Engineering chromosomal rearrangements in mice.

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev (2008) 4.38

AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell (2008) 4.13

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med (2010) 2.81

Genomic disorders on 22q11. Am J Hum Genet (2002) 2.63

N-ethyl-N-nitrosourea mutagenesis: boarding the mouse mutant express. Microbiol Mol Biol Rev (2005) 1.54

A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes. Proc Natl Acad Sci U S A (2009) 1.47

Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: phenotypic consequences of gene dosage imbalance. Mol Cell Biol (2003) 1.42

Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3. PLoS One (2010) 1.37

Tools for fungal proteomics: multifunctional neurospora vectors for gene replacement, protein expression and protein purification. Genetics (2009) 1.31

Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives. Genome Biol (2007) 1.29

Inactivation of the F4/80 glycoprotein in the mouse germ line. Mol Cell Biol (2002) 1.18

Enzymatic engineering of the porcine genome with transposons and recombinases. BMC Biotechnol (2007) 1.14

Contemporary approaches for modifying the mouse genome. Physiol Genomics (2008) 1.10

Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9. J Mol Cell Biol (2015) 1.07

Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line. Biochem Biophys Res Commun (2007) 1.07

The mouse genetics toolkit: revealing function and mechanism. Genome Biol (2011) 1.05

Enhanced cell-permeant Cre protein for site-specific recombination in cultured cells. BMC Biotechnol (2004) 1.04

Crystal structure of a wild-type Cre recombinase-loxP synapse reveals a novel spacer conformation suggesting an alternative mechanism for DNA cleavage activation. Nucleic Acids Res (2003) 1.04

The Saccharomyces cerevisiae SCRaMbLE system and genome minimization. Bioeng Bugs (2012) 1.00

Rearranging the centromere of the human Y chromosome with phiC31 integrase. Nucleic Acids Res (2005) 0.99

Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet (2011) 0.97

Mouse models for Down syndrome-associated developmental cognitive disabilities. Dev Neurosci (2011) 0.95

Modeling chromosomes in mouse to explore the function of genes, genomic disorders, and chromosomal organization. PLoS Genet (2006) 0.95

Modeling multiple sclerosis in laboratory animals. Semin Immunopathol (2009) 0.94

Retinoic Acid Induced 1, RAI1: A Dosage Sensitive Gene Related to Neurobehavioral Alterations Including Autistic Behavior. Curr Genomics (2010) 0.93

An efficient method to generate chromosomal rearrangements by targeted DNA double-strand breaks in Drosophila melanogaster. Genome Res (2004) 0.92

Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model. Drug Metab Dispos (2012) 0.92

Spontaneous lung dysfunction and fibrosis in mice lacking connexin 40 and endothelial cell connexin 43. Am J Pathol (2011) 0.92

Recombination between inverted loxP sites is cytotoxic for proliferating cells and provides a simple tool for conditional cell ablation. Proc Natl Acad Sci U S A (2008) 0.91

Modulation of the active complex assembly and turnover rate by protein-DNA interactions in Cre-LoxP recombination. Biochemistry (2003) 0.90

Mouse models of genomic syndromes as tools for understanding the basis of complex traits: an example with the smith-magenis and the potocki-lupski syndromes. Curr Genomics (2009) 0.90

Mouse chromosome engineering for modeling human disease. Annu Rev Genomics Hum Genet (2006) 0.90

Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos. FEBS Open Bio (2014) 0.87

Inducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombination. Genetics (2008) 0.86

Excision of a viral reprogramming cassette by delivery of synthetic Cre mRNA. Curr Protoc Stem Cell Biol (2012) 0.85

Skeletal defects in Osterix-Cre transgenic mice. Transgenic Res (2014) 0.85

Conditional gene manipulation: Cre-ating a new biological era. J Zhejiang Univ Sci B (2012) 0.85

The neurobiology of mouse models syntenic to human chromosome 15q. J Neurodev Disord (2011) 0.85

Bone morphogenetic protein signaling transcription factor (SMAD) function in granulosa cells. Mol Cell Endocrinol (2011) 0.84

Site-specific recombination for genetic engineering in plants. Plant Cell Rep (2003) 0.83

Engineered chromosome-based genetic mapping establishes a 3.7 Mb critical genomic region for Down syndrome-associated heart defects in mice. Hum Genet (2013) 0.81

A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice. Genetics (2006) 0.81

Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife (2016) 0.80

Modelling human regulatory variation in mouse: finding the function in genome-wide association studies and whole-genome sequencing. PLoS Genet (2012) 0.80

