.01
Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant. Proc Natl Acad Sci U S A (2006) 1.81
A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581 T. Environ Microbiol (2010) 1.70
The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability. Proc Natl Acad Sci U S A (2009) 1.54
Thermoprotection of Bacillus subtilis by exogenously provided glycine betaine and structurally related compatible solutes: involvement of Opu transporters. J Bacteriol (2004) 1.40
Osmolyte effects on protein stability and solubility: a balancing act between backbone and side-chains. Biophys Chem (2011) 1.35
Resurrecting Van Leeuwenhoek's rotifers: a reappraisal of the role of disaccharides in anhydrobiosis. Philos Trans R Soc Lond B Biol Sci (2003) 1.33
Synthesis and uptake of the compatible solutes ectoine and 5-hydroxyectoine by Streptomyces coelicolor A3(2) in response to salt and heat stresses. Appl Environ Microbiol (2008) 1.27
Protein structure, stability and solubility in water and other solvents. Philos Trans R Soc Lond B Biol Sci (2004) 1.25
Backbone additivity in the transfer model of protein solvation. Protein Sci (2010) 1.13
Osmolyte trimethylamine-N-oxide does not affect the strength of hydrophobic interactions: origin of osmolyte compatibility. Biophys J (2005) 1.13
The efficiency of different salts to screen charge interactions in proteins: a Hofmeister effect? Biophys J (2004) 1.13
Mimicking the plant cell interior under water stress by macromolecular crowding: disordered dehydrin proteins are highly resistant to structural collapse. Plant Physiol (2008) 1.13
Chemical chaperones assist intracellular folding to buffer mutational variations. Nat Chem Biol (2012) 1.12
Osmolyte-induced conformational changes in the Hsp90 molecular chaperone. Protein Sci (2010) 1.12
Trimethylamine N-oxide influence on the backbone of proteins: an oligoglycine model. Proteins (2010) 1.12
Biogenesis of gamma-secretase early in the secretory pathway. J Cell Biol (2007) 1.11
Hydrogen bonding progressively strengthens upon transfer of the protein urea-denatured state to water and protecting osmolytes. Biochemistry (2010) 1.09
Rescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones. ACS Chem Biol (2010) 1.08
Proline mechanisms of stress survival. Antioxid Redox Signal (2013) 1.06
The role of hyperosmotic stress in inflammation and disease. Biomol Concepts (2012) 1.05
Preferential hydration of DNA: the magnitude and distance dependence of alcohol and polyol interactions. Biophys J (2006) 1.04
Thermodynamic characterization of interleukin-8 monomer binding to CXCR1 receptor N-terminal domain. FEBS J (2007) 1.03
Thermodynamic dissection of the intrinsically disordered N-terminal domain of human glucocorticoid receptor. J Biol Chem (2012) 0.99
NMR structure of the viral peptide linked to the genome (VPg) of poliovirus. Peptides (2006) 0.99
Restoring assembly and activity of cystathionine β-synthase mutants by ligands and chemical chaperones. J Inherit Metab Dis (2010) 0.98
The osmolyte TMAO stabilizes native RNA tertiary structures in the absence of Mg2+: evidence for a large barrier to folding from phosphate dehydration. J Mol Biol (2010) 0.97
Structure of the nucleocapsid-binding domain from the mumps virus polymerase; an example of protein folding induced by crystallization. J Mol Biol (2008) 0.97
Modulation of functionally significant conformational equilibria in adenylate kinase by high concentrations of trimethylamine oxide attributed to volume exclusion. Biophys J (2011) 0.97
Diversity, distribution and roles of osmoprotective compounds accumulated in halophytes under abiotic stress. Ann Bot (2015) 0.95
Effect of osmotic stress and heat shock in recombinant protein overexpression and crystallization. Protein Expr Purif (2006) 0.95
Structural adaptation of extreme halophilic proteins through decrease of conserved hydrophobic contact surface. BMC Struct Biol (2011) 0.95
Osmolyte-induced folding of an intrinsically disordered protein: folding mechanism in the absence of ligand. Biochemistry (2010) 0.94
Unfolding and refolding of bovine serum albumin at acid pH: ultrasound and structural studies. Biophys J (2006) 0.94
