Published in Proc Natl Acad Sci U S A on September 04, 2001
Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J (2003) 11.27
Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell (2002) 7.10
Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol (2004) 4.24
Class II histone deacetylases: from sequence to function, regulation, and clinical implication. Mol Cell Biol (2005) 3.05
Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. Mol Cell Biol (2002) 2.93
The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin. Proc Natl Acad Sci U S A (2002) 2.69
Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J (2005) 2.35
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J Biol Chem (2008) 2.12
Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. J Biol Chem (2003) 1.93
Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J (2004) 1.88
Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1. J Virol (2004) 1.59
Regulation of HDAC9 gene expression by MEF2 establishes a negative-feedback loop in the transcriptional circuitry of muscle differentiation. Mol Cell Biol (2006) 1.55
Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and disease. Mol Cell Proteomics (2015) 1.49
Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner. J Bone Miner Res (2008) 1.42
Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. Mol Cell Biol (2003) 1.36
Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. Nucleic Acids Res (2002) 1.33
Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. Mol Cell Biol (2004) 1.26
Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation. Mol Cell Biol (2008) 1.23
Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues. Am J Pathol (2004) 1.22
Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade. Proc Natl Acad Sci U S A (2006) 1.16
Roles and targets of class I and IIa histone deacetylases in cardiac hypertrophy. J Biomed Biotechnol (2010) 1.14
Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein. J Biol Chem (2010) 1.09
Evolution of the arginase fold and functional diversity. Cell Mol Life Sci (2008) 1.09
Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity. Immunol Cell Biol (2011) 1.08
A novel method to identify high order gene-gene interactions in genome-wide association studies: gene-based MDR. BMC Bioinformatics (2012) 1.06
Modulation of antigen-presenting cells by HDAC inhibitors: implications in autoimmunity and cancer. Immunol Cell Biol (2011) 1.05
Signal-dependent regulation of transcription by histone deacetylase 7 involves recruitment to promyelocytic leukemia protein nuclear bodies. Mol Biol Cell (2008) 1.05
Developmental expression of histone deacetylase 11 in the murine brain. J Neurosci Res (2008) 1.04
Histone deacetylases 9 and 10 are required for homologous recombination. J Biol Chem (2011) 1.03
Discovery of histone deacetylase 8 selective inhibitors. Bioorg Med Chem Lett (2011) 0.99
Histone deacetylase inhibition-mediated differentiation of RGC-5 cells and interaction with survival. Invest Ophthalmol Vis Sci (2007) 0.97
HDAC inhibition in lupus models. Mol Med (2011) 0.94
Increased risk for developmental delay in Saethre-Chotzen syndrome is associated with TWIST deletions: an improved strategy for TWIST mutation screening. Hum Genet (2003) 0.94
Residues in the 11 A channel of histone deacetylase 1 promote catalytic activity: implications for designing isoform-selective histone deacetylase inhibitors. J Med Chem (2008) 0.93
HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury. J Cell Mol Med (2013) 0.92
Histone deacetylase 9 represses cholesterol efflux and alternatively activated macrophages in atherosclerosis development. Arterioscler Thromb Vasc Biol (2014) 0.90
Histone deacetylase 9 activates gamma-globin gene expression in primary erythroid cells. J Biol Chem (2010) 0.90
Class II histone deacetylases limit GLUT4 gene expression during adipocyte differentiation. J Biol Chem (2010) 0.90
Targeting Histone Deacetylases in Diseases: Where Are We? Antioxid Redox Signal (2014) 0.88
Mapping genomic deletions down to the base: a quantitative copy number scanning approach used to characterise and clone the breakpoints of a recurrent 7p14.2p15.3 deletion. Hum Genet (2004) 0.87
Loss of MEF2D expression inhibits differentiation and contributes to oncogenesis in rhabdomyosarcoma cells. Mol Cancer (2013) 0.86
Visualizing epigenetics: current advances and advantages in HDAC PET imaging techniques. Neuroscience (2013) 0.86
HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells. Am J Stem Cells (2011) 0.85
Dephosphorylation at a conserved SP motif governs cAMP sensitivity and nuclear localization of class IIa histone deacetylases. J Biol Chem (2013) 0.85
Histone deacetylase enzymes as potential drug targets in cancer and parasitic diseases. J Biomed Biotechnol (2006) 0.83
Roles and post-translational regulation of cardiac class IIa histone deacetylase isoforms. J Physiol (2014) 0.82
Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design. J Med Chem (2014) 0.80
Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement. J Biol Chem (2015) 0.79
New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer. Prostate Cancer (2011) 0.79
RhoB upregulation leads to either apoptosis or cytostasis through differential target selection. Endocr Relat Cancer (2015) 0.78
Targeting histone deacetylases: a novel approach in Parkinson's disease. Parkinsons Dis (2015) 0.78
Differential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatum. Neurotoxicology (2014) 0.77
The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair. Nucleic Acids Res (2016) 0.76
A class of their own: exploring the nondeacetylase roles of class IIa HDACs in cardiovascular disease. Am J Physiol Heart Circ Physiol (2016) 0.75
A histone deacetylase-dependent screen in yeast. Bioorg Med Chem (2010) 0.75
Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy. Sci Rep (2016) 0.75
Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradation. J Biol Chem (2015) 0.75
Histone deacetylase 9 regulates breast cancer cell proliferation and the response to histone deacetylase inhibitors. Oncotarget (2016) 0.75
HAT2 mediates histone H4K4 acetylation and affects micrococcal nuclease sensitivity of chromatin in Leishmania donovani. PLoS One (2017) 0.75
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
The sequence of the human genome. Science (2001) 101.55
The language of covalent histone modifications. Nature (2000) 44.92
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54
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Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature (2000) 8.59
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A (2000) 7.92
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Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc Natl Acad Sci U S A (1999) 6.50
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A (2000) 6.49
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HDAC4 deacetylase associates with and represses the MEF2 transcription factor. EMBO J (1999) 5.54
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc Natl Acad Sci U S A (2000) 5.18
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Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5. Proc Natl Acad Sci U S A (2000) 4.27
Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J Biol Chem (1997) 4.16
Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev (2000) 4.00
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Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem (1999) 3.23
HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. Mol Cell Biol (1999) 3.21
Characterization of a human RPD3 ortholog, HDAC3. Proc Natl Acad Sci U S A (1998) 3.05
A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. J Biol Chem (1999) 2.82
MEF-2 function is modified by a novel co-repressor, MITR. EMBO J (1999) 2.71
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Regulation of histone deacetylase 4 by binding of 14-3-3 proteins. Mol Cell Biol (2000) 2.69
Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J Biol Chem (2001) 2.45
Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor. J Biol Chem (2000) 2.19
The transcriptional corepressor MITR is a signal-responsive inhibitor of myogenesis. Proc Natl Acad Sci U S A (2001) 1.76
Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5. Proc Natl Acad Sci U S A (2000) 1.71
Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells. Biochem Biophys Res Commun (1998) 1.62
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Cloning and characterization of a novel human histone deacetylase, HDAC8. Biochem J (2000) 1.42
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dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster. Exp Cell Res (2001) 1.24
Cloning and characterization of human histone deacetylase 8. FEBS Lett (2000) 1.22
Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras. Proc Natl Acad Sci U S A (2000) 1.12
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