Live cell detection of chromosome 2 deletion and Sfpi1/PU1 loss in radiation-induced mouse acute myeloid leukaemia. Leuk Res (2013) 0.79

Genetic dissection of the Down syndrome critical region. Hum Mol Genet (2015) 0.79

Mouse models for cancer research. Chin J Cancer (2011) 0.79

Induction of cre recombinase activity using modified androgen receptor ligand binding domains: a sensitive assay for ligand-receptor interactions. Nucleic Acids Res (2003) 0.79

Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein. Transgenic Res (2016) 0.78

Neurodegeneration and early lethality in superoxide dismutase 2-deficient mice: a comprehensive analysis of the central and peripheral nervous systems. Neuroscience (2012) 0.78

Generation and analysis of partially haploid cells with Cre-mediated chromosome deletion in the lymphoid system. J Biol Chem (2010) 0.78

Targeted genome engineering in Caenorhabditis elegans. Cell Biosci (2016) 0.78

Somatic Engineering of Oncogenic Chromosomal Rearrangements: A Perspective. Cancer Res (2016) 0.77

Split hand/foot malformation genetics supports the chromosome 7 copy segregation mechanism for human limb development. Philos Trans R Soc Lond B Biol Sci (2016) 0.77

Intron-based genomic editing: a highly efficient method for generating knockin zebrafish. Oncotarget (2015) 0.77

Controlled somatic and germline copy number variation in the mouse model. Curr Genomics (2010) 0.76

Newer approaches to genetic modeling in mice: tissue-specific protein expression as studied using angiotensin-converting enzyme (ACE). Am J Pathol (2003) 0.76

Reduced levels of dopamine and altered metabolism in brains of HPRT knock-out rats: a new rodent model of Lesch-Nyhan Disease. Sci Rep (2016) 0.75

One-step generation of mice carrying a conditional allele together with an HA-tag insertion for the delta opioid receptor. Sci Rep (2017) 0.75

Mouse-based genetic modeling and analysis of Down syndrome. Br Med Bull (2016) 0.75

Unraveling the genetic architecture of copy number variants associated with schizophrenia and other neuropsychiatric disorders. J Neurosci Res (2016) 0.75

Phylooncogenomics: Examining the cancer genome in the context of vertebrate evolution. Appl Transl Genom (2013) 0.75

All-in-one construct for genome engineering using Cre-lox technology. DNA Res (2016) 0.75

Generation of NSE-MerCreMer transgenic mice with tamoxifen inducible Cre activity in neurons. PLoS One (2012) 0.75

Revealing hidden complexities of genomic rearrangements generated with Cas9. Sci Rep (2017) 0.75

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature (1992) 25.54

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science (1993) 14.91

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell (1991) 14.89

p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature (1999) 13.21

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev (2000) 11.49

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell (1990) 10.99

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (1995) 8.68

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature (1992) 8.16

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature (1997) 8.04

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature (1993) 6.75

Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature (1984) 6.54

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat Genet (1996) 6.06

p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science (1995) 6.01

A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development (1999) 5.85

Impaired energy homeostasis in C/EBP alpha knockout mice. Science (1995) 5.68

Chromosome engineering in mice. Nature (1995) 5.48

Increased bone formation in osteocalcin-deficient mice. Nature (1996) 4.91

The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature (1999) 4.74

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector. Nature (1986) 4.73

Requirement for Wnt3 in vertebrate axis formation. Nat Genet (1999) 4.68

Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell (2001) 4.61

Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature (2001) 4.41

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene (1993) 4.03

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development (1996) 3.91

Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat Genet (1993) 3.85

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev (1995) 3.84

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature (1991) 3.83

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev (1993) 3.60

Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci U S A (1993) 3.57

Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature (1992) 3.54

Gene targeting in embryonic stem cells. Methods Enzymol (1993) 3.41

Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet (1995) 3.29

Cancer predisposition caused by elevated mitotic recombination in Bloom mice. Nat Genet (2000) 3.28

Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells. Mol Cell Biol (1991) 3.25

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J (1998) 3.12

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Natl Acad Sci U S A (1999) 3.06

Genomic DNA microextraction: a method to screen numerous samples. Anal Biochem (1992) 3.05

Multiple defects and perinatal death in mice deficient in follistatin. Nature (1995) 2.96

The length of homology required for gene targeting in embryonic stem cells. Mol Cell Biol (1991) 2.75

