Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP.

PubWeight™: 2.75‹?› | Rank: Top 1%

🔗 View Article (PMID 11584276)

Published in Nat Cell Biol on October 01, 2001

Authors

N K Hussain1, S Jenna, M Glogauer, C C Quinn, S Wasiak, M Guipponi, S E Antonarakis, B K Kay, T P Stossel, N Lamarche-Vane, P S McPherson

Author Affiliations

1: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada.

Articles citing this

(truncated to the top 100)

Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol (2009) 5.83

Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. J Cell Biol (2006) 3.17

Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains. Cell (2007) 3.04

Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization. PLoS Pathog (2009) 2.59

Dynamin at actin tails. Proc Natl Acad Sci U S A (2002) 2.31

ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma. J Cell Biol (2003) 2.19

Cortactin signalling and dynamic actin networks. Biochem J (2004) 2.16

Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex. Biochem J (2004) 2.08

The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes. Mol Cell (2010) 1.97

Syndapins integrate N-WASP in receptor-mediated endocytosis. EMBO J (2002) 1.95

Synaptic vesicle endocytosis. Cold Spring Harb Perspect Biol (2012) 1.84

DENN domain proteins: regulators of Rab GTPases. J Biol Chem (2011) 1.81

Control of synapse development and plasticity by Rho GTPase regulatory proteins. Prog Neurobiol (2011) 1.77

RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery. Mol Biol Cell (2004) 1.74

The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis. J Cell Biol (2010) 1.70

Nervous wreck interacts with thickveins and the endocytic machinery to attenuate retrograde BMP signaling during synaptic growth. Neuron (2008) 1.69

Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61

Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. Mol Biol Cell (2009) 1.58

A Hip1R-cortactin complex negatively regulates actin assembly associated with endocytosis. EMBO J (2007) 1.57

Sla1p serves as the targeting signal recognition factor for NPFX(1,2)D-mediated endocytosis. J Cell Biol (2002) 1.56

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome. Proc Natl Acad Sci U S A (2008) 1.54

G protein-coupled receptor/arrestin3 modulation of the endocytic machinery. J Cell Biol (2002) 1.53

Small interfering RNA profiling reveals key role of clathrin-mediated endocytosis and early endosome formation for infection by respiratory syncytial virus. J Virol (2007) 1.49

The CRMP family of proteins and their role in Sema3A signaling. Adv Exp Med Biol (2007) 1.43

Delayed reentry of recycling vesicles into the fusion-competent synaptic vesicle pool in synaptojanin 1 knockout mice. Proc Natl Acad Sci U S A (2002) 1.42

Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2. Mol Biol Cell (2006) 1.40

Bridging membrane and cytoskeleton dynamics in the secretory and endocytic pathways. Nat Cell Biol (2011) 1.38

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation. J Cell Biol (2010) 1.35

Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization. Mol Cell Biol (2008) 1.34

Regulation of endocytic traffic by Rho GTPases. Biochem J (2003) 1.31

Dynamin and cytokinesis. Traffic (2006) 1.29

Intersectin-1L nucleotide exchange factor regulates secretory granule exocytosis by activating Cdc42. EMBO J (2006) 1.26

Engineering the Salmonella type III secretion system to export spider silk monomers. Mol Syst Biol (2009) 1.26

Interaction between Epsin/Yap180 adaptors and the scaffolds Ede1/Pan1 is required for endocytosis. Mol Biol Cell (2008) 1.23

Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. Proc Natl Acad Sci U S A (2007) 1.22

Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network. Proc Natl Acad Sci U S A (2008) 1.20

Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation. EMBO J (2011) 1.19

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome. Mamm Genome (2011) 1.19

Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix. EMBO J (2004) 1.17

Cortactin and dynamin are required for the clathrin-independent endocytosis of gammac cytokine receptor. J Cell Biol (2004) 1.16

The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Mol Cell Biol (2006) 1.13