The N(0)-binding region of the vesicular stomatitis virus phosphoprotein is globally disordered but contains transient α-helices. Protein Sci (2011) 0.93
Molecular mechanism for the preferential exclusion of TMAO from protein surfaces. J Phys Chem B (2012) 0.93
Effect of nonadditive repulsive intermolecular interactions on the light scattering of concentrated protein-osmolyte mixtures. J Phys Chem B (2010) 0.92
Chemical chaperone and inhibitor discovery: potential treatments for protein conformational diseases. Perspect Medicin Chem (2007) 0.90
Crowding alone cannot account for cosolute effect on amyloid aggregation. PLoS One (2011) 0.87
Solute's perspective on how trimethylamine oxide, urea, and guanidine hydrochloride affect water's hydrogen bonding ability. J Phys Chem B (2012) 0.87
Endoplasmic reticulum stress and insulin resistance post-trauma: similarities to type 2 diabetes. J Cell Mol Med (2012) 0.87
Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones. Protein Sci (2003) 0.86
Autotransporters: The Cellular Environment Reshapes a Folding Mechanism to Promote Protein Transport. J Phys Chem Lett (2012) 0.86
Measuring the interaction of urea and protein-stabilizing osmolytes with the nonpolar surface of hydroxypropylcellulose. Biochemistry (2008) 0.86
Osmolyte effects on helix formation in peptides and the stability of coiled-coils. Protein Sci (2002) 0.85
Osmophobic effect of glycerol on irreversible thermal denaturation of rabbit creatine kinase. Biophys J (2004) 0.85
Volume exclusion and H-bonding dominate the thermodynamics and solvation of trimethylamine-N-oxide in aqueous urea. J Am Chem Soc (2012) 0.85
Proline to the rescue. Proc Natl Acad Sci U S A (2006) 0.84
Glass-forming property of hydroxyectoine is the cause of its superior function as a desiccation protectant. Front Microbiol (2014) 0.83
The effect of osmolytes on protein fibrillation. Int J Mol Sci (2012) 0.82
Chemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia A. PLoS One (2012) 0.82
Sequence-based analysis of protein energy landscapes reveals nonuniform thermal adaptation within the proteome. Mol Biol Evol (2009) 0.82
Mutational analysis of the stability of the H2A and H2B histone monomers. J Mol Biol (2008) 0.82
Biophysical characterization of Z(SPA-1)--a phage-display selected binder to protein A. Protein Sci (2004) 0.81
Structure of a rabbit muscle fructose-1,6-bisphosphate aldolase A dimer variant. Acta Crystallogr D Biol Crystallogr (2008) 0.81
NADPH-cytochrome P450 oxidoreductase from the mosquito Anopheles minimus: kinetic studies and the influence of Leu86 and Leu219 on cofactor binding and protein stability. Arch Biochem Biophys (2008) 0.81
Analysis of strains lacking known osmolyte accumulation mechanisms reveals contributions of osmolytes and transporters to protection against abiotic stress. Appl Environ Microbiol (2014) 0.81
Chemical assistance in refolding of bacterial inclusion bodies. Biochem Res Int (2011) 0.81
The osmolyte trimethylamine-N-oxide stabilizes the Fyn SH3 domain without altering the structure of its folding transition state. Protein Sci (2009) 0.81
Osmoadaptative Strategy and Its Molecular Signature in Obligately Halophilic Heterotrophic Protists. Genome Biol Evol (2016) 0.81
Beneficial effect of sugar osmolytes on the refolding of guanidine hydrochloride-denatured trehalose-6-phosphate hydrolase from Bacillus licheniformis. Biomed Res Int (2015) 0.79
Strategies to stabilize compact folding and minimize aggregation of antibody-based fragments. Adv Biosci Biotechnol (2013) 0.79
Therapeutic approaches to delay the onset of Alzheimer's disease. J Aging Res (2011) 0.79
Inhibitory effects of choline-O-sulfate on amyloid formation of human islet amyloid polypeptide. FEBS Open Bio (2012) 0.79
Solvation free energy of the peptide group: its model dependence and implications for the additive-transfer free-energy model of protein stability. Biophys J (2013) 0.79
Protein denaturants at aqueous-hydrophobic interfaces: self-consistent correlation between induced interfacial fluctuations and denaturant stability at the interface. J Phys Chem B (2014) 0.79
Ultrasonic studies of alcohol-induced transconformation in beta-lactoglobulin: the intermediate state. Biophys J (2003) 0.78