Mouse ENU mutagenesis. Hum Mol Genet (1999) 2.72

Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells. Proc Natl Acad Sci U S A (1998) 2.71

Functional analysis of activins during mammalian development. Nature (1995) 2.71

The tumor suppressor p53. Biochim Biophys Acta (1993) 2.65

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell (1993) 2.62

Different phenotypes for mice deficient in either activins or activin receptor type II. Nature (1995) 2.62

Congenital heart disease in mice deficient for the DiGeorge syndrome region. Nature (1999) 2.60

Genetic background alters the spectrum of tumors that develop in p53-deficient mice. FASEB J (1993) 2.57

Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments. Cell (1993) 2.45

Disruption of muscle architecture and myocardial degeneration in mice lacking desmin. J Cell Biol (1996) 2.44

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes Dev (1995) 2.41

A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature (1987) 2.33

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat Genet (1998) 2.32

Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol (1993) 2.32

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc Natl Acad Sci U S A (1995) 2.27

The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell (1992) 2.27

Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients. Lancet (1998) 2.26

Clinical and pharmacological properties of ivermectin in rabbits and guinea pigs. Vet Rec (1992) 2.21

Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene (1994) 2.20

Effects of genetic background on tumorigenesis in p53-deficient mice. Mol Carcinog (1995) 2.18

The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages. Genes Dev (1995) 2.07

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc Natl Acad Sci U S A (1998) 2.00

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev (1994) 1.99

Impaired vascular contractility and blood pressure homeostasis in the smooth muscle alpha-actin null mouse. FASEB J (2000) 1.91

Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1. Nature (1997) 1.89

Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. Proc Natl Acad Sci U S A (1994) 1.88

The role and fate of DNA ends for homologous recombination in embryonic stem cells. Mol Cell Biol (1992) 1.71

Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applications. Mol Cell Biol (2000) 1.71

A randomized, controlled trial of routine early abdominal computed tomography in patients presenting with non-specific acute abdominal pain. Clin Radiol (2007) 1.70

Engineering a mouse balancer chromosome. Nat Genet (1999) 1.68

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Proc Natl Acad Sci U S A (1996) 1.62

Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes. J Immunol (1999) 1.61

A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice. Nucleic Acids Res (1999) 1.61

A clone-array pooled shotgun strategy for sequencing large genomes. Genome Res (2001) 1.60

Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice. Proc Natl Acad Sci U S A (1994) 1.60

High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC. Nature (1995) 1.57

Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. Dev Biol (1999) 1.55

The effects of contrast on visual orientation and spatial frequency discrimination: a comparison of single cells and behavior. J Neurophysiol (1987) 1.51

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice. Nat Genet (1995) 1.49

Optical and visual impact of tear break-up in human eyes. Invest Ophthalmol Vis Sci (2000) 1.49

Visual orientation and spatial frequency discrimination: a comparison of single neurons and behavior. J Neurophysiol (1987) 1.49

A new positive/negative selectable marker, puDeltatk, for use in embryonic stem cells. Genesis (2000) 1.49

An anchored framework BAC map of mouse chromosome 11 assembled using multiplex oligonucleotide hybridization. Genomics (1998) 1.46

The chromatic eye: a new reduced-eye model of ocular chromatic aberration in humans. Appl Opt (1992) 1.41

Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics (1998) 1.41

Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin. Cancer Res (1995) 1.40

The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis. Mol Cell Biol (2005) 1.40

Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice. Nat Genet (2001) 1.38

Recycling selectable markers in mouse embryonic stem cells. Mol Cell Biol (1996) 1.34

Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed. Genes Dev (1995) 1.34

Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory. Neuroscience (2002) 1.33

How reliable are commercial allergy tests? Lancet (1987) 1.32

Outcomes of hand surgery. British Society for Surgery of the Hand. J Hand Surg Br (1995) 1.31

Targeting frequency for deletion vectors in embryonic stem cells. Mol Cell Biol (1994) 1.29

From mouse to man: generating megabase chromosome rearrangements. Trends Genet (2001) 1.25

Theory and measurement of ocular chromatic aberration. Vision Res (1990) 1.22

A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus. Hum Mol Genet (1993) 1.22

Requirement of the paraxis gene for somite formation and musculoskeletal patterning. Nature (1996) 1.18

IgA class switch in I alpha exon-deficient mice. Role of germline transcription in class switch recombination. J Clin Invest (1996) 1.17

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Contrast sensitivity in anisometropic amblyopia. Invest Ophthalmol Vis Sci (1981) 1.14