Intersectin regulates fission and internalization of caveolae in endothelial cells. Mol Biol Cell (2003) 1.10

Regulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway. Mol Cell Biol (2007) 1.10

Compartmentalized Ras proteins transform NIH 3T3 cells with different efficiencies. Mol Cell Biol (2010) 1.10

Intersectin 1L guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis. Mol Biol Cell (2003) 1.09

The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery. J Biol Chem (2010) 1.09

Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome. Proc Natl Acad Sci U S A (2009) 1.08

β1 integrins regulate fibroblast chemotaxis through control of N-WASP stability. EMBO J (2011) 1.07

Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors. Infect Immun (2010) 1.07

Synaptic plasticity, a symphony in GEF. ACS Chem Neurosci (2010) 1.06

Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes. PLoS Comput Biol (2006) 1.04

Intersectin regulates dendritic spine development and somatodendritic endocytosis but not synaptic vesicle recycling in hippocampal neurons. J Biol Chem (2009) 1.03

Clathrin-independent endocytosis used by the IL-2 receptor is regulated by Rac1, Pak1 and Pak2. EMBO Rep (2008) 1.02

Intersecting pathways in cell biology. Sci Signal (2010) 1.01

Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin. Mol Biol Cell (2010) 1.00

ARF1-mediated actin polymerization produces movement of artificial vesicles. Proc Natl Acad Sci U S A (2007) 1.00

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. PLoS One (2012) 1.00

Hypoxia-induced alternative splicing in endothelial cells. PLoS One (2012) 0.99

The GTP/GDP cycling of rho GTPase TCL is an essential regulator of the early endocytic pathway. Mol Biol Cell (2003) 0.98

DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior. J Cell Biol (2015) 0.97

Actin is required for endocytosis at the apical surface of Madin-Darby canine kidney cells where ARF6 and clathrin regulate the actin cytoskeleton. Mol Biol Cell (2005) 0.97

Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton. Mol Biol Cell (2011) 0.96

Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated actin polymerization. J Biol Chem (2009) 0.95

A bacterial phytochrome-based optogenetic system controllable with near-infrared light. Nat Methods (2016) 0.94

Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines. Cytoskeleton (Hoboken) (2012) 0.93

Drosophila cyfip regulates synaptic development and endocytosis by suppressing filamentous actin assembly. PLoS Genet (2013) 0.93

Impaired caveolae function and upregulation of alternative endocytic pathways induced by experimental modulation of intersectin-1s expression in mouse lung endothelium. Biochem Res Int (2012) 0.91

Caenorhabditis elegans intersectin: a synaptic protein regulating neurotransmission. Mol Biol Cell (2007) 0.91

Pleiotropic function of intersectin homologue Cin1 in Cryptococcus neoformans. Mol Microbiol (2010) 0.91

Signal-dependent distribution of cell surface P-selectin in clathrin-coated pits affects leukocyte rolling under flow. J Cell Biol (2003) 0.90

Fbx8 makes Arf6 refractory to function via ubiquitination. Mol Biol Cell (2007) 0.90

Endocytosis via caveolae: alternative pathway with distinct cellular compartments to avoid lysosomal degradation? J Cell Mol Med (2009) 0.89

Presynaptic active zones in invertebrates and vertebrates. EMBO Rep (2015) 0.88

Self-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down Syndrome. PLoS One (2015) 0.87

The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. PLoS One (2010) 0.87

Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis. Front Endocrinol (Lausanne) (2013) 0.86

The development of a novel high throughput computational tool for studying individual and collective cellular migration. PLoS One (2013) 0.85

Regulation of dynamin-2 assembly-disassembly and function through the SH3A domain of intersectin-1s. J Cell Mol Med (2011) 0.85

The epsin protein family: coordinators of endocytosis and signaling. Biomol Concepts (2012) 0.85

Emerging roles for intersectin (ITSN) in regulating signaling and disease pathways. Int J Mol Sci (2013) 0.84