Compensating effects of urea and trimethylamine-N-oxide on the heteroassociation of α-chymotrypsin and soybean trypsin inhibitor. J Phys Chem B (2013) 0.78
Molten globule and native state ensemble of Helicobacter pylori flavodoxin: can crowding, osmolytes or cofactors stabilize the native conformation relative to the molten globule? Biophys J (2008) 0.78
Restoration of structural stability and ligand binding after removal of the conserved disulfide bond in tear lipocalin. Biochem Biophys Res Commun (2014) 0.77
IgG Fab fragments forming bivalent complexes by a conformational mechanism that is reversible by osmolytes. J Biol Chem (2012) 0.77
Sorbitol counteracts temperature- and chemical-induced denaturation of a recombinant α-amylase from alkaliphilic Bacillus sp. TS-23. J Ind Microbiol Biotechnol (2012) 0.76
An overview of the importance of conformational flexibility in gene regulation by the transcription factors. J Biophys (2010) 0.76
Osmolyte solutions and protein folding. F1000 Biol Rep (2009) 0.76
An effective solvent theory connecting the underlying mechanisms of osmolytes and denaturants for protein stability. Biophys J (2011) 0.76
The pH Dependence of Saccharides' Influence on Thermal Denaturation of Two Model Proteins Supports an Excluded Volume Model for Stabilization Generalized to Allow for Intramolecular Electrostatic Interactions. J Biol Chem (2016) 0.75
The Effects of Lipid Membranes, Crowding and Osmolytes on the Aggregation, and Fibrillation Propensity of Human IAPP. J Diabetes Res (2015) 0.75
The Proline/Glycine-Rich Region Of The Biofilm Adhesion Protein Aap Forms An Extended Stalk That Resists Compaction. J Mol Biol (2016) 0.75
Stabilization of the predominant disease-causing aldolase variant (A149P) with zwitterionic osmolytes. Biochemistry (2011) 0.75
Honey-induced protein stabilization as studied by fluorescein isothiocyanate fluorescence. ScientificWorldJournal (2013) 0.75
Untangling a Structurally Resolved Protein Folding Intermediate. Biophys J (2016) 0.75
An efficient protocol to enhance recombinant protein expression using ethanol in Escherichia coli. MethodsX (2015) 0.75
Structural characteristic of the initial unfolded state on refolding determines catalytic efficiency of the folded protein in presence of osmolytes. PLoS One (2014) 0.75
Effect of osmolytes on the binding of EGR1 transcription factor to DNA. Biopolymers (2015) 0.75
Testing the ability of non-methylamine osmolytes present in kidney cells to counteract the deleterious effects of urea on structure, stability and function of proteins. PLoS One (2013) 0.75
A small molecule chemical chaperone optimizes its unfolded state contraction and denaturant like properties. Sci Rep (2013) 0.75
Probing the kinetic stabilities of Friedreich's ataxia clinical variants using a solid phase GroEL chaperonin capture platform. Biomolecules (2014) 0.75
The effect of chemical chaperones on the assembly and stability of HIV-1 capsid protein. PLoS One (2013) 0.75
A racemate-rules effect supramolecular polymer for ee determination of malic acid in the high ee region. Chem Commun (Camb) (2016) 0.75
Solvent Properties of Water in Aqueous Solutions of Elastin-Like Polypeptide. Int J Mol Sci (2015) 0.75
How Osmolytes Counteract Pressure Denaturation on a Molecular Scale. Chemphyschem (2017) 0.75
Trimethylamine N-oxide abolishes the chaperone activity of α-casein: an intrinsically disordered protein. Sci Rep (2017) 0.75
Self-association of phosphorylase kinase from rabbit skeletal muscles under conditions close to those of an intracellular environment. Dokl Biochem Biophys (2007) 0.75
Interdomain signaling in a two-domain fragment of the human glucocorticoid receptor. J Biol Chem (1999) 1.24
Pathology of SSLOW, a transmissible and fatal synthetic prion protein disorder, and comparison with naturally occurring classical transmissible spongiform encephalopathies. Neuropathol Appl Neurobiol (2014) 0.87
[Use of a liquid scintillation counter for analyzing luminescence of cell suspensions. Respiratory burst of neutrophils as a collective process]. Dokl Akad Nauk (1994) 0.75
[Ras-like proteins of the invertebrate and vertebrate visual systems. Interaction of exoenzyme C3 substrates with photoactivated squid rhodopsin]. Bioorg Khim (1994) 0.75