Intersectin 1 is required for neuroblastoma tumorigenesis. Oncogene (2012) 0.84

Rescue of glandular dysmorphogenesis in PTEN-deficient colorectal cancer epithelium by PPARγ-targeted therapy. Oncogene (2012) 0.84

The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP). Cell Microbiol (2012) 0.84

Cortactin is a substrate of activated Cdc42-associated kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation. PLoS One (2012) 0.84

Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction. Mol Cell Biol (2011) 0.83

Regulation of membrane trafficking by a novel Cdc42-related protein in Caenorhabditis elegans epithelial cells. Mol Biol Cell (2005) 0.83

Listeria monocytogenes antagonizes the human GTPase Cdc42 to promote bacterial spread. Cell Microbiol (2014) 0.83

Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction. J Biol Chem (2017) 0.83

Regulation of synaptojanin 2 5'-phosphatase activity by Src. Cell Adh Migr (2012) 0.82

The endocytic adaptor proteins of pathogenic fungi: charting new and familiar pathways. Med Mycol (2011) 0.82

RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase. Curr Mol Med (2014) 0.78

Autoinhibition of GEF activity in Intersectin 1 is mediated by the short SH3-DH domain linker. Protein Sci (2010) 0.78

Cancer Stem Cells and Radioresistance: Rho/ROCK Pathway Plea Attention. Stem Cells Int (2016) 0.78

A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode. PLoS One (2013) 0.77

CDC42 Use in Viral Cell Entry Processes by RNA Viruses. Viruses (2015) 0.77

Phosphorylation-dependent Regulation of Connecdenn/DENND1 Guanine Nucleotide Exchange Factors. J Biol Chem (2015) 0.76

Host endoplasmic reticulum COPII proteins control cell-to-cell spread of the bacterial pathogen Listeria monocytogenes. Cell Microbiol (2015) 0.76

Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. J Virol (2016) 0.76

Spatial control of active CDC-42 during collective migration of hypodermal cells in Caenorhabditis elegans. J Mol Cell Biol (2015) 0.76

ITSN2L Interacts with and Negatively Regulates RABEP1. Int J Mol Sci (2015) 0.76

Articles by these authors

Mutation nomenclature extensions and suggestions to describe complex mutations: a discussion. Hum Mutat (2000) 13.25

The DNA sequence of human chromosome 21. Nature (2000) 10.66

Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster. Nature (1982) 9.47

Nonuniform recombination within the human beta-globin gene cluster. Am J Hum Genet (1984) 7.97

Nomenclature for the description of human sequence variations. Hum Genet (2001) 7.90

Tubular membrane invaginations coated by dynamin rings are induced by GTP-gamma S in nerve terminals. Nature (1995) 7.81

Beta-globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man. Proc Natl Acad Sci U S A (1983) 6.50

Scaling the microrheology of living cells. Phys Rev Lett (2001) 6.32

Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man. Nature (1988) 6.01

Nonrandom association of polymorphic restriction sites in the beta-globin gene cluster. Proc Natl Acad Sci U S A (1982) 5.85

Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein. Nature (1979) 5.48

Positional cloning of the APECED gene. Nat Genet (1997) 5.47

Nonmuscle actin-binding proteins. Annu Rev Cell Biol (1985) 5.46

A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein. Nature (1990) 5.42

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene. Proc Natl Acad Sci U S A (1991) 4.84

Actin-binding protein requirement for cortical stability and efficient locomotion. Science (1992) 4.66

Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell (1995) 4.39

Phosphoinositides as regulators in membrane traffic. Science (1996) 4.13

Inversions disrupting the factor VIII gene are a common cause of severe haemophilia A. Nat Genet (1993) 4.12

Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate. Nature (1987) 3.99

OMIM passes the 1,000-disease-gene mark. Nat Genet (2000) 3.92

Interactions of actin, myosin, and a new actin-binding protein of rabbit pulmonary macrophages. II. Role in cytoplasmic movement and phagocytosis. J Cell Biol (1976) 3.84

Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. J Cell Biol (1990) 3.76

Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A. Nat Genet (1995) 3.74

The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome. Proc Natl Acad Sci U S A (1990) 3.72

Phagocytosis: recognition and ingestion. Semin Hematol (1975) 3.63

Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain. Nature (1986) 3.50

Isolation and properties of actin, myosin, and a new actinbinding protein in rabbit alveolar macrophages. J Biol Chem (1975) 3.41

Isolation and properties of phagocytic vesicles from polymorphonuclear leukocytes. J Clin Invest (1971) 3.39

Quantitative studies of phagocytosis. Kinetic effects of cations and heat-labile opsonin. J Cell Biol (1973) 3.14

Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J Nerv Ment Dis (1994) 3.12

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell (1995) 3.08

Interactions between actin, myosin, and an actin-binding protein from rabbit alveolar macrophages. Alveolar macrophage myosin Mg-2+-adenosine triphosphatase requires a cofactor for activation by actin. J Biol Chem (1975) 2.88

Quantitative studies of phagocytosis by polymorphonuclear leukocytes: use of emulsions to measure the initial rate of phagocytosis. J Clin Invest (1972) 2.88

The small GTPase RalA targets filamin to induce filopodia. Proc Natl Acad Sci U S A (1999) 2.87

Cytochalasin B and the structure of actin gels. J Mol Biol (1979) 2.81

Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells. Proc Natl Acad Sci U S A (2006) 2.80

Ca2+ control of actin gelation. Interaction of gelsolin with actin filaments and regulation of actin gelation. J Biol Chem (1980) 2.73

A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals. Proc Natl Acad Sci U S A (1996) 2.70

Resemblance of actin-binding protein/actin gels to covalently crosslinked networks. Nature (1990) 2.58

Myosin in polymorphonuclear leukocytes. J Biol Chem (1973) 2.55

Contractile proteins in leukocyte function. Semin Hematol (1983) 2.55

Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets. Curr Biol (2000) 2.52

The opsonic fragment of the third component of human complement (C3). J Exp Med (1975) 2.51

Recurrent mutations in haemophilia A give evidence for CpG mutation hotspots. Nature (1987) 2.49

SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation. Nat Cell Biol (1999) 2.48

Distribution of actin-binding protein and myosin in macrophages during spreading and phagocytosis. J Cell Biol (1980) 2.45

Interactions of actin, myosin, and an actin-binding protein of rabbit pulmonary macrophages. III. Effects of cytochalasin B. J Cell Biol (1976) 2.42

Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCgamma, Crk, and Grb2. Proc Natl Acad Sci U S A (1996) 2.41

Phagocytosis (third of three parts). N Engl J Med (1974) 2.41

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene. Nat Genet (1992) 2.40

Two patients with cystic fibrosis, nonsense mutations in each cystic fibrosis gene, and mild pulmonary disease. N Engl J Med (1990) 2.37

Neutrophil action dysfunction and abnormal neutrophil behavior. N Engl J Med (1974) 2.35

An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein. N Engl J Med (1980) 2.32

Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. J Cell Biol (2001) 2.29

Myeloperoxidase-mediated iodination by granulocytes. Intracellular site of operation and some regulating factors. J Clin Invest (1974) 2.28

Polycythemia in transgenic mice expressing the human erythropoietin gene. Proc Natl Acad Sci U S A (1989) 2.27

Evidence for reduced recombination on the nondisjoined chromosomes 21 in Down syndrome. Science (1987) 2.27

The gelation of actin by actin-binding protein. J Biol Chem (1978) 2.27

Enhanced motility in NIH 3T3 fibroblasts that overexpress gelsolin. Science (1991) 2.26

Serum-dependent phagocytosis of paraffin oil emulsified with bacterial lipopolysaccharide. J Exp Med (1973) 2.25

Evaluation of opsonic and leukocyte function with a spectrophotometric test in patients with infection and with phagocytic disorders. Blood (1973) 2.25

Evidence for multiple origins of the beta E-globin gene in Southeast Asia. Proc Natl Acad Sci U S A (1982) 2.24

Gelsolin is a downstream effector of rac for fibroblast motility. EMBO J (1998) 2.23

The mechanical properties of actin gels. Elastic modulus and filament motions. J Biol Chem (1994) 2.23

Actin-binding protein promotes the bipolar and perpendicular branching of actin filaments. J Cell Biol (1980) 2.22

Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature (2011) 2.22

The Ca2+-release channel/ryanodine receptor is localized in junctional and corbular sarcoplasmic reticulum in cardiac muscle. J Cell Biol (1993) 2.18

Laryngeal atresia type III (glottic web) with 22q11.2 microdeletion: report of three patients. Am J Med Genet (1997) 2.17

Molecular genetic approach to the characterization of the "Down syndrome region" of chromosome 21. Genomics (1989) 2.16

Interactions of gelsolin and gelsolin-actin complexes with actin. Effects of calcium on actin nucleation, filament severing, and end blocking. Biochemistry (1985) 2.16

Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol (1996) 2.15

Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains. J Biol Chem (1998) 2.13

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina. Proc Natl Acad Sci U S A (1991) 2.10

Dodecamer repeat expansion in cystatin B gene in progressive myoclonus epilepsy. Nature (1997) 2.09

DNA polymorphism and molecular pathology of the human globin gene clusters. Hum Genet (1985) 2.09

Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proc Natl Acad Sci U S A (1991) 2.09

Phosphatidylinositol polyphosphate binding to the mammalian septin H5 is modulated by GTP. Curr Biol (2000) 2.09

Polyphosphoinositide micelles and polyphosphoinositide-containing vesicles dissociate endogenous gelsolin-actin complexes and promote actin assembly from the fast-growing end of actin filaments blocked by gelsolin. J Biol Chem (1987) 2.08

Ca2+ control of actin filament length. Effects of macrophage gelsolin on actin polymerization. J Biol Chem (1981) 2.07

Prenatal diagnosis using DNA polymorphisms. Report on 95 pregnancies at risk for sickle-cell disease or beta-thalassemia. N Engl J Med (1983) 2.06

Purification and structural properties of gelsolin, a Ca2+-activated regulatory protein of macrophages. J Biol Chem (1980) 2.06

Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness. Nat Genet (2001) 2.06

Molecular characterization of seven beta-thalassemia mutations in Asian Indians. EMBO J (1984) 2.04

Structure of macrophage actin-binding protein molecules in solution and interacting with actin filaments. J Mol Biol (1981) 2.04

Distribution of actin-binding protein and myosin in polymorphonuclear leukocytes during locomotion and phagocytosis. Cell (1981) 2.03

rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin. J Cell Biol (1995) 2.02

Prevention of degradation of human polymorphonuclear leukocyte proteins by diisopropylfluorophosphate. Blood (1980) 2.01

Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation. Mol Biol Cell (2000) 2.00

Origin of the beta S-globin gene in blacks: the contribution of recurrent mutation or gene conversion or both. Proc Natl Acad Sci U S A (1984) 2.00

Structure and mobility of actin filaments as measured by quasielastic light scattering, viscometry, and electron microscopy. J Biol Chem (1986) 1.99

Abnormal RNA processing due to the exon mutation of beta E-globin gene. Nature (1982) 1.98

Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity. Am J Hum Genet (1998) 1.98

Regulation of glycogen metabolism in polymorphonuclear leukocytes. J Biol Chem (1970) 1.98

Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc Natl Acad Sci U S A (1997) 1.97

Reversible binding of actin to gelsolin and profilin in human platelet extracts. J Cell Biol (1987) 1.97

Phagocytosis in chronic granulomatous disease and the Chediak-Higashi syndrome. N Engl J Med (1972) 1.96